Liquid phase and mobile phase temperature control device

Abstract

The utility model discloses a temperature control device for a liquid phase and a mobile phase, and belongs to the technical field of liquid chromatographs. Comprising a refrigerating box, a heating box and a mobile phase bottle, the refrigerating box comprises a box body, a power supply, a controller, a semiconductor refrigerator and a box door, the heating box comprises a box body, a spiral pipeline and a heating rod, a water adding opening communicated with an inner cavity of the box body is formed in the top of the box body, the spiral pipeline is arranged in the box body, a liquid inlet and a liquid outlet are formed in the spiral pipeline, the liquid inlet is communicated with a liquid conveying pipe, and the liquid outlet is communicated with a liquid outlet. The liquid outlet is communicated with the liquid pump, the heating rod is installed in the box body and electrically connected with the power supply and the controller through wires, the mobile phase bottle comprises a bottle body, a bottle cap and a liquid conveying pipe, the bottle body is arranged in the box body, the bottle cap is detachably installed on a bottle opening of the bottle body, and the liquid conveying pipe penetrates through the bottle cap and extends into the bottle body. According to the utility model, the liquid-phase mobile phase is refrigerated through the refrigerating box, and the liquid-phase mobile phase can be heated to an experimental temperature through the heating box, so that additional heating equipment is not needed, the operation process is simple, and the efficiency is high.

Description

Technical Field

[0001] This utility model belongs to the field of liquid chromatography technology, and more specifically, it relates to a liquid mobile phase temperature control device. Background Technology

[0002] High-performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS) are commonly used analytical instruments. The mobile phase liquid necessary for sample analysis is contained in a dedicated reservoir bottle and introduced into the chromatographic analysis system through a pump in the instrument via a delivery tube for elution and separation of the sample. The mobile phase reservoir bottle ensures a continuous supply of mobile phase during sample analysis, which is the basis for ensuring that the HPLC can automatically and continuously complete sample analysis. At the same time, the quality of the liquid mobile phase is a key factor affecting the accuracy of experimental results; a deteriorated liquid mobile phase will lead to experimental failure.

[0003] To prevent contamination and deterioration of the liquid mobile phase in the storage bottle, it is necessary to store the liquid mobile phase in a suitable environment. Currently, it is generally recommended to store the liquid mobile phase in a dry, cool, and well-ventilated place, avoiding direct sunlight. Some mobile phases may have specific storage conditions, such as low temperature or constant temperature environments. Mobile phases stored in low temperature or constant temperature environments need to be heated to the test temperature before use. Currently, heating the liquid mobile phase requires a separate heating device, which not only increases the amount of experimental equipment and costs, but also complicates the operation process and affects experimental efficiency. Utility Model Content

[0004] The purpose of this invention is to provide a liquid mobile phase temperature control device to overcome the shortcomings of existing technologies, which require additional experimental equipment and costs, and have complex operating procedures that affect experimental efficiency when heating mobile phases stored in low-temperature or constant-temperature environments.

[0005] This utility model is achieved using the following technical solution:

[0006] A liquid mobile phase temperature control device includes a refrigerator, a heating box, and a mobile phase bottle. The refrigerator includes a box body, a power supply and controller, a thermoelectric cooler, and a door. The power supply and controller are electrically connected to the thermoelectric cooler, which is mounted on the box body. The door is movably installed at the opening of the box body. The heating box includes a box body, a spiral tube, and a heating rod. The top of the box body has a water inlet communicating with its inner cavity. The spiral tube is located inside the box body and has an inlet and an outlet. The inlet is connected to a delivery tube, and the outlet is connected to a liquid pump. The heating rod is installed inside the box body and is electrically connected to the power supply and controller via an electrical wire. The mobile phase bottle includes a bottle body, a cap, and a delivery tube. The bottle body is located inside the box body, and the cap is detachably mounted on the bottle opening. The delivery tube passes through the cap and extends into the bottle body.

[0007] Further, the refrigeration box further comprises two sets of support mechanisms symmetrically arranged in the box body, the support mechanism comprises a support sleeve, a support rod, a spring and a fixed support, the support sleeve is fixedly connected to the inner wall of the box body, the spring is arranged in the support sleeve, the support rod is inserted into the support sleeve and connected with the spring, and the fixed support is fixedly arranged at the outer end of the support rod.

