High-barrier high-temperature-resistant radiation-resistant medical composite film

Abstract

The utility model relates to the technical field of medicinal packaging materials, and discloses a high-barrier high-temperature-resistant radiation-resistant medical composite film which comprises an inner film and an outer film, the inner film comprises a barrier layer, a waterproof layer, a high-temperature-resistant layer, an anti-radiation layer and an antibacterial layer, and the barrier layer, the waterproof layer, the high-temperature-resistant layer, the anti-radiation layer and the antibacterial layer are fixedly connected through adhesive layers; the outer film comprises an aluminum foil layer, a nylon layer and an aluminum oxide coating layer. According to the high-barrier, high-temperature-resistant and radiation-resistant medical composite film, gas permeation is effectively prevented through the barrier layer, it is ensured that drugs are not affected by external gas, the original chemical stability and drug effect of the drugs are kept, the waterproof layer ensures that the interior of a package is dry, and moisture invasion is prevented, and the outer film comprises the aluminum foil layer, the nylon layer and the aluminum oxide coating layer. The protection effect and the service life of the package are improved under the combined action of the materials, and the composite film is suitable for packaging various medical supplies, and is particularly suitable for products needing long-term storage, high-temperature sterilization or radiation sterilization.

Description

Technical Field

[0001] This application relates to the field of pharmaceutical packaging materials technology, specifically to high-barrier, high-temperature resistant, and radiation-resistant medical composite films. Background Technology

[0002] Pharmaceuticals are a special commodity that are easily affected by external environmental factors such as sunlight, humidity, and microorganisms during transportation, which can lead to deterioration and affect public health. Therefore, it is important to select suitable packaging materials. The function of pharmaceutical packaging materials that come into direct contact with pharmaceuticals is to ensure the quality and stability of the drugs. Therefore, pharmaceutical packaging materials should be non-toxic, non-polluting, and safe.

[0003] For some humidity-sensitive pharmaceuticals, the existing composite film may not be able to completely prevent the penetration of moisture and humidity, leading to the pharmaceuticals becoming damp and deteriorating. The penetration of gases such as oxygen may also cause the pharmaceuticals to oxidize and degrade, thus affecting the quality of the pharmaceuticals. Utility Model Content

[0004] To address the shortcomings of existing technologies, this application provides a high-barrier, high-temperature resistant, and radiation-resistant medical composite film. It possesses advantages such as high barrier properties, high temperature resistance, and radiation resistance, and solves the problem that existing composite films may not be able to completely prevent the penetration of moisture and humidity for some humidity-sensitive drugs, leading to drug deterioration due to dampness. The penetration of gases such as oxygen may also cause the drug to oxidize and degrade, thereby affecting the quality of the drug.

[0005] To achieve the above objectives, this application provides the following technical solution: a high-barrier, high-temperature resistant, and radiation-resistant medical composite membrane, comprising an inner membrane and an outer membrane. The inner membrane includes a barrier layer, a waterproof layer, a high-temperature resistant layer, a radiation-proof layer, and an antibacterial layer. The barrier layer, waterproof layer, high-temperature resistant layer, radiation-proof layer, and antibacterial layer are all fixedly connected by an adhesive layer. The outer membrane includes an aluminum foil layer, a nylon layer, and an aluminum oxide coating layer.

[0006] Through the above solutions, the barrier layer effectively prevents gas penetration, ensuring that the medicine is not affected by external gases and maintaining its original chemical stability and efficacy. The waterproof layer ensures that the inside of the packaging is dry and prevents moisture intrusion, which is especially important for medicines that are susceptible to moisture. The high-temperature resistant layer enables the packaging film to withstand high-temperature environments and is suitable for high-temperature sterilization, ensuring the safety and effectiveness of the medicine during the sterilization process. The radiation protection layer provides protection against ionizing radiation, protecting the medicine from radiation damage and is suitable for packaging medical supplies that require radiation sterilization. The antibacterial layer inhibits the growth of bacteria, molds, and other microorganisms, extending the shelf life of the medicine and ensuring the safety of patients. The adhesive layer ensures a tight connection between the functional layers, making it difficult for them to delaminate or fall off, thus improving the overall strength and durability of the packaging film. The outer film includes an aluminum foil layer, a nylon layer, and an alumina coating layer. The combined effect of these materials gives the outer film excellent light-shielding, barrier, abrasion resistance, and tear resistance, improving the protective effect and service life of the packaging. The composite film is suitable for packaging various medical supplies, such as medicines, medical devices, and biological agents, and is particularly suitable for products that require long-term storage, high-temperature sterilization, or radiation sterilization.

