Chromatographic column system

Abstract

The utility model discloses a chromatographic column system which comprises a chromatographic column, a pressure solvent tank, a pressure solvent pump, a solvent supply valve and an emptying pressure relief pipe, one end of the pressure solvent pump is communicated with the chromatographic column, an outlet of the pressure solvent tank is communicated with a liquid outlet valve, and the liquid outlet valve and the solvent supply valve are respectively communicated with the other end of the pressure solvent pump. The chromatographic column is provided with a pressure sensor for monitoring internal pressure, the pressure sensor is in signal connection with the pressure solvent pump, the emptying pressure relief pipe is communicated with the chromatographic column and an inlet of the pressure solvent tank, and the emptying pressure relief pipe is provided with an emptying pressure relief valve. The chromatographic column system has the advantages of achieving material pressure maintaining, improving material pressing quality, enabling a solvent to be recycled and saving cost.

Description

Technical Field

[0001] This utility model relates to the field of food and pharmaceutical packaging machinery and equipment technology, specifically to a chromatography column system. Background Technology

[0002] Existing chromatographic separation equipment generally includes a column, a piston inside the column, and a plug mounted on the bottom of the column with screws. During operation, material is added into the space between the piston and the plug inside the column. The piston is then pressed down, causing the material to solidify under pressure between the piston and the plug. Finally, the solidified material is removed by removing the plug. In practical applications, the piston movement is typically driven by a telescopic actuator. Maintaining the material pressure at a predetermined level is achieved by limiting the telescopic movement of this actuator. However, this pressure-maintaining effect is often unsatisfactory, leading to poor or unqualified product quality.

[0003] Chinese patent application number 202122166946.3 discloses a rodless dynamic axial compression chromatographic column system. Specifically, it discloses a chromatographic column, a pressure solvent tank, and a pressure solvent pump. The column contains a piston with a pressure solvent chamber above it and a packed column bed chamber below it. A pressure solvent connector is located at the upper end of the column, and a second pressure solvent connector is located at the lower end. The outlet of the pressure solvent tank is connected to the inlet of the pressure solvent pump, and the outlet of the pressure solvent pump is connected to an inlet control valve. Both the pressure solvent connector and the second pressure solvent connector are connected to the inlet control valve. While the system discloses switching to the pressure solvent connector via the inlet control valve and pumping pressure solvent into the pressure solvent chamber at the upper end of the column to push the piston downward, forcing the mobile phase in the homogenate within the packed column bed chamber through a fraction collection connector and discharging waste, thus achieving the set pressure in the homogenate within the packed column bed chamber, it does not disclose the technical means for maintaining the pressure, meaning the quality of the compressed material is prone to defects. Utility Model Content

[0004] The technical problem to be solved by this utility model is to overcome the shortcomings of the prior art and provide a chromatographic column system that can achieve material pressure holding, improve the quality of pressed material, enable solvent recycling, and save costs.

[0005] To solve the above-mentioned technical problems, the present invention adopts the following technical solution:

[0006] A chromatographic column system includes a chromatographic column, a pressure solvent tank, a pressure solvent pump, a solvent supply valve, and a venting and pressure relief pipe. One end of the pressure solvent pump is connected to the chromatographic column, and the outlet of the pressure solvent tank is connected to an outlet valve. The outlet valve and the solvent supply valve are respectively connected to the other end of the pressure solvent pump. The chromatographic column is equipped with a pressure sensor for monitoring internal pressure, and the pressure sensor is signal-connected to the pressure solvent pump. The venting and pressure relief pipe connects the inlet of the chromatographic column and the inlet of the pressure solvent tank, and the venting and pressure relief pipe is equipped with a venting and pressure relief valve.

[0007] As a further improvement to the above technical solution:

[0008] The chromatographic column system also includes a pressure-regulating check valve that opens when the pressure exceeds a set pressure. The inlet of the pressure-regulating check valve is connected to the chromatographic column, and the outlet is connected to the inlet of the pressure solvent tank.

[0009] The venting and pressure relief pipe is equipped with a viewing mirror.

[0010] The chromatographic column is equipped with a piston, a pressure solvent chamber is formed on the upper side of the piston, a packed column bed chamber is formed on the lower side of the piston, the pressure solvent pump is connected to the pressure solvent chamber, and the venting and pressure relief pipe is connected to the pressure solvent chamber.

