Composition comprising (pseudo-) ceramide and / or sphingoid base and composed solvent

Abstract

202300151 Foreign Filing 48 Abstract The invention relates to compositions comprising (pseudo-) ceramide and / or sphingoid base and a solvent composed of at least two components, a process for producing a formulation (pseudo-) ceramide and / or sphingoid base and the use of at least one of said composed solvent for 5 stabilization of (pseudo-) ceramide and / or sphingoid base containing composition.

Description

[0001] 202300151 Foreign Filing 1

[0002] Composition comprising (pseudo-) ceramide and / or sphingoid base and composed solvent

[0003] Field of the invention

[0004] The invention relates to compositions comprising (pseudo-) ceramide and / or sphingoid base and a solvent composed of at least two components, a process for producing a formulation (pseudo-) ceramide and / or sphingoid base and the use of at least one of said composed solvent for stabilization of (pseudo-) ceramide and / or sphingoid base containing composition.

[0005] Prior art

[0006] Ceramides are used in many cosmetic formulations. However, their low solubility and strong tendency to recrystallization complicate the stable incorporation into cosmetic formulations. Especially at temperatures just above freezing, formulations often suffer from inhomogeneities. In addition, microbial stabilization of ceramide-containing formulations is challenging since preservatives regularly adversely affect the physical stability of formulations.

[0007] The prior art addresses this problem by various delivery forms.

[0008] For instance, WO1998053797 describes encapsulated water-insoluble active ingredients having amphiphilic character, with a content of water and at least one surfactant from the group of esters of long-chain carboxylic acids with carboxylic acids comprising hydroxyl groups or salts thereof and esters of long-chain carboxylic acids with polyalcohols, in which ceramides may be the waterinsoluble active ingredients.

[0009] WO1999029293 describes a composition for topical application, comprising a combination of a free sphingoid base and a ceramide.

[0010] JP2008297301 describes ceramides and phytosterol derivatives in triglyceride-containing oil solutions in liquid form for incorporation into dermatological preparations.

[0011] The object of the invention was to provide compositions comprising ceramides and / or sphingoid base at high concentrations, which have excellent physical stability.

[0012] Description of the invention

[0013] It has been found that, surprisingly, the compositions described below are able to solve the problem addressed by the invention. 202300151 Foreign Filing 2

[0014] The present invention therefore relates to a composition comprising at least one selected from ceramides and sphingoid bases and a solvent composed of at least two carefully chosen components.

[0015] The invention further relates to a process for producing a cosmetic or pharmaceutical formulation and to the use of at least one of said composed solvent for stabilization of a ceramide- and / or sphingoid base-containing composition.

[0016] An advantage of the present invention is that the compositions according to the invention have increased storage stability and are thus slower to change in their nature over time, particularly with regard to their viscosity, compared to ceramide-containing compositions according to the prior art. Another advantage of the present invention is that the compositions according to the invention tolerate a higher number of freeze-thaw steps without significant loss of viscosity, compared to ceramide-containing compositions according to the prior art.

[0017] Another advantage of the present invention is that the compositions according to the invention tolerate a higher number of freeze-thaw steps without significant increase of crystallization of ceramides, compared to ceramide-containing compositions according to the prior art.

[0018] One advantage of the composition according to the invention is that the composition in formulations has superior sensory properties which lead to an improved skin feel and / or hair feel.

[0019] It is a further advantage of the composition according to the invention that the composition in formulations has improved distributability compared to the individual components.

[0020] Another advantage is that blends with ceramides with high melting points can be pre-formulated at room temperature / ambient temperature.

[0021] It is a further advantage of the composition according to the invention that the composition in formulations has improved absorption compared to the individual components.

[0022] Another advantage of the present invention is that the compositions according to the invention does not need a preservative.

[0023] Another advantage of the present invention is that the compositions according to the invention is the easy incorporation of ceramides into aqueous phases.

[0024] Another advantage of the present invention is that the compositions according to the invention are microbially very stable, in consequence less preservative is needed to microbially stabilize the compositions according to the instant invention.

