Photodynamic balloon catheter and blood vessel treatment system

Abstract

The utility model relates to the technical field of medical instruments, and provides a photodynamic balloon catheter and a blood vessel treatment system. The balloon is a single-layer balloon, the far end of the balloon is sealed, and the near end of the balloon is connected with the far end of the conveying catheter; a plurality of micropores are formed in the side surface of the balloon; external medicine is conveyed into the balloon through the near end of the conveying catheter, the balloon is filled and expanded, and the medicine in the balloon flows out through the micropores under the action of pressure. According to the photodynamic balloon catheter, the balloon is a single-layer balloon, liquid does not need to be independently input to enable the balloon to be filled and expanded, the balloon is directly filled with medicine such as a photosensitizer, and after the balloon is filled, the photosensitizer can be sprayed out to a lesion position along micropores in the balloon. By means of the arrangement, the photosensitizer can be prevented from being lost in the process that the balloon is conveyed to the lesion position. Moreover, due to the design that an inner tube is omitted in the single-layer balloon, the overall outer diameter of the balloon catheter is small, and the balloon catheter can be suitable for small intracranial blood vessels.

Description

Technical Field

[0001] This utility model relates to the field of medical device technology, specifically to a photodynamic balloon catheter and vascular treatment system. Background Technology

[0002] Percutaneous interventional therapy has become one of the commonly used treatment techniques worldwide. For endovascular stenosis, balloon angioplasty or stent implantation are typically used, but both methods have their drawbacks. Post-balloon angioplasty, damage to the endothelium of the dilated arterial segment and rupture of elastic fibers can lead to thrombosis and intimal hyperplasia. Furthermore, the short inflation time of the balloon during use results in a lack of long-term support, making it prone to elastic recoil and remodeling of the vessel wall. Prolonged placement of stents can also trigger a proliferative response in the body, leading to in-stent restenosis. In recent years, a new vascular treatment technology has emerged: natural vascular stents. This technology involves coating a photosensitizer on the surface of a balloon. After the balloon is delivered to the target location in the blood vessel, it inflates, spreading the photosensitizer to the vessel wall. A specific wavelength of light emitted from an optical fiber activates the photosensitizer, inducing cross-linking of amino acid residues in the vessel wall. This allows collagen and elastin to rapidly bind, forming a stent in situ, maintaining the patency of the lumen, and achieving vascular healing and repair.

[0003] However, in existing photodynamic balloon catheters, the photosensitizer is generally coated on the outer surface of the balloon. During the delivery of the photodynamic balloon catheter to the lesion site, some of the photosensitizer is lost due to the flow of blood. Utility Model Content

[0004] Therefore, the technical problem to be solved by this utility model is that in the prior art, the photosensitizer in the photodynamic balloon catheter is generally coated on the outer surface of the balloon. During the process of delivering the photodynamic balloon catheter to the lesion site, a portion of the photosensitizer will be lost due to the flushing of blood flow. This invention provides a photodynamic balloon catheter and vascular treatment system.

[0005] To solve the above-mentioned technical problems, the technical solution of this utility model is as follows:

[0006] On one hand, this utility model provides a photodynamic balloon catheter, comprising: a delivery catheter; a balloon, the balloon being a single-layer balloon, the distal end of the balloon being sealed, and the proximal end of the balloon being connected to the distal end of the delivery catheter; the side of the balloon being provided with a plurality of micropores; external drugs are delivered to the balloon through the proximal end of the delivery catheter and inflate the balloon, and the drugs inside the balloon flow out through the micropores under pressure.

[0007] Furthermore, multiple rows of micropores are spaced apart along the circumferential direction of the balloon, with adjacent micropores in each row spaced apart.

[0008] Furthermore, the photodynamic balloon catheter also includes a distal guide tube, the distal end of which is sealed, and the proximal end of which is connected to the distal end of the balloon.

[0009] Furthermore, the photodynamic balloon catheter also includes an optical fiber, the distal end of which is inserted into the delivery catheter and extends to the distal end of the balloon before being connected to the proximal end of the end guide tube. The proximal end of the optical fiber is used to connect to an external laser generator. A gap is left between the outer wall of the optical fiber and the inner wall of the delivery catheter to allow the drug to pass through.

