Sectional type chromatographic column

Abstract

The utility model discloses a sectional type chromatographic column which comprises a feeding pipe, a column pipe, a discharging pipe and a fastening sleeve, the feeding pipe, the column pipe and the discharging pipe are sequentially connected, the fastening sleeve is movably arranged among the feeding pipe, the column pipe and the discharging pipe in a surrounding mode, a protruding ring is arranged on the middle section of the inner side of the fastening sleeve, and the tail end of the column pipe abuts against the protruding ring. First sleeving sections are arranged on the outer sides of the upper portion and the lower portion of the column pipe, second sleeving sections are arranged on the lower portion of the feeding pipe and the top of the discharging pipe, and the first sleeving sections and the second sleeving sections are sleeved with the fastening sleeves. According to the utility model, the lower part of the feeding pipe and the upper part of the discharging pipe are provided with the second sleeving sections, the upper part and the lower part of the column pipe are provided with the first sleeving sections, and the fastening sleeves are annularly arranged between the first sleeving sections and the second sleeving sections, so that the connection sealing performance is strong; an upper groove and a lower groove are formed in the upper portion and the lower portion of a protruding ring of the fastening sleeve, the first sleeving section and the second sleeving section are arranged in the upper groove and the lower groove in a sleeving mode, and the sleeving depth is accurate. The column pipe height adjusting device is ingenious in design, high in practicability and suitable for popularization.

Description

Technical Field

[0001] This utility model relates to the field of chromatography column technology, and more specifically to a segmented chromatography column. Background Technology

[0002] Most existing chromatography columns are one-piece designs, which often lead to problems such as inconvenient material loading, poor packing effect, and difficulties in unloading and cleaning due to their long length. Deep cleaning of the column is also difficult, potentially contaminating the compounds to be separated. Furthermore, the fixed height of one-piece columns limits their application to a single chromatography operation. While segmented chromatography columns have emerged to facilitate chromatography and cleaning, poor sealing between segments often affects the chromatography process. To address these issues, the inventors propose a segmented chromatography column. This segmented design allows for assembly as needed, facilitating packing and cleaning, as well as disassembly, transportation, and storage. This improves user experience and enhances chromatography quality and efficiency.

[0003] To facilitate the assembly, disassembly, and cleaning of chromatography columns, and to improve their usability, publication number CN215026211U discloses a segmented, detachable chromatography column. This utility model includes a first column segment, a second column segment, and at least one third column segment. The bottom end of the first column segment, the top end of the second column segment, and both the top and bottom ends of the third column segment have annular protrusions. Annular sealing grooves and slots are formed at the bottom of the annular protrusions at the bottom ends of the first and third column segments, with the slots located outside the annular sealing grooves. Annular sealing rings and locking blocks are fixed to the top of the annular protrusions at the top ends of the second and third column segments, with the locking blocks located outside the annular sealing rings. The annular sealing rings engage with the annular sealing grooves, and the locking blocks engage with the slots. This utility model is divided into multiple detachable segments, which facilitates separate elution and improves sample yield.

[0004] This method still has some shortcomings in application. Since the chromatography column adopts a multi-segment structure, the most important thing is the airtightness of the connection between the segmented chromatography columns. It needs to maintain good sealing, otherwise it will affect the chromatography effect. Therefore, the sealing connection structure between the segmented chromatography columns is very important and needs to be precise. At the same time, since each segment of the chromatography column needs to be observed during the chromatography process, including dosage, the connection between the segmented chromatography columns should be transparent. Otherwise, it will affect the operator's observation. Therefore, the structure of the segmented chromatography column needs to be improved to have a good connection structure between the segmented chromatography columns, while facilitating the operation and observation of the experimenters, thereby effectively improving the chromatography quality. Utility Model Content

[0005] The present invention discloses a segmented chromatography column, the main purpose of which is to overcome the above-mentioned deficiencies and shortcomings of the prior art.