[0008] Further, the bottle cap comprises a cap body, a rotating body, a one-way filter valve and a sealing ring, the rotating body is rotationally connected to the top of the cap body, the rotating body is provided with a filter hole and a pipeline through hole which are communicated with the inside of the bottle body, the one-way filter valve is detachably arranged on the filter hole, the infusion tube is arranged through the pipeline through hole, and the sealing ring is arranged between the cap body and the rotating body.

[0009] Further, the bottom of the bottle body is provided with a funnel part, so that all the residual liquid phase flowing phase at the bottom can be pumped out, the liquid phase flowing phase in the bottle is fully utilized, and waste is reduced.

[0010] Further, the refrigeration box further comprises a temperature sensor and a display screen, the temperature sensor and the display screen are electrically connected with the power supply and the controller, the temperature sensor is used for detecting the temperature value in the box body and transmitting the temperature data to the power supply and the controller, and the power supply and the controller control the display screen to display the temperature value in the box body in real time.

[0011] Further, the box door is provided with a perspective window, so that the state in the liquid phase flowing bottle can be observed.

[0012] Compared with the prior art, the beneficial effects of the utility model are:

[0013] (1) the refrigeration box is arranged to refrigerate the liquid phase flowing phase in the liquid storage bottle, so that the breeding of microorganisms in the liquid phase flowing phase is reduced, the liquid phase flowing phase is prevented from deteriorating, the accuracy of the liquid chromatography experimental result is ensured, the liquid phase flowing phase pumped into the chromatography analysis system is heated to the experimental temperature through the heating box, the heating operation and the chromatography analysis experiment are simultaneously performed, additional heating equipment is not needed, the operation process is simple and the efficiency is high.

[0014] (2) water is added into the heating box through the water inlet, the water in the heating box is controlled in temperature through the heating rod, then the water after heating heats the liquid phase flowing phase in the spiral pipeline, the heating time of the liquid phase flowing phase is increased through the spiral pipeline, so that the liquid phase flowing phase in the spiral pipeline is rapidly heated to the experimental temperature.

[0015] (3) The bottle cap of the mobile phase bottle is provided with a rotating body connected with the cap body top, when the cap body is screwed with the bottle body, the rotating body can not rotate with the cap body, the infusion tube passing through the rotating body can not be twisted, the one-way filter valve arranged on the rotating body can realize the air pressure communication between the bottle and the outside, and can filter the impurities in the outside air, prevent the liquid phase mobile phase from being polluted, and also can prevent the harmful gas in the bottle from being discharged to cause air pollution; the funnel part arranged at the bottom of the bottle body can pump out the residual liquid phase mobile phase at the bottom, so that the liquid phase mobile phase in the bottle is fully utilized, and waste is reduced. BRIEF DESCRIPTION OF DRAWINGS

[0016] Figure 1 is the three-dimensional structure schematic diagram of the utility model;

[0017] Figure 2 is the structure schematic diagram of the box door when being opened;

[0018] Figure 3 is the structure schematic diagram of the supporting mechanism;

[0019] Figure 4 is the structure schematic diagram of the warming box;

[0020] Figure 5 is the structure schematic diagram of the mobile phase bottle;

[0021] Figure 6 is Figure 5 the enlarged view of A of

[0022] In the drawing: 1, refrigeration box; 2, warming box; 3, mobile phase bottle; 11, box body; 12, power supply and controller; 13, semiconductor refrigerator; 14, display screen; 15, box door; 151, perspective window; 16, supporting mechanism; 161, supporting sleeve; 162, spring; 163, supporting rod; 164, fixed support; 17, temperature sensor; 21, box body; 22, spiral pipeline; 221, liquid inlet; 222, liquid outlet; 23, heating rod; 24, water inlet; 31, bottle body; 32, bottle cap; 321, cap body; 322, rotating body; 323, one-way filter valve; 324, filter hole; 325, pipeline through hole; 326, sealing ring; 33, infusion tube; 34, funnel part. DETAILED DESCRIPTION

[0023] The utility model will be further described in connection with the drawings.

[0024] A liquid phase mobile phase temperature control device, comprising a refrigeration box 1, a warming box 2 and a mobile phase bottle 3.

[0025] As Figure 1 , Figure 2As shown in the figure, the refrigeration box 1 includes a box body 11, a power supply and controller 12, a semiconductor refrigerator 13 and a box door 15, the box body 11 is used to store the mobile phase bottle 3, the power supply and controller 12 is electrically connected with the semiconductor refrigerator 13, used to provide power for the semiconductor refrigerator 13 to refrigerate and control the refrigeration temperature of the semiconductor refrigerator 13, the semiconductor refrigerator 13 is arranged on the box body 11, used to refrigerate the inside of the box body 11, and the temperature in the box body 11 is controlled between 4℃-10℃, the box door 15 is movably installed at the opening of the box body 11, used to open to take and place the mobile phase bottle 3 and seal the box body 11.

