Small automatic dip dyeing device for cell smear

Abstract

The utility model relates to a small-sized automatic dip dyeing device for a cell smear. The small-sized automatic dip dyeing device comprises a box body, a clear water tank, a sewage tank, a dyeing assembly and a moving assembly, the dyeing assembly comprises a slide rack, a dye liquor cylinder, a cleaning loop and an air drying cylinder; the slide frame is provided with a slide groove, and a slide can be vertically placed in the slide groove; the moving assembly comprises a lead screw module, a rotating motor module and a four-rod assembly, and the slide rack is fixedly connected with the four-rod assembly. Compared with the prior art, the device is small in size, can be placed in an operating room, and is low in dye consumption and high in dyeing efficiency and dyeing quality.

Description

TECHNICAL FIELD

[0001] The utility model relates to medical clinical test technical field especially is related to a cell smear small -size automatic immersion dyeing device. BACKGROUND

[0002] On-site rapid evaluation is that pathologists observe the specimen dyeing on site and feed back in time whether the specimen meets the pathological diagnosis demand. On-site rapid evaluation reduces the biopsy frequency and operation time, obtains effective specimen in a short time, avoids repeated biopsy damage and long-time anesthesia, reduces the adverse effect on patients and has high clinical application value. The on-site rapid evaluation method is that the biopsy sample smeared on the slide is fixed in the fixing liquid, soaked in the Diff A solution for twenty to thirty seconds, then immersed in the Diff B solution for dyeing for about twenty to thirty seconds, then washed with distilled water and dried, and then read under the microscope to make cytological diagnosis quickly.

[0003] At present, most of the hospitals in China perform diagnostic intervention operation manually. The existing slide dyeing device occupies a large space and cannot be placed in the operating room, so it is not suitable for on-site rapid evaluation during the diagnostic intervention operation process, and most of them use drop dyeing technology, which has low dye utilization rate.

[0004] Patent application No. CN202410717133.4 discloses a full-automatic cell smear pipetting and dyeing integrated machine. First, the cell specimen is extracted and sampled at the cell sample pipetting device, and the cell specimen is extracted into the cell smear device. At this time, the conveying device moves the cell smear device to the centrifugal device in the close direction. The centrifugal device receives the cell smear device output by the cell sample pipetting device and completes the centrifugal operation for the cell specimen in the cell smear device. After the centrifugal device completes the centrifugal operation and outputs the cell smear device, the conveying device moves the cell smear device to the dyeing device for targeted dyeing, so as to realize automatic sampling, centrifugation and dyeing of the cell specimen in the cell smear device, replace manual operation, improve the efficiency of cell centrifugation smear production, effectively prevent the decrease of cell activity, and effectively realize independent sheet making of a single cell specimen and avoid cross infection between multiple cell specimens. However, the device has a large volume and a complex conveying mechanism structure, and cannot improve the dyeing efficiency. UTILITY MODEL CONTENT

[0005] The utility model aims at overcoming the above-mentioned defects of the prior art and provides a cell smear small -size automatic immersion dyeing device, which has a small volume, can be placed in the operating room, has a small amount of dye, and has high dyeing efficiency and dyeing quality.

[0006] The utility model provides a cell smear small -size automatic dip dyeing device, and the device is small in size and can be placed in the operating room to realize automatic slide staining in the biopsy process. The use of the device is favorable for reducing the dye consumption, improving the dyeing efficiency and enhancing the dyeing quality.

[0007] The utility model provides a cell smear small -size automatic dip dyeing device, and the device is small in size and can be placed in the operating room to realize automatic slide staining in the biopsy process. The use of the device is favorable for reducing the dye consumption, improving the dyeing efficiency and enhancing the dyeing quality.

[0008] The dyeing assembly includes a slide rack, a dyeing solution cylinder, a cleaning circuit and a air drying cylinder.

[0009] The moving assembly includes a lead screw module, a rotating motor module and a four-bar assembly, and the slide rack is fixedly connected with the four-bar assembly.

[0010] Further, the lead screw module includes a lead screw guide rail, a lead screw sliding block and a stepping motor, the lead screw guide rail is fixedly connected to the box body, the lead screw sliding block is arranged on the lead screw guide rail, the lead screw sliding block can slide along the lead screw guide rail, and the stepping motor drives the lead screw to realize linear movement.

