Sample cryopreservation box
By employing a raised groove snap-fit and hollow structure design in the cryopreservation box, the problems of easy bursting of cryopreservation tubes and difficulty in label positioning are solved, thus achieving stable storage and efficient sampling of cryopreservation tubes.
Patent Information
- Application Number
- CN202520298590.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-02-24
- Publication Date
- 2026-01-27
- Estimated Expiration
- 2035-02-24
AI Technical Summary
The cryopreservation tubes in existing cryopreservation boxes are prone to bursting and the labels are difficult to locate quickly, which affects sampling efficiency.
Design a sample cryopreservation box that uses a snap-fit structure with protrusions and grooves between a large box and a small box to fix the cryopreservation tubes, and a hollow structure inside the small box to allow liquid nitrogen to flow through. Combined with horizontal and vertical partitions to form a placement compartment, it prevents the cryopreservation tubes from bursting and makes the labels visible.
It effectively prevents cryopreservation tubes from bursting, improves sampling efficiency, ensures that cryopreservation tube labels are visible, and enhances retrieval convenience and space utilization.
Smart Images
Figure CN223836089U_ABST
Abstract
Description
Technical Field
[0001] This invention belongs to the field of cell cryopreservation technology, and specifically relates to a sample cryopreservation box. Background Technology
[0002] Cell or tissue samples used in scientific research require long-term cryopreservation in liquid nitrogen. While cryopreservation boxes vary in size, one known example places cryovials horizontally within a fixed compartment inside the box. While this horizontal placement reduces the risk of bursting, the cryovial head is completely exposed when the box lid (door) is opened. Without any obstruction, excessive liquid nitrogen can easily enter the cryovial, and the horizontal placement alone is insufficient to release the pressure caused by the rapid evaporation of the nitrogen, inevitably leading to bursting. Poor quality cryovials with inadequate seals allow liquid nitrogen to slowly seep in during liquid nitrogen exposure. When removed from the liquid nitrogen environment, the liquid nitrogen inside the cryovial evaporates rapidly, causing a sharp increase in pressure. (If the cap is of poor quality, it may burst.) Furthermore, labels on cryovials are typically affixed to the side wall. When the cryovial is placed horizontally in the cryopreservation box, the box is fixed inside, making it difficult to quickly locate the target specimen. Each specimen must be removed and checked individually, increasing the difficulty of retrieval and significantly extending the time other samples are exposed to room temperature.
[0003] Therefore, in order to address the above-mentioned technical problems, the design of sample cryopreservation boxes should not only prevent cryopreservation tubes from bursting, but also ensure that the labels on the side walls of the cryopreservation tubes are directly visible when they need to be retrieved, so as to facilitate retrieval. These are technical problems that need to be solved by those skilled in the art. Utility Model Content
[0004] To address the aforementioned issues, this invention provides a sample cryopreservation box that not only prevents cryopreservation tubes from bursting but also ensures that the label on the side wall of the cryopreservation tube is directly visible when it needs to be retrieved, making it convenient to handle.
[0005] To achieve the above objectives, this utility model provides the following solution:
[0006] A sample cryopreservation box includes a large box and a small box that is inserted into and removed from the large box. The small box includes a bottom plate and side plates that are sequentially connected to the bottom plate to form a closed loop. The side plates enclose an area with transverse and longitudinal partitions that divide the enclosed area into multiple placement compartments.
[0007] Preferably, the side wall of the placement compartment is provided with a first protrusion that engages with the first groove on the cryopreservation tube.
[0008] Preferably, a second protrusion is provided on the inner wall of the large box, and a second groove is provided on the outer wall of the side plate to cooperate with the second protrusion.
[0009] Preferably, a third groove is formed at the corresponding position of the first protrusion on the outer wall of the placement compartment, and a third protrusion is provided on the inner wall of the large box away from the insertion end, the third protrusion cooperating with the third groove away from the insertion end of the large box.
[0010] Preferably, the third protrusion is provided as one.
[0011] Preferably, the side of the large box away from the insertion end is provided with a first hollow structure.
[0012] Preferably, the first hollow structure is disposed at both ends perpendicular to the insertion direction of the small box.
[0013] Preferably, the bottom of the placement grid is provided with a second hollow structure.
[0014] Preferably, the cross-sectional area of the second hollow structure is 1 / 3 of the area of the placement grid base plate.
[0015] Preferably, the large box has multiple partitions evenly spaced along its height, which divide the large box into multiple small box placement cavities.
[0016] The present invention achieves the following technical advantages over the prior art:
[0017] First, by inserting and placing the small boxes inside the large box, and forming a storage compartment through the bottom plate, side plates, and horizontal and vertical partitions, the cryovials can be placed horizontally. When the cryovials are taken out, the entire circumference of the cryovials can be blocked, thereby preventing the cryovials from bursting. Moreover, once the small box is pulled out of the large box, the label attached to the side wall of the cryovial can be seen directly, making it convenient to take out the cryovials without having to take out each cryovial to check, thus improving the efficiency of cryovial retrieval.