[0007] Furthermore, the nylon layer is fixedly disposed at the bottom of the aluminum foil layer, the aluminum oxide coating layer is fixedly disposed at the bottom of the nylon layer, and the upper end of the inner film is fixedly connected to the outer film.

[0008] In the above scheme, the nylon layer, as an intermediate layer, is fixedly placed between the aluminum foil layer and the alumina coating layer, playing a connecting and supporting role. The aluminum foil layer, as the main barrier layer, has excellent light-shielding and gas barrier properties, effectively preventing light and gas from affecting the medicine inside the packaging. At the same time, the alumina coating layer further enhances the barrier performance, improving the sealing and protective effect of the packaging. The alumina coating layer not only has excellent barrier properties but also good heat resistance and corrosion resistance, ensuring the safety and efficacy of the medicine.

[0009] Furthermore, the barrier layer is made of polyvinylidene chloride.

[0010] Through the above methods, polyvinylidene chloride can be made into a film with excellent moisture resistance, airtightness, and aroma retention, as well as excellent resistance to strong acids, strong alkalis, chemicals, and oils, providing comprehensive protection for the items inside the packaging.

[0011] Furthermore, the waterproof layer is made of PET material.

[0012] Through the above solution, PET material itself has a certain degree of waterproof performance, which can effectively prevent water molecules from penetrating and ensure the dryness of the inside of the composite film, thereby protecting the items inside the packaging from moisture erosion. PET material also has excellent weather resistance and can resist the erosion of harsh environmental factors such as ultraviolet rays, high temperature, and low temperature.

[0013] Furthermore, the high-temperature resistant layer is made of polyimide.

[0014] Through the above-mentioned methods, polyimide has excellent high-temperature resistance, reaching temperatures above 400°C. This allows polyimide to maintain stable physical and chemical properties in high-temperature environments, making it less prone to decomposition or degradation. At the same time, polyimide material has excellent resistance to various types of radiation, and can withstand high doses of radiation while maintaining its various properties.

[0015] Furthermore, the radiation shielding layer is made of boron-containing polyethylene.

[0016] Through the above scheme, boron-containing polyethylene is a material with excellent radiation protection performance. Boron has a large reaction cross section with low-energy neutrons, which can effectively absorb neutrons and thus play a role in shielding radiation. At the same time, boron-containing polyethylene also has good chemical stability and mechanical properties, and can maintain its radiation protection performance in harsh environments.

[0017] Furthermore, the antibacterial layer is a silver ion coating.

[0018] Through the above method, silver ions have a strong antibacterial effect and can inhibit the growth of bacteria, viruses and fungi.

[0019] Furthermore, all four adhesive layers are made of vinyl alcohol copolymer adhesive.

[0020] The above scheme uses ethylene alcohol copolymer adhesive as an adhesive layer in packaging materials to improve the barrier properties of packaging materials and extend the shelf life of medicines.

