Automatic sample injector of liquid chromatograph

Abstract

The utility model provides an automatic sample injector of a liquid chromatograph, which relates to the technical field of liquid chromatography detection and comprises a bottom plate, a front vertical plate and a rear vertical plate, the front vertical plate and the rear vertical plate are respectively arranged on two sides above the bottom plate, and an injection valve and a six-way valve are respectively arranged at two ends above the outer side of the front vertical plate. A first sliding block is movably arranged on one side of the rear vertical plate through a sliding rail. The first sliding block moves on the rear vertical plate to drive the sampling needle to move transversely, the second sliding block moves along the first support to drive the sampling needle to move vertically, multi-axis movement of the sampling needle in the space is achieved, the sample frame can move longitudinally on the bottom plate, and sample bottles can be placed on the sample frame. The sampling needle can be used for positioning any sample bottle on the sample rack and vertically puncturing the sample bottle in cooperation with the transverse and vertical movement of the sampling needle in the space, and the injection pump is used for sucking a sample from the sampling needle, so that the function of automatic sample injection is achieved, and higher repeatability and higher reliability are achieved.

Description

Technical Field

[0001] This utility model relates to the field of liquid chromatography detection technology, and in particular to an automatic sampler for a liquid chromatograph. Background Technology

[0002] A liquid chromatography detection system is a highly efficient analytical instrument system based on chromatographic principles. It separates different substances by utilizing the difference in partition coefficients between the stationary and mobile phases, converts the component concentrations into electrical signals through a detector, and then analyzes them through a data processing system to achieve qualitative and quantitative analysis of samples.

[0003] In the operation of a liquid chromatography detection system, sample injection is required. The sample is quantitatively taken and sent into the chromatographic column of the liquid chromatograph for testing. In the prior art, sample injection is generally done manually. Manual operation is labor-intensive, and the control of injection speed, injection volume, and cross-contamination between samples is difficult to achieve with high repeatability due to different human techniques, making it unreliable. Therefore, this utility model proposes an automatic sampler for liquid chromatographs to solve the problems existing in the prior art. Utility Model Content

[0004] To address the aforementioned problems, this utility model proposes an autosampler for liquid chromatographs. This autosampler achieves automated sample injection, high repeatability, and greater reliability.

[0005] To achieve the purpose of this utility model, the utility model is implemented through the following technical solution: an automatic sampler for liquid chromatograph, including a base plate, a front plate and a rear plate, the front plate and the rear plate are respectively disposed on the two sides above the base plate, and an injection valve and a six-way valve are respectively provided at the two ends of the outer side of the front plate. A first slider is movably disposed on one side of the rear plate via a slide rail, and a first support is provided on the first slider. A second slider is movably disposed on one side of the first support, and a sampling needle is provided on one side of the second slider.

[0006] The tail of the sampling needle is connected to a six-way valve via a liquid line, and the six-way valve is connected to an injection valve via a liquid line. An injection pump is provided at one end of the lower outer side of the front upright plate, and the injection pump is connected to the injection valve above it. A sample rack is movably provided above the base plate, and a sample needle cleaning pool is provided on the base plate at one end of the sample rack.

[0007] A further improvement is that: a second bracket is provided at one end of the inner side of the front upright plate, and a third slider is movably provided on the inner side of the second bracket via a slide rail; a first motor is provided below the inner side of the second bracket, and a first lead screw adapted to the third slider is provided at the output end of the first motor.

[0008] A further improvement is that a connecting frame is provided on one side of the third slider, and the connecting frame extends through the front upright plate, and the connecting frame is connected to the piston of the injection pump.

[0009] A further improvement is that a second motor is provided above the second bracket, and the second motor is connected to the valve core of the injection valve via a coupling.

[0010] A further improvement is that a second lead screw is rotatably provided above one side of the rear upright plate via a shaft plate. The second lead screw passes through the first slider and is threadedly adapted. A third motor is provided at one end of the outer side of the rear upright plate. A synchronous pulley is provided at one end of the second lead screw. A synchronous belt is connected between the output end of the third motor and the synchronous pulley.

[0011] A further improvement is that a third lead screw is rotatably provided on the inner side of the first bracket, and the third lead screw passes through the second slider and is threadedly adapted. A fourth motor is provided above the first bracket, and the output end of the fourth motor is connected to the third lead screw.

[0012] Further improvements include: guide rails are provided at both ends of the top of the base plate, the sample holder is movably mounted on the guide rails, synchronous pulleys are rotatably provided on both sides of the middle position of the top of the base plate, and a synchronous belt is wound around the two sets of synchronous pulleys. One set of synchronous pulleys is driven to rotate by a fifth motor, and the bottom of the sample holder is connected to one end of the synchronous belt.

