Freeze-thaw protection device

Abstract

The utility model discloses a freeze thawing protection device which comprises a frame body forming a disposable container containing space, limiting devices used for fixing a disposable container in the containing space are arranged in the containing space, the limiting devices comprise the fixed limiting device and the movable limiting device, the fixed limiting device is fixed to the frame body, and the movable limiting device is fixed to the frame body. And the movable limiting device is detachably connected with the frame body. According to the freeze-thaw protection device disclosed by the utility model, the disposable container is fixed through the structure that the fixed limiting device and the movable limiting device are arranged in the containing space, and the movable limiting device is detachably connected with the frame body, so that the movable limiting device can be used for fixing the disposable containers with multiple sizes.

Description

TECHNICAL FIELD

[0001] The utility model relates to the field of biopharmaceuticals, in particular to a freeze-thaw protection device. BACKGROUND

[0002] The whole process of biopharmaceuticals contains multiple steps, and the feed liquid is usually stored in batches by freezing during the process of circulation and storage between steps to ensure its quality and simplify the development process.

[0003] Since the feed liquid needs to be frozen, in the prior art, a disposable container such as a stainless steel vessel, a plastic bottle or a plastic bag, a flexible bag, etc. is usually used to store the feed liquid, but the disposable container is easily damaged due to factors such as freezing brittleness, vibration, wear, impact, or improper operation of the operator, so that the feed liquid is lost, and therefore a freeze-thaw protection device is provided to protect the disposable container.

[0004] In the prior art, a system for freezing, storing and thawing biopharmaceutical materials disclosed in Chinese Patent No. CN101932235B includes a container for storing biopharmaceutical materials therein, a holder having a cavity, the container being received in the cavity, the holder including a first portion and a second portion, the container being received between the first portion and the second portion for connecting the container with the holder, the holder including an inner tray having a bottom and a rim extending from the bottom, the tray defining a boundary of the cavity, an outer flange connected with the tray and separated from the cavity, the outer flange defining a boundary of a protection cavity of the holder, and wherein the bottom includes an inner surface facing the cavity receiving the container and an outer surface, the outer surface of the bottom being recessed relative to an outer surface of the outer flange.

[0005] The container disclosed in the above patent can only be applied to a disposable container of one size, and there are many sizes of disposable containers, so there is an urgent need in the market for a freeze-thaw protection device that can be applied to disposable containers of different sizes. UTILITY MODEL CONTENT

[0006] To solve the problems in the prior art, the utility model discloses a freeze-thaw protection device.

[0007] A freeze-thaw protection device includes a frame body forming a disposable container containing space, a limiting device for fixing the disposable container in the containing space is arranged in the containing space, the limiting device includes a fixed limiting device and a movable limiting device, the fixed limiting device is fixed with the frame body, and the movable limiting device is detachably connected with the frame body.

[0008] Specifically, the position of the disposable container is fixed by the limiting device arranged in the accommodating space, and since the movable limiting device is detachably connected with the frame body, the disposable container can be fixed in the accommodating space as long as the volume of the disposable container is smaller than the accommodating space, that is, the freeze-thaw protection device can be adapted to disposable containers of various sizes.

[0009] Preferably, the movable limiting device is a clamping block, the frame body is provided with a plurality of connecting ports for detachably connecting the clamping blocks, and the clamping block is provided with at least one connecting port.

[0010] Specifically, since the clamping block is detachably connected with the frame body and is provided with a plurality of connecting ports, and the clamping blocks are detachably connected and are provided with a plurality of connecting ports, the relative positions of the clamping blocks and the frame body and the relative positions of the clamping blocks can be adjusted according to the size of the disposable container and the position of the disposable container in the accommodating space, so as to achieve good fixation of the disposable container.

[0011] Preferably, the clamping block comprises a first clamping block and a second clamping block arranged on both sides of the disposable container, and a fixing device is formed between the first clamping block and the second clamping block, and the disposable container is provided with a fixing portion adapted to the fixing device.

[0012] Specifically, the first clamping block and the second clamping block are used to clamp and fix the disposable container, and the cooperation of the fixing device and the fixing portion makes the position of the entire disposable container more stable.

[0013] Taking a flexible bag as an example, the fixing device is a fixing column arranged on the first clamping block or the second clamping block and a groove arranged on both sides of the fixing column, the fixing limiting device is a columnar protrusion arranged on the frame body, and the fixing portion is a positioning through hole arranged on the flexible bag, and the positioning through hole is sleeved on the fixing column and the columnar protrusion to fix the position of the flexible bag.