[0011] Further, the four-bar assembly includes a linear push rod module, a connecting rod and a push rod turntable, the linear push rod module includes a linear push rod and a linear push rod motor, the linear push rod is slidingly connected to the linear push rod motor to realize length change of the linear push rod module, the connecting rod is provided with a connecting rod pivot, the connecting rod pivot is concentrically matched with a hole arranged at one end of the linear push rod to realize rotation around the pivot.

[0012] Further, the rotating motor module includes a rotating motor and a gear, the gear includes a large gear and a small gear which are meshed with each other, and the small gear is fixedly connected with the rotating shaft of the rotating motor.

[0013] Further, the linear push rod module is fixedly connected to the large gear and the push rod turntable respectively, the large gear and the push rod turntable are arranged on the lead screw sliding block, and the large gear and the push rod turntable can rotate on the lead screw sliding block.

[0014] Further, a through hole is formed in the side surface of the box body, and the connecting rod of the four-bar assembly can extend out of the through hole.

[0015] The four-bar assembly has a first working position and a second working position; when the four-bar assembly is in the first working position, the connecting rod is in a horizontal position, and the slide rack is fixedly arranged on the connecting rod; when the four-bar assembly is in the second working position, the connecting rod is in a vertical position, and the slide rack is at the same horizontal level as the cylinder body, and the slide block of the screw module moves transversely to realize that the slide rack can move into the dyeing liquid cylinder, the cleaning cylinder of the cleaning loop, and the air drying cylinder in sequence.

[0016] Further, when the four-bar assembly is in the first working position, the linear push rod module is retracted to the shortest, the rotating motor works, and the connecting rod is in a vertical position; the screw moves until it is aligned with the lower cylinder body, the rotating motor works, and the linear push rod module is elongated, so that the four-bar assembly is in the second working position, and the slide rack vertically descends to the working position; after the corresponding processing operation is completed, the rotating motor works and the linear push rod module is shortened, so that the slide rack vertically ascends to leave the cylinder body; in sequence, the slide rack enters the three dyeing liquid cylinders, the cleaning cylinder, and the air drying cylinder, and the slide rack is processed; the lower linear push rod module is elongated, the rotating motor works, and the four-bar assembly is in the first working position, and the slide rack is taken out.

[0017] Further, the cleaning loop comprises two peristaltic pumps, a hose, and a cleaning cylinder; the cleaning cylinder is provided with a water inlet and a water outlet, one peristaltic pump connects the clean water tank and the water inlet through the hose, and the other peristaltic pump connects the sewage tank and the water outlet through the hose.

[0018] Further, when the four-bar assembly is in the second working position and the slide rack is placed in the cleaning cylinder, the peristaltic pump connected with the water inlet works to push the clean water from the clean water tank to the water inlet, so as to realize the flushing of the slide, and the peristaltic pump connected with the water outlet works to push the excess waste water into the sewage tank, so as to avoid the water from being collected in the cleaning cylinder.

[0019] Further, the air drying cylinder comprises a fan and a wind shield, one side of the wind shield is fixedly connected with the fan, and the other side of the wind shield is provided with a ventilation hole; when the four-bar assembly is in the second working position and the slide rack is placed in the air drying cylinder, the fan is started to realize the drying treatment of the slide.

[0020] The working principle is:

[0021] The four-bar assembly is in a horizontal position and extends from the through hole, that is, in a first working position. A user places five glass slides to be treated into the slide rack and fixes the slide rack to the connecting rod, and waits for staining. The two linear push rod modules are retracted to the shortest, the rotating motor works, so that the connecting rod is in a vertical position. The lead screw moves until the slide rack is aligned with the lower staining cylinder, the rotating motor works, and the two linear push rod modules are elongated, so that the four-bar assembly is in a second working position, the slide rack vertically descends into the cylinder, the glass slides are immersed in the fixing liquid, and the fixing is completed. The rotating motor works, and the two linear push rod modules are shortened, so that the slide rack vertically ascends and leaves the cylinder body. The same principle is sequentially used to enter two staining cylinders, a cleaning cylinder and an air drying cylinder, so that the subsequent staining of the staining liquid A and the staining liquid B, the cleaning of the glass slides and the air drying of the glass slides are completed. When the slide rack is in the cleaning cylinder, the two peristaltic pumps work. The peristaltic pump connected with the water inlet pushes clean water from the clean water tank to the water inlet, so that the glass slides are washed, and the peristaltic pump connected with the water outlet pushes the excess waste water to the sewage tank, so that water is prevented from being collected in the cleaning cylinder. When the slide rack is in the air drying cylinder, the fan starts to realize the drying treatment of the glass slides, and the treatment of the glass slides is completed. The lower linear push rod module is elongated, the rotating motor works, so that the four-bar assembly is in the first working position, and the glass slides are taken out.

[0022] Compared with the prior art, the cell smear small automatic immersion staining device has the following advantages:

[0023] The cell smear small automatic immersion staining device has the advantages of small size, can be placed in an operating room, small amount of dye, high dyeing efficiency and high dyeing quality. The four-bar assembly realizes automatic glass slide immersion staining, has small size, and is accurately positioned and efficient. The clean water tank, the sewage tank, the dyeing assembly and the moving assembly are matched to realize efficient dyeing. Meanwhile, the number of dyeing cylinders can be increased or decreased according to needs, and the cell smear small automatic immersion staining device has flexibility. BRIEF DESCRIPTION OF DRAWINGS

[0024] Figure 1 It is a structural schematic view of the cell smear small automatic immersion staining device;

[0025] Figure 2 It is a front view schematic view of the cell smear small automatic immersion staining device in the first working position;

[0026] Figure 3 It is a structural schematic view of the moving assembly of the cell smear small automatic immersion staining device;

[0027] Figure 4 It is a front view schematic view of the cell smear small automatic immersion staining device in the first working position;

[0028] Figure 5 It is a left view schematic view of the cell smear small automatic immersion staining device in the first working position;

[0029] Figure 6 It is a front view schematic view of the cell smear small automatic immersion staining device in the second working position;

[0030] Figure 7 A schematic diagram of the cleaning circuit structure of a small-scale automated cell smear staining device;

[0031] Figure 8 A cross-sectional schematic diagram of the cleaning tank structure of a small-scale automated cell smear staining device;

[0032] Figure 9 A schematic diagram of the drying cylinder structure of a small-scale automated cell smear staining device.

[0033] Reference numerals: 1-Box body, 11-Through hole, 2-Clean water tank, 3-Sewage tank, 41-Slide holder, 42-Dyeing solution tank, 43-Washing circuit, 431-Peristaltic pump, 432-Hose, 433-Washing tank, 434-Inlet, 435-Outlet, 44-Drying tank, 441-Fan, 442-Wind shield, 443-Ventilation hole, 6-Lead screw module, 61-Lead screw slider, 62-Lead screw guide rail, 63-Stepper motor, 7-Rotary motor module, 71-Gear, 72-Rotary motor, 8-Four-bar linkage, 81-Linear push rod module, 811-Linear push rod, 812-Linear push rod motor, 82-Connecting rod, 821-Connecting rod shaft, 83-Push rod turntable. Detailed Implementation

[0034] The present invention will now be described in detail with reference to the accompanying drawings and specific embodiments. Component models, material names, connection structures, control methods, algorithms, and other features not explicitly described in this technical solution are considered common technical features disclosed in the prior art.

[0035] Example 1

[0036] This embodiment provides a small-scale automated cell smear staining device, such as... Figure 1 , 2 As shown in 3, 7, 8, and 9, it includes: a box body 1, a clean water tank 2, a wastewater tank 3, and a dyeing assembly and a moving assembly located inside the box body 1;

[0037] The staining assembly includes: a slide holder 41, three staining solution tanks 42, a washing circuit 43, and a drying tank 44; the slide holder 41 is provided with five slide slots, which can vertically hold five slides.

[0038] The moving assembly includes a lead screw module 6, a rotary motor module 7, and a four-bar linkage 8. The slide holder 41 is fixedly connected to the four-bar linkage 8. The slide holder 41 is fixedly connected to the connecting rod 82 of the four-bar linkage 8.

