Array sample application device for medicament detection

Abstract

The utility model relates to an array sample application device for medicament detection, which belongs to the technical field of medicament detection and comprises a base, two vertical plates are fixed at the top of the base, a top plate is fixed between the tops of the two vertical plates, a driving component is mounted at the top of the base, and a sample application component is mounted at the top of the base. The sample application assembly comprises a connecting plate, an anti-skid pad bonded to the top of the connecting plate, a sample application base plate placed on the top of the anti-skid pad, a plurality of receiving plates fixedly installed on the left side and the right side of the top of the connecting plate, two abutting pieces fixed to the top of the connecting plate and a limiting groove formed in the top of the connecting plate. The limiting block is slidably connected to the inner side of the limiting groove, the two bolts penetrate through and are in threaded connection with the top of the limiting block, and the abutting plate is fixed to one side of the back face of the limiting block. According to the array sample application device for reagent detection, the sample application precision can be improved, and meanwhile, the array sample application position can be accurately arranged and positioned.

Description

TECHNICAL FIELD

[0001] The application relates to the technical field of medicament detection, in particular to an array spotting device for medicament detection. BACKGROUND

[0002] In the field of medicament research and development, high-throughput spotting technology is the key to realizing rapid drug screening and quality control. The process of adding droplets of sample solution to be separated and identified to a thin layer plate is called spotting. Spotting is the main source of quantitative error. In the preparation process of sample solution, different spotting equipment, spotting volume and spotting method are all factors causing errors. How to quickly and accurately perform array spotting is a problem to be solved in the prior art.

[0003] According to the multi-channel array spotting device for medical detection disclosed in Chinese Patent No. CN216117656U, the device can simultaneously perform multiple spotting on the substrate by starting the driving motor, and can displace the substrate after one spotting is completed, that is, array spotting can be realized. Therefore, compared with the traditional spotting method, the technical solution can effectively improve work efficiency.

[0004] However, the transmission mode of the patent has certain deficiencies in actual application. In order to make the push plate perform a downward movement, the patent achieves this effect by cooperation between multiple structures. During transmission, a certain degree of precision is inevitably lost, and the cooperation between structures is required to be higher. The utility is not good, and the patent is not convenient for accurate positioning of the spotting position, resulting in a certain error in the uniformity of the array. To this end, the application provides an array spotting device for medicament detection to solve the above problems. CONTENT OF THE UTILITY MODEL

[0005] In view of the deficiencies of the prior art, the application provides an array spotting device for medicament detection, which has the advantages of improving spotting precision and allowing accurate arrangement and positioning of array spotting positions. The shortcomings of the prior art are solved, that is, the transmission precision of the prior art is not good, which affects the spotting precision.

[0006] To achieve the above-mentioned purpose, the application provides the following technical solution: an array spotting device for medicament detection, comprising a base, two vertical plates are fixed on the top of the base, a top plate is fixed between the tops of the two vertical plates, a driving assembly is installed on the top of the base, and a spotting assembly is installed on the top of the base.

[0007] The sample application assembly comprises a connecting plate, a non-slip pad attached to the top of the connecting plate, a sample application substrate placed on the top of the non-slip pad, a plurality of receiving plates fixedly installed on the left and right sides of the top of the connecting plate, two abutting plates fixed to the top of the connecting plate, a limiting groove opened on the top of the connecting plate, a limiting block slidingly connected to the inner side of the limiting groove, two bolts threaded and connected to the top of the limiting block, an abutting plate fixed to one side of the back of the limiting block, a medicine box threaded through and fixed to the bottom of the medicine box, two laser sensors fixedly installed on the left and right sides of the medicine box, a plurality of sample application needle tubes threaded and fixed to the bottom of the medicine box, and a nano-level nozzle fixedly installed at the bottom end of the sample application needle tube.

[0008] By adopting the above technical scheme, the sample application precision can be improved, and the array sample application positions can be accurately arranged and positioned.

[0009] Further, the driving assembly comprises a moving table fixed to the top of the base, a driving groove opened on the top of the moving table, a threaded rod rotationally connected to the inner side of the driving groove through a bearing, a moving block threadedly connected to the outer side of the threaded rod, two guide grooves opened on the top of the moving table, a sliding rail fixedly installed on the inner bottom wall of the guide groove, a sliding block slidingly connected to the outer side of the sliding rail, and a servo motor fixedly installed on the back of the moving table.

[0010] By adopting the above technical scheme, the moving table can be linearly moved by the driving assembly.

[0011] Further, the top of the medicine box is fixed with a support plate, the back of the medicine box is fixed with a feeding pipe, the top of the support plate is fixedly installed with a hydraulic cylinder, and the output shaft of the hydraulic cylinder is fixedly installed with an extrusion plate.

