Sterile subpackaging device for small-capacity injection

Abstract

The utility model relates to the field of medicine production and preparation devices, in particular to a small-capacity injection sterile subpackaging device which comprises a machine table, a telescopic rod is arranged on the machine table, a subpackaging head is arranged at the bottom of the telescopic rod, the subpackaging head comprises a shell, a subpackaging channel is formed in the shell, a non-return assembly is arranged in the subpackaging channel, and the non-return assembly is arranged on the machine table. A positioning assembly is further arranged in the shell, the positioning assembly communicates with the non-return assembly through a gas flow channel, and the gas flow channel is located outside the shell and located below the horizontal plane of the non-return assembly and provided with a liquid level hole. The positioning assembly controls the non-return assembly to open and close the split charging channel according to the contact state of the liquid level hole and the liquid level. According to the utility model, the injection amount of each time is uniform, and misjudgment is avoided.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical production and preparation equipment, specifically a sterile dispensing device for small-volume injection solutions. Background Technology

[0002] Aseptic dispensing devices for injections are used to quantitatively dispense sterile drugs into clean, sterile containers (such as ampoules and vials) under aseptic conditions. These devices play a crucial role in the pharmaceutical industry, especially in the production of sterile injectable drugs. Aseptic dispensing devices for injections are mainly divided into two types based on their dispensing principle: Screw dispensing: This method utilizes the intermittent rotation of a screw, controlling the screw's speed to quantitatively dispense the drug into the vial. The screw conveys the internal drug along its axis to the dispensing mechanism outlet, where it falls into the vial below the dispensing head. Airflow dispensing: This method utilizes vacuum to draw a quantitative volume of drug, then uses the pressure of clean compressed air to blow it into the vial.

[0003] For dispensing liquid drugs, Chinese patent CN220976553U discloses a rapid aseptic dispensing device for vaccine semi-finished products, relating to the field of vaccine filling technology. The device includes a base, with a vertical frame fixedly connected to the top of the base. A drive motor is fixedly connected to the top of the vertical frame, and a vertical moving screw is fixedly connected to the output end of the drive motor. A crossbar is threaded into the outer wall of the vertical moving screw. This invention features release discs evenly spaced on the crossbar. The release discs release vaccine liquid into the vaccine vial. A sealing cylinder is provided outside the release discs, and a release component is located at the top of the sealing cylinder. When the release discs are removed from the vaccine vial, the release component can drive the sealing cylinder to close the liquid outlet of the release discs.

[0004] However, quantitative injection of liquid drugs into containers is required, but the existing technology makes it difficult to achieve quantitative liquid input. The existing technology generally uses sensors to detect the liquid level. However, when the liquid drug is injected quickly and the container space is small, splashing liquid drug can easily cause sensor misjudgment, which can easily lead to uneven injection volume. Therefore, a small-volume injection aseptic dispensing device is proposed. Utility Model Content

[0005] To address the aforementioned problems in the existing technology, this utility model provides a sterile dispensing device for small-volume injection solutions.

[0006] The objective of this utility model can be achieved through the following technical solutions:

[0007] This utility model discloses a sterile dispensing device for small-volume injection solutions, comprising a machine base, a telescopic rod on the machine base, a dispensing head at the bottom of the telescopic rod, a housing, a dispensing channel within the housing, a check valve assembly within the dispensing channel, and a positioning assembly within the housing. The positioning assembly and the check valve assembly are connected by a gas flow channel, which has a liquid level hole located outside the housing and below the horizontal plane of the check valve assembly. The positioning assembly controls the opening and closing of the dispensing channel by the check valve assembly according to the contact state between the liquid level hole and the liquid surface.

[0008] Furthermore, the check valve assembly includes a valve seat, a valve stem, and a rocker arm. The valve seat is connected to the inner wall of the dispensing channel. A grid is provided below the valve seat, and a small spring is provided on the grid. The bottom of the valve stem is disposed on the small spring, and the top of the valve stem abuts against the valve seat. The rocker arm is rotatably disposed within the housing, with one end extending into the dispensing channel and abutting against the bottom of the valve stem. The positioning component is separated from the rocker arm to open the check valve assembly, and the positioning component pushes the rocker arm to close the check valve assembly.