[0039] In a specific embodiment, the lead screw module 6 includes: a lead screw guide rail 62, a lead screw slider 61, and a stepper motor 63; the lead screw guide rail 62 is fixedly connected to the housing 1, the lead screw slider 61 is disposed on the lead screw guide rail 62, the lead screw slider 61 can slide along the lead screw guide rail 62, and the stepper motor 63 drives the lead screw to achieve linear movement.

[0040] In a specific embodiment, the four-bar assembly 8 includes: two linear push rod modules 81, a connecting rod 82, and a push rod turntable 83; the linear push rod module 81 includes a linear push rod 811 and a linear push rod motor 812, the linear push rod 811 is slidably connected to the linear push rod motor 812 to realize the change of the length of the linear push rod module 81; the connecting rod 82 is provided with two connecting rod shafts 821, the connecting rod shafts 821 are concentrically engaged with the holes provided at one end of the linear push rod 811 to realize rotation around the shaft;

[0041] In a specific embodiment, the rotating motor module 7 includes a rotating motor 72 and a gear 71. The gear includes a large gear and a small gear that mesh with each other, and the small gear is fixedly connected to the rotating shaft of the rotating motor 72.

[0042] In a specific embodiment, two linear push rod modules 81 are fixedly connected to the large gear and the push rod turntable 83, respectively. The large gear and the push rod turntable 83 are mounted on the lead screw slider 61, and the large gear and the push rod turntable 83 can rotate on the lead screw slider 61.

[0043] In a specific embodiment, a through hole 11 is provided on the side of the housing 1 for the connecting rod 82 of the four-bar assembly 8 to extend out;

[0044] like Figure 4 , 5 As shown in Figure 6, the four-bar assembly 8 has a first working position and a second working position. When the four-bar assembly 8 is in the first working position, the connecting rod 82 is in a horizontal position and extends from the through hole 11, fixing the slide holder 41 for loading or unloading five glass slides onto the connecting rod 82. When the four-bar assembly 8 is in the second working position, the connecting rod 82 is in a vertical position, and the slide holder 41 is at the same horizontal height as the cylinder. With the cooperation of the lead screw slider 61 of the lead screw module 6 moving laterally, the slide holder 41 can be moved into the two dyeing tanks 42, the cleaning tank 433 of the cleaning circuit 43, and the drying tank 44 respectively. The drying tank 44, the cleaning tank 433, and the three dyeing tanks 42 are arranged laterally in sequence inside the housing 1.

[0045] In a specific implementation, the four-bar assembly 8 is in the first working position. After the slide holder 41 is inserted, the two linear push rod modules 81 retract to their shortest length, and the rotating motor 72 operates, causing the connecting rod 82 to be in a vertical position. The lead screw moves until it aligns with the lower cylinder, the rotating motor 72 operates, and at the same time, the two linear push rod modules 81 extend, causing the four-bar assembly 8 to be in the second working position, realizing the vertical descent of the slide holder 41 to the working position. After completing the corresponding processing operation, the rotating motor 72 operates, and the two linear push rod modules 81 shorten, realizing the vertical rise of the slide holder 41 to leave the cylinder. It sequentially enters the three dyeing tanks 42, the cleaning tank 433, and the drying tank 44 to complete the dyeing, cleaning, and drying, and the slide processing is completed. The lower linear push rod module 81 extends, the rotating motor 72 operates, causing the four-bar assembly 8 to be in the first working position, and the slide is removed.

[0046] In a specific embodiment, the cleaning circuit 43 includes: two peristaltic pumps 431, a hose 432, and a cleaning cylinder 433; the cleaning cylinder 433 is provided with an inlet 434 and an outlet 435, one peristaltic pump 431 is connected to the clean water tank 2 and the inlet 434 through the hose 432, and the other peristaltic pump 431 is connected to the wastewater tank 3 and the outlet 435 through the hose 432.

