Automatic slice scanning device

By designing an automated slice scanning device, using multi-axis motor drive and photoelectric sensors, three-dimensional scanning of large-area slices was achieved, solving the problem of limited scanning range of traditional microscopes and providing more comprehensive scientific research data support.

CN223841783UActive Publication Date: 2026-01-27WEIFANG MEDICAL UNIV
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Patent Information

Application Number
CN202420140125.3
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-01-19
Publication Date
2026-01-27
Estimated Expiration
2034-01-19

AI Technical Summary

Technical Problem

Traditional microscopes, once adjusted along the Z-axis, cannot perform comprehensive scanning of large-area slices, thus limiting their applicability and failing to meet research needs.

Method used

Design an automated slicing and scanning device that uses a multi-axis moving component driven by Z-axis, Y-axis and X-axis motors, combined with photoelectric sensors and cameras, to achieve multi-angle photography and image stitching of slices in three-dimensional space.

Benefits of technology

It enables panoramic scanning of large-area slices, providing clearer and more complete slice images, and meeting the multi-angle field of view requirements of scientific research data.

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Abstract

The utility model relates to an automatic slice scanning device, which belongs to the technical field of microscopes and comprises a camera, a Z-axis motor and a Y-axis moving assembly. The Z-axis motor is fixed on the mirror base and is in transmission connection with the Z-axis knob; the Y-axis moving assembly comprises a Y-axis sliding plate, a Y-axis rack, a Y-axis rotary knob and a Y-axis motor. A Y-axis sliding groove is formed in the bottom face of the Y-axis sliding plate, and the Y-axis sliding plate is slidably connected to the fixing plate. The Y-axis rack is fixed on the bottom surface of the fixed plate; a Y-axis rotary knob is rotationally connected to the Y-axis sliding plate, a Y-axis gear is fixed to a Y-axis rotary rod fixed to the Y-axis rotary knob, and the Y-axis gear is connected with the Y-axis rack in a meshed mode. And the Y-axis motor is fixed on the Y-axis sliding plate and is in transmission connection with the Y-axis knob through a belt. According to the utility model, the Z-axis knob is rotated by the Z-axis motor, and the position of the fixed plate in the Z-axis direction is adjusted; then the Y-axis motor is used for rotating the Y-axis knob, the position of the Y-axis sliding plate in the Y-axis direction is adjusted, the position of the Y-axis sliding plate can be changed in a two-dimensional space, a multi-angle photographing view field is provided for the camera, and the scientific research data requirement is met.
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Description

Technical Field

[0001] This utility model relates to the field of microscope technology, and in particular to an automated slide scanning device. Background Technology

[0002] A microscope is an optical instrument consisting of one or more lenses, and it marks humanity's entry into the atomic age. It is primarily used to magnify tiny objects so that they can be seen with the naked eye.

[0003] Traditional microscopes can only adjust the objective lens position along the Z-axis. When scanning and sampling large-area slices, they cannot obtain a comprehensive image, which limits the scope of application of the microscope and cannot meet the current scientific research needs.

[0004] Therefore, how to design an automated slice scanning device is a problem that urgently needs to be solved by those skilled in the art. Utility Model Content

[0005] This invention provides an automated slide scanning device that solves the technical problem that traditional microscopes have limited adjustment direction and range, making it impossible to scan large-area slides.

