Gamma cyclodextrin centrifugal separation system

Abstract

The utility model belongs to the technical field of cyclodextrin separation, and particularly relates to a gamma cyclodextrin centrifugal separation system which comprises a centrifugal machine, the bottom of the centrifugal machine is connected with a washing tank, a washing liquid inlet is formed in the top of the washing tank, and an upper-layer separation bin and a lower-layer separation bin are arranged in the centrifugal machine. A connecting gear is arranged on the outer side of the bottom of the connecting channel, the connecting gear is connected with a motor, a mother liquor tank is connected to the top of the centrifugal machine, and a liquid inlet is formed in the upper portion of the centrifugal machine. After the rotating speed of the centrifugal machine is controlled in a layering mode, residues of gamma cyclodextrin crystals in mother liquor can be effectively reduced, and the yield of gamma cyclodextrin is improved.

Description

Technical Field

[0001] This utility model belongs to the field of cyclodextrin separation technology, specifically relating to a centrifugal separation system for gamma cyclodextrin. Background Technology

[0002] Centrifugation is a crucial solid-liquid separation process in the production and refining of cyclodextrin. It creates favorable conditions for subsequent refining steps, such as crystallization and chromatographic separation, and improves the purity and yield of the final product. Centrifugation separates gamma-cyclodextrin from most soluble impurities, making it the most critical step in improving product purity and yield. After separation, the mother liquor containing impurities is discarded or processed. To further improve purity, the collected precipitate is washed with clean cold water or a dilute solvent to remove impurities from the mother liquor adhering to the surface of the precipitate particles.

[0003] The centrifugation process for gamma-cyclodextrin is primarily used to efficiently separate the crystallized gamma-cyclodextrin crystals from the mother liquor, simplifying the process and reducing material transfer losses. Currently used centrifuges consume significant amounts of electrical energy during high-speed rotation, and the friction between the high-speed rotating rotor and the air generates substantial heat, which can significantly impact sample activity. Utility Model Content

[0004] In view of the shortcomings of the prior art, the technical problem to be solved by this utility model is to provide a centrifugal separation system for gamma cyclodextrin, so as to achieve effective separation of gamma cyclodextrin and reduce the impact on product activity.

[0005] The technical solution adopted by this utility model to solve its technical problem is:

[0006] A gamma cyclodextrin centrifugal separation system includes a centrifuge, a washing tank connected to the bottom of the centrifuge, a washing liquid inlet at the top of the washing tank, an upper separation chamber and a lower separation chamber inside the centrifuge, a connecting channel inside the lower separation chamber, the top of the connecting channel being connected to the upper separation chamber, a connecting gear at the bottom outside of the connecting channel, a motor connected to the connecting gear, a mother liquor tank connected to the top of the centrifuge, and a liquid inlet at the top of the centrifuge.

[0007] in:

[0008] The liquid inlet is located in the middle of the upper separation chamber and is connected to the raw liquid tank.

[0009] A material pump is installed between the liquid inlet and the raw liquid tank.

[0010] The upper separation chamber has a spiral channel on its inner wall.

[0011] The bottom of the connecting channel extends through the bottom of the lower separation chamber and is equipped with a connecting gear. The lower part of the connecting channel is movably connected to the bottom of the lower separation chamber, and the connecting gear is meshed with the motor output end.

[0012] A funnel-shaped inclined plate is provided between the upper separation chamber and the connecting channel.

[0013] The top of the funnel-shaped inclined plate is fixed to the inner wall of the upper separation chamber.

[0014] The connecting channel is movably connected to the bottom of the funnel-shaped inclined plate.

[0015] The washing tank is equipped with a cooling jacket on its exterior.

[0016] The cooling jacket has a cooling water inlet at the bottom and a cooling water outlet at the top.

[0017] The beneficial effects of this utility model are:

[0018] This invention effectively reduces the residue of gamma-cyclodextrin crystals in the mother liquor by controlling the rotation speed of the centrifuge in layers, thereby increasing the yield of gamma-cyclodextrin. Since the prepared gamma-cyclodextrin stock solution contains various substances, it can be recycled and reused, reducing resource waste. The two-stage separation process yields a clearer mother liquor, reducing both the loss of gamma-cyclodextrin and the processing cost of mother liquor recovery. Due to the different particle sizes of gamma-cyclodextrin, the lighter cyclodextrin crystals are easily separated with the upper mother liquor. The spiral channel inside the upper separation chamber acts as an interceptor, causing the lighter gamma-cyclodextrin to rotate along the spiral channel to the lower separation chamber. The mother liquor is then centrifuged again in the connecting channel of the lower separation chamber, ensuring that all the gamma-cyclodextrin falls into the washing tank. Attached Figure Description

[0019] Figure 1 This is a schematic diagram of the structure of this utility model;

[0020] Figure 2 This is a schematic diagram of the centrifuge structure of this utility model;

[0021] In the diagram: 1. Centrifuge; 2. Washing tank; 3. Mother liquor tank; 4. Raw liquid tank; 5. Liquid inlet; 6. Upper separation chamber; 7. Lower separation chamber; 8. Material pump; 9. Connecting channel; 10. Washing liquid inlet; 11. Connecting gear; 12. Motor; 201. Cooling jacket; 601. Spiral channel; 901. Funnel-shaped inclined plate. Detailed Implementation

[0022] The embodiments of this utility model will be further described below with reference to the accompanying drawings.