[0047] In a specific implementation, when the four-bar assembly 8 is in the second working position and the slide holder 41 is placed inside the cleaning tank 433, the peristaltic pump 431 connected to the water inlet 434 works to push clean water from the clean water tank 2 to the water inlet 434 to rinse the slide. At the same time, the peristaltic pump 431 connected to the water outlet 435 works to push excess wastewater into the wastewater tank 3 to prevent water from accumulating in the cleaning tank 433.

[0048] In a specific embodiment, the drying cylinder 44 includes two fans 441 and a wind shield 442. One side of the wind shield 442 is fixedly connected to the fan 441, and the other side of the wind shield 442 is provided with a ventilation hole 443. When the four-bar assembly 8 is in the second working position and the slide holder 41 is placed inside the drying cylinder 44, the fan 441 is started to realize the drying process of the slide.

[0049] The working principle is as follows:

[0050] The four-bar assembly 8 is in a horizontal position and extends from the through hole 11, i.e., in the first working position. The user places the five slides to be processed into the slide holder 41 and fixes them to the connecting rod 82, waiting for staining. The two linear push rod modules 81 retract to their shortest position, and the rotating motor 72 operates, so that the connecting rod 82 is in a vertical position. The lead screw moves until the slide holder 41 is aligned with the staining tank 42 below, the rotating motor 72 operates, and at the same time, the two linear push rod modules 81 extend, so that the four-bar assembly 8 is in the second working position, so that the slide holder 41 descends vertically into the tank, immersing the slides in the fixative, completing the fixation. The rotating motor 72 operates, and at the same time, the two linear push rod modules 81 shorten, so that the slide holder 41 rises vertically and leaves the tank. The same principle is followed by the slides entering the two staining tanks 42, the cleaning tank 433, and the drying tank 44 in sequence to complete the subsequent staining with staining solutions A and B, the cleaning of the slides, and the drying of the slides. When the slide holder 41 is inside the cleaning tank 433, two peristaltic pumps 431 operate. The peristaltic pump 431 connected to the inlet 434 pushes clean water from the clean water tank 2 to the inlet 434, rinsing the slides. The peristaltic pump 431 connected to the outlet 435 pushes excess wastewater into the wastewater tank 3, preventing water from accumulating in the cleaning tank 433. When the slide holder 41 is inside the drying tank 44, the fan 441 starts to dry the slides, completing the slide processing. The lower linear push rod module 81 extends, and the rotating motor 72 operates, positioning the four-bar assembly 8 in the first working position, allowing the slide to be removed.

[0051] Components not described in detail in this embodiment are all existing components that can be purchased through public channels.

[0052] The above description of the embodiments is provided to enable those skilled in the art to understand and use the utility model. It will be apparent to those skilled in the art that various modifications can be easily made to these embodiments, and the general principles described herein can be applied to other embodiments without inventive effort. Therefore, the present utility model is not limited to the above embodiments, and any improvements and modifications made by those skilled in the art based on the disclosure of the present utility model without departing from its scope should be within the protection scope of the present utility model.

Claims

1. A small-sized automatic staining device for cell smears, characterized by comprising: The utility model relates to a kind of automatic slide dyeing machine, including: Box (1), clean water tank (2), sewage tank (3) and the dyeing component and moving component located in the inside of box (1); The dyeing component includes: slide rack (41), dyeing solution jar (42), cleaning circuit (43) and air drying jar (44);The slide rack (41) is provided with slide groove, and slide can be vertically placed into slide; The moving component includes: lead screw module (6), rotating motor module (7) and four-bar linkage (8), and the slide rack (41) is fixedly connected with the four-bar linkage (8).

2. The small-sized automatic staining device for cell smears according to claim 1, wherein The lead screw module (6) includes: lead screw guide rail (62), lead screw slider (61) and step motor (63);The lead screw guide rail (62) is fixedly connected on the box (1), the lead screw slider (61) is arranged on the lead screw guide rail (62), the lead screw slider (61) can slide along the lead screw guide rail (62), and the step motor (63) drives the lead screw to realize linear movement.