[0009] Furthermore, the positioning component includes a large spring and a limiting mechanism. A push rod is provided at the bottom of the large spring, and the vertical section of the push rod is slidably disposed within the housing. The limiting mechanism is used to limit and release the push rod.

[0010] Furthermore, the limiting mechanism includes a limiting rod, a negative pressure chamber, and a negative pressure membrane. The limiting rod is horizontally slidably disposed within the limiting channel of the housing. The negative pressure membrane covers the rear opening of the limiting channel. The limiting rod is connected to the negative pressure membrane. The negative pressure membrane pulls the limiting rod to slide horizontally according to the pressure change within the negative pressure chamber.

[0011] Furthermore, the upper and lower horizontal sections of the push rod extend outside the housing, with the lower horizontal section pressing against the container to lift the push rod and separate it from the swing arm.

[0012] Furthermore, the head of the limiting rod is an inclined surface.

[0013] Furthermore, a turntable is provided on the machine platform, the turntable is located below the dispensing head, and the turntable is provided with a mounting groove for placing containers.

[0014] The beneficial effects of this utility model are as follows:

[0015] (1) By setting a gas flow channel in the housing of the dispensing head, the gas flow channel is connected to the outside of the dispensing head and the positioning component and the check component. Since the check component is located in the dispensing channel, the channel at the position of the check component is relatively narrow during the drug injection process. After the drug flows through, a negative pressure will be formed in this area, and air will be drawn in from the outside through the gas flow channel. When the dispensing head is deep into the container, during the process of injecting liquid drug, as the liquid level increases, the drug can continue to be injected before the liquid level hole is submerged by the liquid drug. Until the liquid level hole is submerged, the gas flow channel cannot draw in air from the outside. Since the gas flow channel is connected to the positioning component, the negative pressure will cause the positioning component to drive the check component to close and stop injecting liquid into the container. Therefore, after the liquid level reaches the position of the liquid level hole each time, the check component will close the dispensing channel and stop injecting liquid. Thus, the amount injected each time is uniform and there will be no misjudgment.

[0016] (2) The negative pressure chamber is connected to the channel on the valve seat and the liquid level hole. The negative pressure membrane is capable of sealing the limiting channel. The negative pressure membrane is made of elastic material or the rear end of the negative pressure membrane is provided with an elastic structure to push the negative pressure membrane towards the limiting rod. When the push rod is limited by the limiting rod, the liquid flows out from the dispensing channel and forms a negative pressure between the valve stem and the valve seat. The negative pressure draws air from outside the liquid level hole along the gas flow channel until the liquid level hole is submerged. Since the liquid level hole is blocked, the negative pressure causes the negative pressure membrane at the end of the limiting channel to contract and move towards the negative pressure chamber. The contraction and movement of the negative pressure membrane pulls the limiting rod to move towards the rear end. The movement of the limiting rod causes the push rod to be released under the action of the large spring. After the push rod is released, it slides down and abuts against the rocker arm. The channel between the valve stem and the valve seat is closed by the rocker arm. Attached Figure Description

[0017] To facilitate understanding by those skilled in the art, the present invention will be further described below with reference to the accompanying drawings.

[0018] Figure 1 This is a schematic diagram of the closed structure of the check valve assembly of this utility model;

[0019] Figure 2 This is a schematic diagram of the structure of the check valve assembly of this utility model when it is in operation;

[0020] Figure 3 for Figure 2 A partially enlarged schematic diagram of the limiting rod extending from point A;

[0021] Figure 4 for Figure 2 A partially enlarged schematic diagram of the retracted limiting rod at point A;

[0022] Figure 5 This is a schematic diagram of the main structure of the present utility model;

[0023] Legend: 1. Machine base; 2. Telescopic rod; 3. Turntable; 4. Mounting slot; 5. Dispensing head; 501. Grid; 502. Small spring; 503. Swing rod; 504. Push rod; 505. Valve stem; 506. Gas flow channel; 507. Valve seat; 508. Large spring; 509. Negative pressure chamber; 510. Limiting rod; 511. Negative pressure diaphragm. Detailed Implementation

[0024] To further illustrate the technical means and effects adopted by this utility model in order to achieve the intended utility model purpose, the following detailed description of the specific implementation methods, structure, features and effects of this utility model is provided in conjunction with the accompanying drawings and preferred embodiments.