[0010] Furthermore, the distal end of the optical fiber is welded to the proximal end of the end guide tube.

[0011] Furthermore, the photodynamic balloon catheter also includes a guidewire; the optical fiber has a hollow inner cavity, and the guidewire and the optical fiber are coaxially disposed in the inner cavity.

[0012] Furthermore, the guidewire is a metal guidewire.

[0013] Furthermore, the photodynamic balloon catheter also includes a catheter seat, which is connected to the proximal end of the delivery catheter. The catheter seat is provided with an injection port, through which external drugs enter the delivery catheter.

[0014] Furthermore, the medication inside the balloon is a photosensitizer or a drug that inhibits restenosis.

[0015] On the other hand, the present invention also provides a vascular treatment system, including the photodynamic balloon catheter described in any one of the above.

[0016] The technical solution of this utility model has the following advantages:

[0017] The photodynamic balloon catheter provided by this invention features a single-layer balloon. It eliminates the need for separate fluid infusion to inflate the balloon; instead, medication, such as a photosensitizer, is directly administered to inflate the balloon. After inflation, the photosensitizer is ejected through micropores on the balloon to the lesion site. This design, compared to coating the balloon's outer surface with medication, prevents photosensitizer loss during delivery to the lesion. Furthermore, the absence of an inner tube in the single-layer balloon design results in a smaller overall outer diameter, making it suitable for smaller intracranial vessels. Additionally, the dosage, concentration, and volume of the photosensitizer can be controlled according to the vessel type, enhancing its applicability. Attached Figure Description

[0018] To more clearly illustrate the specific embodiments of this utility model or the technical solutions in the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this utility model. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0019] Figure 1 This is a schematic diagram of the photodynamic balloon catheter in an embodiment of the present invention;

[0020] Figure 2 This is a front view of the photodynamic balloon catheter in an embodiment of this utility model;

[0021] Figure 3 This is a cross-sectional view of the photodynamic balloon catheter in an embodiment of the present invention;

[0022] Figure 4 This is a cross-sectional view of the balloon in the photodynamic balloon catheter in an embodiment of the present invention;

[0023] Figure 5 This is a schematic diagram of the optical fiber in the photodynamic balloon catheter in an embodiment of the present invention;

[0024] Figure 6 This is a front view of the optical fiber in the photodynamic balloon catheter in this embodiment of the present invention;

[0025] Figure 7 for Figure 6 Sectional view at point BB.

[0026] Explanation of reference numerals in the attached figures:

[0027] 1. Balloon; 2. Delivery catheter; 3. Optical fiber; 4. Terminal guide tube; 5. Catheter seat; 6. Injection port; 7. Guide wire; 8. Micropore. Detailed Implementation

[0028] The technical solution of this utility model will now be clearly and completely described with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this utility model.

[0029] In the description of this utility model, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the accompanying drawings and are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0030] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0031] Furthermore, the technical features involved in the different embodiments of this utility model described below can be combined with each other as long as they do not conflict with each other.

[0032] like Figure 1 , Figure 2 , Figure 3 as well as Figure 4 As shown, this embodiment provides a photodynamic balloon catheter, comprising: a delivery catheter 2; and a balloon 1, wherein the balloon 1 is a single-layer balloon 1, the distal end of the balloon 1 is sealed, and the proximal end of the balloon 1 is connected to the distal end of the delivery catheter 2, for example, the balloon 1 and the delivery catheter 2 can be bonded together. The balloon 1 has a plurality of micropores 8 on its side, the micropores 8 connecting the inner and outer sides of the balloon 1; external medication is delivered to the balloon 1 through the proximal end of the delivery catheter 2, causing the balloon 1 to inflate, and the medication inside the balloon 1 flows out through the micropores 8 under pressure. For example, the medication inside the balloon 1 can be a photosensitizer or a drug that inhibits restenosis.

