Evaporative crystallization device convenient to clean and used for purifying serum protein

Abstract

The utility model discloses a serum protein purification evaporative crystallization device convenient to clean, which comprises an evaporative crystallization tank, a cover plate is arranged at the top of the evaporative crystallization tank, the outer wall of the cover plate is attached to the inner wall of the evaporative crystallization tank, and a U-shaped frame is fixed at the top of the outer wall of the evaporative crystallization tank. A driving mechanism for moving the cover plate is mounted on the U-shaped frame, an annular scraping strip is mounted on the edge of the top of the cover plate, the edge of the annular scraping strip is tightly attached to the inner wall of the evaporative crystallization tank, and a flushing mechanism is mounted in the cover plate. According to the device, materials adhered to the inner wall of the evaporative crystallization tank are scraped, meanwhile, the materials adhered to the guide rod and the threaded lead screw are respectively cleaned under the action of the scraping ring and the cleaning ring, a certain cleaning effect is achieved, the materials adhered to the inner wall of the evaporative crystallization tank are effectively reduced, and after scraping, the cover plate can be driven to move upwards to be away from the evaporative crystallization tank, so that the operation is convenient. The bottom of the cover plate is convenient to clean.

Description

TECHNICAL FIELD

[0001] The utility model relates to animal serum protein purification equipment technical field, especially serum protein purification evaporation crystallization device convenient to clean. BACKGROUND

[0002] The purification of animal serum protein is the basis for studying the structure, chemical composition and biological function of protein. The current development trend of protein separation and purification technology tends to be the comprehensive use of fine and diversified technology, but the basic principles are based on the properties of protein. The purification of animal serum protein usually includes breaking tissue cells, extracting protein mixture, using salting-out method, organic solvent precipitation method and the like to coarsely extract protein, and the coarsely extracted protein can be further separated and purified by electrophoresis and chromatography technology, and then the protein is crystallized. Evaporation crystallization is the most commonly used protein crystallization method at present, the solvent is evaporated, the solution changes from unsaturated to saturated, and the excess solute will be precipitated in the form of crystals by continuing evaporation, which is called evaporation crystallization. Therefore, the evaporation crystallization device is indispensable.

[0003] However, the material remaining in the traditional evaporation crystallization device is not cleaned in time, the inner wall is prone to scaling, manual repeated cleaning is required after each use, and the cleaning is not convenient, which greatly reduces the efficiency of evaporation crystallization. In view of this, we design a serum protein purification evaporation crystallization device convenient to clean. UTILITY MODEL CONTENT

[0004] The utility model aims at solving the shortcomings in the prior art and provides a serum protein purification evaporation crystallization device convenient to clean.

[0005] In order to achieve the above-mentioned purpose, the utility model adopts the following technical scheme:

[0006] A serum protein purification evaporation crystallization device convenient to clean, including evaporation crystallization jar, the top of evaporation crystallization jar is provided with cover plate, the outer wall of cover plate is attached to the inner wall of evaporation crystallization jar and is provided, the outer wall top of evaporation crystallization jar is fixed with U-shaped support, the U-shaped support is installed with the drive mechanism that realizes the movement of cover plate, the top edge of cover plate is installed with annular scraping strip, and the edge of annular scraping strip is attached to the inner wall of evaporation crystallization jar and is provided, the flush mechanism is installed in cover plate.

[0007] As a further scheme of the utility model, the drive mechanism includes a threaded screw rod rotatably arranged at the bottom of the inner wall of the evaporation crystallization tank, a hole is formed in the top of the cover plate, and a screw nut is fixed in the hole, the screw nut is matched with the threaded screw rod, a bidirectional motor is fixed on the U-shaped support, and the output shaft of the bidirectional motor is coaxially fixed with the threaded screw rod.

[0008] As a further scheme of the present utility model, the inner wall bottom of the evaporation crystallization tank is fixed with two symmetrical guide rods, the cover plate is provided with guide holes for the guide rods to pass through, and the top of the guide rod is fixed with the bottom of the U-shaped frame.

[0009] As a further scheme of the present utility model, the top of the outer wall of the evaporation crystallization tank is provided with a feeding pipe, and the bottom discharge port of the evaporation crystallization tank is fixed with a discharge valve.

[0010] As a further scheme of the present utility model, the top of the lead screw nut is fixed with a cleaning ring, and the inner wall of the cleaning ring is uniformly fixed with bristles.

[0011] As a further scheme of the present utility model, the top of the cover plate is fixed with a scraping ring which is sleeved on the outer wall of the guide rod.

[0012] As a further scheme of the present utility model, the flushing mechanism comprises a water inlet installed on the top of the cover plate, and the bottom of the water inlet is fixed with a water storage box, and the outer wall of the water storage box is fixed with high-pressure nozzles at equal intervals.