[0018] Secondly, by dividing the large box into three placement chambers, while ensuring that the storage capacity of the large box is consistent with that of the existing cryogenic tube storage device, it can be matched with the existing liquid nitrogen rack, thereby ensuring efficient use of space.
[0019] Third, by engaging the first groove of the cryopreservation tube with the first protrusion of the small box, and engaging the third protrusion of the large box with the third groove of the small box, the cryopreservation tube and the small box, as well as the small box and the large box, can be secured simultaneously. Even if the large box or the small box alone is accidentally dropped or flipped over, the specimen inside the cryopreservation tube will not scatter. Attached Figure Description
[0020] To more clearly illustrate the technical solutions in this utility model or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.
[0021] Appendix Figure 1 This is a schematic diagram of the overall structure of the sample cryopreservation box as disclosed in the embodiment of this utility model.
[0022] Appendix Figure 2 This is a schematic diagram of the overall structure of the sample cryopreservation box disclosed in the embodiment of this utility model.
[0023] Appendix Figure 3 This is a side view structural diagram of the sample cryopreservation box disclosed in the embodiment of this utility model;
[0024] Among them, 1. large box; 2. third protrusion; 3. first hollow structure; 4. partition plate; 5. small box; 6. second hollow structure; 7. first protrusion; 8. horizontal partition; 9. vertical partition; 10. placement grid; 11. third groove. Detailed Implementation
[0025] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.
[0026] The purpose of this invention is to provide a sample cryopreservation box that not only prevents cryopreservation tubes from bursting, but also makes the label on the side wall of the cryopreservation tube directly visible when it needs to be retrieved, making it convenient to take out.
[0027] To make the above-mentioned objectives, features and advantages of this utility model more apparent and understandable, the utility model will be further described in detail below with reference to the accompanying drawings and specific embodiments.
[0028] refer to Figure 1 and Figure 2The sample cryopreservation box disclosed in this embodiment of the present invention includes at least a large box 1 and a small box 5 that is inserted and removed from the large box 1. The small box 5 includes a bottom plate and side plates that are sequentially connected to form a closed loop on the bottom plate. The area enclosed by the side plates is provided with a horizontal partition 8 and a vertical partition 9 that divide the enclosed area into multiple placement compartments 10. The placement compartments 10 are used to place cryopreservation tubes. By inserting and removing the small box 5 into the large box 1, and by forming placement compartments 10 through the bottom plate, side plates, horizontal partition 8 and vertical partition 9, the small box 5 can block the entire circumference of the cryopreservation tube when it is taken out, thereby preventing the cryopreservation tube from bursting. Moreover, once the small box 5 is removed from the large box 1, the label attached to the side wall of the cryopreservation tube can be seen directly, which is convenient for taking out the cryopreservation tube without having to take out the cryopreservation tubes one by one to check, thus improving the efficiency of taking out the cryopreservation tube.
[0029] It should be noted that the small box 5 is designed as a drawer structure and is rectangular. The small box 5 includes a bottom plate and four side plates connected in sequence.
[0030] refer to Figure 1 and Figure 2 In one embodiment, the side wall of the placement compartment 10 is provided with a first protrusion 7 that engages with the first groove on the cryopreservation tube. By providing the cooperation between the first protrusion 7 and the first groove, the cryopreservation tube can be fixed in the placement compartment 10, preventing the cryopreservation tube from sliding out of the placement compartment 10.
[0031] refer to Figure 2 and Figure 3 In one embodiment, a second protrusion is provided on the inner wall of the large box 1, and a second groove is provided on the outer wall of the side plate of the small box 5 to cooperate with the second protrusion. The cooperation between the second protrusion and the second groove can fix the small box 5 in the large box 1 and prevent the small box 5 from sliding out of the large box 1.
[0032] It should be noted that the second protrusion is set to be one, that is, only one second protrusion cooperates with one second groove. This can not only fix the small box 5, but also avoid the problem that too many limiting structures make it difficult to insert or remove the small box 5 from the small box 5.
[0033] refer to Figure 1 and Figure 2 In one embodiment, a third groove 11 is formed at the corresponding position of the first protrusion 7 on the outer wall of the placement compartment 10. A third protrusion 2 is provided on the inner wall of the large box 1 away from the insertion end. The third protrusion 2 cooperates with the third groove 11 away from the insertion end of the large box 1. Because the third protrusion 2 is provided on the inner wall of the large box 1 away from the insertion end, it can both fix the small box 5 and facilitate the insertion and removal of the small box 5.
[0034] refer to Figure 1 and Figure 2As one implementation method, the third protrusion 2 is set as one, which can both fix the small box 5 and facilitate the insertion and removal of the small box 5.
[0035] refer to Figure 1 and Figure 2 In one embodiment, the side of the large box 1 away from the insertion end is provided with a first hollow structure 3. The first hollow structure 3 facilitates the entry and exit of liquid nitrogen and also makes it easy to push the small box 5 outward with a finger.