[0014] Preferably, a buffer plate is further included, the buffer plate is used to separate the disposable container from the frame body, and one side of the buffer plate is attached to the outside of the disposable container.

[0015] Specifically, the buffer plate separates the frame body from the disposable container, and since the material of the frame body is usually a relatively hard material, the structure of the buffer plate can effectively prevent the frame body from damaging the disposable container, especially the flexible film material disposable container (such as a flexible bag), and can also provide secondary protection for the disposable container (the primary protection is the frame body).

[0016] Preferably, the buffer plate is provided with two pieces, and the two pieces of the buffer plate are any combination of a corrugated plate, a flat plate, and a concave plate.

[0017] Specifically, when the disposable container is a flexible bag, the corrugated plate not only has the functions of anti-adhesion and protection, but also can extrude the flexible bag to keep the liquid level in the bag as consistent as possible, thereby ensuring uniform fluid distribution and freezing in the bag; the concave plate ensures that the lowest positions of the extruded surfaces on both sides of the flexible bag in the empty shell state are in close contact with each other, thereby ensuring that the flexible bag is in close contact with the concave plate when the flexible bag is filled with any amount of liquid within the working capacity range, and avoiding the risk of reducing the heat transfer rate and prolonging the freezing / thawing time.

[0018] In addition, the shape of the buffer plate is not limited to a corrugated plate, a flat plate, and a concave plate, and any shape of the buffer plate that can achieve the above functions should be considered as an equivalent alternative of the present application.

[0019] Preferably, the concave plate is recessed towards the disposable container, and the concave plate includes a fixed portion close to the frame and an extrusion portion close to the disposable bag, and the fixed portion and the extrusion portion are connected by a slope.

[0020] Preferably, the buffer plate is provided with at least one observation window, and the total area of the observation window is not greater than the area of the buffer plate.

[0021] Specifically, the buffer plate can be made of transparent material, and in this case, the area of the observation window is equal to the area of the buffer plate.

[0022] Preferably, the frame includes a detachable cover plate and a connecting frame, the cover plate is provided with two pieces, the connecting frame is arranged between the two cover plates, and the connecting frame includes a plurality of detachable skeletons.

[0023] The skeletons and the cover plates are made of the same or different materials.

[0024] Specifically, in this structure, the frame as a whole adopts a detachable structure connection, and the skeletons and the cover plates can be made of the same or different materials, so that appropriate skeletons and cover plates can be selected for assembly according to the actual situation of the disposable container, so that the frame has the smallest weight while meeting the strength and hardness requirements.

[0025] For example, the skeletons and the cover plates can be made of metal or plastic, and metal has high strength but is heavy, while plastic is light but has relatively poor strength, so the metal skeletons and cover plates and the plastic skeletons and cover plates can be assembled according to the actual situation.

[0026] Preferably, the cover plate is provided with a plurality of through holes, and some of the through holes coincide with the positions of the observation windows.

[0027] Specifically, the structure of arranging a plurality of through holes on the cover plate can further reduce the weight of the cover plate and has little effect on the strength of the cover plate, and in addition, the operator can observe the state of the disposable container through the through holes and the observation window.

[0028] Preferably, the side of the cover plate away from the disposable container is provided with a foot pad or a positioning hole, and the foot pad and the positioning hole are arranged on different cover plates.

[0029] Specifically, the structure of the foot pad and the positioning hole facilitates the stacking of the freeze-thaw protection device in multiple layers, prevents the freeze-thaw protection device from being displaced after being stacked, and ensures the stability of the freeze-thaw protection device after being stacked.

[0030] Compared with the prior art, the freeze-thaw protection device has the advantages that:

[0031] By arranging the fixed limiting device and the movable limiting device in the accommodating space, the disposable container is fixed, wherein the movable limiting device is detachably connected with the frame body, so that the movable limiting device can be used to fix a plurality of disposable containers of different sizes.

[0032] By arranging the frame body in a detachable structure, the components of the frame body are made of different or same materials, and the components of the frame body are appropriately selected according to the strength and weight requirements of the frame body during actual use, and then assembled. BRIEF DESCRIPTION OF DRAWINGS

[0033] Figure 1 An assembly view of the freeze-thaw protection device is provided.

[0034] Figure 2 A top view of the freeze-thaw protection device without a cover plate (one movable limiting device) is provided.

[0035] Figure 3 A Figure 2 A sectional view in the A-A direction.

[0036] Figure 4 An assembly view of the freeze-thaw protection device without a cover plate (two movable limiting devices) is provided.

[0037] Figure 5 A top view of the freeze-thaw protection device without a cover plate (four movable limiting devices) is provided.

