High-airtightness dry type granulator structure

Abstract

The utility model relates to a high-airtightness dry type granulator structure. The high-airtightness dry type granulator structure comprises a process area, a conveying area, a driving area and a sealing cavity surrounding the process area and the conveying area, the sealing cavity is connected to the equipment frame, and the process area is used for processing materials into particles; the conveying area is used for feeding of materials and discharging of particles; and the driving area is used for providing power for the process assembly. The front side of the sealing cavity is rotationally connected with a sealing door through a rotating shaft, and an inflation sealing ring is arranged on the periphery of the inner side of the sealing door. An output shaft of a driving device in the driving area penetrates through the sealing cavity, and an isolation sealing ring is arranged between the output shaft and the sealing cavity. The sealing cavity is connected with a feeding barrel through a hopper cover, and the lower end of the sealing cavity is connected with a material receiving barrel. The utility model aims to provide the high-airtightness dry type granulator structure for overcoming the existing defects, and the occupied space is reduced while the airtightness of a production area and a conveying area of the dry type granulator is maintained.

Description

Technical Field

[0001] This utility model relates to a structure of a high-density closed dry granulation machine. Background Technology

[0002] Dry granulation is a method in which drug raw materials are mixed with diluents, disintegrants, lubricants and other dispersants, and then rolled into thin sheets of the required hardness and thickness. The sheets are then crushed by a fragmentation paddle and granulation paddle to form granules.

[0003] In the production process of conventional dry granulation machines, the sealing requirements are limited to simple mechanical seals, without the need for online wetting or negative pressure in the chamber. Therefore, they do not meet the Occupational Exposure Level (OEB4) required by GMP (Good Manufacturing Practice) and FDA (Food and Drug Administration). This can lead to personal injury to personnel operating the machines for extended periods, especially when producing potent drugs such as antitumor agents.

[0004] Currently, dry granulation machines use an acrylic outer casing for sealing. The pressure rollers, crushing paddles, granulation paddles, and related auxiliary process equipment are all installed inside the acrylic casing, occupying a large space. Maintaining the airtightness of the dry granulation machine while minimizing its space requirements is a technical problem that needs to be solved.

[0005] Therefore, a high-density closed dry granulation machine structure is proposed to address the above problems. Utility Model Content

[0006] The purpose of this utility model is to overcome the existing defects and provide a highly sealed dry granulation machine structure that maintains the airtightness of the production area and conveying area of ​​the dry granulation machine while reducing the space occupied.

[0007] The technical solution to achieve the above objective is: a high-density closed dry granulation machine structure, including a process zone, a conveying zone, a drive zone, and a sealed cavity surrounding the process zone and the conveying zone;

[0008] The sealed cavity is connected to the equipment frame; the process area is used to process materials into granules; the conveying area is used for material entry and granule exit; and the drive area is used to provide power to the process components.

[0009] Preferably, the front side of the sealed cavity is rotatably connected to a sealing door via a rotating shaft, and an inflatable sealing ring is provided around the inner side of the sealing door.

[0010] Preferably, the output shaft of the drive device in the drive zone extends through the sealed cavity, and an isolation sealing ring is provided between the output shaft and the sealed cavity.

[0011] Preferably, the sealed cavity is connected to the feed hopper via a hopper cover, and the lower end of the sealed cavity is connected to the receiving hopper.

[0012] Preferably, an air inlet butterfly valve and an air outlet butterfly valve are connected to the back of the sealed cavity; the air inlet butterfly valve is connected to an air supply device; and the air outlet butterfly valve is connected to an exhaust device.

[0013] Preferably, the sealed door is equipped with operating gloves.

[0014] Preferably, the top of the sealed cavity is connected to a manual cleaning diaphragm valve, a cleaning spray gun diaphragm valve, and an internal cleaning pipeline diaphragm valve, respectively. The manual cleaning diaphragm valve is connected to a manual cleaning spray gun, the cleaning spray gun diaphragm valve is connected to the cavity cleaning spray gun, and the internal cleaning pipeline diaphragm valve is connected to the cavity cleaning pipeline.

[0015] The beneficial effects of this utility model are: the structure of this high-density closed dry granulation machine only surrounds the process area and the conveying area with a sealed cavity, without the need to surround and cover other components, making the overall device smaller; the sealed cavity maintains a negative pressure environment to prevent leakage of drugs during production and avoid personal injury. Attached Figure Description

[0016] Figure 1 This is a detailed internal view of the structure of the high-density closed dry granulation machine of this utility model;

[0017] Figure 2 This is a front view of the structure of the high-density closed dry granulation machine of this utility model;

[0018] Figure 3 This is a top view of the structure of the high-density closed dry granulation machine of this utility model.

[0019] In the diagram: 1. Sealed cavity; 2. Hopper cover; 3. Sealed door; 4. Inlet butterfly valve; 5. Exhaust butterfly valve; 6. Manual cleaning spray gun; 7. Cavity cleaning spray gun; 8. Cavity cleaning pipeline; 9. Equipment frame; 10. Operating gloves. Detailed Implementation

[0020] The technical solution of this utility model will now be clearly and completely described in conjunction with the accompanying drawings. In the description of this utility model, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the accompanying drawings and are only for the convenience of describing this utility model and simplifying the description. They do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0021] The present invention will be further described below with reference to the accompanying drawings.