[0012] By adopting the above technical scheme, the medicine can be normally discharged.

[0013] Further, the support plate is detachably connected to the top of the top plate, and the output shaft of the hydraulic cylinder penetrates the top of the support plate and the medicine box.

[0014] By adopting the above technical scheme, the support plate can play a role of mounting and supporting the medicine box.

[0015] Further, the extrusion plate is located in the interior of the medicine box, and the outer side of the extrusion plate is adapted to the inner side of the medicine box.

[0016] By adopting the above technical scheme, when the extrusion plate is pressed down, the liquid in the interior of the medicine box can be discharged.

[0017] Further, the top of the moving block and the sliding block are fixedly connected with the bottom of the connecting plate, and the output shaft of the servo motor penetrates through the back of the moving table and is fixedly connected with the back end of the threaded rod.

[0018] By adopting the above technical scheme, the connecting plate can be driven to move linearly under the threaded connection between the threaded rod and the moving block, and the servo motor can drive the threaded rod to rotate.

[0019] Further, the front and back surfaces of the sample spotting substrate are respectively abutted with the abutment plate and the opposite side of the abutment piece, the limiting block is composed of a long strip-shaped block and a rectangular block fixed to the top of the long strip-shaped block, and the bottom end of the bolt is abutted with the inner bottom wall of the limiting groove.

[0020] By adopting the above technical scheme, the sample spotting substrate can be abutted and limited, the limiting block can be limited to slide in the inner side of the limiting groove, and the bolt can simply position the limiting block through the abutment friction between the bolt and the inner bottom wall of the limiting groove.

[0021] Further, the two laser sensors correspond to the positions of the two side receiving plates respectively, and the positions of the two side receiving plates correspond one by one.

[0022] By adopting the above technical scheme, the laser sensor can accurately sense the position of the receiving plate.

[0023] Compared with the prior art, the technical scheme of the present application has the following beneficial effects:

[0024] The array sample spotting device for medicament detection can improve the sample spotting precision and accurately arrange and position the array sample spotting position through the cooperation between the driving assembly and the sample spotting assembly on the top of the base, so as to realize more delicate sample spotting requirements, thereby realizing high precision, high efficiency and high stability of the sample spotting process in medicament detection, and significantly improving the efficiency and accuracy of medicament research and development and quality control, so that the practicality of the array sample spotting device for medicament detection is effectively improved. BRIEF DESCRIPTION OF DRAWINGS

[0025] Figure 1 It is a structural schematic diagram of the present application;

[0026] Figure 2 It is a structure of the present application Figure 1 It is a top view schematic diagram of the moving table connecting structure in the present application;

[0027] Figure 3 It is a structure of the present application Figure 2 It is a three-dimensional schematic diagram of the limiting block connecting structure in the present application.

[0028] In the figure: 1, base; 2, vertical plate; 3, top plate; 400, driving assembly; 401, moving table; 402, driving groove; 403, threaded rod; 404, moving block; 405, guide groove; 406, sliding rail; 407, sliding block; 408, servo motor; 500, spotting assembly; 501, connecting plate; 502, non-slip pad; 503, spotting substrate; 504, receiving plate; 505, abutting piece; 506, limiting groove; 507, limiting block; 508, bolt; 509, abutting plate; 510, medicine box; 511, laser sensor; 512, spotting needle tube; 513, nanoscale nozzle; 601, support plate; 602, feed pipe; 603, hydraulic cylinder; 604, extrusion plate. DETAILED DESCRIPTION

[0029] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by a person of ordinary skill in the art without creative work fall within the scope of protection of the present application.

[0030] Please refer to Figures 1 to 3 The present application provides a technical solution: an array spotting device for medicine detection, comprising a base 1, two vertical plates 2 fixed on the top of the base 1, a top plate 3 fixed between the top of the two vertical plates 2, a driving assembly 400 installed on the top of the base 1, and a spotting assembly 500 installed on the top of the base 1; through the cooperation between the driving assembly 400 and the spotting assembly 500 on the top of the base 1, the spotting precision can be improved, and the array spotting position can be accurately arranged and positioned, so as to realize more delicate spotting requirements, thereby realizing high precision, high efficiency and high stability of the spotting process in medicine detection, and significantly improving the efficiency and accuracy of medicine research and quality control, so that the practicability of the array spotting device for medicine detection is effectively improved.

[0031] The spotting assembly 500 in the embodiment is a structure for accurately positioning the array spotting position of the medicine.

