Defoaming device for reduced pressure distillation of low-boiling-point feed liquid of liquid preparation system

Abstract

The utility model relates to the technical field of defoaming devices, one embodiment of the utility model provides a defoaming device for reduced pressure distillation of low-boiling-point feed liquid of a liquid preparation system, and the defoaming device is characterized by comprising a shell, a stirring shaft, a stirring paddle and a defoaming paddle, the stirring shaft is rotatably arranged in the shell; the stirring paddle is arranged on the periphery of the stirring shaft; the defoaming paddle is arranged on the stirring shaft and located above the stirring paddle, and defoaming teeth are arranged at the bottom of the defoaming paddle. According to the technical scheme, the problem that in a biological liquid preparation system in the related technology, during purification, the material liquid with the low boiling point is prone to bumping is solved.

Description

TECHNICAL FIELD

[0001] Embodiments of the present disclosure relate to the technical field of defoaming device, in particular, to a defoaming device for low-boiling-point feed liquid in a liquid preparation system. BACKGROUND

[0002] In a biological liquid preparation system, vacuum distillation is used to purify products. During the purification, low-boiling-point feed liquid is prone to violent boiling. When the feed liquid violently boils, it will overflow from the container, which not only causes loss of the feed liquid, but also pollutes the surrounding equipment and environment, and may even enter the vacuum system, affecting the normal operation of the vacuum system. CONTENT

[0003] To overcome the above defects, embodiments of the present disclosure provide a defoaming device for low-boiling-point feed liquid in a liquid preparation system, which solves the problem of violent boiling of low-boiling-point feed liquid in a biological liquid preparation system during purification in the related art.

[0004] According to one aspect, at least one embodiment of the present disclosure provides a defoaming device for low-boiling-point feed liquid in a liquid preparation system, comprising,

[0005] a shell,

[0006] a stirring shaft rotatably arranged in the shell;

[0007] a stirring paddle arranged on the periphery of the stirring shaft;

[0008] a defoaming paddle arranged on the stirring shaft above the stirring paddle, the bottom of the defoaming paddle having defoaming teeth.

[0009] According to another aspect, at least one embodiment of the present disclosure also provides a defoaming device for low-boiling-point feed liquid in a liquid preparation system, the longitudinal cross-sectional shape of the defoaming teeth is sawtooth-shaped, needle-shaped or hook-shaped.

[0010] According to another aspect, at least one embodiment of the present disclosure also provides a defoaming device for low-boiling-point feed liquid in a liquid preparation system, the number of stirring paddles is two, and arranged in an up-down direction, the end of the lower stirring paddle away from the stirring shaft is bent upward, and the end of the upper stirring paddle away from the stirring shaft is bent downward.

[0011] According to another aspect, at least one embodiment of the present disclosure also provides a defoaming device for low-boiling-point feed liquid in a liquid preparation system, further comprising,

[0012] a liquid level switch arranged on the shell above the defoaming paddle, the liquid level switch being electrically connected to the control module.

[0013] A vacuum degree regulating valve, an inlet end of the vacuum degree regulating valve being in communication with the inside of the shell, a controlled end of the vacuum degree regulating valve being used for electrical connection with the control module.

[0014] According to another aspect, the disclosure at least one embodiment also provides a defoaming device for low-boiling-point feed liquid vacuum distillation of a liquid preparation system, further comprising,

[0015] A pneumatic valve, one end of the pneumatic valve being in communication with the inside of the shell;

[0016] A filter, the other end of the pneumatic valve being in communication with one end of the filter, the other end of the filter being in communication with the inlet end of the vacuum degree regulating valve.

[0017] According to another aspect, the disclosure at least one embodiment also provides a defoaming device for low-boiling-point feed liquid vacuum distillation of a liquid preparation system, further comprising a nitrogen valve, the outlet end of the nitrogen valve and the inlet end of the vacuum degree regulating valve both being in communication with the same end of the filter.