[0033] The photodynamic balloon catheter provided in this embodiment uses a single-layer balloon 1. It eliminates the need for separate fluid infusion to inflate the balloon 1; instead, medication, such as a photosensitizer, is directly used to inflate the balloon 1. After inflation, the photosensitizer is ejected through micropores 8 on the balloon 1 to the lesion site. This design, compared to coating the outer surface of the balloon 1 with medication, prevents photosensitizer loss during delivery to the lesion. Furthermore, the absence of an inner tube in the single-layer balloon 1 results in a smaller overall outer diameter, making it suitable for smaller intracranial blood vessels. Additionally, the dosage, concentration, and volume of the medication, such as the photosensitizer, can be controlled according to the type of blood vessel, resulting in better applicability.

[0034] like Figure 4 As shown, multiple rows of micropores 8 can be spaced apart along the circumferential direction of the balloon 1. The spacing between adjacent rows of micropores 8 can be designed as needed, and adjacent micropores 8 in each row can be equally spaced. For example, the micropores 8 can be circular. For example, the size of the micropores 8 can be designed as needed, so that when drug delivery stops, the pressure inside the balloon 1 is insufficient to allow the drug inside the balloon 1 to flow out through the micropores 8.

[0035] The photodynamic balloon catheter also includes a distal guide tube 4, the distal end of which is sealed, and the proximal end of which is connected to the distal end of the balloon 1. The distal end of the distal guide tube 4 can be freely bent to facilitate its advancement within tortuous blood vessels.

[0036] The photodynamic balloon catheter also includes an optical fiber 3. The distal end of the optical fiber 3 is inserted into the delivery catheter 2 and extends to the distal end of the balloon 1, where it connects to the proximal end of the distal guide tube 4. The proximal end of the optical fiber 3 is used to connect to an external laser generator. A gap is left between the outer wall of the optical fiber 3 and the inner wall of the delivery catheter 2 to allow drug passage. For example, the optical fiber 3 can be used to emit light with a wavelength of 400-500 nm to activate a photosensitizer, thereby inducing cross-linking of proteins in the blood vessel wall to form a natural vascular scaffold, thus maintaining the dilated blood vessel.

[0037] like Figure 5 , Figure 6 as well as Figure 7 As shown, the photodynamic balloon catheter also includes a guidewire 7; the optical fiber 3 has a hollow inner cavity, and the guidewire 7 and the optical fiber 3 are coaxially disposed in the inner cavity. This configuration integrates the light beam and the guidewire 7 into one unit, using the optical fiber 3 as the guidewire 7. No additional guidewire 7 is required; the balloon catheter 1 can be guided to the lesion site using the optical fiber 3. Compared to traditional techniques that require first using the guidewire 7 to deliver the balloon catheter 1 to the lesion site, then withdrawing the guidewire 7 and inserting the optical fiber 3, this reduces surgical steps and shortens the surgical time.

[0038] The distal end of the optical fiber 3 is welded to the proximal end of the end guide tube 4 as a single unit. This arrangement facilitates the control of the end guide tube 4 for pushing via the optical fiber 3.

[0039] The guide wire 7 is a metal guide wire. This configuration helps to improve the pushing force of the optical fiber 3.

[0040] The photodynamic balloon catheter also includes a catheter seat 5, which is connected to the proximal end of the delivery catheter 2. The catheter seat 5 is provided with a drug injection port 6, through which external drugs enter the delivery catheter 2.

[0041] In use, balloon 1 is introduced to the lesion site in the blood vessel via optical fiber 3. A photosensitizer is injected through injection port 6. The photosensitizer reaches balloon 1 along delivery catheter 2, inflating balloon 1. The photosensitizer is then continuously injected and discharged from micropores 8 on balloon 1 to the lesion site. Then, optical fiber 3 is connected to an external laser generator, causing optical fiber 3 to emit light with a wavelength of 400-500nm, which activates the photosensitizer and triggers cross-linking of proteins in the blood vessel wall, forming a natural vascular stent, thus maintaining the dilated blood vessel. Then, the injection of photosensitizer is stopped, and excess photosensitizer in balloon 1 is aspirated, causing balloon 1 to depressurize and contract before being withdrawn from the body.