[0006] The technical solution adopted in this utility model is as follows:

[0007] A segmented chromatography column includes a feed tube, a column tube, a discharge tube, and a fastening sleeve. The feed tube, the column tube, and the discharge tube are connected sequentially from top to bottom. The fastening sleeve has a movable ring disposed between the feed tube, the column tube, and the discharge tube. A protruding ring is provided in the middle section of the inner side of the fastening sleeve, and the end of the column tube abuts against the protruding ring. The upper and lower parts of the column tube have a first sleeve section on the outer side, and the lower part of the feed tube and the top of the discharge tube have a second sleeve section. The first sleeve section and the second sleeve section are adapted to fit into the fastening sleeve. The outer wall of the fastening sleeve has several arc-shaped grooves.

[0008] Furthermore, the fastening sleeve is made of transparent rubber.

[0009] Furthermore, the diameter of the protruding ring is the same as the wall diameter of the column tube.

[0010] Furthermore, the column tube is connected end to end by the fastening sleeve and has a measuring scale on its outer wall.

[0011] Furthermore, the inner side of the fastening sleeve is provided with an upper groove and a lower groove, the depth of which is consistent with that of the first sleeve section and the second sleeve section.

[0012] Furthermore, there are multiple of the column tube and the fastening sleeve, and the height of the column tube includes any one of 20cm, 30cm and 50cm.

[0013] As can be seen from the above description of this utility model, compared with the prior art, the advantages of this utility model are as follows:

[0014] This invention firstly establishes a second connecting section at the lower part of the feed pipe and the upper part of the discharge pipe, while simultaneously establishing a first connecting section at the upper and lower parts of several column tubes. A fastening sleeve is annularly installed between the first and second connecting sections. This design achieves a segmented, sealed connection of the chromatography column, resulting in a simple structure and strong sealing performance. Next, the fastening sleeve is made of transparent rubber and features a protruding ring in the middle of its inner side. The protruding ring has upper and lower grooves at its upper and lower parts. The first and second connecting sections fit into these grooves with precise insertion depth and good sealing, facilitating improved chromatography quality. Finally, the column height can be any of 20cm, 30cm, or 50cm, allowing for flexible combinations to be set according to experimental needs, enabling various chromatography operations. This invention is ingeniously designed, achieving segmented chromatography column connection with high sealing performance, adjustable height, and convenient assembly and disassembly, making it suitable for widespread application. Attached Figure Description

[0015] Figure 1 This is a front view structural diagram of the present invention.

[0016] Figure 2 This is a structural schematic diagram of the fastening sleeve of this utility model.

[0017] Figure 3 This is a schematic diagram of the column tube structure of this utility model.

[0018] Figure 4 This is a top view schematic diagram of the fastening sleeve of this utility model. Detailed Implementation

[0019] The specific embodiments of this utility model will be further described below with reference to the accompanying drawings.

[0020] like Figures 1 to 4 As shown, a segmented chromatography column includes a feed pipe 1, a column tube 2, a discharge pipe 3, and a fastening sleeve 4. The feed pipe 1, the column tube 2, and the discharge pipe 3 are connected sequentially from top to bottom. The fastening sleeve 4 is movably disposed between the feed pipe 1, the column tube 2, and the discharge pipe 3. A protruding ring 41 is provided in the middle section of the inner side of the fastening sleeve 4. The end of the column tube 2 abuts against the protruding ring 41. The upper and lower parts of the column tube 2 are provided with a first sleeve section 5 on the outer side. The lower part of the feed pipe 1 and the top of the discharge pipe 3 are provided with a second sleeve section 6. The first sleeve section 5 and the second sleeve section 6 are adapted to fit into the fastening sleeve 4. The outer wall of the fastening sleeve 4 is provided with several arc-shaped grooves 7.

[0021] Furthermore, the fastening sleeve 4 is made of transparent rubber.

[0022] Furthermore, the diameter of the protruding ring 41 is the same as the diameter of the tube wall of the column tube 2.

[0023] Furthermore, the column tube 2 is connected end to end by the fastening sleeve 4 and has a measuring scale 8 on its outer side wall.