[0025] The present invention therefore relates to a composition comprising

[0026] A) at least one selected from ceramides, sphingoid bases and pseudo-ceramides, the latter being ceramides, in which the fatty acid joined by an amide bond, is substituted by a non-fatty carboxylic acid, and 202300151 Foreign Filing 3

[0027] B) at least one combination of at least one different member of each subgroup Xi and X2 and if the case optionally X3 with X = I to V of the following group combination I selected from the subgroup I1 consisting of betaine, choline chloride, citric acid, creatine, creatinine, ectoine, fructose, glucose, glycerol, glycine, malic acid, maltose, mannose, proline, rhamnose, sophorose, sorbitol, sucrose, tetraalkylammonium halogenide, trehalose, urea, xylitol and zinc(ll)chloride, the subgroup h consisting of ascorbic acid, betaine, choline chloride, citric acid, erythritol, ethylene glycol, fructose, glucose, glycerol, isomaltose, malic acid, maltose, mannitol, mannose, proline, rhamnose, sophorose, sorbitol, sucrose, threitol, trehalose, urea, xylitol and zinc(ll)chloride, the subgroup I3 consisting of betaine, choline chloride, citric acid, erythritol, ethylene glycol, fructose, glucose, glycerol, isomaltose, malic acid, maltose, mannitol, mannose, proline, rhamnose, sophorose, sorbitol, sucrose, threitol, trehalose, urea, xylitol and zinc(ll)chloride, combination II selected from the subgroup Hi consisting of citric acid, glycerol, lactic acid, maleic acid, malic acid and tetraalkyllammonium halogenide, and the subgroup II2 consisting of capric acid, caprylic acid, citric acid, diethylenglycolmonoethylether, glycerol, glycine, lactic acid, oleic acid, perlargonic acid, pyroglutamic acid, transcutol and undecelynic acid, combination III selected from the subgroup Illi consisting of beta-citronellol, camphor, carvacrol, carvone, eugenol, fenchone, geraniol, linalool, menthol, panthenol and thymol, and the subgroup III2 consisting of arachic acid, arachidonic acid, behenic acid, capric acid, caproic acid, caprylic acid, docosahexaenoic acid, eicosapentaenoic acid, elaidic acid, erucic acid, gadoleic acid, isostearic acid, lauric acid, linoleic acid, linolenic acid, myristic acid, oleic acid, palmitic acid, palmitoleic acid, pelargonic acid, petroselinic acid, sodium lauryl lactylate, stearic acid and undecylenic acid, preferably capric acid, pelargonic acid and sodium lauryl lactylate, combination IV selected from the subgroup IV1 consisting of fatty acids, preferably selected from the group consisting of arachic acid, arachidonic acid, behenic acid, capric acid, caproic acid, caprylic acid, docosahexaenoic acid, eicosapentaenoic acid, elaidic acid, erucic acid, gadoleic acid, isostearic acid, lauric acid, linoleic acid, linolenic acid, myristic acid, oleic acid, palmitic acid, palmitoleic acid, pelargonic acid, petroselinic acid, stearic acid and undecylenic acid, with capric acid, caproic acid, caprylic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, palmitoleic acid, perlagonic acid and undecylenic acid being preferred, with caproic acid, caprylic acid, capric acid, perlagonic acid and undecylenic acid being especially preferred, and the subgroup IV2 consisting of fatty acids as named in IV1, and 202300151 Foreign Filing 4 combination V selected from the subgroup Vi consisting of anisic acid, benzoic acid, cinnamic acid, citric acid, lactic acid, tricresol, o-cresol, para-toluenesulfonic acid, p-cresol, phenol, phenylacetic acid and salicylic acids, and the subgroup V2 consisting of benzoic alcohol, betaine, choline chloride, creatine, creatinine, ectoine, glycine, niacin, nicotinamide, proline and tetraalkyllammonium halogenide.

[0028] In the context of the present invention, the term “ceramide” is understood to mean acylated sphingoid bases, where the sphingoid bases are preferably selected from sphingosine, sphinganine, 6-hydroxysphingosine and phytosphingosine, also in glycosylated form, for example as glucosylceramides.