[0042] Among them, the photosensitizer can be a material that promotes angiogenesis repair, for example, it can be a naphthalimide dimer and its derivatives.

[0043] In addition, restenosis inhibitors can be delivered to the lesion site through the injection port 6. The restenosis inhibitors are injected through the injection port 6 and ejected from the micropores 8 on the balloon 1, which can be used to treat vascular stenosis and occlusion.

[0044] Among them, drugs that inhibit restenosis can include macrolide immunosuppressants, macrolide antibiotics, rapamycin, structural derivatives and functional analogs of rapamycin, everolimus, structural derivatives and functional analogs of everolimus, paclitaxel, taxanes, tamsurolimus compounds, zoromolimus, sirolimus, biolimus, tacrolimus, tamsurolimus, and everolimus, etc.

[0045] On the other hand, the present invention also provides a vascular treatment system, including the photodynamic balloon catheter described in any one of the above.

[0046] In summary, the photodynamic balloon catheter of this application features a single-layer balloon 1 and eliminates the need for an inner tube, resulting in a smaller overall outer diameter of balloon 1 (traditional balloons are double-layered, and conventional catheters typically have an outer and inner tube), making it suitable for smaller intracranial blood vessels. Furthermore, the integration of the optical fiber 3 and guidewire 7, with the optical fiber 3 serving as the guidewire 7, allows the balloon 1 to be guided to the lesion site using only the optical fiber 3, reducing surgical steps and shortening the operation time.

[0047] Obviously, the above embodiments are merely illustrative examples for clear explanation and are not intended to limit the implementation. Those skilled in the art will recognize that other variations or modifications can be made based on the above description. It is neither necessary nor possible to exhaustively list all possible implementations here. However, obvious variations or modifications derived therefrom are still within the protection scope of this invention.

Claims

1. A photodynamic balloon catheter, characterized in that, include: Delivery conduit (2); A balloon (1) is a single-layer balloon (1). The distal end of the balloon (1) is sealed, and the proximal end of the balloon (1) is connected to the distal end of the delivery conduit (2). Several micropores (8) are provided on the side of the balloon (1). External drugs are delivered to the balloon (1) through the proximal end of the delivery conduit (2) and the balloon (1) is inflated. The drugs in the balloon (1) flow out through the micropores (8) under pressure.

2. The photodynamic balloon catheter according to claim 1, characterized in that, Multiple rows of micropores (8) are spaced apart along the circumferential direction of the balloon (1), with adjacent micropores (8) in each row spaced apart.

3. The photodynamic balloon catheter according to claim 1, characterized in that, It also includes a distal guide tube (4), the distal end of which is sealed, and the proximal end of which is connected to the distal end of the balloon (1).

4. The photodynamic balloon catheter according to claim 3, characterized in that, It also includes an optical fiber (3), the distal end of which is inserted into the delivery conduit (2) and extends to the distal end of the balloon (1) and is connected to the proximal end of the end guide tube (4). The proximal end of the optical fiber (3) is used to connect to an external laser generator. A gap is left between the outer wall of the optical fiber (3) and the inner wall of the delivery conduit (2) to allow the drug to pass through.

5. The photodynamic balloon catheter according to claim 4, characterized in that, The distal end of the optical fiber (3) is welded to the proximal end of the end guide tube (4) as a single unit.

6. The photodynamic balloon catheter according to claim 4, characterized in that, It also includes the guidewire (7); The optical fiber (3) has a hollow inner cavity, and the guide wire (7) is coaxially disposed in the inner cavity with the optical fiber (3).

7. The photodynamic balloon catheter according to claim 6, characterized in that, The guide wire (7) is a metal guide wire (7).

8. The photodynamic balloon catheter according to claim 1, characterized in that, It also includes a catheter seat (5), which is connected to the proximal end of the delivery catheter (2). The catheter seat (5) is provided with a drug injection port (6), through which external drugs enter the delivery catheter (2).

9. The photodynamic balloon catheter according to claim 1, characterized in that, The drug inside the balloon (1) is a photosensitizer or a drug that inhibits restenosis.

10. A vascular treatment system, characterized in that, The photodynamic balloon (1) catheter includes any one of claims 1-9.

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