Crude product precipitation and dehydration device for preparing heparin sodium by salt hydrolysis method
By designing a detachable dehydration device, the problem of difficult cleaning of dehydration devices in existing technologies was solved, achieving efficient dehydration and impurity removal of crude heparin sodium, and ensuring the smooth progress of subsequent processes.
Patent Information
- Application Number
- CN202422634147.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-30
- Publication Date
- 2025-12-23
- Estimated Expiration
- 2034-10-30
AI Technical Summary
Existing salting-out methods for preparing heparin sodium using crude product precipitation and dehydration devices are easily affected by the environment during natural dehydration, pressing dehydration may damage the precipitate structure, while centrifugal dehydration makes it difficult to clean the residue, and the fixed connection between the dehydration chamber and the motor makes cleaning difficult.
A device comprising a cylinder, a dehydration chamber, an annular plate, a rack, a gear, a threaded rod, and a motor was designed. The dehydration chamber is detachable through the cooperation of the gear and the threaded rod, which facilitates the cleaning of residual impurities and enables efficient dehydration through centrifugal force.
It enables convenient impurity removal, improves dehydration efficiency, avoids damage to precipitates by residues, and ensures the smooth progress of subsequent drying and refining processes.
Smart Images
Figure CN223697032U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of dehydration equipment technology, and in particular to a crude product precipitation and dehydration device for preparing heparin sodium by salting out. Background Technology
[0002] Heparin sodium is an anticoagulant that interferes with many aspects of the blood clotting process, exhibiting anticoagulant effects both in vivo and in vitro. The salting-out method for preparing heparin sodium is technically mature, has a relatively simple production process, high production efficiency, and low cost. Dehydration equipment after precipitation in the salting-out method can dehydrate crude heparin sodium, providing a strong guarantee for subsequent drying and refining. Current crude heparin sodium precipitation and dehydration devices for the salting-out method typically include natural dehydration, pressing dehydration, and centrifugal dehydration. Natural dehydration may be affected by environmental humidity and temperature, while pressing dehydration may affect the structure of the precipitate. Although centrifugal dehydration can efficiently dehydrate crude heparin sodium, it easily throws some residue onto the inner wall of the cylinder or leaves some heparin sodium residue inside the dehydration chamber. Since the dehydration chamber is generally fixedly connected to the output rod on the motor, it is difficult to clean the inside of the cylinder or dehydration chamber. Utility Model Content
[0003] This invention provides a crude product precipitation and dehydration device for preparing heparin sodium by salting out, which solves the problems in the background art.
[0004] To achieve the above objectives, the present invention adopts the following technical solution:
[0005] A crude product precipitation and dehydration device for preparing heparin sodium by salting out includes a base, a cylinder is installed at the top of the base, a cover is provided at the top of the cylinder, and a water outlet pipe is installed at the bottom of the cylinder.
[0006] The cylinder is provided with a dehydration chamber inside, and a first annular plate is provided on the upper surface of the dehydration chamber, and a second annular plate is provided at the top of the first annular plate.
[0007] The inner wall of the second annular plate is connected to a rack, and the surface of the rack is connected to a gear, and the center of the gear is connected to a threaded rod;
[0008] The inner wall of the cylinder is rotatably connected to a third annular plate.
[0009] As a further description of the above technical solution:
[0010] The second annular plate has a groove at its inner bottom end, and a slider that is rotatably connected to the bottom end of the threaded rod is slidably connected inside the groove.
[0011] As a further description of the above technical solution:
[0012] The first annular plate and the third annular plate are connected by a snap-fit mechanism.
[0013] As a further description of the above technical solution:
[0014] The bottom end of the dehydration chamber is connected to a sleeve, and the inner wall of the sleeve is connected to a partition plate. The top of the partition plate is symmetrically provided with slots. The bottom end of the cylinder is equipped with a motor, and the top of the motor is connected to a rotating rod. The surface of the rotating rod is symmetrically provided with sleeves. The top of the inside of the sleeve is connected to a spring, and the top of the spring is connected to a connecting plate. The top of the connecting plate is connected to a connecting rod that contacts the inside of the slot.