[0022] like Figure 1-3 As shown, a high-density dry granulation machine structure includes a process zone, a conveying zone, a drive zone, and a sealed cavity 1 surrounding the process zone and the conveying zone. The sealed cavity 1 is connected to the equipment frame 9. The process zone is used to process materials into granules; the conveying zone is used for material entry and granule discharge; and the drive zone is used to provide power to the process components. The sealed cavity 1 is only set outside the process zone and the conveying zone, eliminating the need to surround and cover other components, resulting in a smaller overall device. A negative pressure environment is maintained within the sealed cavity to prevent leakage during drug production and potential personal injury.

[0023] Specifically, the front of the sealing cavity 1 is rotatably connected to the sealing door 3 via a rotating shaft, and an inflatable sealing ring is installed around the inner perimeter of the sealing door 3. The sealing door 3 rotates around the rotating shaft to open or close. The inflatable sealing ring surrounds the sealing door 3. When the sealing door 3 is rotated to the closed position, there is a gap between the sealing door 3 and the side wall of the sealing cavity 1. The inflatable sealing ring is inflated to fill the space between the sealing door 3 and the sealing cavity 1, ensuring a sealing effect between the sealing door 3 and the sealing cavity 1.

[0024] Specifically, the output shaft of the drive unit in the drive zone extends through the sealed cavity 1, and an isolation sealing ring is installed between the output shaft and the sealed cavity 1. A drive motor is installed in the drive zone, and the drive shaft of the drive motor maintains a relative seal with the sealed cavity 1. The drive motor is fixed in the pellet mill frame, and its drive shaft extends into the process area. A sealing ring is installed between the drive shaft and the side wall of the front panel for better sealing.

[0025] Specifically, the sealed cavity 1 is connected to the feed hopper via the hopper cover 2, and the lower end of the sealed cavity 1 is connected to the receiving hopper. The feed hopper is used for feeding material, and the receiving hopper is used for receiving material. Material is fed into the granulator body through the feed hopper, and then processed into granules by the screw conveyor, pressure rollers, crushing paddle, and granulation paddle. The produced granules enter the receiving hopper. The hopper cover 2 includes a connecting pipe and a PU hose, and a negative pressure environment is maintained inside the sealed cavity 1.

[0026] Specifically, an inlet butterfly valve 4 and an exhaust butterfly valve 5 are connected to the back of the sealed cavity 1, respectively; the inlet butterfly valve 4 is connected to the air supply device; and the exhaust butterfly valve 5 is connected to the exhaust device. Filters are installed on the pipes connecting the air supply device and the exhaust device to improve the cleanliness of the airflow.

[0027] Specifically, an operating glove 10 is installed on the sealed door 3. The operating glove 10 is installed on the sealed door 3, and a sealed connection is maintained between the operating glove and the sealed cavity 1. The operating glove keeps the sealed cavity 1 closed inside and out. The operating glove is inserted into the sealed cavity 1, allowing the operator to perform corresponding manual operations inside without direct contact causing contamination.

[0028] Specifically, the top of the sealed cavity 1 is connected to a manual cleaning diaphragm valve, a cleaning spray gun diaphragm valve, and an internal cleaning pipeline diaphragm valve, respectively. The manual cleaning diaphragm valve is connected to the manual cleaning spray gun 6, the cleaning spray gun diaphragm valve is connected to the cavity cleaning spray gun 7, and the internal cleaning pipeline diaphragm valve is connected to the cavity cleaning pipeline 8.

[0029] This high-density dry granulation machine has a structure that only surrounds the process area and the conveying area with a sealed cavity 1, without the need to surround and cover other components, making the overall device smaller; the sealed cavity maintains a negative pressure environment to prevent drug leakage during production and avoid personal injury.

[0030] The above embodiments are only used to illustrate the technical solutions of this utility model, and are not intended to limit it. Although the utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features therein. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of this utility model.

Claims

1. A high-density closed dry granulation machine structure, characterized in that, It includes a process area, a conveying area, a driving area, and a sealed cavity (1) surrounding the process area and the conveying area; The sealed cavity (1) is connected to the equipment frame (9). The process area is used to process materials into granules; the conveying area is used for the entry of materials and the discharge of granules; and the drive area is used to provide power to the process components.

2. The high-density closed dry granulation machine structure according to claim 1, characterized in that, The front side of the sealed cavity (1) is rotatably connected to the sealing door (3) via a rotating shaft, and an inflatable sealing ring is provided around the inner side of the sealing door (3).

3. The high-density closed dry granulation machine structure according to claim 1, characterized in that, The output shaft of the drive device in the drive area extends through the sealed cavity (1), and an isolation sealing ring is provided between the output shaft and the sealed cavity (1).

4. The high-density closed dry granulation machine structure according to claim 1, characterized in that, The sealed cavity (1) is connected to the feed bucket through the hopper cover (2), and the lower end of the sealed cavity (1) is connected to the receiving bucket.

5. The high-density closed dry granulation machine structure according to claim 1, characterized in that, The back of the sealed cavity (1) is connected to an air inlet butterfly valve (4) and an air outlet butterfly valve (5); the air inlet butterfly valve (4) is connected to an air supply device; and the air outlet butterfly valve (5) is connected to an exhaust device.

6. The high-density closed dry granulation machine structure according to claim 2, characterized in that, Operating gloves (10) are provided on the sealed door (3).

7. The high-density closed dry granulation machine structure according to claim 1, characterized in that, The top of the sealed cavity (1) is connected to a manual cleaning diaphragm valve, a cleaning spray gun diaphragm valve and an internal cleaning pipeline diaphragm valve, respectively. The manual cleaning diaphragm valve is connected to a manual cleaning spray gun (6), the cleaning spray gun diaphragm valve is connected to a cavity cleaning spray gun (7), and the internal cleaning pipeline diaphragm valve is connected to a cavity cleaning pipeline (8).

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