[0018] According to another aspect, the disclosure at least one embodiment also provides a defoaming device for low-boiling-point feed liquid vacuum distillation of a liquid preparation system, further comprising,

[0019] A temperature control jacket, the temperature control jacket being arranged outside the shell;

[0020] A liquid inlet valve, one end of the liquid inlet valve being used for communication with a liquid outlet of a TCU temperature control system, the other end of the liquid inlet valve being in communication with the inside of the temperature control jacket;

[0021] A liquid return valve, one end of the liquid return valve being in communication with the inside of the temperature control jacket, the other end of the liquid return valve being used for communication with a liquid return of the TCU temperature control system.

[0022] According to another aspect, the disclosure at least one embodiment also provides a defoaming device for low-boiling-point feed liquid vacuum distillation of a liquid preparation system, further comprising a heat preservation layer, the heat preservation layer being arranged outside the temperature control jacket.

[0023] According to another aspect, the disclosure at least one embodiment also provides a defoaming device for low-boiling-point feed liquid vacuum distillation of a liquid preparation system, further comprising a cleaning and sterilization valve, an inlet of the cleaning and sterilization valve being used for communication with a cleaning and sterilization pump, an outlet of the cleaning and sterilization valve being in communication with the inside of the shell.

[0024] According to another aspect, the disclosure also provides a defoaming device for low-boiling-point feed liquid in a liquid preparation system, which comprises a shell, a stirring shaft, a stirring paddle, a defoaming paddle, a defoaming tooth, a liquid level switch, a vacuum degree adjusting valve, a pneumatic valve, a filter, a nitrogen valve, a temperature control jacket, an inlet valve, a return valve, an insulation layer, a cleaning and sterilizing valve, and a spray ball.

[0025] The embodiment of the disclosure has the following beneficial effects: the stirring shaft rotates in the shell; the stirring paddle is arranged on the periphery of the stirring shaft; the defoaming paddle is arranged on the stirring shaft and above the stirring paddle, and the bottom of the defoaming paddle is provided with the defoaming tooth. The rotation of the stirring shaft drives the stirring paddle and the defoaming paddle to rotate. The rotation of the stirring paddle can form convection in the shell, so that the feed liquid is fully mixed, and the feed liquid can be heated more uniformly during the vacuum distillation process, thereby reducing the risk of boiling caused by local high temperature. After the bubbles are generated, the rotation of the stirring shaft and the stirring paddle can also play a role in defoaming. When the foam level rises to the defoaming paddle, the defoaming tooth at the bottom of the defoaming paddle can penetrate into the foam layer to destroy the surface tension of the foam, thereby breaking the foam for secondary defoaming. The probability of overflow of the feed liquid from the shell can be effectively reduced, the loss of the feed liquid can be greatly reduced, the yield during the product purification process can be ensured, and the production efficiency and economic benefits can be improved. The feed liquid will not overflow, so it will not pollute the surrounding equipment and environment, and the production environment can be kept clean and safe. When the feed liquid does not overflow, the feed liquid will not be sucked into the vacuum system, so that the normal operation of the vacuum system can be ensured, and the cost of equipment maintenance and replacement can be reduced. BRIEF DESCRIPTION OF DRAWINGS

[0026] In order to more clearly illustrate the technical solutions in the embodiments of the disclosure, the following will briefly introduce the drawings needed in the description of the embodiments of the disclosure. Obviously, the drawings in the following description are only some example embodiments of the disclosure. Those skilled in the art can obtain other drawings according to the content of the example embodiments of the disclosure and these drawings without creating any inventive labor.

[0027] Figure 1 The structural schematic diagram of one embodiment of the disclosure.

[0028] In the figure: 1, shell, 2, stirring shaft, 3, stirring paddle, 4, defoaming paddle, 5, defoaming tooth, 6, liquid level switch, 7, vacuum degree adjusting valve, 8, pneumatic valve, 9, filter, 10, nitrogen valve, 11, temperature control jacket, 12, inlet valve, 13, return valve, 14, insulation layer, 15, cleaning and sterilizing valve, 16, spray ball, 17, rotary drive mechanism. DETAILED DESCRIPTION

[0029] The present disclosure will be further described in details with reference to the drawings and examples. It can be understood that the specific examples described herein are merely used to explain the present disclosure, but not to limit the present disclosure.

