Safety smear and thermosetting integrated mycobacterium detection slide prefabricating system

Abstract

The utility model discloses a safety smear and thermosetting integrated mycobacterium detection slide prefabricating system. Comprising a main shell, a slide storage unit, a station switching unit, a slide loading unit, an electric heating table which is smoothly connected with the upper surface of the front side of the slide loading unit, and a sample adding unit, a smear unit and a slide taking port which are arranged on the right side of the slide storage unit, the multi-slide storage, loading, smearing and heating processes are integrated automatically, workers are replaced, and the infection risk is reduced; in addition, through an electric heating mode, a traditional method that an alcohol lamp is adopted for heating and has unsafe risks is abandoned; the safety of the equipment is improved, and a thought is provided for controlling the heating temperature of the slide in the future; in the scheme, air cylinder components are not adopted, all stations are linearly arranged, high integration is achieved, the equipment size is reduced, the manufacturing cost is saved, and scheme popularization is better facilitated.

Description

TECHNICAL FIELD

[0001] The embodiment of the utility model belongs to the mycobacterium detection slide pretreatment technical field, more particularly, relates to a safe smear, heat solid integrated mycobacterium detection slide prefabricated system. BACKGROUND

[0002] Mycobacterium tuberculosis, commonly known as tubercle bacillus, belongs to the genus Mycobacterium and is the pathogenic bacteria causing tuberculosis. It can invade all organs of the body, but pulmonary tuberculosis is the most common. Tuberculosis is still an important infectious disease. According to the WHO report, about 8 million new cases occur every year, and at least 3 million people die from the disease. Mycobacterium tuberculosis is a long and slightly curved bacillus, 1-4 x 0.4 μm in size, with a unique lipid content (up to 60%) in its bacterial cell wall structure, especially the presence of mycolic acid, which surrounds the peptidoglycan layer outside the cell wall, forming an acid-resistant barrier that is difficult to penetrate, allowing the bacteria to resist the decolorization effect of hydrochloric alcohol during staining. Medical workers use this acid-fast phenomenon to distinguish Mycobacterium tuberculosis in sputum and other body fluid samples from other types of bacteria. The sputum sample smear (uniformly smeared on a glass slide to form a 10mm x 20mm film) and heating fixation process are important steps in acid-fast staining. When performing smear operations on sputum from tuberculosis patients in an open environment, aerosols are easily generated, leading to the risk of airborne transmission of Mycobacterium tuberculosis. At the same time, using an alcohol lamp to heat and fix the slide is not only difficult to control the temperature, but also has the risk of causing a fire or triggering a smoke sensor. The above will pose a risk to the safety of medical personnel. Therefore, providing a safe smear, heat solid integrated mycobacterium detection slide prefabricated system to reduce the frequency of contact with the human body is of positive significance to the health and safety of operating personnel and improves work efficiency.

[0003] In order to solve the above technical problems, Chinese invention patent CN106771288B discloses a Mycobacterium tuberculosis automatic detection equipment, including machine body, rotating plate device, sputum smearing device, dyeing device and flushing device; the machine body is installed with PLC controller, the rotating plate device is located in the middle of the machine body, the sputum smearing device is located in the left part of the machine body, the dyeing device is located in the front part of the machine body, and the flushing device is located in the right part of the machine body: the Mycobacterium tuberculosis automatic detection equipment provided by the application realizes the automatic operation of sputum film, dyeing, decolorization and restaining process in the process of Mycobacterium tuberculosis detection, reduces the time of medical personnel contacting pathogenic bacteria, and is beneficial to the health of medical workers.