[0024] Furthermore, the inner side of the fastening sleeve 4 is provided with an upper groove 42 and a lower groove 43, the depths of which are the same as those of the first sleeve segment 5 and the second sleeve segment 6.

[0025] Furthermore, there are multiple of the column tube 2 and the fastening sleeve 4, and the height of the column tube 2 includes any one of 20cm, 30cm and 50cm.

[0026] [Example]

[0027] First, determine the height of the chromatography column according to the experimental requirements, thereby determining the number and size of column tubes 2, including any one of 20cm, 30cm, and 50cm. Next, place the discharge tube 3 at the bottom, and insert the second connecting segment 6 at the top of the discharge tube 3 into the lower groove 43 of the fastening sleeve 4. Then, insert the first connecting segment 5 of the column tube 2 into the upper groove 42 and lower groove 43 of the fastening sleeve 4 to connect the ends of the column tube 2. Insert the second connecting segment 6 of the feed tube 1 at the top into the upper groove 42 of the top fastening sleeve 4 to complete the overall installation of the chromatography column and perform chromatography operation. Since the column tube 2 has a metering scale and the fastening sleeve 4 is transparent, it is easy for the staff to observe. Finally, after the operation is completed, the feed tube 1, column tube, and discharge tube 3 are disassembled from the fastening sleeve 4 one by one. The operation is very convenient and easy to clean and store.

[0028] As can be seen from the above description of this utility model, compared with the prior art, the advantages of this utility model are as follows:

[0029] This invention firstly establishes a second connecting section at the lower part of the feed pipe and the upper part of the discharge pipe, while simultaneously establishing a first connecting section at the upper and lower parts of several column tubes. A fastening sleeve is annularly installed between the first and second connecting sections. This design achieves a segmented, sealed connection of the chromatography column, resulting in a simple structure and strong sealing performance. Next, the fastening sleeve is made of transparent rubber and features a protruding ring in the middle of its inner side. The protruding ring has upper and lower grooves at its upper and lower parts. The first and second connecting sections fit into these grooves with precise insertion depth and good sealing, facilitating improved chromatography quality. Finally, the column height can be any of 20cm, 30cm, or 50cm, allowing for flexible combinations to be set according to experimental needs, enabling various chromatography operations. This invention is ingeniously designed, achieving segmented chromatography column connection with high sealing performance, adjustable height, and convenient assembly and disassembly, making it suitable for widespread application.

[0030] The above are merely specific embodiments of this utility model, but the design concept of this utility model is not limited thereto. Any non-substantial improvements made to this utility model using this concept should be considered as infringing on the protection scope of this utility model.

Claims

1. A segmented chromatography column, characterized in that: The device includes a feed pipe, a column pipe, a discharge pipe, and a fastening sleeve. The feed pipe, the column pipe, and the discharge pipe are connected sequentially from top to bottom. The fastening sleeve has a movable ring located between the feed pipe, the column pipe, and the discharge pipe. The middle section of the inner side of the fastening sleeve has a protruding ring. The end of the column pipe abuts against the protruding ring. The upper and lower parts of the column pipe have a first sleeve section on the outer side. The lower part of the feed pipe and the top of the discharge pipe have a second sleeve section. The first sleeve section and the second sleeve section are adapted to fit into the fastening sleeve. The outer wall of the fastening sleeve has several arc-shaped grooves.

2. The segmented chromatography column according to claim 1, characterized in that: The fastening sleeve is made of transparent rubber.

3. The segmented chromatography column according to claim 1, characterized in that: The diameter of the protruding ring is the same as that of the tube wall.

4. The segmented chromatography column according to claim 1, characterized in that: The column tube is connected end to end by the fastening sleeve and has a measuring scale on its outer wall.

5. A segmented chromatography column according to claim 1, characterized in that: The inner side of the fastening sleeve is provided with an upper groove and a lower groove, and the depth of the upper groove and the lower groove is the same as that of the first sleeve section and the second sleeve section.

6. A segmented chromatography column according to claim 1, characterized in that: There are several of the column tubes and the fastening sleeves, and the height of the column tubes includes any one of 20cm, 30cm and 50cm.

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