[0038] Figure 6 A parts view of the recessed plate of the freeze-thaw protection device is provided.

[0039] Figure 7 A stacking schematic view of the freeze-thaw protection device is provided. DETAILED DESCRIPTION

[0040] The utility model will be further described below in combination with the drawings and specific embodiments.

[0041] As Figure 1 shown, a freeze-thaw protection device, including the frame that forms disposable container 70 containing space, containing space is equipped with for fixing disposable container 70 in containing space in the limiting device, limiting device includes fixed limiting device 20 and movable limiting device 30, fixed limiting device 20 is fixed with frame, movable limiting device 30 is detachably connected with frame.

[0042] The position of disposable container 70 is fixed by setting limiting device in containing space, since movable limiting device 30 is detachably connected with frame, therefore, as long as the volume of disposable container 70 is less than containing space, this disposable container 70 can be fixed in containing space;That is to say, the freeze-thaw protection device provided in the embodiment can be adapted to a variety of sizes disposable container 70.

[0043] As Figures 2-5 shown, movable limiting device 30 is clamping block, frame is equipped with a plurality of connecting ports 11 for detachably connecting clamping block, clamping block is equipped with at least one, when clamping block is equipped with multiple, and clamping block has connecting relationship between clamping block, clamping block is detachably connected, and clamping block is equipped with at least one connecting place for connecting with other clamping block.

[0044] Since clamping block and frame are detachably connected, and are equipped with a plurality of connecting ports 11, clamping block and clamping block are detachably connected, and are equipped with a plurality of connecting places, therefore, the mutual position between clamping block and frame, clamping block and clamping block can be adjusted according to the size of disposable container 70, the position of disposable container 70 in containing space, so as to realize good fixation of disposable container 70.

[0045] Clamping block includes first clamping block 32 and second clamping block 33 separately arranged on both sides of disposable container 70, and a fixing device 31 is formed between the first clamping block 32 and the second clamping block 33, and the disposable container 70 is provided with a fixing portion matched with the fixing device 31.

[0046] The first clamping block 32 and the second clamping block 33 are used to clamp and fix the disposable container 70, and the cooperation structure of the fixing device 31 and the fixing portion makes the position of the entire disposable container 70 more stable.

[0047] For example, the fixing device 31 is a fixing column arranged on the first clamping block 32 or the second clamping block 33 and a groove arranged on both sides of the fixing column, the fixing limiting device 20 is a columnar protrusion arranged on the frame body, and the fixing position is a positioning through hole arranged on the flexible bag, and the positioning through hole is sleeved on the fixing column and the columnar protrusion to fix the position of the flexible bag.

[0048] The buffer plate 40 is further included, which is used to separate the disposable container 70 from the frame body, and one side of the buffer plate 40 is fitted with the outside of the disposable container 70.

[0049] The buffer plate 40 separates the frame body from the disposable container 70. Since the material of the frame body is usually a relatively hard material, the structure of the buffer plate 40 can effectively prevent the frame body from damaging the disposable container 70, especially the disposable container 70 made of a flexible film material (such as a flexible bag), and can also provide secondary protection for the disposable container 70 (the primary protection is the frame body).

[0050] The buffer plate 40 is provided with two pieces, and the two pieces of the buffer plate 40 are any combination of a wave plate, a flat plate, and a recessed plate 50.

[0051] When the disposable container 70 is a flexible bag, the wave plate not only has the functions of anti-adhesion and protection, but also can uniformly extrude the flexible bag to keep the liquid level in the bag as consistent as possible, thereby ensuring uniform fluid distribution and freezing in the bag. The wave plate also has the advantage of easy cleaning; the recessed plate 50 makes the lowest positions of the extruded surfaces on both sides of the flexible bag in the empty shell state adhere to each other, thereby ensuring that the flexible bag is tightly attached to the recessed plate 50 when filling any amount of liquid within the working capacity range, and avoiding the risk of reducing the heat transfer rate and prolonging the freezing / thawing time.

[0052] In addition, the shape of the buffer plate 40 is not limited to a wave plate, a flat plate, and a recessed plate. As long as the above functions can be achieved, any shape of the buffer plate 40 should be considered as an equivalent alternative of the present scheme.

[0053] As shown in FIG. 1, the buffer plate 40 is arranged on the frame body, and the buffer plate 40 is arranged on the frame body. Figure 6 As shown in FIG. 1, the buffer plate 40 is arranged on the frame body, and the buffer plate 40 is arranged on the frame body.

[0054] The buffer plate 40 is provided with at least one observation window, and the total area of the observation window is not greater than the area of the buffer plate 40.