[0011] The upper end of the chromatographic column is equipped with a pressure solvent connector, and the pressure solvent pump is connected to the pressure solvent connector.

[0012] The outlet of the pressure solvent pump is connected to the pressure solvent chamber via an inlet control valve.

[0013] The chromatographic column is equipped with a quick-release plug at the upper end. The chromatographic column system also includes a drain pipe, which is connected to the outlet of the pressure solvent pump and the inlet of the liquid inlet control valve. The drain pipe is equipped with a drain valve.

[0014] A feed tube is inserted through the center of the piston. One end of the feed tube is connected to the bed cavity of the packed column, and the other end is connected to the material supply device. The bottom end of the chromatographic column is provided with a detachable end cap, and the end cap is provided with a through hole.

[0015] The pressure solvent chamber is equipped with a spray assembly, which is connected to a spray valve. The spray valve is connected to the outlet of the pressure solvent pump.

[0016] The outlet of the pressure solvent tank is located at the bottom of the pressure solvent tank, and the inlet is located at the top of the pressure solvent tank.

[0017] Compared with the prior art, the advantages of this utility model are:

[0018] This chromatographic column system, on the one hand, maintains the pressure within the pressure solvent chamber within a preset range during the pressing process through the cooperation of a pressure sensor and a pressure solvent pump, achieving material pressure holding and improving pressing quality; on the other hand, the venting and pressure relief pipe connects the inlet of the chromatographic column and the pressure solvent tank. During the venting step, the completeness of venting can be determined by observing or detecting whether liquid enters the pressure solvent tank (if liquid enters the pressure solvent tank, it proves that the gas in the pressure solvent chamber has been vented completely). Furthermore, the solvent that enters the pressure solvent tank through the venting and pressure relief pipe during the venting process can be used to provide solvent for the pressure solvent chamber during the pressure holding pressing step, enabling solvent recycling and saving costs.

[0019] This chromatographic column system is equipped with a pressure-regulating check valve. When the pressure in the pressure solvent chamber of the chromatographic column exceeds the upper limit pressure value of the pressure-regulating check valve, the solvent in the pressure solvent chamber of the chromatographic column enters the pressure solvent tank through the pressure-regulating check valve, thereby relieving the pressure in the pressure solvent chamber and preventing the material from being overpressurized.

[0020] This chromatographic column system is equipped with a fluoroscopy lens on the purging and pressure relief tube, allowing for easy observation of whether solution passes through during the purging step. The presence of solvent indicates successful purging. Of course, if solvent passes through the fluoroscopy lens during the purging step, purging can continue for a certain period to ensure the pressure solvent tank has the solvent required for the pressure-holding step. Attached Figure Description

[0021] Figure 1 This is a schematic diagram of the chromatographic column system of this utility model during exhaust.

[0022] Figure 2 This is a schematic diagram of the chromatographic column system of this utility model during material loading.

[0023] Figure 3 This is a schematic diagram of the chromatographic column system of this utility model under pressure.

[0024] Figure 4 This is a schematic diagram of the chromatographic column system of this utility model when depressurized.

[0025] Figure 5 This is a schematic diagram of the chromatographic column system of this utility model during column disassembly.

[0026] Figure 6 This is a schematic diagram of the chromatographic column system of this utility model during liquid discharge.

[0027] Figure 7 This is a schematic diagram of the chromatographic column system of this utility model during cleaning.

[0028] The labels in the diagram represent:

[0029] 1. Chromatographic column; 10. Piston; 11. Pressure solvent chamber; 12. Packed column bed chamber; 13. Pressure solvent connector; 14. Quick-release plug; 15. Feed tube; 16. Material supply device; 17. End cap; 18. Through hole; 2. Pressure solvent tank; 21. Discharge valve; 3. Pressure solvent pump; 31. Inlet control valve; 4. Solvent supply valve; 5. Pressure sensor; 6. Pressure stabilizing check valve; 7. Drainage and pressure relief pipe; 71. Drainage and pressure relief valve; 72. Lens; 8. Drainage pipe; 81. Drainage valve; 9. Spray assembly; 91. Spray valve. Detailed Implementation

[0030] The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0031] In the description of this utility model, it should be understood that the terms "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0032] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this utility model, "a plurality of" means two or more, unless otherwise explicitly specified.