[0021] Compared with the prior art, the technical solution of this application has the following beneficial effects:

[0022] This high-barrier, high-temperature resistant, and radiation-resistant medical composite film effectively prevents gas permeation through its barrier layer, ensuring that the medicine is not affected by external gases and maintaining its original chemical stability and efficacy. The waterproof layer ensures the interior of the packaging remains dry, preventing moisture intrusion, which is especially important for moisture-sensitive medicines. The high-temperature resistant layer allows the packaging film to withstand high-temperature environments, making it suitable for high-temperature sterilization and ensuring the safety and efficacy of the medicine during sterilization. The radiation-resistant layer provides protection against ionizing radiation, protecting the medicine from radiation damage and is suitable for packaging medical supplies requiring radiation sterilization. The antibacterial layer inhibits bacteria and mold growth. The film inhibits the growth of microorganisms, extends the shelf life of medicines, and ensures the safety of patients. The adhesive layer ensures a tight connection between the functional layers, preventing delamination or detachment and improving the overall strength and durability of the packaging film. The outer film consists of an aluminum foil layer, a nylon layer, and an alumina coating layer. These materials work together to give the outer film excellent light-blocking, barrier, abrasion resistance, and tear resistance, improving the protective effect and service life of the packaging. The composite film is suitable for packaging various medical supplies, such as medicines, medical devices, and biological agents, and is especially suitable for products that require long-term storage, high-temperature sterilization, or radiation sterilization. Attached Figure Description

[0023] Figure 1 This is a schematic diagram of the overall structure of this application;

[0024] Figure 2 This is an overall sectional view of the structure of this application;

[0025] Figure 3 This is a schematic diagram of the internal structure of the structure in this application;

[0026] Figure 4 This is a schematic diagram of the adhesive structure of the present application.

[0027] In the picture:

[0028] 1. Inner membrane; 2. Outer membrane; 101. Barrier layer; 102. Waterproof layer; 103. High temperature resistant layer; 104. Radiation protection layer; 105. Antibacterial layer; 106. Adhesive layer; 201. Aluminum foil layer; 202. Nylon layer; 203. Alumina coating layer. Detailed Implementation

[0029] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0030] Please see Figure 1 , Figure 2 and Figure 3 In this embodiment, the high-barrier, high-temperature resistant, and radiation-resistant medical composite film includes an inner film 1 and an outer film 2. The inner film 1 includes a barrier layer 101, a waterproof layer 102, a high-temperature resistant layer 103, a radiation-proof layer 104, and an antibacterial layer 105. The barrier layer 101 effectively prevents gas penetration, ensuring that the medicine is not affected by external gases and maintaining its original chemical stability and efficacy. The waterproof layer 102 ensures that the inside of the packaging is dry and prevents moisture intrusion, which is especially important for medicines that are susceptible to moisture. The high-temperature resistant layer 103 enables the packaging film to withstand high-temperature environments and is suitable for high-temperature sterilization, ensuring the safety and effectiveness of the medicine during the sterilization process. The radiation-proof layer 104 provides protection against ionizing radiation, protecting the medicine from radiation damage and is suitable for medicines requiring radiation sterilization. In the medical supplies packaging, the antibacterial layer 105 can inhibit the growth of microorganisms such as bacteria and mold, extending the shelf life of the medicine. The barrier layer 101, waterproof layer 102, high temperature resistant layer 103, radiation protection layer 104, and antibacterial layer 105 are all fixedly connected by the adhesive layer 106. The adhesive layer 106 ensures that the functional layers are tightly connected and not easily delaminated or detached, improving the overall strength and durability of the packaging film. The outer film 2 includes an aluminum foil layer 201, a nylon layer 202, and an alumina coating layer 203. The combined effect of these materials gives the outer film 2 excellent light-blocking, barrier, abrasion resistance, and tear resistance, improving the protective effect and service life of the packaging.

[0031] Please see Figure 1 , Figure 3 and Figure 4 The nylon layer 202 is fixedly disposed at the bottom end of the aluminum foil layer 201, and the alumina coating layer 203 is fixedly disposed at the bottom end of the nylon layer 202. The upper end of the inner film 1 is fixedly connected to the outer film 2. The nylon layer 202, as an intermediate layer, is fixedly disposed between the aluminum foil layer 201 and the alumina coating layer 203, playing a connecting and supporting role. The aluminum foil layer 201, as the main barrier layer 101, has excellent light-shielding and gas barrier properties, which can effectively prevent light and gas from affecting the medicine inside the packaging. At the same time, the alumina coating layer 203 further enhances the barrier performance, improves the sealing and protective effect of the packaging. The alumina coating layer 203 not only has excellent barrier performance, but also has good heat resistance and corrosion resistance, ensuring the safety and efficacy of the medicine.