[0015] As a further description of the above technical solution:
[0016] The distance between the center points of the two slots is the same as the distance between the center points of the two connecting rods.
[0017] In summary, due to the adoption of the above technical solution, the beneficial effects of this utility model are:
[0018] In this invention, by rotating the second annular plate, the rack moves on the surfaces of multiple gears, which drives the gears and threaded rod to rotate on the surface of the slider. This allows the threaded rod to be removed from the inside of the third annular plate, making it easier to remove the sleeve at the bottom of the dehydration chamber from the surface of the rotating rod. This facilitates the cleaning of impurities remaining in the dehydration chamber and the inner wall of the cylinder, preventing excessive residual impurities from affecting subsequent dehydration efficiency. Attached Figure Description
[0019] Figure 1 A schematic diagram of a crude product precipitation and dehydration device for preparing heparin sodium by salting out;
[0020] Figure 2 This is a schematic diagram of the surface structure of the middle cylinder of this utility model;
[0021] Figure 3 This is a schematic diagram of the surface structure of the dehydration chamber in this utility model;
[0022] Figure 4 This is a schematic diagram of the internal structure of the second annular plate in this utility model;
[0023] Figure 5 This is a schematic diagram of the internal structure of the sleeve in this utility model;
[0024] Figure 6 This is a schematic diagram of the surface structure of the rotating rod in this utility model;
[0025] Figure 7 This is a schematic diagram of the internal structure of the sleeve in this utility model.
[0026] Legend:
[0027] 1. Base; 2. Cylinder; 3. Cover; 4. Water outlet pipe; 5. Dehydration chamber; 6. First annular plate; 7. Second annular plate; 8. Rack; 9. Gear; 10. Threaded rod; 11. Third annular plate; 12. Slide groove; 13. Slider; 14. Sleeve; 15. Partition plate; 16. Hole groove; 17. Motor; 18. Rotating rod; 19. Sleeve; 20. Spring; 21. Connecting plate; 22. Connecting rod. Detailed Implementation
[0028] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of the present utility model.
[0029] Reference Figures 1-7 A crude product precipitation and dehydration device for preparing heparin sodium by salting out includes a base 1, a cylinder 2 mounted on the top of the base 1, a cover 3 at the top of the cylinder 2, and a water outlet pipe 4 at the bottom of the cylinder 2; a dehydration chamber 5 is disposed inside the cylinder 2, a first annular plate 6 is disposed on the upper surface of the dehydration chamber 5, and a second annular plate 7 is disposed at the top of the first annular plate 6; a rack 8 is connected to the inner wall of the second annular plate 7, a gear 9 is connected to the surface of the rack 8, and a threaded rod 10 is connected to the center of the gear 9; the cylinder... The inner wall of body 2 is rotatably connected to a third annular plate 11. By rotating the second annular plate 7, the rack 8 on its inner wall can move on the surface of the gear 9, which in turn drives the threaded rod 10 to move. This allows the threaded rod 10 to be removed from the inside of the third annular plate 11, thereby removing the dehydration chamber 5 from the inside of the cylinder 2. This facilitates the cleaning of impurities remaining in the dehydration chamber 5 or the inner wall of the cylinder 2. The surfaces of the first annular plate 6 and the third annular plate 11 are equidistantly provided with the same number of threaded grooves as the threaded rod 10.
[0030] Furthermore, a groove 12 is provided at the bottom of the inner side of the second annular plate 7, and a slider 13 is slidably connected inside the groove 12 and rotatably connected to the bottom of the threaded rod 10. This is to facilitate the movement of the second annular plate 7 on the surface of the slider 13 through the groove 12, so that the rack 8 on its inner wall can rotate on the surface of the gear 9.
[0031] Furthermore, the first annular plate 6 and the third annular plate 11 are engaged, which facilitates the engagement of the first annular plate 6 and the third annular plate 11 so that the threaded grooves on the first annular plate 6 and the third annular plate 11 are aligned, so that the threaded rod 10 can be threadedly connected to it. The bottom end of the first annular plate 6 is provided with a locking block, and the top end of the third annular plate 11 is provided with a locking groove. The locking block and the locking groove are engaged.