[0026] As shown in the figure, Figure 4 The warming box 2 includes a box body 21, a spiral pipeline 22 and a heating rod 23, the box body 21 is provided with a water adding port 24 communicating with the inner cavity, water can be added to the box body 21 through the water adding port 24, the spiral pipeline 22 is arranged in the box body 21, the spiral pipeline 22 is provided with a liquid inlet 221 and a liquid outlet 222, the liquid inlet 221 is communicated with the infusion tube 33, the liquid outlet 222 is communicated with the liquid pump, the heating rod 23 is installed in the box body 21 and is electrically connected with the power supply and controller 12 through the wire. Of course, from the perspective of heat recycling, the refrigeration box 1 and the warming box 2 can be designed to exchange heat, and then actual warming is carried out.

[0027] When heating, a certain amount of water is first added to the box body 21 through the water adding port 24, then the heating rod 23 is powered on to heat the water in the box body 21, after heating to the set temperature, the liquid pump is started to extract the liquid in the mobile phase bottle 3, the heated water heats the liquid phase mobile phase liquid flowing through the spiral pipeline 22, and the spiral pipeline 22 can increase the heating time of the liquid phase mobile phase in the water, so that the liquid phase mobile phase in the spiral pipeline 22 is quickly heated to the experimental temperature.

[0028] As shown in the figure, Figure 5 The mobile phase bottle 3 includes a bottle body 31, a bottle cap 32 and an infusion tube 33, the bottle body 31 is arranged in the box body 11 and is used to store the liquid phase mobile phase liquid, the bottle cap 32 is detachably installed on the bottle mouth of the bottle body 31 through the thread and is used to seal the bottle mouth, the infusion tube 33 penetrates into the bottle body 31 through the bottle cap 32 and is used to transport the liquid phase mobile phase liquid to the warming box 2.

[0029] Further, as shown in the figure, Figure 3As shown, the refrigeration box 1 further comprises two sets of support mechanisms 16 symmetrically arranged in the box body 11, the support mechanism 16 comprises a support sleeve 161, a support rod 163, a spring 162 and a fixed support 164, the support sleeve 161 is fixedly connected to the inner wall of the box body 11, the spring 162 is arranged inside the support sleeve 161, the support rod 163 is inserted into the support sleeve 161 and connected with the spring 162, and the fixed support 164 is fixedly arranged at the outer end of the support rod 163. The fixed supports 164 of the two support mechanisms 16 are clamped on the two sides of the bottle body 31, the fixed support 164 adopts an arc shape which is in close contact with the bottle body 31, and the support mechanism 16 makes the fixed support 164 closely contact with the flow phase bottle 3 through the elastic force of the spring 162, so that the flow phase bottle 3 can be prevented from shaking or falling when subjected to external force.

[0030] Further, as shown in Figure 6 The bottle cap 32 comprises a cap body 321, a rotating body 322, a one-way filter valve 323 and a sealing ring 326. The rotating body 322 is rotationally connected to the top of the cap body 321. The rotating body 322 is provided with a filter hole 324 and a pipeline through hole 325 which are in communication with the inside of the bottle body 31. The one-way filter valve 323 is detachably installed on the filter hole 324 by screwing. The infusion tube 33 passes through the pipeline through hole 325. The sealing ring 326 is arranged between the cap body 321 and the rotating body 322 to seal the joint between the cap body 321 and the rotating body 322, so as to prevent the volatilization and leakage of the reagent in the bottle, thereby preventing air pollution.

[0031] When the cap body 321 is threadedly connected and sealed with the bottle body 31, the rotating body 322 can not rotate with the cap body 321, so that the infusion tube 33 passing through the rotating body 322 can be prevented from being twisted. The one-way filter valve 323 arranged on the rotating body 322 can realize the communication between the inside and outside of the bottle in terms of air pressure, facilitate pumping, filter impurities in the external air when air is introduced, prevent the external air from polluting the liquid phase flow phase, and prevent harmful gas in the bottle from being discharged to cause air pollution.

[0032] Further, as shown in Figure 5 The bottle body 31 is provided with a funnel portion 34 at the bottom. The funnel portion 34 can collect the liquid phase flow phase liquid remaining at the bottom, and then facilitate pumping of the liquid phase flow phase remaining at the bottom, so that the liquid phase flow phase in the bottle can be fully utilized and waste can be reduced.