[0030] For the simplicity of the drawings, only the parts related to the disclosure are shown in each drawing, and they do not represent the actual structure of the product. In addition, for the simplicity of the drawings and easy understanding, in some drawings, only one of the parts with the same structure or function is shown schematically, or only one of them is marked. In this document, "one" not only means "only one", but also means "more than one", and "several" includes "two" and "more than two".

[0031] In this document, it should be noted that, unless otherwise specified and limited, the terms "mounting", "connecting", "connection" should be understood broadly, for example, it can be fixed connection, or detachable connection, or integrally connected; it can be mechanical connection, or electrical connection; it can be directly connected, or indirectly connected through intermediate medium, or the communication inside two elements. For those skilled in the art, the specific meaning of the above terms in the present disclosure can be understood according to the specific circumstances.

[0032] In the present disclosure, unless otherwise specified and limited, the "upper" or "lower" of the first feature to the second feature can include that the first and second features are in direct contact, or that the first and second features are not in direct contact but are in contact through another feature between them. Moreover, the "upper", "above" and "on" of the first feature to the second feature includes that the first feature is directly above and obliquely above the second feature, or only means that the horizontal height of the first feature is higher than that of the second feature. The "under", "below" and "under" of the first feature to the second feature includes that the first feature is directly below and obliquely below the second feature, or only means that the horizontal height of the first feature is less than that of the second feature.

[0033] In the description of the present embodiment, the terms "upper", "lower", "left", "right" and other orientation or position relationship are based on the orientation or position relationship shown in the drawings, which are only for the convenience of description and simplification of operation, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation of the present disclosure.

[0034] In addition, in the description of the present application, the terms "first", "second" and the like are only used to distinguish the description, and cannot be understood as indicating or implying relative importance.

[0035] As Figure 1As shown, it shows a defoaming device for low-boiling-point feed liquid in a liquid preparation system in an embodiment of the present disclosure, which includes a shell 1, a stirring shaft 2, a stirring paddle 3, a defoaming paddle 4, and the stirring shaft 2 is rotatably arranged in the shell 1; the stirring paddle 3 is arranged on the periphery of the stirring shaft 2; the defoaming paddle 4 is arranged on the stirring shaft 2 and above the stirring paddle 3, and the bottom of the defoaming paddle 4 is provided with defoaming teeth 5.

[0036] In the present disclosure, the rotating drive mechanism 17 can drive the stirring shaft 2 to rotate in the shell 1, and the stirring shaft 2 drives the stirring paddle 3 and the defoaming paddle 4 to rotate. The rotation of the stirring paddle 3 can form convection in the shell 1, so that the feed liquid is fully mixed, and the feed liquid can be heated more uniformly during the vacuum distillation process, reducing the risk of local overheating, thereby reducing the risk of boiling caused by local high temperature to a certain extent. After the bubbles begin to form, the rotation of the stirring shaft 2 and the stirring paddle 3 can also have a defoaming effect. When the foam level rises to the defoaming paddle 4, the defoaming teeth 5 at the bottom of the defoaming paddle 4 can penetrate into the foam layer, destroy the surface tension of the foam, and thus break the foam for secondary defoaming. It can effectively reduce the probability of feed liquid overflowing from the shell 1, greatly reduce the loss of feed liquid, ensure the yield during product purification, and has important significance for improving production efficiency and economic benefits. The feed liquid will not overflow, so it will not pollute the surrounding equipment and environment, and can keep the production environment clean and safe. When the feed liquid does not overflow, the feed liquid will not be sucked into the vacuum system, thereby ensuring the normal operation of the vacuum system, and reducing the cost of equipment maintenance and replacement.