[0025] like Figures 1-5 As shown, a small-volume injection sterile dispensing device of this utility model includes a machine base 1, a telescopic rod 2 on the machine base 1, a dispensing head 5 at the bottom of the telescopic rod 2, a dispensing head 5 including a housing, a dispensing channel inside the housing, a check valve assembly inside the dispensing channel, and a positioning assembly inside the housing. The positioning assembly and the check valve assembly are connected by a gas flow channel 506. The gas flow channel 506 has a liquid level hole outside the housing and below the horizontal plane of the check valve assembly. The positioning assembly controls the opening and closing of the dispensing channel by the check valve assembly according to the contact state between the liquid level hole and the liquid surface.

[0026] In existing technologies, liquid level is typically detected using sensors. However, with rapid injection of liquid medication and limited container space, splashing liquid medication can easily cause sensor misjudgments, leading to uneven injection volume. To ensure uniform injection volume, a gas flow channel 506 is incorporated within the housing of the dispensing head 5. This channel connects to the outside of the dispensing head 5, as well as the positioning and check valve components. Since the check valve component is located within the dispensing channel, the channel at its location is relatively narrow during medication injection. As the medication flows through, a negative pressure is created in this area, which then... Air is drawn in from the outside through the gas channel 506. As the dispensing head 5 penetrates the container, during the injection of liquid medication, the medication continues to be injected until the liquid level hole is submerged. Once the liquid level hole is submerged, the gas channel 506 can no longer draw in air. Because the gas channel 506 connects to the positioning component, the negative pressure causes the positioning component to close the check valve, stopping the injection of liquid into the container. Therefore, each time the liquid level reaches the liquid level hole, the check valve closes the dispensing channel, stopping the injection. This ensures a uniform injection volume and prevents misjudgment. Since the dispensing of liquid medication is generally performed in a sterile environment, the intake of ambient air does not cause medication contamination.

[0027] Specifically, a pipeline and a liquid injection pump are connected to the dispensing head 5. During use, a turntable 3 is arranged on the machine table 1. The turntable 3 is located below the dispensing head 5. Installation grooves 4 are arranged on the turntable 3 for placing containers. There are multiple installation grooves 4 arranged around the turntable 3. A control device is arranged in the machine table 1 and is electrically connected to the telescopic rod 2, the liquid injection pump and the turntable 3 for linkage control. After the liquid injection of one container is completed, the telescopic rod 2 rises and the turntable 3 rotates to continue the dispensing and liquid injection of the next container. During the process of the telescopic rod 2 driving the dispensing head 5 to move downward, the positioning component on the dispensing head 5 will abut against the top of the container, separating the positioning component from the check valve component and opening the check valve component. Then, liquid is injected into the container and the telescopic rod 2 will retract to leave a reset space for the positioning component. Until the liquid in the container reaches the liquid level hole, the positioning component is reset and abuts against the check valve component to close the check valve component, completing the injection of the liquid medicine into the container.

[0028] The principle of the positioning component being reset when the liquid level hole is flooded is as follows: Since the gas flow channel 506 is connected to the check valve component and the positioning component from the liquid level hole, there is a channel in the check valve component for the liquid to flow out. When the liquid flows through the narrow channel in the check valve component, a negative pressure will be formed, causing the gas flow channel 506 to suck in air from outside the liquid level hole to balance the air pressure. After the liquid level hole is flooded with liquid and air cannot be sucked in from the outside, a negative pressure is generated in the positioning component, causing the positioning component to be reset and abut against the check valve component.