[0006] The technical solution of this utility model to solve the above-mentioned technical problems is as follows: an automated slice scanning device includes: a mirror base, a mirror arm, a mirror tube, an eyepiece, a converter, an objective lens, a Z-axis rack, a Z-axis knob, and a fixing plate. The vertical axis of the mirror base is the Z-axis, the sagittal axis is the Y-axis, and the coronal axis is the X-axis. The bottom end of the mirror arm is fixed to the mirror base, and its side wall is provided with a Z-axis groove extending along the Z-axis direction. The mirror tube is tilted and fixed to the mirror arm. The eyepiece is fixed and connected to the top end of the mirror tube. The converter is fixed to the lower side wall of the mirror arm. The objective lens is fixed to the converter. The Z-axis rack is slidably connected to the Z-axis groove. The Z-axis knob is rotatably connected to the side wall of the mirror arm, and a Z-axis rotating rod fixed thereto rotates into the Z-axis groove. The inserted end of the Z-axis rotating rod into the Z-axis groove is fixed with a Z-axis gear, and the Z-axis gear meshes with the Z-axis rack. The assembly includes: a camera, a Z-axis motor, and a Y-axis moving component; the camera is fixed to the eyepiece; the Z-axis motor is fixed to the lens mount and is connected to the Z-axis knob via a belt; the Y-axis moving component includes a Y-axis slide plate, a Y-axis rack, a Y-axis knob, and a Y-axis motor; the bottom surface of the Y-axis slide plate has a Y-axis groove extending along the Y-axis direction, and the Y-axis groove passes through both ends of the Y-axis slide plate in the Y-axis direction and is slidably connected to the fixed plate; the Y-axis rack is fixed to the bottom surface of the fixed plate along the Y-axis direction; the Y-axis knob is rotatably connected to the Y-axis slide plate, and a Y-axis gear is fixed on a Y-axis rotating rod fixed thereon, the Y-axis gear meshing with the Y-axis rack; the Y-axis motor is fixed to the Y-axis slide plate and is connected to the Y-axis knob via a belt.

[0007] The beneficial effects of this utility model are as follows: First, the Z-axis motor is used to rotate the Z-axis knob to adjust the position of the fixing plate in the Z-axis direction; then, the Y-axis motor is used to rotate the Y-axis knob to adjust the position of the Y-axis slide in the Y-axis direction. The position of the Y-axis slide can be changed in two-dimensional space, thereby providing the camera with a multi-angle shooting field of view. The photos obtained from the multi-angle field of view are then overlapped and stitched together to form a cross-sectional view, which meets the needs of scientific research data.

[0008] Based on the above technical solution, the present invention can be further improved as follows.

[0009] Furthermore, it also includes an X-axis moving assembly, which includes an X-axis slide bar, an X-axis rack, an X-axis knob, and an X-axis motor. The top surface of the Y-axis slide plate is provided with an X-axis groove extending along the X-axis direction. The X-axis slide bar is slidably connected to the X-axis groove. The X-axis rack is fixed to the X-axis slide bar along the X-axis direction. An X-axis rotating rod fixed to the X-axis knob is rotatably connected to the Y-axis slide plate, and the X-axis rotating rod rotates and extends into the X-axis groove. An X-axis gear is fixed to the end of the X-axis rotating rod that extends into the X-axis groove, and the X-axis gear meshes with the X-axis rack. The X-axis motor is fixed to the Y-axis slide plate and is driven by the X-axis knob via a belt.

[0010] The further beneficial effect of adopting the above is that by using the X-axis motor to rotate the X-axis knob and adjust the position of the X-axis slider in the Z-axis direction, the position of the X-axis slider can be changed in three-dimensional space, thereby providing the camera with a multi-angle field of view in three-dimensional space, obtaining a clearer and more complete slice view, and meeting the requirements of scientific research data.

[0011] Furthermore, it also includes a slice clamp, which is rotatably connected to the X-axis slide bar.

[0012] The further beneficial effect of adopting the above is that by using a slice clamp to hold the slice placed on the X-axis slider, abnormal deviation of the slice from its position can be avoided, thus improving the stability of the slice placement.

[0013] Furthermore, the Y-axis knob, the Y-axis rotating rod, and the Y-axis gear are all provided with interconnected through holes in their middle portions; the X-axis knob is rotatably connected to the bottom end of the Y-axis knob, and the X-axis rotating rod passes through multiple interconnected through holes.

[0014] Furthermore, it also includes a photoelectric sensor, and there are two eyepieces, with the camera fixed on one eyepiece and the photoelectric sensor fixed on the other eyepiece.

[0015] The further beneficial effects of adopting the above are: by using a photoelectric sensor to sense the brightness of the slice in real time, when the detected slice brightness is greater than the threshold set by the photoelectric sensor, it is determined that there is no slice image in the objective lens field of view, and the camera skips this shot; when the detected slice brightness is less than the threshold set by the photoelectric sensor, it is determined that there is a slice image in the objective lens field of view, and the camera performs this shot; thereby reducing the invalid overlapping parts of the images and improving the convenience and integrity of multi-angle field-of-view photo stitching.