[0004] The above-mentioned patented technology uses automated devices to assist in the automatic processing of glass slides, thereby reducing the risk of infection for workers. However, there are still the following technical problems or areas for improvement: (1) In the above-mentioned patented technology, the multi-station operation is achieved by using cylinders. On the one hand, it requires the use of an air compressor, which can easily cause significant pollution. On the other hand, it increases the size and cost of the equipment, making it difficult for small and medium-sized institutions to accept and hindering the promotion of the solution. (2) The above-mentioned solution completely simulates the manual operation steps. However, the alcohol lamp heating process involves flammable materials and has certain dangers. It is not the optimal choice among automated devices. Under the premise of ensuring the quality of glass slide processing, the original operation limitations should be broken through to improve the safety and reliability of the system. Utility Model Content

[0005] To address the aforementioned deficiencies or improvement needs of existing technologies, this utility model provides a safe, integrated thermosetting and coating system for mycobacterial detection slide preparation. By automating the storage, loading, coating, and heating processes of multiple slides, it replaces manual labor, reducing the risk of infection. Furthermore, the use of electric heating eliminates the unsafe methods of traditional alcohol lamp heating, improving equipment safety and providing insights for future controllable slide heating temperatures. The system also eliminates the use of cylinder components, and the linear arrangement of each workstation achieves high integration, reducing equipment size, saving manufacturing costs, and facilitating wider adoption.

[0006] To achieve the above objectives, a safe, thermosetting integrated slide preparation system for mycobacterial detection includes:

[0007] The system comprises a main housing, a slide storage unit located diagonally above the main housing for storing slides to be loaded, a workstation switching unit located on the bottom surface of the inner cavity of the main housing, a slide loading unit fixed to the output end of the workstation switching unit for retrieving slides one by one from the slide storage unit, an electric heating stage smoothly connected to the upper front surface of the slide loading unit, and a sample application unit, a smearing unit, and a slide retrieval port located on the right side of the slide storage unit.

[0008] The slide storage unit includes an inclined storage groove, a slide inlet located at the upper end of the inclined storage groove, an inlet cover, and a slide outlet located at the lower end of the inclined storage groove to facilitate slide leakage.

[0009] Preferably, the workstation switching unit includes:

[0010] A drive motor is fixed to the inner side of the main housing; a lead screw is fixedly connected to the output shaft of the drive motor in a horizontal direction; and a slide is connected to the lead screw in a linear threaded transmission. The slide is fixedly connected to the glass slide loading unit.

[0011] Preferably, the slide loading unit includes:

[0012] An L-shaped base fixedly connected to the slide table, a guide arc on the right side of the base, a side connecting rod on the front and rear sides of the L-shaped base and a loading trigger assembly fixedly connected to the right end of the side connecting rod, a reversing sliding channel for guiding the sliding glass slide between the loading trigger assembly and the guide arc, and a glass slide blocking assembly at the lower port of the glass slide storage unit.

[0013] Preferably, the loading trigger component includes:

[0014] An arc-shaped guide block facing away from the guide arc, an arc-shaped trigger block that is rotatably connected to the upper right side of the arc-shaped guide block, and a pull-back spring disposed between the lower end face of the arc-shaped trigger block and the arc-shaped guide block; the left arc surface of the arc-shaped trigger block and the arc surface of the arc-shaped guide block are smoothly transitioned.

[0015] Preferably, the slide blocking assembly includes:

[0016] A baffle that is connected to the lower port of the inclined storage slot via a second hinge, a limiting block fixedly connected to the main housing and located on the right side of the baffle, and a push spring fixedly connected to the right side of the baffle, the other end of which is fixedly connected to the main housing.

[0017] Preferably, the sample dispensing unit includes:

[0018] A card interface for inserting a sample tube, and an elastic clamping part provided on the side wall of the card interface, wherein the elastic clamping part is a rubber block.

[0019] Preferably, the coating unit includes:

[0020] A blower that blows the sample droplets on the glass slide apart, and a filter exhaust port located on the inner wall of the main housing.

[0021] In summary, compared with the prior art, the above-described technical solution conceived by this utility model can achieve the following beneficial effects:

[0022] (1) The present invention provides a safe, thermosetting integrated slide prefabrication system for mycobacterial detection. By automatically integrating the storage, loading, coating, and heating processes of multiple slides, it replaces manual labor and reduces the risk of infection. In addition, by using electric heating, it eliminates the unsafe method of traditional alcohol lamp heating. This not only improves the safety of the equipment but also provides ideas for future controllable slide heating temperature. Furthermore, the solution does not use cylinder components, and the workstations are arranged linearly, achieving high integration, reducing the size of the equipment, saving manufacturing costs, and making the solution more suitable for promotion.