[0013] A further improvement is that a sample needle cleaning pump is provided at one end of the top of the base plate, and the sample needle cleaning pump is connected to the sample needle cleaning tank through a liquid line. The six-way valve is also connected to a quantitative loop and a liquid line connected to the liquid chromatography system.

[0014] The beneficial effects of this utility model are as follows:

[0015] 1. This utility model achieves multi-axis motion of the sampling needle in space by moving the first slider on the rear upright plate to drive the sampling needle to move laterally, and by moving the second slider along the first support to drive the sampling needle to move vertically. The sample holder can move longitudinally on the base plate and can hold sample bottles. With the lateral and vertical motion of the sampling needle in space, the sampling needle can be positioned on any sample bottle on the sample holder and vertically puncture the sample bottle. The tail of the sampling needle is connected to a six-way valve, which is connected to an injection valve, which is connected to an injection pump. The injection pump draws samples from the sampling needle, thereby achieving automated sample injection, high repeatability, and greater reliability.

[0016] 2. The sample needle cleaning pump of this utility model is connected to the sample needle cleaning tank through a liquid line and a cleaning solution is introduced to facilitate the insertion of the sampling needle into the sample needle cleaning tank from above for cleaning. The six-way valve is also connected to a quantitative loop and a liquid line connected to the liquid chromatography system. Attached Figure Description

[0017] Figure 1 This is the front view of the present invention;

[0018] Figure 2 This is a side view of the present invention.

[0019] The components are as follows: 1. Base plate; 2. Front upright plate; 3. Rear upright plate; 4. Injection valve; 5. Six-way valve; 6. First slider; 7. First support; 8. Second slider; 9. Sampling needle; 10. Sample needle cleaning tank; 11. Injection pump; 12. Sample holder; 13. Second support; 14. Third slider; 15. First motor; 16. First lead screw; 17. Connecting frame; 18. Second motor; 19. Second lead screw; 20. Third motor; 21. Third lead screw; 22. Fourth motor; 23. Guide rail; 24. Synchronous belt; 25. Fifth motor; 26. Sample needle cleaning pump. Detailed Implementation

[0020] To deepen the understanding of this utility model, the following detailed description will be provided in conjunction with embodiments. These embodiments are only used to explain this utility model and do not constitute a limitation on the scope of protection of this utility model.

[0021] Example 1

[0022] according to Figure 1 , 2 As shown, this embodiment proposes an automatic sampler for a liquid chromatograph, including a base plate 1, a front plate 2, and a rear plate 3. The front plate 2 and the rear plate 3 are respectively located on both sides above the base plate 1. An injection valve 4 and a six-way valve 5 are respectively provided at the two ends of the upper outer side of the front plate 2. A first slider 6 is movably provided on one side of the rear plate 3 via a slide rail, and a first support 7 is provided on the first slider 6. A second slider 8 is movably provided on one side of the first support 7, and a sampling needle 9 is provided on one side of the second slider 8.

[0023] The tail of the sampling needle 9 is connected to the six-way valve 5 through a liquid line pipe, and the six-way valve 5 is connected to the injection valve 4 through a liquid line pipe. An injection pump 11 is provided at one end of the lower outer side of the front upright plate 2, and the injection pump 11 is connected to the injection valve 4 above. A sample rack 12 is movably provided above the base plate 1, and a sample needle cleaning pool 10 is provided on the base plate 1 at one end of the sample rack 12. In use, the first slider 6 moves on the rear upright plate 3, driving the sampling needle 9 to move laterally. The second slider 8 moves along the first support 7, driving the sampling needle 9 to move vertically, thus realizing the multi-axis movement of the sampling needle 9 in space. The sample holder 12 can move longitudinally on the base plate 1. Sample bottles can be placed on the sample holder 12. With the lateral and vertical movement of the sampling needle 9 in space, the sampling needle 9 can be positioned on any sample bottle on the sample holder 12 and vertically puncture the sample bottle. The tail of the sampling needle 9 is connected to the six-way valve 5, the six-way valve 5 is connected to the injection valve 4, and the injection valve 4 is connected to the injection pump 11. The injection pump 11 draws samples from the sampling needle 9, thereby achieving the function of automated sample injection.

[0024] A second bracket 13 is provided at one end of the lower inner side of the front upright plate 2, and a third slider 14 is movably mounted on the inner side of the second bracket 13 via a slide rail. A first motor 15 is provided at the lower inner side of the second bracket 13, and a first lead screw 16 adapted to the third slider 14 is provided at the output end of the first motor 15. A connecting frame 17 is provided on one side of the third slider 14, and the connecting frame 17 extends through the front upright plate 2. The connecting frame 17 is connected to the piston of the injection pump 11. In use, the first motor 15 drives the first lead screw 16 to rotate, driving the third slider 14 to move along the slide rail, driving the connecting frame 17 to move, and pulling the piston of the injection pump 11 to achieve the purpose of sampling and dispensing.