[0055] The buffer plate 40 can be made of transparent material, in which case the area of the observation window is equal to the area of the buffer plate 40.

[0056] The frame includes a detachable cover plate 13 and a connecting frame. There are two cover plates 13, and the connecting frame is located between the two cover plates 13. The connecting frame includes several detachable skeletons 14.

[0057] The frame 14 and the cover plate 13 may be made of the same or different materials.

[0058] In this structure, the frame is connected in a detachable manner, and the frame 14 and the cover plate 13 can be made of the same or different materials. Therefore, the appropriate frame 14 and cover plate 13 can be selected for assembly according to the actual situation of the disposable container 70, so that the frame has the minimum weight while meeting the requirements of strength and hardness.

[0059] For example, the frame 14 and the cover plate 13 can be made of metal or plastic. Metal has high strength but is heavy, while plastic is light but relatively weak. The metal frame 14 and cover plate 13, and the plastic frame 14 and cover plate 13 can be assembled according to the actual situation.

[0060] The cover plate 13 has several through holes 61, some of which coincide with the location of the observation window.

[0061] The structure of providing several through holes 61 on the cover plate 13 can further reduce the weight of the cover plate 13 and have a negligible impact on the strength of the cover plate 13. In addition, it can also make it convenient for the operator to observe the state of the disposable container 70 through the through holes 61 and the observation window.

[0062] like Figure 1 , 7 As shown, a foot pad 62 or a positioning hole 63 is provided on the side of the cover plate 13 away from the disposable container 70. The foot pad 62 and the positioning hole 63 are respectively provided on different cover plates 13, and the foot pad 62 is adapted to the positioning hole 63.

[0063] The structure of the foot pads 62 and the positioning holes 63 facilitates the stacking of multiple layers of freeze-thaw protection devices, prevents mutual displacement of the freeze-thaw protection devices after stacking, and ensures the stability of the freeze-thaw protection devices after stacking.

Claims

1. A freeze protection device comprising a frame forming a space for accommodating a disposable container, characterized in that, The accommodating space is provided with a limiting device for fixing the disposable container in the accommodating space, the limiting device comprises a fixed limiting device and a movable limiting device, the fixed limiting device is fixed with the frame body, and the movable limiting device is detachably connected with the frame body; The movable limiting device is a clamping block, the frame body is provided with a plurality of connecting ports for detachably connecting the clamping blocks, the clamping block is provided with at least one, when the clamping block is provided with a plurality of clamping blocks and the clamping blocks have a connection relationship, the clamping blocks are detachably connected, and the clamping block is provided with at least one connecting portion for connecting other clamping blocks.

2. The freeze protection apparatus of claim 1, wherein, The clamping block comprises a first clamping block and a second clamping block arranged on both sides of the disposable container, and a fixing device is formed between the first clamping block and the second clamping block, and the disposable container is provided with a fixing portion matched with the fixing device.

3. The freeze protection apparatus of claim 1, wherein, Further comprising a buffer plate, the buffer plate is used for separating the disposable container and the frame body, and one side of the buffer plate is matched with the outside of the disposable container.

4. The freeze protection apparatus of claim 3, wherein, The buffer plate is provided with two, and the two buffer plates are any combination of wave plates, flat plates and recessed plates.

5. The freeze protection apparatus of claim 4, wherein, The recessed plate is recessed towards the disposable container, and the recessed plate comprises a fixed portion close to the frame body and an extrusion portion close to the disposable container bag, and the fixed portion and the extrusion portion are connected through an inclined surface.

6. The freeze protection apparatus of claim 3, wherein, The buffer plate is provided with at least one observation window, and the total area of the observation window is not greater than the area of the buffer plate.

7. The freeze protection apparatus of claim 6, wherein, The frame body comprises a detachable cover plate and a connecting frame, the cover plate is provided with two, the connecting frame is arranged between the two cover plates, and the connecting frame comprises a plurality of detachable skeletons. The skeleton and the cover plate are made of the same or different materials.

8. The freeze protection apparatus of claim 7, wherein, The cover plate is provided with a plurality of through holes, and part of the through holes coincide with the positions of the observation windows.

9. The freeze protection apparatus of claim 7, wherein, The side of the cover plate away from the disposable container is provided with a foot pad or a positioning hole, the foot pad and the positioning hole are arranged on different cover plates, and the foot pad is matched with the positioning hole. The side of the cover plate away from the disposable container is provided with a foot pad or a positioning hole, the foot pad and the positioning hole are arranged on different cover plates, and the foot pad is matched with the positioning hole.

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