[0029] In an embodiment, the check valve component includes a valve seat 507, a valve rod 505 and a swing rod 503. The valve seat 507 is connected to the inner wall of the dispensing channel. A grid 501 is arranged below the valve seat 507. A small spring 502 is arranged on the grid 501. The bottom of the valve rod 505 is arranged on the small spring 502. The top of the valve rod 505 abuts against the valve seat 507. The swing rod 503 is rotatably arranged in the shell and one end extends into the dispensing channel and abuts against the bottom of the valve rod 505. The positioning component is separated from the swing rod 503 to open the check valve component, and the positioning component pushes the swing rod 503 to close the check valve component.

[0030] The grid 501 is at the bottom of the dispensing channel in the shell. The four sides of the grid 501 are connected to the side walls of the dispensing channel. A channel for the liquid to flow through is arranged in the middle of the grid 501. The small spring 502 is arranged on the grid 501. The valve rod 505 is pushed by the grid 501 as a fulcrum to abut against the valve seat 507. At the same time, the swing rod 503 at the bottom of the valve rod 505 is pushed by the positioning component in the initial state, causing the valve rod 505 and the valve seat 507 to be in a closed state. Then, under the action of the liquid injection pump in the dispensing channel, the liquid cannot be output. Only when the positioning component is separated from the swing rod 503 can the liquid in the dispensing channel be injected into the container.

[0031] Specifically, the positioning component includes a large spring 508 and a limiting mechanism. A push rod 504 is provided at the bottom of the large spring 508. The vertical section of the push rod 504 is slidably disposed in the housing. The limiting mechanism is used to limit and release the push rod 504. The upper horizontal section and the lower horizontal section on the push rod 504 extend out of the housing. The lower horizontal section is squeezed against the container to lift the push rod 504 and separate it from the swing arm 503.

[0032] The push rod 504 can slide up and down inside the housing. In the initial state, the push rod 504 pushes the swing rod 503, which abuts against the bottom of the valve stem 505 to close the dispensing channel, through the action of the large spring 508. Before injecting liquid into the container, the dispensing head 5 is driven down by the telescopic rod 2 until the push rod 504 is in the horizontal section outside the housing and abuts against the top of the container. The push rod 504 is then raised until it is stopped by the limiting mechanism. At this time, the large spring 508 is compressed and stores force. The liquid in the dispensing channel is squeezed out from the valve stem 505 under the pressure of the injection pump. After the liquid is injected into the submerged liquid level hole, the limiting mechanism is subjected to negative pressure and releases the push rod 504. The push rod 504 is reset under the elastic force of the large spring 508 and pushes the swing rod 503, which abuts against the bottom of the valve stem 505 to close the channel between the valve stem 505 and the valve seat 507.

[0033] To isolate the dispensing channel from the positioning components, a partition is provided outside the dispensing channel inside the housing. The push rod 504 slides and fits against the partition to prevent liquid leakage.

[0034] Specifically, the limiting mechanism includes a limiting rod 510, a negative pressure chamber 509, and a negative pressure membrane 511. The limiting rod 510 is horizontally slidably disposed in the limiting channel of the housing. The negative pressure membrane 511 covers the rear opening of the limiting channel. The limiting rod 510 is connected to the negative pressure membrane 511. The negative pressure membrane 511 pulls the limiting rod 510 to slide horizontally according to the pressure change in the negative pressure chamber 509. The head of the limiting rod 510 is an inclined surface.

[0035] The negative pressure chamber 509 is interconnected with the channel on the valve seat 507 and the liquid level hole. The negative pressure diaphragm 511 is capable of sealing and limiting the channel. The negative pressure diaphragm 511 is made of elastic material or has an elastic structure at its rear end to push the negative pressure diaphragm 511 towards the limiting rod 510. When the push rod 504 is limited by the limiting rod 510, liquid flows out from the dispensing channel and forms a negative pressure between the valve rod 505 and the valve seat 507. The negative pressure is drawn in from outside the liquid level hole along the gas flow channel 506. Air is introduced until the liquid level hole is submerged. Because the liquid level hole is blocked, the negative pressure causes the negative pressure diaphragm 511 at the end of the limiting channel to contract and move towards the negative pressure chamber 509. The contraction and movement of the negative pressure diaphragm 511 pulls the limiting rod 510 to move to the rear end. The movement of the limiting rod 510 causes the push rod 504 to be released under the action of the large spring 508. After the push rod 504 is released, it slides downward and abuts against the rocker arm 503, closing the channel between the valve stem 505 and the valve seat 507 through the rocker arm 503.