[0033] Further, as shown in Figure 1 The refrigeration box 1 further comprises a temperature sensor 17 and a display screen 14. The temperature sensor 17 and the display screen 14 are electrically connected with the power supply and controller 12. The temperature sensor 17 is used for detecting the temperature value in the box body 11 and transmitting the temperature data to the power supply and controller 12. The power supply and controller 12 controls the display screen 14 to display the temperature value in the box body 11 in real time, so as to facilitate the maintenance of the equipment by the experimenters.

[0034] Further, as shown in Figure 1 、 Figure 2 In order to facilitate observation of the state in the mobile phase bottle 3, the box door 15 is provided with a perspective window 151.

[0035] On the basis of the above-mentioned embodiments, the technical features involved therein and the functions and roles of the technical features in the utility model are described in detail to help the skilled in the art fully understand the technical scheme of the utility model and reproduce it.

[0036] Finally, although the present specification is described in terms of embodiments, not every embodiment contains only one independent technical solution, and the description manner of the specification is only for the sake of clarity, the skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can be combined appropriately to form other embodiments that can be understood by the skilled in the art.

Claims

1. A liquid phase mobile phase temperature control device, characterized by: The application relates to a refrigeration box (1), a warming box (2) and a mobile phase bottle (3), wherein the refrigeration box (1) comprises a box body (11), a power supply and a controller (12), a semiconductor refrigerator (13) and a box door (15), the power supply and the controller (12) are electrically connected with the semiconductor refrigerator (13), the semiconductor refrigerator (13) is arranged on the box body (11), the box door (15) is movably arranged on the opening of the box body (11), the warming box (2) comprises a box body (21), a spiral pipeline (22) and a heating rod (23), the top of the box body (21) is provided with a water inlet (24) communicating with the inner cavity of the box body (21), the spiral pipeline (22) is arranged in the box body (21), the spiral pipeline (22) is provided with a liquid inlet (221) and a liquid outlet (222), the liquid inlet (221) is communicated with a liquid conveying pipe (33), the liquid outlet (222) is communicated with a liquid pump, the heating rod (23) is arranged in the box body (21) and is electrically connected with the power supply and the controller (12) through an electric wire, and the mobile phase bottle (3) comprises a bottle body (31), a bottle cap (32) and the liquid conveying pipe (33), the bottle body (31) is arranged in the box body (11), the bottle cap (32) is detachably arranged on the bottle mouth of the bottle body (31), and the liquid conveying pipe (33) penetrates through the bottle cap (32) and extends into the bottle body (31).

2. The liquid phase mobile phase temperature control apparatus of claim 1, wherein: The refrigeration box (1) further comprises two groups of support mechanisms (16) symmetrically arranged in the box body (11), the support mechanism (16) comprises a support sleeve (161), a support rod (163), a spring (162) and a fixed support (164), the support sleeve (161) is fixedly connected to the inner wall of the box body (11), the spring (162) is arranged in the support sleeve (161), the support rod (163) is inserted into the support sleeve (161) and is connected with the spring (162), and the fixed support (164) is fixedly arranged at the outer end of the support rod (163), and the support supports of the two groups of support mechanisms (16) are clamped on the two sides of the bottle body (31).

3. The liquid phase mobile phase temperature control apparatus of claim 1, wherein: The bottle cap (32) comprises a cap body (321), a rotating body (322), a one-way filter valve (323) and a sealing ring (326), the rotating body (322) is rotationally connected to the top of the cap body (321), the rotating body (322) is provided with a filter hole (324) and a pipeline through hole (325) communicating with the inside of the bottle body (31), the one-way filter valve (323) is detachably arranged on the filter hole (324), the liquid conveying pipe (33) penetrates through the pipeline through hole (325), and the sealing ring (326) is arranged between the cap body (321) and the rotating body (322).

4. The liquid phase mobile phase temperature control apparatus of claim 1, wherein: The bottom of the bottle body (31) is provided with a funnel part (34).

5. The liquid phase mobile phase temperature control apparatus of claim 1, wherein: The refrigeration box (1) further comprises a temperature sensor (17) and a display screen (14), and the temperature sensor (17) and the display screen (14) are electrically connected with the power supply and the controller (12).

6. The liquid phase mobile phase temperature control apparatus of claim 1, wherein: The box door (15) is provided with a perspective window (151).

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