[0023] (2) The present invention provides a safe smear and thermosetting integrated mycobacterial detection slide prefabrication system. By adding a slide loading unit, the automatic pushing, slide leakage and arc-shaped guide sliding actions are effectively integrated to realize the automatic slide loading function. The structure of this solution is simple and only uses elastic components to complete the loading action, which solves the technical defects of the existing technology that use cylinders, resulting in high manufacturing costs and high noise. Attached Figure Description

[0024] Figure 1 This is a schematic diagram of the overall structure of a safe smear and thermosetting integrated mycobacterial detection slide prefabrication system according to an embodiment of the present invention;

[0025] Figure 2 A partial enlarged view (A) shows a safe smear and thermosetting integrated mycobacterial detection slide prefabrication system according to an embodiment of this utility model.

[0026] Figure 3 This is a schematic diagram of the slide loading unit of a safe smear and thermosetting integrated mycobacterial detection slide prefabrication system according to an embodiment of the present invention.

[0027] Figure 4 This is a schematic diagram of the sample application unit structure of a safe smear and thermosetting integrated mycobacterial detection slide prefabrication system according to an embodiment of the present invention;

[0028] In all the accompanying drawings, the same reference numerals denote the same technical features, specifically: 1-main housing, 2-slide storage unit, 201-sloping storage groove, 202-slide inlet, 203-inlet cover, 204-slide outlet, 3-station switching unit, 301-drive motor, 302-lead screw, 303-slide table, 4-slide loading unit, 400-base, 401-guide arc, 402-side connecting rod, 410-loading trigger assembly, 411-arc 412-Arc-shaped trigger block, 413-First hinge, 414-Pull-back spring, 420-Reversing sliding channel, 430-Slide holding assembly, 431-Second hinge, 432-Baffle, 433-Limiting stop block, 434-Pushing spring, 5-Electric heating stage, 6-Sampling unit, 610-Card interface, 611-Elastic clamping part, 620-Sampling tube, 7-Smear unit, 701-Fan, 702-Filter exhaust port, 8-Slide picking port. Detailed Implementation

[0029] In the description of this application, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", etc., indicating the orientation or positional relationship are based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this utility model and simplifying the description, and are not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model.

[0030] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this utility model, "a plurality of" means two or more, unless otherwise explicitly specified.

[0031] In this application, unless otherwise expressly specified and limited, the terms "installation," "connection," "linking," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0032] To make the objectives, technical solutions, and advantages of this utility model clearer, the present utility model will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only for explaining the present utility model and are not intended to limit the present utility model. Furthermore, the technical features involved in the various embodiments of the present utility model described below can be combined with each other as long as they do not conflict with each other.

[0033] like Figures 1-4 As shown in this embodiment of the invention, the safe smear and thermosetting integrated mycobacterial detection slide prefabrication system includes:

[0034] The main housing 1, a slide storage unit 2 located diagonally above the main housing 1 for storing slides to be loaded, a work station switching unit 3 located on the bottom surface of the inner cavity of the main housing 1, a slide loading unit 4 fixed to the output end of the work station switching unit 3 for obtaining slides one by one from the slide storage unit 2, an electric heating stage 5 smoothly connected to the front upper surface of the slide loading unit 4, a sample application unit 6, a smearing unit 7, and a slide retrieval port 8 located on the right side of the slide storage unit 2;

[0035] The slide storage unit 2 includes an inclined storage groove 201, a slide inlet located at the upper end of the inclined storage groove 201, an inlet cover plate 203, and a slide outlet 204 located at the lower end of the inclined storage groove 201 to facilitate the slide sliding down.

[0036] In this embodiment of the invention, the storage, loading, coating, and heating processes of multiple glass slides are automatically integrated, replacing manual labor and reducing the risk of infection. Furthermore, the use of electric heating eliminates the unsafe method of traditional alcohol lamp heating, improving equipment safety and providing insights for future controllable glass slide heating temperatures. Moreover, the solution eliminates the use of cylinder components, and the linear arrangement of each workstation achieves high integration, reducing equipment size, saving manufacturing costs, and facilitating wider adoption of the solution.