[0023] Example 1

[0024] like Figure 1-2 As shown, the gamma cyclodextrin centrifugal separation system of this utility model includes a centrifuge 1, a washing tank 2 connected to the bottom of the centrifuge 1, a washing liquid inlet 10 provided at the top of the washing tank 2, an upper separation chamber 6 and a lower separation chamber 7 provided inside the centrifuge 1, a connecting channel 9 provided inside the lower separation chamber 7, the top of the connecting channel 9 being connected to the upper separation chamber 6, a connecting gear 11 provided on the outer side of the bottom of the connecting channel 9, a motor 12 connected to the connecting gear 11, a mother liquor tank 3 connected to the top of the centrifuge 1, and a liquid inlet 5 provided at the top of the centrifuge 1.

[0025] The liquid inlet 5 is located in the middle of the upper separation chamber 6, and the liquid inlet 5 is connected to the raw liquid tank 4.

[0026] A material pump 8 is installed between the liquid inlet 5 and the raw liquid tank 4.

[0027] A spiral channel 601 is provided on the inner wall of the upper separation chamber 6.

[0028] A connecting gear 11 is provided at the bottom of the connecting channel 9, which passes through the bottom of the lower separation chamber 7. The lower part of the connecting channel 9 is movably connected to the bottom of the lower separation chamber 7, and the connecting gear 11 is meshed with the output end of the motor 12.

[0029] A funnel-shaped inclined plate 901 is provided between the upper separation chamber 6 and the connecting channel 9.

[0030] The top of the funnel-shaped inclined plate 901 is fixed to the inner wall of the upper separation chamber 6.

[0031] The connecting channel 9 is movably connected to the bottom of the funnel-shaped inclined plate 901.

[0032] The washing tank 2 is equipped with a cooling jacket 201.

[0033] The cooling jacket 201 has a cooling water inlet at the bottom and a cooling water outlet at the top.

[0034] Working principle and process:

[0035] The prepared gamma-cyclodextrin stock solution is transported to the stock solution tank 4. Then, the gamma-cyclodextrin stock solution in the stock solution tank is flushed into the upper separation chamber 6 inside the centrifuge 1 by the material pump 8. The stock solution is then initially separated by the spiral channel 601 in conjunction with the material pump 8, causing the mother liquor to rise and the solids to fall. The mother liquor enters the mother liquor tank 3 for recovery, and then the solids enter the connecting channel 9. The speed of the connecting channel 9 is adjusted by the motor 12 to further separate the mother liquor. After the mother liquor comes into contact with the spiral channel 601, the fine solid particles are trapped on the spiral channel 601 and then return to the connecting channel 9. The solid particles enter the washing tank 2 at the bottom of the connecting channel 9. Then, the cooling jacket 201 is turned on to cool down the liquid and prevent the temperature from getting too high. Detergent is added to the washing tank 2 through the washing liquid inlet 10 to wash the gamma-cyclodextrin and remove impurities from the surface of the gamma-cyclodextrin, which is convenient for subsequent refining.

Claims

1. A gamma cyclodextrin centrifugal separation system comprising a centrifuge (1), characterized in that, The centrifuge (1) is connected with a washing tank (2) at the bottom, the washing tank (2) is provided with a washing liquid inlet (10) at the top, the centrifuge (1) is provided with an upper separation bin (6) and a lower separation bin (7) inside, the lower separation bin (7) is provided with a connecting channel (9) inside, the connecting channel (9) is communicated with the upper separation bin (6) at the top, the connecting channel (9) is provided with a connecting gear (11) outside at the bottom, the connecting gear (11) is connected with a motor (12), the centrifuge (1) is connected with a mother liquor tank (3) at the top, and the centrifuge (1) is provided with a liquid inlet (5) at the upper portion.

2. The gamma cyclodextrin centrifugation system of claim 1, wherein, The liquid inlet (5) is arranged in the middle of the upper separation bin (6), and the liquid inlet (5) is connected with a raw liquid tank (4).

3. The gamma cyclodextrin centrifugation system of claim 2, wherein, A material pump (8) is arranged between the liquid inlet (5) and the raw liquid tank (4).

4. The gamma cyclodextrin centrifugation system of claim 1, wherein, A spiral channel (601) is arranged on the inner wall of the upper separation bin (6).

5. The gamma cyclodextrin centrifugation system of claim 1, wherein, The connecting channel (9) is provided with a connecting gear (11) penetrating through the bottom of the lower separation bin (7) at the bottom, the connecting channel (9) is movably connected with the bottom of the lower separation bin (7) at the lower portion, and the connecting gear (11) is meshed with the output end of the motor (12).

6. The gamma cyclodextrin centrifugation system of claim 1, wherein, A funnel-shaped inclined plate (901) is arranged between the upper separation bin (6) and the connecting channel (9).

7. The gamma cyclodextrin centrifugation system of claim 6, wherein, The funnel-shaped inclined plate (901) is fixed on the inner wall of the upper separation bin (6) at the top.

8. The gamma cyclodextrin centrifugation system of claim 6, wherein, The connecting channel (9) is movably connected with the bottom of the funnel-shaped inclined plate (901).

9. The gamma cyclodextrin centrifugation system of claim 1, wherein, The washing tank (2) is provided with a cooling jacket (201) outside.

10. The gamma cyclodextrin centrifugation system of claim 9, wherein, The cooling jacket (201) is provided with a cooling water inlet at the lower portion and a cooling water outlet at the upper portion.

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