[0037] In some examples, the longitudinal section shape of the defoaming teeth 5 is sawtooth-shaped, needle-shaped or hook-shaped. The tooth tip of the sawtooth-shaped defoaming teeth 5 is relatively sharp at the lower end, and such shape can easily pierce the foam and destroy its surface tension when inserted into the foam layer, so that it breaks and dissipates. Moreover, such shape can continuously contact the foam at different positions and play a defoaming role during rotation. The needle-shaped defoaming teeth 5 are relatively slender and sharp, and can accurately penetrate into the foam. For relatively fine foam, the needle-shaped structure can easily penetrate the thin wall of the foam, destroy its structural stability, and make the foam difficult to maintain its original shape and break, so that a better defoaming effect can be achieved. The lower end of the hook-shaped defoaming teeth 5 is bent into a hook shape. After being inserted into the foam layer, the hook-shaped part can pull the foam under the action of the rotation of the stirring paddle 3, overcome the viscosity of the foam, further destroy the integrity of the foam, accelerate its rupture, and more effectively achieve the purpose of defoaming and prevent foam accumulation.

[0038] The defoaming teeth 5 can be evenly distributed in a straight line along the bottom edge of the defoaming paddle 4. For example, at the bottom of a long strip of defoaming paddle 4, a defoaming tooth 5 is set at a certain distance along the length of the defoaming paddle 4. All the defoaming teeth 5 are arranged in a straight line. This arrangement ensures that when the stirring shaft 2 drives the defoaming paddle 4 to rotate, no matter which angle it contacts the foam layer, there will be evenly distributed defoaming teeth 5 to deal with the foam, and there will be no situation where the foam cannot be dealt with locally.

[0039] The defoaming teeth 5 can also be arranged in a staggered pattern, similar to fish scales. For example, at the bottom of a long strip of defoaming paddle 4, at least two rows of defoaming teeth 5 are arranged along the width of the defoaming paddle 4. All the defoaming teeth 5 in the same row are arranged at intervals along the length of the defoaming paddle 4. The defoaming teeth 5 in adjacent rows are staggered. This arrangement can increase the density of contact between the defoaming teeth 5 and the foam layer. During rotation, it can more comprehensively cover the foam layer. Especially for cases where the amount of foam generated is large and the foam layer is thick, the staggered defoaming teeth 5 can more fully destroy the foam and improve the defoaming efficiency.

[0040] In some examples, there are two agitators 3, arranged vertically, with the lower agitator 3 extending upwards at the end away from the agitator shaft 2, and the upper agitator 3 extending downwards at the end away from the agitator shaft 2.

[0041] For example, such as Figure 1 As shown, the different bending directions of the upper and lower stirring paddles 3 can generate strong flow of the liquid at different heights and in the horizontal direction, making the liquid mix more thoroughly. This can further improve the uniformity of heating of the liquid and more effectively reduce the risk of boiling over caused by local overheating, thereby better ensuring the stability and safety of the vacuum distillation process.

[0042] In some examples, a level switch 6 and a vacuum regulating valve 7 are also included. The level switch 6 is mounted on the housing 1 and located above the defoaming paddle 4. The level switch 6 is used for electrical connection with the control module. The inlet end of the vacuum regulating valve 7 is connected to the inside of the housing 1, and the controlled end of the vacuum regulating valve 7 is used for electrical connection with the control module.

[0043] For example, such as Figure 1As shown, the outlet of the vacuum regulating valve 7 is connected to the vacuum pump. After boiling, the liquid level rises to the level switch 6, which then sends a signal to the control module to turn on the vacuum pump. The control module controls the vacuum regulating valve 7 to adjust the vacuum level inside the housing 1. By reducing the vacuum level inside the housing 1, vacuum defoaming can be performed. Working in conjunction with the stirring paddle 3 and the defoaming paddle 4, three-stage defoaming can be performed during the vacuum distillation process, ensuring thorough distillation of the liquid to the maximum extent while preventing overflow from the housing 1, thus reducing liquid loss. This automated vacuum distillation saves on labor and time costs. The level switch 6 is preferably a capacitive level switch.

[0044] In some examples, a pneumatic valve 8 and a filter 9 are also included. The pneumatic valve 8 is located outside the housing 1, and one end of the pneumatic valve 8 is connected to the inside of the housing 1. The filter 9 is located outside the housing 1, and the other end of the pneumatic valve 8 is connected to one end of the filter 9. The other end of the filter 9 is connected to the inlet end of the vacuum regulating valve 7.