[0037] like Figure 1 As shown in this embodiment of the utility model, the workstation switching unit 3 includes:

[0038] A drive motor 301 is fixed to the inner side of the main housing 1; a lead screw 302 is fixedly connected to the output shaft of the drive motor 301 in a horizontal direction; and a slide 303 is connected to the lead screw 302 for linear thread transmission. The slide 303 is fixedly connected to the glass slide loading unit.

[0039] like Figures 1-3 As shown, in this embodiment of the present invention, the slide loading unit 4 includes:

[0040] An L-shaped base 400 fixedly connected to the slide table 303 includes a guide arc 401 on the right side of the base 400, a side connecting rod 402 on the front and rear sides of the L-shaped base 400 and a loading trigger assembly 410 fixedly connected to the right end of the side connecting rod 402, a reversing sliding channel 420 for guiding the sliding glass slide between the loading trigger assembly 410 and the guide arc 401, and a glass slide blocking assembly 430 located at the lower port of the glass slide storage unit 2.

[0041] like Figures 1-2 As shown, in this embodiment of the present invention, the loading trigger component 410 includes:

[0042] The arc-shaped guide block 411 facing away from the guide arc 401, the arc-shaped trigger block 412 which is rotatably connected to the upper right side of the arc-shaped guide block 411, and the pull-back spring 414 located between the lower end face of the arc-shaped trigger block 412 and the arc-shaped guide block 411; the left arc surface of the arc-shaped trigger block 412 and the arc surface of the arc-shaped guide block 411 are smoothly transitioned.

[0043] like Figure 1 andFigure 2 As shown, in this embodiment of the present invention, the glass slide blocking assembly 430 includes:

[0044] The second hinge part 431 is connected to the lower port of the inclined storage slot 201 by a baffle 432 that is kept open and closed, a limiting block 433 that is fixedly connected to the main housing 1 and located on the right side of the baffle 432, and a push spring 434 that is fixedly connected to the right side of the baffle 432. The other end of the push spring 434 is fixedly connected to the main housing 1.

[0045] like Figure 1 and Figure 4 As shown in this embodiment of the invention, the sample addition unit 6 includes:

[0046] A card interface 610 for inserting the sample tube 620, and an elastic clamping part 611 provided on the side wall of the card interface 610, wherein the elastic clamping part 611 is a rubber block.

[0047] like Figure 1 As shown in this embodiment of the invention, the smear unit 7 includes:

[0048] A blower 701 that blows the sample droplets on the glass slide apart, and a filter exhaust port 702 located on the inner wall of the main housing 1.

[0049] The working principle of this utility model embodiment is as follows: First, glass slides are loaded in batches into the inclined storage groove 201. Under the action of the push spring 434, the baffle 432 tightly closes the lower port of the inclined storage groove 201, preventing the glass slides from sliding out. The sample tube 620 is then inserted into the card interface 610, waiting for sample addition. Next, the system is started, controlling the drive motor 301 to rotate, thereby driving the glass slide loading unit to move to the right. Consequently, the upper end of the arc-shaped trigger block 412 abuts against the lower end of the baffle 432 and pushes it to the right, thereby opening the lower port of the inclined storage groove 201. The glass slides slide down from the glass slide outlet 204 along the reversing downward sliding channel 420 into the electric heating... Step 5; Next, continue to control the drive motor 301 to rotate, switching the workstation to the sample application area. Manually squeeze the sample application tube 620 to add sample droplets to the glass slide on the electric heating stage 5; Next, continue to control the drive motor 301 to rotate, switching the workstation to the smear area, and start the fan 701. Under the action of the wind, the droplets are blown flat onto the surface of the glass slide, and the internal gas is discharged outward from the filter exhaust port 702; Next, start the electric heating stage 5 to evaporate the water in the droplets on the glass slide, thus completing the glass slide preparation operation for mycobacterial detection; Next, continue to control the drive motor 301 to rotate, and the slide can be manually removed from the glass slide removal port.

[0050] In this embodiment of the utility model, by adding a glass slide loading unit 4, the automatic pushing, glass slide lowering and curved surface guiding sliding actions are effectively integrated, realizing the automatic glass slide loading function. The structure of this solution is simple, and the loading action is completed by using only elastic components, which solves the technical defects of the prior art that use cylinder method, resulting in high manufacturing cost and high noise.