[0033] In this utility model, unless otherwise explicitly specified and limited, the terms "assembly," "connection," "joining," and "fixing" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0034] Figures 1 to 7An embodiment of the chromatographic column system of this utility model is shown. The chromatographic column system of this embodiment includes a chromatographic column 1, a pressure solvent tank 2, a pressure solvent pump 3, a solvent supply valve 4, and a venting and pressure relief pipe 7. One end (e.g., the inlet end) of the pressure solvent pump 3 is connected to the chromatographic column 1. The outlet of the pressure solvent tank 2 is connected to an outlet valve 21. The outlet valve 21 and the solvent supply valve 4 are respectively connected to the other end (e.g., the outlet end) of the pressure solvent pump 3. The chromatographic column 1 is equipped with a pressure sensor 5 for monitoring the internal pressure. The pressure sensor 5 is signal-connected to the pressure solvent pump 3. The venting and pressure relief pipe 7 is connected to the inlet of the chromatographic column 1 and the pressure solvent tank 2. The venting and pressure relief pipe 7 is equipped with a venting and pressure relief valve 71.

[0035] The working process of this chromatographic column system is as follows: Step 1, as... Figure 1 As shown, connect the inlet of solvent supply valve 4 to an external solvent supply device, close the outlet valve 21, open the venting and pressure relief valve 71, start the pressure solvent pump 3, inject solvent into the chromatographic column 1, and purge the gas from the pressure solvent chamber 11 of the chromatographic column 1; the second step, as shown... Figure 2 As shown, continuously turn on the pressure solvent pump 3 to inject solvent into the pressure solvent chamber 11 of the chromatographic column 1, causing the piston 10 to press down on the material in the packed column bed chamber 12; the third step, as... Figure 3 As shown, when the pressure sensor 5 detects that the pressure has reached the set value, it opens the liquid outlet valve 21 and closes the solvent supply valve 4. The pressure solvent pump 3 adjusts its operating state according to the monitoring signal of the pressure sensor 5, and delivers the solution in the pressure solvent tank 2 to the pressure solvent chamber 11, so that the pressure in the pressure solvent chamber 11 is maintained within the preset range. On the one hand, during the pressing process, the pressure sensor 5 and the pressure solvent pump 3 work together to maintain the pressure in the pressure solvent chamber 11 within the preset range, thereby achieving material pressure holding and improving the pressing quality. On the other hand, the venting and pressure relief pipe 7 connects the inlet of the chromatographic column 1 and the pressure solvent tank 2. In the venting step (first step), the completeness of venting can be determined by observing or detecting whether liquid enters the pressure solvent tank 2 (if liquid enters the pressure solvent tank 2, it proves that the gas in the pressure solvent chamber 11 has been vented). Furthermore, the solvent that enters the pressure solvent tank 2 through the venting and pressure relief pipe 7 during the venting process can be used to provide solvent for the pressure solvent chamber 11 in the pressure holding pressing step (third step), so that the solvent can be recycled and costs are saved.

[0036] Furthermore, in this embodiment, the chromatographic column system also includes a pressure-stabilizing check valve 6 that opens when the pressure exceeds a set pressure. The inlet of the pressure-stabilizing check valve 6 is connected to the chromatographic column 1, and the outlet is connected to the inlet of the pressure solvent tank 2. Because of the pressure-stabilizing check valve 6, when the pressure in the pressure solvent chamber 11 of the chromatographic column 1 exceeds the upper limit pressure value of the pressure-stabilizing check valve 6, the solvent in the pressure solvent chamber 11 of the chromatographic column 1 enters the pressure solvent tank 2 through the pressure-stabilizing check valve 6, thereby relieving pressure in the pressure solvent chamber 11 and preventing overpressure of the material.

[0037] Furthermore, in this embodiment, the venting and pressure relief pipe 7 is equipped with a viewing mirror 72 to facilitate observation of whether any solution passes through during the venting step. If solvent passes through, it proves that the venting is complete. Of course, if solvent passes through the viewing mirror 72 during the venting step, venting can continue for a certain period of time to ensure that the pressure solvent tank 2 has the solvent required for the pressure holding step.

[0038] Furthermore, in this embodiment, the chromatographic column 1 is provided with a piston 10, a pressure solvent chamber 11 is formed on the upper side of the piston 10, a packed column bed chamber 12 is formed on the lower side of the piston 10, the outlet of the pressure solvent pump 3 is connected to the pressure solvent chamber 11, and the venting and pressure relief pipe 7 is connected to the pressure solvent chamber 11.