[0045] For example, such as Figure 1 As shown, a filter element is installed in the filter 9. The pneumatic valve 8 controls the passage between the housing 1 and the filter 9. When the vacuum regulating valve 7 is opened, some impurities or tiny particles may be carried in during the process of the vacuum pump drawing gas from the housing 1. After passing through the filter 9, these impurities can be filtered out to prevent them from entering the vacuum pump, thus protecting the normal operation of the vacuum pump, extending the service life of the vacuum pump, and saving maintenance costs.

[0046] In some examples, a nitrogen valve 10 is also included, the outlet of which and the inlet of the vacuum regulating valve 7 are both connected to the same end of the filter 9.

[0047] For example, such as Figure 1 As shown, the nitrogen valve 10 is connected to the nitrogen source. When it is necessary to add nitrogen into the shell 1 to maintain an oxygen-free state, the nitrogen valve 10 is opened. The nitrogen enters the shell 1 after passing through the filter 9, which can prevent impurities from entering the shell 1 with the nitrogen and affecting the distillation effect.

[0048] In some examples, a temperature control jacket 11, an inlet valve 12, and a return valve 13 are also included. The temperature control jacket 11 is disposed on the periphery of the housing 1. One end of the inlet valve 12 is used to communicate with the outlet of the TCU temperature control system, and the other end of the inlet valve 12 is used to communicate with the inside of the temperature control jacket 11. One end of the return valve 13 is used to communicate with the inside of the temperature control jacket 11, and the other end of the return valve 13 is used to communicate with the return port of the TCU temperature control system.

[0049] For example, such as Figure 1As shown, by the cooperation of the TCU temperature control system, the liquid inlet valve 12 and the liquid return valve 13, the temperature of the liquid in the temperature control jacket 11 can be accurately controlled, thereby controlling the temperature of the material liquid in the shell 1, so that the material liquid can always be kept in a suitable temperature range during the distillation process, which can further improve the uniformity of the material liquid heating, reduce the boiling and other unstable conditions caused by temperature fluctuations, and improve the quality and efficiency of product purification.

[0050] In some examples, a heat preservation layer 14 is further included, which is arranged outside the temperature control jacket 11.

[0051] For example, as shown in FIG. 1, Figure 1 The heat preservation layer 14 can reduce heat loss, so that the heat in the temperature control jacket 11 can be more effectively transferred to the material liquid in the shell 1, while the temperature in the shell 1 can be kept stable, reducing energy consumption and improving energy utilization efficiency, which helps to maintain stable distillation conditions and improve the economy and stability of production.

[0052] In some examples, a cleaning and sterilization valve 15 is further included, the inlet of the cleaning and sterilization valve 15 is used to communicate with a cleaning and sterilization pump, and the outlet of the cleaning and sterilization valve 15 communicates with the inside of the shell 1.

[0053] For example, as shown in FIG. 1, Figure 1 When the shell 1 needs to be cleaned, WFI (water for injection) is used for cleaning, the cleaning and sterilization valve 15 is opened, the water for injection is delivered into the cleaning and sterilization valve 15 by the cleaning and sterilization pump, and then sprayed into the inside of the shell 1 to clean the inner wall of the shell 1 and each component in the shell 1 until the cleaning water conductivity is qualified, and then the cleaning water is drained. When the shell 1 needs to be sterilized, the cleaning and sterilization valve 15 is opened, pure steam is delivered into the cleaning and sterilization valve 15 by the cleaning and sterilization pump, and then sprayed into the inside of the shell 1 to sterilize the inner wall of the shell 1 and each component in the shell 1. Through cleaning and sterilization, the risk of microbial growth can be reduced, and cross contamination between different batches of material liquid can be prevented, which better ensures the stability and safety of product quality.

[0054] In some examples, a spray ball 16 is further included, which is arranged inside the shell 1, and the inlet of the spray ball 16 communicates with the outlet of the cleaning and sterilization valve 15.

[0055] For example, as shown in FIG. 1, Figure 1 The spray ball 16 can provide sufficient spray pressure and flow to achieve complete wetting of the inner surface of the shell 1, ensure that the water for injection and the pure steam have sufficient contact time with the equipment surface, and the cleaning and sterilization effect is better. When the liquid level switch 6 is provided, the liquid level switch 6 is located between the spray ball 16 and the defoaming paddle 4.