[0025] A second motor 18 is provided above the second bracket 13, and the second motor 18 is connected to the valve spindle of the injection valve 4 via a coupling. In use, the second motor 18 drives the valve spindle of the injection valve 4 to rotate via the coupling, thereby controlling the opening or closing of the injection valve 4.

[0026] A second lead screw 19 is rotatably mounted on one side of the rear upright plate 3 via a shaft plate. The second lead screw 19 passes through the first slider 6 and is threadedly fitted. A third motor 20 is mounted on one end of the outer side of the rear upright plate 3. A synchronous pulley is mounted on one end of the second lead screw 19. A synchronous belt connects the output end of the third motor 20 and the synchronous pulley. In use, the third motor 20 drives the second lead screw 19 to rotate, causing the first slider 6 to move along the slide rail, thereby driving the sampling needle 9 to move laterally.

[0027] A third lead screw 21 is rotatably mounted on the inner side of the first bracket 7, and the third lead screw 21 passes through the second slider 8 and is threadedly fitted. A fourth motor 22 is mounted above the first bracket 7, and the output end of the fourth motor 22 is connected to the third lead screw 21. In use, the fourth motor 22 drives the third lead screw 21 to rotate, causing the second slider 8 to move along the slide rail, thereby driving the sampling needle 9 to move vertically.

[0028] The base plate 1 has guide rails 23 at both ends of its top. The sample holder 12 is movably mounted on the guide rails 23. Synchronous pulleys are rotatably mounted on both sides of the middle position of the top of the base plate 1, and a synchronous belt 24 is wound around each of the two sets of synchronous pulleys. One set of synchronous pulleys is driven to rotate by a fifth motor 25. The bottom of the sample holder 12 is connected to one end of the synchronous belt 24. In use, the fifth motor 25 drives the synchronous pulleys to rotate, causing the synchronous belt 24 to run, which in turn moves the sample holder 12 along the guide rails 23. The sample holder 12 can move longitudinally on the base plate 1.

[0029] Example 2

[0030] according to Figure 1 , 2 As shown, this embodiment proposes an automatic sampler for a liquid chromatograph, including a base plate 1, a front plate 2, and a rear plate 3. The front plate 2 and the rear plate 3 are respectively located on both sides above the base plate 1. An injection valve 4 and a six-way valve 5 are respectively provided at the two ends of the upper outer side of the front plate 2. A first slider 6 is movably provided on one side of the rear plate 3 via a slide rail, and a first support 7 is provided on the first slider 6. A second slider 8 is movably provided on one side of the first support 7, and a sampling needle 9 is provided on one side of the second slider 8.

[0031] The tail of the sampling needle 9 is connected to the six-way valve 5 through a liquid line pipe, and the six-way valve 5 is connected to the injection valve 4 through a liquid line pipe. An injection pump 11 is provided at one end of the lower outer side of the front upright plate 2, and the injection pump 11 is connected to the injection valve 4 above. A sample rack 12 is movably provided above the base plate 1, and a sample needle cleaning pool 10 is provided on the base plate 1 at one end of the sample rack 12. In use, the first slider 6 moves on the rear upright plate 3, driving the sampling needle 9 to move laterally. The second slider 8 moves along the first support 7, driving the sampling needle 9 to move vertically, thus realizing the multi-axis movement of the sampling needle 9 in space. The sample holder 12 can move longitudinally on the base plate 1. Sample bottles can be placed on the sample holder 12. With the lateral and vertical movement of the sampling needle 9 in space, the sampling needle 9 can be positioned on any sample bottle on the sample holder 12 and vertically puncture the sample bottle. The tail of the sampling needle 9 is connected to the six-way valve 5, the six-way valve 5 is connected to the injection valve 4, and the injection valve 4 is connected to the injection pump 11. The injection pump 11 draws samples from the sampling needle 9, thereby achieving the function of automated sample injection.

[0032] A sample needle cleaning pump 26 is provided at one end of the top of the base plate 1, and the sample needle cleaning pump 26 is connected to the sample needle cleaning tank 10 through a liquid line. The six-way valve 5 is also connected to a quantitative loop and a liquid line connected to the liquid chromatography system. In use, the sample needle cleaning tank 10 has a hole at the top to facilitate the insertion of the sampling needle 9 for cleaning and the injection of cleaning solution. The sample needle cleaning pump 26 is connected to the sample needle cleaning tank 10 through a liquid line, and the cleaning solution can be extracted for replacement. During cleaning, the sampling needle 9 is inserted into the sample needle cleaning tank 10 from above for cleaning. The six-way valve 2 is also connected to a quantitative loop and a liquid line connected to the liquid chromatography system.