[0016] Furthermore, a sensitivity adjustment potentiometer is electrically mounted on the photoelectric sensor.

[0017] The further beneficial effect of adopting the above is that the sensitivity adjustment potentiometer can adjust the threshold of the photoelectric sensor according to different slices.

[0018] Furthermore, it also includes a controller, which is electrically connected to the Z-axis motor, Y-axis motor, X-axis motor, camera, and photoelectric sensor, respectively.

[0019] Furthermore, there are two Y-axis knobs, which are rotatably connected to opposite sides of the telescope arm, and the two ends of the Y-axis rotating rod rotatably pass through opposite sides of the telescope arm and are respectively fixed to the two Y-axis knobs. Attached Figure Description

[0020] Figure 1 This is a three-dimensional structural diagram of the left side of an automated slicing and scanning device according to the present invention;

[0021] Figure 2 This is a three-dimensional structural diagram of the right side of an automated slice scanning device according to the present invention;

[0022] Figure 3 This is a three-dimensional structural diagram of a partially disassembled part of the automated slicing and scanning device of this utility model.

[0023] The attached diagram lists the components represented by each number as follows:

[0024] 1. Lens mount, 2. Lens arm, 3. Lens tube, 4. Eyepiece, 5. Converter, 6. Objective lens, 7. Z-axis rack, 8. Z-axis knob, 9. Mounting plate, 10. Camera, 11. Z-axis motor, 12. Y-axis moving assembly, 121. Y-axis slide, 122. Y-axis rack, 123. Y-axis knob, 124. Y-axis motor, 13. X-axis moving assembly, 131. X-axis slide bar, 132. X-axis rack, 133. X-axis knob, 134. X-axis motor, 14. Slice holder, 15. Photoelectric sensor. Detailed Implementation

[0025] The principles and features of this utility model are described below with reference to the accompanying drawings. The examples given are only for explaining this utility model and are not intended to limit the scope of this utility model.

[0026] like Figure 1 and Figure 3As shown, an automated slide scanning device includes: a mirror base 1, a mirror arm 2, a mirror tube 3, an eyepiece 4, a converter 5, an objective lens 6, a Z-axis rack 7, a Z-axis knob 8, and a fixing plate 9. The vertical axis of the mirror base 1 is the Z-axis, the sagittal axis is the Y-axis, and the coronal axis is the X-axis. The bottom end of the mirror arm 2 is fixed to the mirror base 1, and its side wall is provided with a Z-axis groove extending along the Z-axis direction. The mirror tube 3 is tilted and fixed to the mirror arm 2. The eyepiece 4 is fixed and connected to the top end of the mirror tube 3. The converter 5 is fixed to the lower side wall of the mirror arm 2. The objective lens 6 is fixed to the converter 5. The Z-axis rack 7 is mounted on the Z-axis. The lens is rotatably connected to the Z-axis slide groove; the Z-axis knob 8 is rotatably connected to the side wall of the lens arm 2, and the Z-axis rotating rod fixed thereon rotates and extends into the Z-axis slide groove. The Z-axis gear is fixed at the end of the Z-axis rotating rod extending into the Z-axis slide groove, and the Z-axis gear meshes with the Z-axis rack 7; the fixing plate 9 is fixed to the Z-axis rack 7 below the objective lens 6; it also includes: a camera 10, a Z-axis motor 11, and a Y-axis moving assembly 12. The camera 10 is fixed to the eyepiece 4; the Z-axis motor 11 is fixed to the lens mount 1 and is connected to the Z-axis knob 8 via a belt; the Y-axis moving assembly... Component 12 includes a Y-axis slide plate 121, a Y-axis rack 122, a Y-axis knob 123, and a Y-axis motor 124. The bottom surface of the Y-axis slide plate 121 has a Y-axis groove extending along the Y-axis direction, which passes through both ends of the Y-axis slide plate 121 and is slidably connected to the fixed plate 9. The Y-axis rack 122 is fixed to the bottom surface of the fixed plate 9 along the Y-axis direction. The Y-axis knob 123 is rotatably connected to the Y-axis slide plate 121, and a Y-axis gear is fixed on a Y-axis rotating rod fixed thereon. The Y-axis gear meshes with the Y-axis rack 122. The Y-axis motor 124... 4. Fixed on the Y-axis slide plate 121 and connected to the Y-axis knob 123 via a belt; In the above structure, the Z-axis motor 11 is used to rotate the Z-axis knob 8 to adjust the position of the fixing plate 9 in the Z-axis direction; then the Y-axis motor 124 is used to rotate the Y-axis knob 123 to adjust the position of the Y-axis slide plate 121 in the Y-axis direction. The position of the Y-axis slide plate 121 can be changed in two-dimensional space, thereby providing the camera 10 with a multi-angle shooting field of view. The photos obtained from the angle field of view are then overlapped and stitched together to form a cross-sectional view, which meets the needs of scientific research data.