[0036] refer to Figure 1 and Figure 2 In one embodiment, the first hollow structure 3 is set at both ends of the vertical insertion direction of the small box 5, that is, the two ends of the panel of the large box 1 away from the insertion end are hollow, which makes it convenient for fingers to be inserted into the large box 1 from both ends and push out the small box 5.
[0037] refer to Figure 1 and Figure 2 As one implementation method, a second hollow structure 6 is provided at the bottom of the placement grid 10. By providing the second hollow structure 6, it is convenient for liquid nitrogen to enter and exit, and it is also convenient to push the cryopreservation tube outward with your fingers.
[0038] refer to Figure 1 and Figure 2 As one implementation method, the cross-sectional area of the second hollow structure 6 is 1 / 3 of the floor area of the placement grid 10. This ensures that fingers can be inserted into the placement grid 10 through the hollow structure, while also providing support for the cryopreservation tubes. This prevents the cryopreservation tubes from slipping out of the second hollow structure 6 due to insufficient support area.
[0039] refer to Figure 1 and Figure 2 In one implementation, multiple partitions 4 are equally spaced along the height direction inside the large box 1, and the multiple partitions 4 divide the large box 1 into multiple small box placement cavities.
[0040] In this embodiment, there are two partition plates 4, that is, the large box 1 is divided into three placement cavities, which can hold three small boxes 5. The placement grid 10 in the small box 5 has 27 grids, that is, it is arranged in 9 rows and 3 columns. The entire large box 1 can hold 3 small boxes 5 and a total of 81 cryopreservation tubes.
[0041] The method of using this utility model is as follows: When it is necessary to store cryovials, the first groove of the cryovial is engaged with the first protrusion 7 of the small box 5 to fix the cryovial, and the label of the cryovial is set upwards for easy viewing when retrieving the cryovial. Then, the small box 5 is inserted into the large box 1, and the third protrusion 2 of the large box 1 is engaged with the third groove 11 of the small box 5 to fix the small box 5. Then, the large box 1 is placed on the liquid nitrogen cryopreservation rack. The first hollow structure 3 and the second hollow structure 6 allow liquid nitrogen to circulate between the small box 5 and the large box 1, ensuring the freezing effect of the sample in the cryovial. When it is necessary to remove the cryovial, the finger is inserted through the first hollow structure 3, and the small box 5 is pushed out of the large box 1 with the push of the finger. Then, the cryovial to be removed is located according to the label, and the finger is inserted through the second hollow structure 6, and the cryovial is removed from the small box 5 with the push of the finger. Then, the small box 5 is put back into the large box 6.
[0042] Any adaptive changes made according to actual needs are within the protection scope of this utility model.
[0043] It should be noted that, for those skilled in the art, it is obvious that this utility model is not limited to the details of the above exemplary embodiments, and that this utility model can be implemented in other specific forms without departing from the spirit or essential characteristics of this utility model. Therefore, the embodiments should be considered as exemplary and non-limiting in all respects, and the scope of this utility model is defined by the appended claims rather than the foregoing description. Therefore, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within the utility model. No reference numerals in the claims should be construed as limiting the scope of the claims.
Claims
1. A sample cryopreservation box, characterized in that, It includes a large box and a small box that is inserted into the large box. The small box includes a bottom plate and side plates that are sequentially connected to the bottom plate to form a closed loop. The side plates enclose an area with horizontal and vertical partitions that divide the enclosed area into multiple placement compartments. The side wall of the placement compartment is provided with a first protrusion that engages with the first groove on the cryopreservation tube; The bottom of the placement grid is provided with a second hollow structure; It allows the cryovials to be placed horizontally, and when the cryovials are taken out, it can also block the entire circumference of the cryovials, thereby preventing the cryovials from bursting.
2. The sample cryopreservation box according to claim 1, characterized in that, The inner wall of the large box is provided with a second protrusion, and the outer wall of the side plate is provided with a second groove that cooperates with the second protrusion.
3. The sample cryopreservation box according to claim 1, characterized in that, A third groove is formed at the corresponding position of the first protrusion on the outer wall of the placement compartment, and a third protrusion is provided on the inner wall of the large box away from the insertion end. The third protrusion cooperates with the third groove away from the insertion end of the large box.
4. The sample cryopreservation box according to claim 3, characterized in that, The third protrusion is set to one.
5. The sample cryopreservation box according to claim 1, characterized in that, The side of the large box away from the insertion end has a first hollow structure.
6. The sample cryopreservation box according to claim 5, characterized in that, The first hollow structure is located at both ends perpendicular to the insertion direction of the small box.
7. The sample cryopreservation box according to claim 1, characterized in that, The cross-sectional area of the second hollow structure is 1 / 3 of the area of the placement grid base plate.
8. The sample cryopreservation box according to claim 1, characterized in that, The large box has multiple partitions evenly spaced along its height, which divide the large box into multiple small box placement cavities.