[0013] The present utility model has the advantages that:

[0014] The present utility model has the advantages that:

[0015] The present utility model has the advantages that: BRIEF DESCRIPTION OF DRAWINGS

[0016] Figure 1 The present utility model has the advantages that:

[0017] Figure 2 A second three-dimensional structure schematic view of the serum protein purification evaporation crystallization device convenient to clean is provided in the utility model.

[0018] Figure 3 A driving mechanism partial three-dimensional structure schematic view of the serum protein purification evaporation crystallization device convenient to clean is provided in the utility model.

[0019] Figure 4 A partial expanded three-dimensional structure schematic view of the serum protein purification evaporation crystallization device convenient to clean is provided in the utility model.

[0020] In the drawing: 1, evaporation crystallization tank; 2, cover plate; 3, discharge valve; 4, feeding pipe; 5, U-shaped frame; 6, driving mechanism; 7, water inlet; 8, water storage box; 9, high-pressure spray head; 10, screw nut; 11, threaded screw rod; 12, guide rod; 13, guide hole; 14, scraper ring; 15, circular ring scraping strip; 16, cleaning ring. DETAILED DESCRIPTION

[0021] The technical solutions in the embodiments of the utility model will be apparently and completely described below with reference to the drawings in the embodiments of the utility model, and obviously, the described embodiments are only part of the embodiments of the utility model, rather than all the embodiments.

[0022] It should be noted that the embodiments in the present application and the features in the embodiments can be combined with each other without conflict. The utility model will be described in detail below with reference to the drawings and in combination with the embodiments.

[0023] Reference Figures 1-4 A serum protein purification evaporation crystallization device convenient to clean, comprising an evaporation crystallization tank 1, the top of the evaporation crystallization tank 1 is provided with a cover plate 2, the outer wall of the cover plate 2 is attached to the inner wall of the evaporation crystallization tank 1, the top of the outer wall of the evaporation crystallization tank 1 is fixed with a U-shaped frame 5, the U-shaped frame 5 is installed with a driving mechanism 6 for moving the cover plate 2, the top edge of the cover plate 2 is installed with a circular ring scraping strip 15, the edge of the circular ring scraping strip 15 is attached to the inner wall of the evaporation crystallization tank 1, and a flushing mechanism is installed in the cover plate 2.

[0024] In the embodiment, the driving mechanism 6 comprises a threaded screw rod 11 rotatably arranged at the bottom of the inner wall of the evaporation crystallization tank 1, a hole is formed in the top of the cover plate 2, and a screw nut 10 is fixed in the hole, the screw nut 10 is matched with the threaded screw rod 11, a bidirectional motor is fixed on the U-shaped frame 5, and the output shaft of the bidirectional motor is coaxially fixed with the threaded screw rod 11.

[0025] In the embodiment, the bottom of the inner wall of the evaporation crystallization tank 1 is fixed with two symmetrical guide rods 12, a guide hole 13 is formed in the cover plate 2 for the guide rods 12 to pass through, and the top of the guide rod 12 is fixed with the bottom of the U-shaped frame 5.

[0026] In this embodiment, the outer wall of the evaporation crystallization tank 1 is provided with a feeding pipe 4 at the top, and a discharge valve 3 is fixed to the bottom discharge port of the evaporation crystallization tank 1.

[0027] In this embodiment, the top of the screw nut 10 is fixed with a cleaning ring 16, and the inner wall of the cleaning ring 16 is uniformly fixed with brush hairs.

[0028] In this embodiment, the top of the cover plate 2 is fixed with a scraping ring 14 which is sleeved on the outer wall of the guide rod 12.

[0029] In this embodiment, the flushing mechanism includes a water inlet 7 installed on the top of the cover plate 2, and a water storage box 8 is fixed to the bottom of the water inlet 7, and high-pressure nozzles 9 are fixed equidistantly on the outer wall of the water storage box 8. The flushing mechanism includes the water inlet 7, the water storage box 8 and the high-pressure nozzles 9. The water inlet 7 is connected to a water source, and the water is sprayed through the high-pressure nozzles 9. As the cover plate 2 moves downward, the high-pressure nozzles 9 move downward to spray, which realizes better flushing of the inner wall of the evaporation crystallization tank 1. In combination with the circular ring hanging strip 15, better flushing and scraping effect is realized.