[0051] The above are merely preferred embodiments of this application and are not intended to limit this application. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of this application should be included within the protection scope of this application. The above are merely preferred embodiments of this application. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the technical principles of this application, and these improvements and modifications should also be considered within the protection scope of this application.

Claims

1. A safety smear, heat fixed, integral Mycobacterium detection slide pre- system, characterized in that, Include: The main shell (1), the slide storage unit (2) for storing the slide to be loaded is arranged in the oblique upper side of the main shell (1), the work station switching unit (3) is arranged in the bottom surface of the inner cavity of the main shell (1), the slide loading unit (4) is fixed to the output end of the work station switching unit (3) for obtaining the slide from the slide storage unit (2) single slide, the electric heating table (5) is smoothly connected with the front side upper surface of the slide loading unit (4), the sample adding unit (6) is arranged in the right side of the slide storage unit (2), the smear unit (7) and the slide taking port (8) are arranged in the right side of the slide storage unit (2); The slide storage unit (2) comprises an oblique storage groove (201), a slide loading port located at the upper end of the oblique storage groove (201), an inlet cover plate (203), and a slide sliding outlet (204) arranged at the lower end of the oblique storage groove (201) to facilitate the downward sliding of the slide.

2. The safety smear, heat fixed, integral Mycobacterium detection slide pre- system of claim 1, wherein, The work station switching unit (3) comprises: The driving motor (301) is fixed to the inner side of the main shell (1), the screw rod (302) is fixedly connected with the output shaft of the driving motor (301) in the horizontal direction, and the sliding table (303) is linearly transmitted with the screw rod (302) in the thread. The sliding table (303) is fixedly connected with the slide loading unit.

3. A safety smear, heat fixed, integral Mycobacterium detection slide pre- system according to claim 2, wherein, The slide loading unit (4) comprises: The L-shaped base (400) is fixedly connected with the sliding table (303), the guide arc (401) is arranged on the right side of the base (400), the side link (402) is arranged on the front and rear sides of the L-shaped base (400), the loading trigger assembly (410) is fixedly connected with the right end of the side link (402), the reversing downward sliding channel (420) is arranged between the loading trigger assembly (410) and the guide arc (401) for guiding the sliding of the slide, and the slide blocking assembly (430) is arranged at the lower port of the slide storage unit (2).

4. The safety smear, heat fixed, integral Mycobacterium detection slide pre- system of claim 3, wherein, The loading trigger assembly (410) comprises: The arc-shaped guide block (411) faces away from the guide arc (401), the arc-shaped trigger block (412) is rotatably connected with the right side edge of the upper end of the arc-shaped guide block (411), the return spring (414) is arranged between the lower end surface of the arc-shaped trigger block (412) and the arc-shaped guide block (411), and the left arc surface of the arc-shaped trigger block (412) and the arc surface of the arc-shaped guide block (411) are smoothly connected.

5. The safety smear, heat fixed, integral Mycobacterium detection slide pre- system of claim 4, wherein, The slide blocking assembly (430) comprises: The baffle (432) is hingedly connected with the lower port of the oblique storage groove (201) through the second hinge part (431), the limiting block (433) is fixedly connected with the main shell (1) and arranged on the right side of the baffle (432), and the push spring (434) is fixedly connected with the right side surface of the baffle (432). The other end of the push spring (434) is fixedly connected with the main shell (1).

6. A safety smear, thermofixed, integral Mycobacterium detection slide pre- system according to any one of claims 1 to 5, characterized in that, The sample adding unit (6) comprises: The clamping port (610) for inserting the sample adding tube (620), the elastic clamping part (611) arranged on the side wall of the clamping port (610), and the elastic clamping part (611) is a rubber block.

7. A safety smear, heat fixed, integral Mycobacterium detection slide pre- system according to claim 6, wherein, The smearing unit (7) comprises: A fan (701) for blowing and spreading the sample droplet on the slide, and a bacteria filter exhaust port (702) arranged on the inner wall of the main shell (1).

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