[0039] Furthermore, in this embodiment, the upper end of the chromatographic column 1 is provided with a pressure solvent connector 13, and the outlet of the pressure solvent pump 3 is connected to the pressure solvent connector 13. The pressure solvent connector 13 at the upper end of the chromatographic column 1 facilitates connection with the pressure solvent pump 3 via a pipeline.

[0040] Furthermore, in this embodiment, the pressure solvent pump 3 and the pressure solvent chamber 11 are connected through the liquid inlet control valve 31, which facilitates the discharge of solvent from the pressure solvent chamber 11 by subsequently closing the connection between the pressure solvent pump 3 and the pressure solvent chamber 11.

[0041] Furthermore, in this embodiment, the upper end of the chromatographic column 1 is provided with a quick-release plug 14, and the chromatographic column system also includes a drain pipe 8, which is connected to the outlet of the pressure solvent pump 3 and the inlet of the liquid inlet control valve 31. The drain pipe 8 is provided with a drain valve 81 to facilitate the subsequent discharge of solvent from the pressure solvent chamber 11.

[0042] Furthermore, such as Figure 1 As shown, in this embodiment, a feed tube 15 passes through the center of the piston 10. One end of the feed tube 15 communicates with the packed column bed 12, and the other end communicates with the material supply device 16. The bottom end of the chromatographic column 1 is provided with a detachable end cap 17, which has a through hole 18. The material supply device 16 injects material into the packed column bed 12 through the feed tube 15. The end cap 17 is detachable from the bottom end of the chromatographic column 1, facilitating disassembly for column removal.

[0043] Furthermore, in this embodiment, a spray assembly 9 is provided inside the pressure solvent chamber 11, and the spray assembly 9 is connected to a spray valve 91, which is connected to the outlet of the pressure solvent pump 3. This facilitates spray cleaning inside the pressure solvent chamber 11.

[0044] Furthermore, in this embodiment, the outlet of the pressure solvent tank 2 is located at the bottom of the pressure solvent tank 2, and the inlet is located at the top of the pressure solvent tank 2.

[0045] The working process of this chromatographic column system is as follows: Step 1, as... Figure 1 As shown, connect the inlet of solvent supply valve 4 to an external solvent supply device, close the outlet valve 21, open the venting and pressure relief valve 71, start the pressure solvent pump 3, inject solvent into the chromatographic column 1, and purge the gas from the pressure solvent chamber 11 of the chromatographic column 1; the second step, as shown... Figure 2 As shown, continuously turn on the pressure solvent pump 3 to inject solvent into the pressure solvent chamber 11 of the chromatographic column 1, causing the piston 10 to press down on the material in the packed column bed chamber 12; the third step, as... Figure 3 As shown, when the pressure sensor 5 detects that the pressure has reached the set value, it opens the outlet valve 21 and closes the solvent supply valve 4. The pressure solvent pump 3 adjusts its operating state according to the monitoring signal from the pressure sensor 5, and delivers the solution in the pressure solvent tank 2 to the pressure solvent chamber 11, so that the pressure in the pressure solvent chamber 11 is maintained within the preset range; the fourth step, as shown... Figure 4 As shown, after the material in the compressed packing column bed cavity 12 is compressed to the standard, the venting and pressure relief valve 71 is opened to release the pressure of the material; the fifth step, as... Figure 5 As shown, remove the end cap 17 at the bottom of column 1, connect the inlet of solvent supply valve 4 to an external solvent supply device, close the outlet valve 21 and the venting and pressure relief valve 71, turn on the pressure solvent pump 3, inject solvent into column 1, causing piston 10 to descend and force out the material in the packed column bed chamber 12, thus disassembling the column; sixth step, as... Figure 6 As shown, remove the quick-release plug 14 to open the opening, extend one end of a drain pipe through the opening to the bottom of the pressure solvent chamber 11, connect the other end of the drain pipe to the inlet of the solvent supply valve 4, close the outlet valve 21 and the inlet control valve 31, open the solvent supply valve 4 and the drain valve 81, start the pressure solvent pump 3, and drain the solvent in the pressure solvent chamber 11 (the solvent in the pressure solvent chamber 11 is discharged through the drain pipe and the drain pipe 8); as Figure 7 As shown, close the liquid outlet valve 21, the venting and pressure relief valve 71 and the liquid drain valve 81, open the solvent supply valve 4 and the liquid inlet control valve 31, connect the inlet of the solvent supply valve 4 to the water supply equipment, turn on the pressure solvent pump 3 to supply water to the spray assembly 9, and the spray assembly 9 sprays and cleans the inside of the pressure solvent chamber 11.