[0032] Please see Figure 2 , Figure 3 and Figure 4The barrier layer 101 is made of polyvinylidene chloride (PVDC). PVDC can be made into a film with excellent moisture resistance, airtightness, and aroma retention. It also has excellent resistance to strong acids, alkalis, chemicals, and oils, providing comprehensive protection for the contents of the package. The waterproof layer 102 is made of PET material. PET material itself has a certain degree of waterproof performance, effectively preventing water molecules from penetrating and ensuring the dryness of the interior of the composite film, thus protecting the contents of the package from moisture erosion. PET material also has excellent weather resistance, resisting the erosion of harsh environmental factors such as ultraviolet rays, high temperatures, and low temperatures. The high-temperature resistant layer 103 is made of polyimide. Polyimide has excellent high-temperature resistance, with a temperature resistance of over 400℃, allowing it to maintain stable physical and chemical properties under high-temperature environments and preventing oxidation. The polyimide material is biodegradable and degradable, and it has excellent resistance to various types of radiation, able to withstand high doses of radiation while maintaining its properties. The radiation shielding layer 104 is made of boron-containing polyethylene, a material with excellent radiation shielding properties. Boron has a large reaction cross section with low-energy neutrons, which can effectively absorb neutrons and thus shield radiation. At the same time, boron-containing polyethylene also has good chemical stability and mechanical properties, and can maintain its radiation shielding performance under harsh environments. The antibacterial layer 105 is a silver ion coating. Silver ions have a strong antibacterial effect and can inhibit the growth of bacteria, viruses and fungi. The four adhesive layers 106 are all ethylene alcohol copolymer adhesives. Ethylene alcohol copolymer adhesives are used as adhesive layers for packaging materials to improve the barrier properties of packaging materials and extend the shelf life of medicines.

[0033] In this embodiment, the high-barrier, high-temperature resistant, and radiation-resistant medical composite film effectively prevents gas penetration through the barrier layer 101, ensuring that the medicine is not affected by external gases and maintaining its original chemical stability and efficacy. The waterproof layer 102 ensures that the inside of the packaging is dry and prevents moisture intrusion, which is especially important for medicines that are susceptible to moisture. The high-temperature resistant layer 103 enables the packaging film to withstand high-temperature environments and is suitable for high-temperature sterilization, ensuring the safety and effectiveness of the medicine during the sterilization process. The radiation-resistant layer 104 provides protection against ionizing radiation, protecting the medicine from radiation damage and is suitable for medical product packaging that requires radiation sterilization. The antibacterial layer 105 can inhibit microbial growth. The growth of microorganisms such as bacteria and mold is prevented, extending the shelf life of medicines and ensuring patient safety. The adhesive layer 106 ensures a tight connection between the functional layers, preventing delamination or detachment and improving the overall strength and durability of the packaging film. The outer film 2 includes an aluminum foil layer 201, a nylon layer 202, and an alumina coating layer 203. These materials work together to give the outer film 2 excellent light-shielding, barrier, abrasion resistance, and tear resistance, improving the protective effect and service life of the packaging. The composite film is suitable for packaging various medical supplies, such as medicines, medical devices, and biological agents, and is especially suitable for products that require long-term storage, high-temperature sterilization, or radiation sterilization.