[0030] Working principle: through the evaporation crystallization tank 1, the cover plate 2, the U-shaped frame 5, the driving mechanism 6 and the circular ring hanging strip 15, etc. The driving mechanism 6 includes a threaded screw rod 11, a guide rod 12, a bidirectional motor and a guide hole 13, and is provided with a cleaning ring 16 and a guide hole 13. When it is necessary to clean the evaporation crystallization tank 1, the bidirectional motor is started, the threaded screw rod 11 is rotated, the cover plate 2 moves downward under the action of the guide rod 12, the circular ring hanging strip 15 on the cover plate 2 moves downward, the materials adhered to the inner wall of the evaporation crystallization tank 1 are scraped off, and the materials adhered to the guide rod 12 and the threaded screw rod 11 are cleaned under the action of the scraping ring 14 and the cleaning ring 16, respectively, which has a certain cleaning effect, effectively reduces the materials adhered to the inner wall of the evaporation crystallization tank 1, and after scraping, the cover plate 2 can be driven to move upward and away from the evaporation crystallization tank 1, which is convenient for cleaning the bottom of the cover plate 2. Further, the flushing mechanism is provided, which includes the water inlet 7, the water storage box 8 and the high-pressure nozzles 9. The water inlet 7 is connected to a water source, and the water is sprayed through the high-pressure nozzles 9. As the cover plate 2 moves downward, the high-pressure nozzles 9 move downward to spray, which realizes better flushing of the inner wall of the evaporation crystallization tank 1. In combination with the circular ring hanging strip 15, better flushing and scraping effect is realized.

[0031] For purposes of the description hereinafter, spatial

[0032] It is also to be noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments in accordance with the present application. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be further understood that the terms "comprises" and / or "comprising," when used in this specification, specify the presence of stated features, steps, operations, devices, components and / or combinations thereof, but do not preclude the presence or addition of one or more other features, steps, operations, devices, components and / or combinations thereof.

[0033] The preferred embodiments of the present application have been described above with the intent to enable those skilled in the art to make and use it. Various modifications to these embodiments will occur to those skilled in the art and are intended to be encompassed by the description. The structures and devices disclosed herein are to be considered in all respects as illustrative and not restrictive. Accordingly, the scope of the application is indicated by the appended claims rather than by the description. What is claimed is:

Claims

1. A serum protein purification evaporative crystallization apparatus that facilitates cleaning, comprising an evaporative crystallization tank (1), characterized in that, The top of the evaporation crystallization tank (1) is provided with a cover plate (2), the outer wall of the cover plate (2) is attached to the inner wall of the evaporation crystallization tank (1), the top of the outer wall of the evaporation crystallization tank (1) is fixed with a U-shaped frame (5), the U-shaped frame (5) is provided with a driving mechanism (6) for moving the cover plate (2), the top edge of the cover plate (2) is provided with a circular ring scraping strip (15), the edge of the circular ring scraping strip (15) is attached to the inner wall of the evaporation crystallization tank (1), and a flushing mechanism is installed in the cover plate (2).

2. The evaporative crystallization apparatus for purification of serum proteins according to claim 1, wherein The driving mechanism (6) comprises a threaded screw rod (11) rotatably arranged at the bottom of the inner wall of the evaporation crystallization tank (1), a hole is formed in the top of the cover plate (2), and a screw rod nut (10) is fixed in the hole, the screw rod nut (10) is matched with the threaded screw rod (11), a bidirectional motor is fixed on the U-shaped frame (5), and the output shaft of the bidirectional motor is coaxially fixed with the threaded screw rod (11).

3. The evaporative crystallization apparatus for purification of serum proteins according to claim 2, wherein The bottom of the inner wall of the evaporation crystallization tank (1) is fixed with two symmetrical guide rods (12), the cover plate (2) is provided with guide holes (13) for the guide rods (12) to pass through, and the top of the guide rods (12) is fixed with the bottom of the U-shaped frame (5).

4. The evaporative crystallization apparatus for purification of serum proteins according to claim 1, wherein The top of the outer wall of the evaporation crystallization tank (1) is provided with a feeding pipe (4), and the bottom discharge port of the evaporation crystallization tank (1) is fixed with a discharge valve (3).

5. The evaporative crystallization apparatus for purification of serum proteins according to claim 3, wherein The top of the screw rod nut (10) is fixed with a cleaning ring (16), and the inner wall of the cleaning ring (16) is uniformly fixed with bristles.

6. The evaporative crystallization apparatus for purification of serum proteins according to claim 5, wherein The top of the cover plate (2) is fixed with a scraping ring (14) sleeved on the outer wall of the guide rod (12).

7. The evaporative crystallization apparatus for purification of serum proteins according to claim 1, wherein The flushing mechanism comprises a water inlet (7) installed on the top of the cover plate (2), and the bottom of the water inlet (7) is fixed with a water storage box (8), the outer wall of the water storage box (8) is fixed with high-pressure nozzles (9) at equal intervals.

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