3. The small-sized automatic staining device for cell smears according to claim 1, wherein The four-bar linkage (8) includes: linear push rod module (81), connecting rod (82), push rod turntable (83);The linear push rod module (81) includes linear push rod (811) and linear push rod motor (812), and the linear push rod (811) is slidably connected to the linear push rod motor (812), to change the length of the linear push rod module (81), and the connecting rod (82) is provided with connecting rod pivot (821), and the connecting rod pivot (821) is concentrically matched with the hole provided at one end of the linear push rod (811), to realize rotation around the shaft.

4. The small-sized automatic staining device for cell smears according to claim 3, wherein The rotating motor module (7) includes: rotating motor (72) and gear (71), and the gear includes large gear and small gear that are engaged with each other, and the small gear is fixedly connected with the rotating shaft of the rotating motor (72).

5. The small-sized automatic staining device for a cell smear according to claim 4, wherein The linear push rod module (81) is fixedly connected to the large gear and the push rod turntable (83) respectively, and the large gear and the push rod turntable (83) are arranged on the lead screw slider (61), and the large gear and the push rod turntable (83) can rotate on the lead screw slider (61).

6. The small-sized automatic staining device for cell smears according to claim 1, wherein A through hole (11) is formed in the side of the box (1) for the connecting rod (82) of the four-bar linkage (8) to extend out of the through hole (11); The four-bar linkage (8) has a first working position and a second working position;When the four-bar linkage (8) is located at the first working position, the connecting rod (82) is in a horizontal position and extends out of the through hole (11), and the slide rack (41) for loading or taking out slides is fixedly arranged on the connecting rod (82);When the four-bar linkage (8) is located at the second working position, the connecting rod (82) is in a vertical position, and the slide rack (41) is at the same horizontal height as the cylinder body, and cooperates with the lead screw slider (61) of the lead screw module (6) to move horizontally, so that the slide rack (41) can be moved into the dyeing solution jar (42), the cleaning cylinder (433) of the cleaning circuit (43) and the air drying jar (44) respectively.

7. The small-sized automatic staining device for cell smears according to claim 1, wherein The four-bar assembly (8) is located in the first working position, after being loaded into the slide rack (41), the linear push rod module (81) is retracted to the shortest, the rotating motor (72) works, so that the connecting rod (82) is in the vertical position; the lead screw moves until it is aligned below the cylinder, the rotating motor (72) works, while the linear push rod module (81) is elongated, so that the four-bar assembly (8) is located in the second working position, realizing the vertical descent of the slide rack (41) to the working position; after completing the corresponding processing operation, the rotating motor (72) works while the linear push rod module (81) is shortened, realizing the vertical ascent of the slide rack (41) to leave the cylinder; sequentially enter the three dyeing cylinders (42), the cleaning cylinder (433) and the air drying cylinder (44), complete dyeing, cleaning and air drying, and the slide processing is completed; the lower linear push rod module (81) is elongated, the rotating motor (72) works, so that the four-bar assembly (8) is located in the first working position, and the slide is taken out.

8. The small-sized automatic staining device for cell smears according to claim 1, wherein The cleaning circuit (43) comprises two peristaltic pumps (431), hoses (432) and a cleaning cylinder (433); the cleaning cylinder (433) is provided with a water inlet (434) and a water outlet (435), one peristaltic pump (431) connects the water tank (2) and the water inlet (434) through the hose (432), and the other peristaltic pump (431) connects the sewage tank (3) and the water outlet (435) through the hose (432).

9. The small-sized automatic staining device for cell smears according to claim 1, wherein When the four-bar assembly (8) is in the second working position and the slide rack (41) is placed inside the cleaning cylinder (433), the peristaltic pump (431) connected with the water inlet (434) works to push the clean water from the water tank (2) to the water inlet (434), realizing the flushing of the slide, while the peristaltic pump (431) connected with the water outlet (435) works to push the excess wastewater into the sewage tank (3), avoiding the water from gathering in the cleaning cylinder (433).

10. The small-sized automatic staining device for cell smears according to claim 1, wherein The air drying cylinder (44) comprises a fan (441) and a wind shield (442), one side of the wind shield (442) is fixedly connected with the fan (441), and the other side of the wind shield (442) is provided with a ventilation hole (443); when the four-bar assembly (8) is in the second working position and the slide rack (41) is placed inside the air drying cylinder (44), the fan (441) is started to realize the drying treatment of the slide.

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