[0034] The working principle of the above embodiments is as follows:

[0035] Barrier layer 101 is made of polyvinylidene chloride, possessing excellent moisture resistance, airtightness, and aroma retention. When the composite film is used to package medical supplies, barrier layer 101 effectively prevents external gases from penetrating into the packaging, thereby maintaining the original chemical stability and efficacy of the medicine or other medical supplies. Waterproof layer 102 is made of PET material, exhibiting excellent waterproof performance. In humid environments, waterproof layer 102 prevents water molecules from penetrating into the packaging, ensuring the dryness of the composite film interior. This is particularly important for moisture-sensitive medicines, as moisture can cause deterioration or ineffectiveness. High-temperature resistant layer 103 is made of polyimide, possessing excellent high-temperature resistance. In applications requiring high-temperature sterilization, high-temperature resistant layer 103 ensures the composite film maintains stable physical and chemical properties in high-temperature environments, resisting decomposition or degradation. This ensures the safety and effectiveness of the medicine during sterilization. Radiation protection... The radiation shielding layer 104 is made of boron-containing polyethylene, which has excellent radiation protection properties. In medical product packaging that requires radiation sterilization, the radiation shielding layer 104 can absorb ionizing radiation and protect the medicine from radiation damage. At the same time, boron-containing polyethylene also has good chemical stability and mechanical properties, and can maintain its radiation protection performance in harsh environments. The antibacterial layer 105 is a silver ion coating, which has a strong antibacterial effect. Silver ions can inhibit the growth of bacteria, viruses and fungi, thereby extending the shelf life of the medicine. The adhesive layer 106 is made of ethylene alcohol copolymer adhesive and is used to tightly connect the various functional layers together. The presence of the adhesive layer 106 ensures the overall strength and durability of the composite film and prevents the functional layers from delaminating or falling off. The outer film 2 includes an aluminum foil layer 201, a nylon layer 202 and an aluminum oxide coating layer 203. The combined effect of these materials gives the outer film 2 excellent light-shielding, barrier, abrasion resistance and tear resistance.

[0036] It should be noted that, in this document, relational terms such as "first" and "second" are used merely to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes the element.

[0037] Although embodiments of this application have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of this application, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A high-barrier, high-temperature resistant, and radiation-resistant medical composite membrane, comprising an inner membrane (1) and an outer membrane (2), characterized in that: The inner membrane (1) includes a barrier layer (101), a waterproof layer (102), a high-temperature resistant layer (103), a radiation-proof layer (104), and an antibacterial layer (105). The barrier layer (101), the waterproof layer (102), the high-temperature resistant layer (103), the radiation-proof layer (104), and the antibacterial layer (105) are all fixedly connected by an adhesive layer (106). The outer membrane (2) includes an aluminum foil layer (201), a nylon layer (202), and an aluminum oxide coating layer (203).

2. The high-barrier, high-temperature resistant, and radiation-resistant medical composite membrane according to claim 1, characterized in that: The nylon layer (202) is fixedly disposed at the bottom of the aluminum foil layer (201), the aluminum oxide coating layer (203) is fixedly disposed at the bottom of the nylon layer (202), and the upper end of the inner film (1) is fixedly connected to the outer film (2).

3. The high-barrier, high-temperature resistant, and radiation-resistant medical composite membrane according to claim 1, characterized in that: The barrier layer (101) is made of polyvinylidene chloride.

4. The high-barrier, high-temperature resistant, and radiation-resistant medical composite membrane according to claim 1, characterized in that: The waterproof layer (102) is made of PET material.

5. The high-barrier, high-temperature resistant, and radiation-resistant medical composite membrane according to claim 1, characterized in that: The high-temperature resistant layer (103) is made of polyimide.

6. The high-barrier, high-temperature resistant, and radiation-resistant medical composite membrane according to claim 1, characterized in that: The radiation shielding layer (104) is made of boron-containing polyethylene.

7. The high-barrier, high-temperature resistant, and radiation-resistant medical composite membrane according to claim 1, characterized in that: The antibacterial layer (105) is a silver ion coating.

8. The high-barrier, high-temperature resistant, and radiation-resistant medical composite membrane according to claim 1, characterized in that: All four adhesive layers (106) are vinyl alcohol copolymer adhesives.

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