[0033] The autosampler of this liquid chromatograph moves the sampling needle 9 laterally via the movement of the first slider 6 on the rear upright plate 3, and vertically via the movement of the second slider 8 along the first support 7, achieving multi-axis movement of the sampling needle 9 in space. The sample holder 12 can move longitudinally on the base plate 1, and sample vials can be placed on the sample holder 12. Combined with the lateral and vertical movement of the sampling needle 9 in space, the sampling needle 9 can be positioned on any sample vial on the sample holder 12 and vertically puncture the sample vial. The tail of the sampling needle 9 is connected to a six-way valve 5, which is connected to an injection valve 4, which is connected to an injection pump 11. The injection pump 11 draws samples from the sampling needle 9, thus achieving automated sample injection, high repeatability, and greater reliability. Furthermore, the sample needle cleaning pump 26 is connected to the sample needle cleaning tank 10 via a liquid line, allowing the flow of cleaning solution, facilitating the insertion of the sampling needle 9 into the sample needle cleaning tank 10 from above for cleaning. The six-way valve 2 is also connected to a quantitative loop and a liquid line connecting to the liquid chromatograph.

[0034] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claimed utility model. The scope of protection of this utility model is defined by the appended claims and their equivalents.

Claims

1. A liquid chromatograph autosampler comprising a base plate (1), a front upright plate (2) and a rear upright plate (3), characterized in that: The front vertical plate (2) and the rear vertical plate (3) are arranged on the two sides above the bottom plate (1), and the two ends above the outer side of the front vertical plate (2) are respectively provided with an injection valve (4) and a six-way valve (5); one side of the rear vertical plate (3) is movably provided with a first sliding block (6) through a slide rail, and a first support (7) is arranged on the first sliding block (6); one side of the first support (7) is movably provided with a second sliding block (8), and a sampling needle (9) is arranged on one side of the second sliding block (8). The tail of the sampling needle (9) is connected with the six-way valve (5) through a liquid path pipe, the six-way valve (5) is connected with the injection valve (4) through a liquid path pipe, one end below the outer side of the front vertical plate (2) is provided with an injection pump (11), and the upper side of the injection pump (11) is connected with the injection valve (4); the upper side of the bottom plate (1) is movably provided with a sample rack (12), and a sample needle cleaning tank (10) is arranged on the bottom plate (1) at one end position of the sample rack (12).

2. The auto-sampler for liquid chromatography as claimed in claim 1, wherein: One end below the inner side of the front vertical plate (2) is provided with a second support (13), and the inner side of the second support (13) is movably provided with a third sliding block (14) through a slide rail; the lower side of the inner side of the second support (13) is provided with a first motor (15), and the output end of the first motor (15) is provided with a first lead screw (16) matched with the third sliding block (14).

3. The auto-sampler for liquid chromatography as claimed in claim 2, wherein: One side of the third sliding block (14) is provided with a connecting frame (17), and the connecting frame (17) penetrates out of the front vertical plate (2); the connecting frame (17) is connected with the piston of the injection pump (11).

4. The liquid chromatograph autosampler of claim 3, wherein: The upper side of the second support (13) is provided with a second motor (18), and the second motor (18) is connected with the valve core shaft of the injection valve (4) through a shaft coupling.

5. The liquid chromatograph autosampler of claim 1, wherein: The upper side of one side of the rear vertical plate (3) is rotatably provided with a second lead screw (19) through an axle plate, the second lead screw (19) penetrates the first sliding block (6) and is threadedly matched, one end of the outer side of the rear vertical plate (3) is provided with a third motor (20), one end of the second lead screw (19) is provided with a synchronous pulley, and a synchronous belt is connected between the output end of the third motor (20) and the synchronous pulley.

6. The liquid chromatograph autosampler of claim 1, wherein: The inner side of the first support (7) is rotatably provided with a third lead screw (21), and the third lead screw (21) penetrates the second sliding block (8) and is threadedly matched; the upper side of the first support (7) is provided with a fourth motor (22), and the output end of the fourth motor (22) is connected with the third lead screw (21).

7. The liquid chromatograph autosampler of claim 1, wherein: Both ends of the top of the bottom plate (1) are provided with guide rails (23), the sample rack (12) is movably arranged on the guide rails (23), both sides of the middle position of the top of the bottom plate (1) are rotatably provided with synchronous pulleys, and a synchronous belt (24) is wound on the two groups of synchronous pulleys, one group of the synchronous pulleys is driven to rotate by a fifth motor (25), and the lower side of the sample rack (12) is connected with one end surface of the synchronous belt (24).

8. The liquid chromatograph autosampler of claim 1, wherein: One end of the top of the bottom plate (1) is provided with a sample needle cleaning pump (26), and the sample needle cleaning pump (26) is connected with the sample needle cleaning tank (10) through a liquid path pipe; the six-way valve (5) is further connected with a quantitative ring and a liquid path pipe connected with a liquid chromatograph.

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