[0027] In some specific embodiments, an X-axis moving assembly 13 may also be included. The X-axis moving assembly 13 includes an X-axis slide bar 131, an X-axis rack 132, an X-axis knob 133, and an X-axis motor 134. The top surface of the Y-axis slide plate 121 is provided with an X-axis groove extending along the X-axis direction. The X-axis slide bar 131 is slidably connected to the X-axis groove. The X-axis rack 132 is fixed to the X-axis slide bar 131 along the X-axis direction. An X-axis rotating rod fixed to the X-axis knob 133 is rotatably connected to the Y-axis slide plate 121, and the X-axis rotating rod rotates and extends into the X-axis groove. An X-axis gear is fixed to the end of the X-axis slide groove, and the X-axis gear meshes with the X-axis rack 132; the X-axis motor 134 is fixed on the Y-axis slide plate 121 and is connected to the X-axis knob 133 via a belt; with the above structure, by rotating the X-axis knob 133 with the X-axis motor 134, the position of the X-axis slide bar 131 in the Z-axis direction can be adjusted, and the position of the X-axis slide bar 131 can be changed in three-dimensional space, thereby providing the camera 10 with a multi-angle field of view in three-dimensional space, obtaining a clearer and more complete slice view, and meeting the requirements of scientific research data.

[0028] In some specific embodiments, a slice clamp 14 may also be included, which is rotatably connected to the X-axis slide bar 131.

[0029] Specifically, the Y-axis knob 123, the Y-axis rotating rod, and the Y-axis gear are all provided with interconnected through holes in the middle; the X-axis knob 133 is rotatably connected to the bottom end of the Y-axis knob 123 and the X-axis rotating rod passes through multiple interconnected through holes.

[0030] In some specific embodiments, a photoelectric sensor 15 may also be included, and there are two eyepieces 4, with the camera 10 fixed on one eyepiece 4 and the photoelectric sensor 15 fixed on the other eyepiece 4.

[0031] In some specific embodiments, a sensitivity adjustment potentiometer is electrically mounted on the photoelectric sensor 15.

[0032] In some specific embodiments, a controller may also be included, which is electrically connected to the Z-axis motor 11, the Y-axis motor 124, the X-axis motor 134, the camera 10, and the photoelectric sensor 15, respectively.

[0033] In some specific embodiments, there are two Y-axis knobs 123, which are rotatably connected to opposite sides of the lens arm 2, and the two ends of the Y-axis rotating rod rotatably pass through opposite sides of the lens arm 2 and are respectively fixed on the two Y-axis knobs 123.

[0034] The above are merely preferred embodiments of the present utility model and are not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model shall be included within the protection scope of the present utility model.