[0056] In some examples, the number of spray balls 16 is multiple, and all the spray balls 16 are uniformly arranged around the axis of the shell 1.

[0057] For example, as shown in Figure 1 The multiple spray balls 16 can jointly expand the coverage of the water for injection and the pure steam in the shell 1, and further improve the cleaning and sterilization effect.

[0058] It should be noted that the above examples are only used to illustrate the technical solutions of the present disclosure but not limit the present disclosure. Although the present disclosure has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present disclosure can be modified or replaced equivalently without departing from the spirit and scope of the technical solutions of the present disclosure, and all should be covered in the scope of the claims of the present disclosure.

Claims

1. A defoaming device for vacuum distillation of low-boiling-point feed liquid in a liquid preparation system, characterized in that: Comprising, a shell (1), a stirring shaft (2) rotatably arranged in the shell (1); a stirring paddle (3) arranged on the periphery of the stirring shaft (2); a defoaming paddle (4) arranged on the stirring shaft (2) above the stirring paddle (3), the bottom of the defoaming paddle (4) having defoaming teeth (5).

2. The defoaming device for low-boiling-point feed liquid vacuum distillation of a liquid preparation system according to claim 1, characterized in that: The longitudinal section shape of the defoaming teeth (5) is sawtooth, needle or hook.

3. The defoaming device for low-boiling-point feed liquid vacuum distillation of a liquid preparation system according to claim 1, characterized in that: The number of the stirring paddles (3) is two, arranged in up and down direction, the lower stirring paddle (3) is bent upward at the end away from the stirring shaft (2), and the upper stirring paddle (3) is bent downward at the end away from the stirring shaft (2).

4. The defoaming device for low-boiling-point feed liquid vacuum distillation of a liquid preparation system according to claim 1, characterized in that: Further comprising, a liquid level switch (6) arranged on the shell (1) above the defoaming paddle (4), the liquid level switch (6) being electrically connected with a control module; a vacuum degree regulating valve (7) having an inlet communicating with the inside of the shell (1), and a controlled end electrically connected with the control module.

5. The defoaming device for low-boiling-point feed liquid vacuum distillation of a liquid preparation system according to claim 4, characterized in that: Further comprising, a pneumatic valve (8) arranged outside the shell (1), one end of the pneumatic valve (8) communicating with the inside of the shell (1); a filter (9) arranged outside the shell (1), the other end of the pneumatic valve (8) communicating with one end of the filter (9), and the other end of the filter (9) communicating with the inlet of the vacuum degree regulating valve (7).

6. The defoaming device for low-boiling-point feed liquid vacuum distillation of a liquid preparation system according to claim 5, characterized in that: Further comprising a nitrogen valve (10), the outlet of the nitrogen valve (10) and the inlet of the vacuum degree regulating valve (7) both communicating with the same end of the filter (9).

7. The defoaming device for low-boiling liquid feed low-pressure distillation of a liquid preparation system according to claim 1, characterized in that: Further comprising, a temperature control jacket (11) arranged on the periphery of the shell (1); a liquid inlet valve (12) having one end communicating with the liquid outlet of a TCU temperature control system, and the other end communicating with the inside of the temperature control jacket (11); a liquid return valve (13) having one end communicating with the inside of the temperature control jacket (11), and the other end communicating with the liquid return of the TCU temperature control system.

8. The defoaming device for low-boiling-point feed liquid vacuum distillation of a liquid preparation system according to claim 7, characterized in that: Further comprising a heat preservation layer (14) arranged on the periphery of the temperature control jacket (11).

9. The defoaming device for low-boiling-point feed liquid vacuum distillation of a liquid preparation system according to claim 1, characterized in that: Further comprising a cleaning and sterilizing valve (15) having an inlet communicating with a cleaning and sterilizing pump, and an outlet communicating with the inside of the shell (1).

10. The defoaming device for low-boiling-point feed liquid vacuum distillation of a liquid preparation system according to claim 9, characterized in that: Further comprising a spray ball (16) arranged in the inside of the shell (1), the inlet of the spray ball (16) communicating with the outlet of the cleaning and sterilizing valve (15).

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