[0036] The principle by which the negative pressure between valve stem 505 and valve seat 507 can draw in gas from the level hole and negative pressure chamber 509 is as follows: When fluid flows through a constricting pipe or device, such as flowing from a larger area into a smaller area, the flow velocity increases to maintain a constant total flow rate due to the continuity of flow (i.e., conservation of mass). According to Bernoulli's principle, an increase in flow velocity leads to a decrease in pressure. This is because an increase in flow velocity means an increase in the fluid's kinetic energy, and according to the principle of conservation of energy, the total energy per unit time remains constant. Therefore, when kinetic energy increases, the pressure must decrease.

[0037] The above description is merely a preferred embodiment of the present utility model and is not intended to limit the present utility model in any way. Although the present utility model has been disclosed above with reference to a preferred embodiment, it is not intended to limit the present utility model. Any person skilled in the art can make some modifications or alterations to the above-disclosed technical content to create equivalent embodiments without departing from the scope of the present utility model. Any simple modifications, equivalent changes and alterations made to the above embodiments based on the technical essence of the present utility model without departing from the scope of the present utility model shall still fall within the scope of the present utility model.

Claims

1. A device for aseptically dispensing small volume injections, characterized in that: The machine table is provided with a telescopic rod, the bottom of the telescopic rod is provided with a sub-packaging head, the sub-packaging head comprises a shell, a sub-packaging channel is formed in the shell, a check valve assembly is arranged in the sub-packaging channel, a positioning assembly is further arranged in the shell, the positioning assembly and the check valve assembly are communicated through a gas flow channel, a liquid level hole is formed in the shell outside and below the horizontal plane of the check valve assembly, and the positioning assembly controls the on-off of the sub-packaging channel according to the contact state of the liquid level hole with the liquid level.

2. A small volume injection aseptic dispensing device according to claim 1, characterized in that: The check valve assembly comprises a valve seat, a valve rod and a swing rod, the valve seat is connected to the inner wall of the sub-packaging channel, a grid is arranged below the valve seat, a small spring is arranged on the grid, the bottom of the valve rod is arranged on the small spring, the top of the valve rod abuts against the valve seat, the swing rod is rotationally arranged in the shell and one end of the swing rod extends into the sub-packaging channel and abuts against the bottom of the valve rod, the positioning assembly is separated from the swing rod to open the check valve assembly, and the positioning assembly pushes the swing rod to close the check valve assembly.

3. A small volume injection aseptic dispensing device as claimed in claim 2 wherein: The positioning assembly comprises a large spring and a limiting mechanism, the bottom of the large spring is provided with a push rod, the vertical section of the push rod is slidingly arranged in the shell, and the limiting mechanism is used for limiting and releasing the push rod.

4. A small volume injection aseptic dispensing device as claimed in claim 3 wherein: The limiting mechanism comprises a limiting rod, a negative pressure cavity and a negative pressure film, the limiting rod is slidingly arranged in the limiting channel of the shell, the negative pressure film covers the opening at the rear end of the limiting channel, the limiting rod is connected to the negative pressure film, and the negative pressure film pulls the limiting rod to slide horizontally according to the pressure change in the negative pressure cavity.

5. A small volume syringe aseptic dispensing device according to claim 3, wherein: The upper horizontal section and the lower horizontal section of the push rod extend out of the shell, the lower horizontal section is extruded by the container to lift the push rod and separate the push rod from the swing rod.

6. A small volume syringe aseptic dispensing device according to claim 4, wherein: The head of the limiting rod is an inclined surface.

7. A small volume injection aseptic dispensing device as claimed in claim 1 wherein: The machine table is provided with a rotating disc, the rotating disc is below the sub-packaging head, and the rotating disc is provided with a mounting groove for placing the container.

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