[0032] Furthermore, a sleeve 14 is connected to the bottom end of the dehydration chamber 5, and a partition 15 is connected to the inner wall of the sleeve 14. The top of the partition 15 is symmetrically provided with slots 16. A motor 17 is installed at the bottom end of the cylinder 2, and a rotating rod 18 is connected to the top of the motor 17. Sleeves 19 are symmetrically provided on the surface of the rotating rod 18. A spring 20 is connected to the top of the inside of the sleeve 19, and a connecting plate 21 is connected to the top of the spring 20. A connecting rod 22, which contacts the inside of the slot 16, is connected to the top of the connecting plate 21. This connects the sleeve 14 and the rotating rod... The surfaces of the sleeve 18 are connected and pressed together, pressing the connecting rod 22 into the inside of the sleeve 19. When the motor 17 drives the rotating rod 18 and the sleeve 19 to rotate, the connecting rod 22 inside the sleeve 19 can be moved to the bottom of the slot 16. Through the action of the spring 20, the connecting plate 21 connected to it can drive the connecting rod 22 to move into the slot 16. Thus, when the rotating rod 18 rotates, it can drive the sleeve 14 and the dehydration chamber 5 to rotate, so as to dehydrate the crude heparin sodium inside the dehydration chamber 5 by centrifugal force.
[0033] Furthermore, the distance between the center points of the two slots 16 is the same as the distance between the center points of the two connecting rods 22. This is so that when the rotating rod 18 drives the sleeve 19 to rotate, the connecting rod 22 can be rotated to the surface of the slot 16 for connection.
[0034] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.
Claims
1. A device for precipitating and dehydrating crude heparin sodium using a salting-out method, comprising a base (1), characterized in that: The top of the base (1) is fitted with a cylinder (2), and the top of the cylinder (2) is fitted with a cover (3), and the bottom of the cylinder (2) is fitted with a water outlet pipe (4). The cylinder (2) is provided with a dehydration chamber (5) inside, and a first annular plate (6) is provided on the upper surface of the dehydration chamber (5), and a second annular plate (7) is provided at the top of the first annular plate (6). The inner wall of the second annular plate (7) is connected to a rack (8), and the surface of the rack (8) is connected to a gear (9), and a threaded rod (10) is connected to the center of the gear (9); The inner wall of the cylinder (2) is rotatably connected to a third annular plate (11).
2. The apparatus for crude product precipitation and dehydration in the salting-out method for preparing heparin sodium according to claim 1, characterized in that: The second annular plate (7) has a groove (12) at its inner bottom end, and a slider (13) that is rotatably connected to the bottom end of the threaded rod (10) is slidably connected inside the groove (12).
3. The apparatus for crude product precipitation and dehydration in the salting-out method for preparing heparin sodium according to claim 1, characterized in that: The first annular plate (6) and the third annular plate (11) are connected by a snap-fit connection.
4. The apparatus for crude product precipitation and dehydration in the salting-out method for preparing heparin sodium according to claim 1, characterized in that: The bottom end of the dehydration chamber (5) is connected to a sleeve (14), and the inner wall of the sleeve (14) is connected to a partition (15). The top of the partition (15) is symmetrically provided with slots (16). The bottom end of the cylinder (2) is equipped with a motor (17), and the top of the motor (17) is connected to a rotating rod (18). The surface of the rotating rod (18) is symmetrically provided with sleeves (19). The top of the inside of the sleeve (19) is connected to a spring (20), and the top of the spring (20) is connected to a connecting plate (21). The top of the connecting plate (21) is connected to a connecting rod (22) that contacts the inside of the slots (16).
5. The apparatus for crude product precipitation and dehydration in the preparation of heparin sodium by salting out according to claim 4, characterized in that: The distance between the center points of the two slots (16) is the same as the distance between the center points of the two connecting rods (22).