[0032] As Figure 1 , Figure 2 and Figure 3As shown, the spotting assembly 500 comprises a connecting plate 501, a non-slip pad 502 attached to the top of the connecting plate 501, a spotting substrate 503 placed on the top of the non-slip pad 502, a plurality of receiving plates 504 fixedly installed on the left and right sides of the top of the connecting plate 501, two abutting pieces 505 fixed to the top of the connecting plate 501, a limiting groove 506 opened on the top of the connecting plate 501, a limiting block 507 slidingly connected to the inner side of the limiting groove 506, two bolts 508 threadedly connected to the top of the limiting block 507, an abutting plate 509 fixed to one side of the back of the limiting block 507, a medicine box 510 threaded through the top of the top plate 3, two laser sensors 511 fixedly installed on the left and right sides of the medicine box 510, a plurality of spotting needle tubes 512 threaded through and fixed to the bottom of the medicine box 510, and nanoscale nozzles 513 fixedly installed at the bottom ends of the spotting needle tubes 512.

[0033] It should be noted that the top of the medicine box 510 is fixed with a support plate 601, the back of the medicine box 510 is fixed with a feeding pipe 602, the top of the support plate 601 is fixedly installed with a hydraulic cylinder 603, the output shaft of the hydraulic cylinder 603 is fixedly installed with an extrusion plate 604, and the support plate 601 is detachably connected to the top of the top plate 3, so that the support plate 601 can play a role of installation support for the medicine box 510. The output shaft of the hydraulic cylinder 603 penetrates the top of the support plate 601 and the medicine box 510, the extrusion plate 604 is located inside the medicine box 510, and the outer side of the extrusion plate 604 is matched with the inner side of the medicine box 510. Specifically, the extrusion plate 604 plays the role of a piston, so that when the extrusion plate 604 is pressed down, the liquid inside the medicine box 510 can be discharged.

[0034] In addition, the front and back of the spotting substrate 503 abut against the side opposite to the abutting plate 509 and the abutting piece 505 respectively, so that the spotting substrate 503 can be abutted and limited. The limiting block 507 is composed of an elongated block and a rectangular block fixed to the top of the elongated block. Specifically, the inner side of the limiting groove 506 is matched with the outer side of the limiting block 507, so that the limiting block 507 can slide on the inner side of the limiting groove 506.

[0035] Meanwhile, the bottom end of the bolt 508 abuts against the inner bottom wall of the limiting groove 506, so that the bolt 508 can simply position the limiting block 507 through the abutting friction force between the bolt 508 and the inner bottom wall of the limiting groove 506. The two laser sensors 511 correspond to the positions of the two receiving plates 504 respectively, and the positions of the two receiving plates 504 correspond one by one. The receiving plate 504 is a laser receiving piece for receiving and reflecting laser, so that the laser sensor 511 can accurately sense the position of the receiving plate 504.

[0036] The driving assembly 400 in this embodiment is a structure for driving the spotting substrate 503 to linearly displace.

[0037] As Figure 1 And Figure 2 As shown in the drawings, the driving assembly 400 comprises a moving table 401 fixed on the top of the base 1, a driving groove 402 opened on the top of the moving table 401, a threaded rod 403 rotatably connected to the inner side of the driving groove 402 through a bearing, a moving block 404 threadedly connected to the outer side of the threaded rod 403, two guide grooves 405 opened on the top of the moving table 401, a sliding rail 406 fixedly installed on the inner bottom wall of the guide groove 405, a sliding block 407 slidingly connected to the outer side of the sliding rail 406, and a servo motor 408 fixedly installed on the back of the moving table 401.

[0038] It should be noted that the top of the moving block 404 and the sliding block 407 are fixedly connected with the bottom of the connecting plate 501, so that the connecting plate 501 can be driven to move linearly under the threaded connection between the threaded rod 403 and the moving block 404, and the output shaft of the servo motor 408 penetrates through the back of the moving table 401 and is fixedly connected with one end of the back of the threaded rod 403, so that the servo motor 408 can drive the threaded rod 403 to rotate.

[0039] The working principle of the above embodiment is as follows:

[0040] When the sample is tested, the sample is placed in the inside of the sample tank 510 through the feeding pipe 602, the sample placement substrate 503 is placed on the top of the anti-skid pad 502, and the back of the sample placement substrate 503 abuts against the front of the abutting piece 505. The abutting plate 509 is moved, so that the limiting block 507 moves in the inside of the limiting groove 506, the abutting plate 509 abuts against and limits the sample placement substrate 503, and finally the sample placement substrate 503 is positioned by the screw 508. The servo motor 408 is started to drive the threaded rod 403 to rotate, the connecting plate 501 can be displaced forward and backward under the cooperation between the sliding rail 406 and the sliding block 407, so that the connecting plate 501 can be positioned at each position to improve the uniformity of array spotting, and the hydraulic cylinder 603 is started to push the extrusion plate 604 downward for extrusion, so that the sample in the inside of the sample tank 510 flows out through the sample placement needle tube 512 and the nano-level nozzle 513 and drops on the sample placement substrate 503, thereby completing the array spotting work in the sample detection work.