Claims

1. An automated slice scanning device, comprising: The system comprises a mirror base (1), a mirror arm (2), a mirror tube (3), an eyepiece (4), a converter (5), an objective lens (6), a Z-axis rack (7), a Z-axis knob (8), and a mounting plate (9). The vertical axis of the mirror base (1) is the Z-axis, the sagittal axis is the Y-axis, and the coronal axis is the X-axis. The bottom end of the mirror arm (2) is fixed to the mirror base (1), and its side wall is provided with a Z-axis groove extending along the Z-axis direction. The mirror tube (3) is tilted and fixed to the mirror arm (2). The eyepiece (4) is fixed and connected to the [missing information - likely a specific component or part of the system]. The top of the lens tube (3); the converter (5) is fixed to the lower side wall of the lens arm (2); the objective lens (6) is fixed to the converter (5); the Z-axis rack (7) is slidably connected to the Z-axis groove; the Z-axis knob (8) is rotatably connected to the side wall of the lens arm (2) and the Z-axis rotating rod fixed thereon rotates into the Z-axis groove, and the Z-axis rotating rod is fixed to the Z-axis groove at the end of the Z-axis rotating rod that extends into the Z-axis groove, and the Z-axis gear is meshed with the Z-axis rack (7); The fixing plate (9) is fixed to the Z-axis rack (7) below the objective lens (6); characterized in that it further includes: The system includes a camera (10), a Z-axis motor (11), and a Y-axis moving assembly (12). The camera (10) is fixed to the eyepiece (4). The Z-axis motor (11) is fixed to the lens mount (1) and is connected to the Z-axis knob (8) via a belt. The Y-axis moving assembly (12) includes a Y-axis slide plate (121), a Y-axis rack (122), a Y-axis knob (123), and a Y-axis motor (124). The bottom surface of the Y-axis slide plate (121) is provided with a Y-axis groove extending along the Y-axis direction and the Y-axis groove passes through the eyepiece (4). The Y-axis slide plate (121) is slidably connected to both ends of the Y-axis direction on the fixed plate (9); the Y-axis rack (122) is fixed to the bottom surface of the fixed plate (9) along the Y-axis direction; the Y-axis knob (123) is rotatably connected to the Y-axis slide plate (121) and a Y-axis gear is fixed on the Y-axis rotating rod fixed thereon, and the Y-axis gear meshes with the Y-axis rack (122); the Y-axis motor (124) is fixed to the Y-axis slide plate (121) and is connected to the Y-axis knob (123) via a belt.

2. The automated slice scanning device according to claim 1, characterized in that, It also includes an X-axis moving assembly (13), which includes an X-axis slide bar (131), an X-axis rack (132), an X-axis knob (133), and an X-axis motor (134). The top surface of the Y-axis slide plate (121) is provided with an X-axis groove extending along the X-axis direction. The X-axis slide bar (131) is slidably connected to the X-axis groove. The X-axis rack (132) is fixed to the X-axis slide bar (131) along the X-axis direction. The X-axis rotary rod fixed on the X-axis knob (133) is rotatably connected to the Y-axis slide plate (121), and the X-axis rotary rod rotates and extends into the X-axis slide groove. The X-axis gear is fixed at the end of the X-axis rotary rod that extends into the X-axis slide groove, and the X-axis gear meshes with the X-axis rack (132). The X-axis motor (134) is fixed on the Y-axis slide plate (121) and is connected to the X-axis knob (133) via a belt.

3. The automated slice scanning device according to claim 2, characterized in that, It also includes a slicer clip (14), which is rotatably connected to the X-axis slide bar (131).

4. The automated slice scanning device according to claim 2, characterized in that, The Y-axis knob (123), the Y-axis rotating rod, and the Y-axis gear are all provided with interconnected through holes in their middle parts; the X-axis knob (133) is rotatably connected to the bottom end of the Y-axis knob (123), and the X-axis rotating rod passes through multiple interconnected through holes.

5. The automated slice scanning device according to claim 3, characterized in that, It also includes a photoelectric sensor (15), and there are two eyepieces (4). The camera (10) is fixed on one of the eyepieces (4), and the photoelectric sensor (15) is fixed on the other eyepiece (4).

6. The automated slice scanning device according to claim 5, characterized in that, The photoelectric sensor (15) is electrically equipped with a sensitivity adjustment potentiometer.

7. An automated slice scanning device according to claim 5, characterized in that, It also includes a controller, which is electrically connected to the Z-axis motor (11), Y-axis motor (124), X-axis motor (134), camera (10) and photoelectric sensor (15), respectively.

8. The automated slice scanning device according to claim 1, characterized in that, There are two Y-axis knobs (123), which are rotatably connected to opposite sides of the arm (2). The two ends of the Y-axis rotating rod rotatably pass through opposite sides of the arm (2) and are fixed to the two Y-axis knobs (123).