[0046] Furthermore, in this embodiment, the outlet of the pressure solvent pump 3 is connected to the inlet control valve 31 through a one-way valve 32, which is used to prevent solvent from flowing from the inlet control valve 31 to the pressure solvent pump 3.

[0047] Although the present invention has been disclosed above with reference to preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make many possible variations and modifications to the present invention, or modify it into equivalent embodiments, without departing from the scope of the present invention. Therefore, any simple modifications, equivalent changes, and modifications made to the above embodiments based on the technical essence of the present invention, without departing from the content of the present invention, should fall within the protection scope of the present invention.

Claims

1. A chromatographic column system, characterized in that: The system includes a chromatographic column (1), a pressure solvent tank (2), a pressure solvent pump (3), a solvent supply valve (4), and a venting and pressure relief pipe (7). One end of the pressure solvent pump (3) is connected to the chromatographic column (1), and the outlet of the pressure solvent tank (2) is connected to a liquid outlet valve (21). The liquid outlet valve (21) and the solvent supply valve (4) are respectively connected to the other end of the pressure solvent pump (3). The chromatographic column (1) is equipped with a pressure sensor (5) for monitoring internal pressure. The pressure sensor (5) is connected to the pressure solvent pump (3) for signal transmission. The venting and pressure relief pipe (7) is connected to the inlet of the chromatographic column (1) and the pressure solvent tank (2). The venting and pressure relief pipe (7) is equipped with a venting and pressure relief valve (71).

2. The chromatographic column system according to claim 1, characterized in that: The chromatographic column system also includes a pressure-regulating check valve (6) that opens when the pressure exceeds a set pressure. The inlet of the pressure-regulating check valve (6) is connected to the chromatographic column (1), and the outlet is connected to the inlet of the pressure solvent tank (2).

3. The chromatographic column system according to claim 1, characterized in that: The venting and pressure relief pipe (7) is equipped with a viewing mirror (72).

4. The chromatographic column system according to claim 1, characterized in that: The chromatographic column (1) is provided with a piston (10), a pressure solvent chamber (11) is formed on the upper side of the piston (10), a packed column bed chamber (12) is formed on the lower side of the piston (10), the outlet of the pressure solvent pump (3) is connected to the pressure solvent chamber (11), and the venting and pressure relief pipe (7) is connected to the pressure solvent chamber (11).

5. The chromatographic column system according to claim 4, characterized in that: The upper end of the chromatographic column (1) is provided with a pressure solvent connector (13), and the pressure solvent pump (3) is connected to the pressure solvent connector (13).

6. The chromatographic column system according to claim 4, characterized in that: The pressure solvent pump (3) is connected to the pressure solvent chamber (11) via the liquid inlet control valve (31).

7. The chromatographic column system according to claim 6, characterized in that: The chromatographic column (1) is provided with a quick-release plug (14) at the upper end. The chromatographic column system also includes a drain pipe (8). The drain pipe (8) is connected to the outlet of the pressure solvent pump (3) and the inlet of the liquid inlet control valve (31). The drain pipe (8) is provided with a drain valve (81).

8. The chromatographic column system according to claim 4, characterized in that: A feed tube (15) is provided through the center of the piston (10). One end of the feed tube (15) is connected to the bed cavity (12) of the packed column, and the other end is used to connect to the material supply device (16). The bottom end of the chromatographic column (1) is provided with a detachable end cap (17), and the end cap (17) is provided with a through hole (18).

9. The chromatographic column system according to claim 4, characterized in that: The pressure solvent chamber (11) is equipped with a spray assembly (9), which is connected to a spray valve (91). The spray valve (91) is connected to the outlet of the pressure solvent pump (3).

10. The chromatographic column system according to any one of claims 1 to 9, characterized in that: The outlet of the pressure solvent tank (2) is located at the bottom of the pressure solvent tank (2), and the inlet is located at the top of the pressure solvent tank (2).

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