[0041] Compared with the prior art, the array spotting device for drug detection can improve the spotting precision and accurately arrange and position the array spotting position through the cooperation between the driving assembly 400 on the top of the base 1 and the spotting assembly 500, so as to meet more fine spotting requirements, realize high precision, high efficiency and high stability in the spotting process of drug detection, and significantly improve the efficiency and accuracy of drug research and development and quality control, so that the practicability of the array spotting device for drug detection is effectively improved, and the shortcomings that the transmission precision of the existing multi-channel array spotting device for medical detection is poor in the actual operation process, thereby affecting the spotting precision are solved.

[0042] The electrical components in the present application are electrically connected with the main controller and the power supply. The power supply is a common knowledge in the field. The main controller can be a computer or other conventional known device that can be controlled. The main controller can be programmed by a person skilled in the art. The power connection technology is known in the art and will not be described in detail.

Claims

1. An array spotting device for the detection of a medicament comprising a base (1) characterised in that: The top of the base (1) is fixed with two vertical plates (2), the top of the two vertical plates (2) is fixed with a top plate (3), the top of the base (1) is provided with a driving assembly (400), the top of the base (1) is provided with a spotting assembly (500); The spotting assembly (500) comprises a connecting plate (501), an antiskid pad (502) attached to the top of the connecting plate (501), a spotting substrate (503) placed on the top of the antiskid pad (502), a plurality of receiving plates (504) fixedly installed on the left and right sides of the top of the connecting plate (501), two abutting plates (505) fixed to the top of the connecting plate (501), a limiting groove (506) formed in the top of the connecting plate (501), a limiting block (507) slidably connected to the inner side of the limiting groove (506), two bolts (508) penetratingly and threadedly connected to the top of the limiting block (507), an abutting plate (509) fixed to one side of the back of the limiting block (507), a medicine box (510) penetratingly provided in the top of the top plate (3), two laser sensors (511) fixedly installed on the left and right sides of the medicine box (510) respectively, a plurality of spotting needle tubes (512) penetratingly and fixedly provided in the bottom of the medicine box (510), and nanoscale nozzles (513) fixedly installed at the bottom ends of the spotting needle tubes (512).

2. The array spotting device for drug detection according to claim 1, characterized in that: The driving assembly (400) comprises a moving table (401) fixed to the top of the base (1), a driving groove (402) formed in the top of the moving table (401), a threaded rod (403) rotationally connected to the inner side of the driving groove (402) through a bearing, a moving block (404) threadedly connected to the outer side of the threaded rod (403), two guide grooves (405) formed in the top of the moving table (401), a sliding rail (406) fixedly installed on the inner bottom wall of the guide groove (405), a sliding block (407) slidably connected to the outer side of the sliding rail (406), and a servo motor (408) fixedly installed on the back of the moving table (401).

3. The array spotting device for drug detection according to claim 1, wherein: The top of the medicine box (510) is fixed with a supporting plate (601), the back of the medicine box (510) is fixed with a feeding pipe (602), the top of the supporting plate (601) is fixedly installed with a hydraulic cylinder (603), and the output shaft of the hydraulic cylinder (603) is fixedly installed with an extrusion plate (604).

4. The array spotting device for detecting a drug according to claim 3, wherein: The supporting plate (601) is detachably connected to the top of the top plate (3), and the output shaft of the hydraulic cylinder (603) penetrates the top of the supporting plate (601) and the medicine box (510).

5. The array spotting device for detecting a drug according to claim 3, wherein: The extrusion plate (604) is located in the interior of the medicine box (510), and the outer side of the extrusion plate (604) is matched with the inner side of the medicine box (510).

6. The array spotting device for drug detection according to claim 2, wherein: The top of the moving block (404) and the top of the sliding block (407) are fixedly connected with the bottom of the connecting plate (501), and the output shaft of the servo motor (408) penetrates the back of the moving table (401) and is fixedly connected with one end of the back of the threaded rod (403).

7. The array spotting device for agent detection according to claim 1, wherein: The front and back of the sample substrate (503) respectively abut against the abutting plate (509) and the side opposite to the abutting piece (505), the limiting block (507) is composed of a long strip block and a rectangular block fixed on the top of the long strip block, the bottom end of the bolt (508) abuts against the inner bottom wall of the limiting groove (506).

8. The array spotting device for agent detection according to claim 1, wherein: Two laser sensors (511) respectively correspond to the positions of two side receiving plates (504), and the positions of the two side receiving plates (504) one-to-one correspond.

Images