[0029] However, in the context of the instant invention non-glycosylated ceramides and non-glycosylated pseudo-ceramides are preferred.

[0030] The “pH” in connection with the present invention is defined as the value which is measured for the relevant composition at 22°C after stirring for five minutes using a pH electrode calibrated in accordance with ISO 4319 (1977).

[0031] In the context of the present invention, the terms “liquid” is understood to be liquid at a temperature of 25°C and a pressure of 1013 mbar.

[0032] Where average values are stated hereinbelow, then, unless stated otherwise, these are number- averaged average values.

[0033] Unless stated otherwise, percentages are data in per cent by weight. The same is true for parts per million (ppm).

[0034] Wherever measurement values are stated hereinbelow, then, unless stated otherwise, these have been determined at a temperature of 25°C and a pressure of 1013 mbar.

[0035] The composition according to the instant invention preferably is at a temperature of 25°C and a pressure of 1013 mbar a liquid composition.

[0036] The composition according to the instant invention preferably is characterized in that said combination I, II or V additionally comprises water, preferably in an amount of from 6.0 wt.-% to 60 wt.%, more preferable in an amount of from 8.0 wt.-% to 45 wt.%, most preferable in an amount of from 9.0 wt.-% to 35 wt.% , wherein the weight percentages refer to the total sum of respective Xi and respective X2 and water. 202300151 Foreign Filing 5

[0037] It is preferred in accordance with the instant invention that the composition according to the instant invention is characterized in that said combination I is selected from betaine and ascorbic acid, preferably with a molar ratio of 1 :1 to 3:1 , betaine and glucose, preferably with a molar ratio of 3:1 to 5:1 , alternatively preferably with a molar ratio of 1 :2 to 2:1 , betaine and glycerol, preferably with a molar ratio of 1 :1 .5 to 2:1 , betaine and glycerol, preferably with a molar ratio of 1 :2 to 1 :5, more preferably 1 :3 to 1 :4, betaine and malic acid, preferably with a molar ratio of 1 :2 to 2:1 , betaine and sorbitol, preferably with a molar ratio of 1 :2 to 2:1 , betaine and trehalose, preferably with a molar ratio of 3:1 to 5:1 , betaine and urea, preferably with a molar ratio of 2:1 to 1 :1 , choline chloride and glucose, preferably with a molar ratio of 1 :3 to 1 :5, choline chloride and urea, preferably with a molar ratio of 1 :1 to 1 :3, glycerol and glycine, preferably with a molar ratio of 2:1 to 4:1 glycerol and citric acid, preferably with a molar ratio of 1 :1 to 3:1 , urea and choline chloride, preferably with a molar ratio of 1 :1 to 3:1 , proline and urea, preferably with a molar ratio of 1 :1 to 1 :3, more preferably 1 :1 to 1 :2, and proline and sorbitol, preferably with a molar ratio of 1 :2 to 2:1 .

[0038] It is more preferred in accordance with the instant invention that the composition according to the instant invention is characterized in that said combination I is selected from betaine and glucose, preferably with a molar ratio of 3:1 to 5:1 , betaine and glycerol, preferably with a molar ratio of 1 :1 .5 to 2:1 , betaine and malic acid, preferably with a molar ratio of 1 :2 to 2:1 , betaine and sorbitol, preferably with a molar ratio of 1 :2 to 2:1 , betaine and trehalose, preferably with a molar ratio of 3:1 to 5:1 , betaine and urea, preferably with a molar ratio of 2:1 to 1 :1 , most preferably betaine and sorbitol, preferably with a molar ratio of 1 :2 to 2:1 .

[0039] A preferred composition according to the instant invention is characterized in that said combination I is selected from glucose, sucrose and fructose, preferably with a molar ratio of 0.8 to 1 .5 : 0.8 to1 .5 : 0.8 to 1 .5, more preferably 0.9 to 1.1 : 0.9 to 1.1 : 0.9 to 1.1 , glucose, xylitol and fructose, preferably with a molar ratio of 0.7 to 1 .4 : 0.7 to 1 .4 : 0.7 to 1 .4, more preferably 0.9 to 1 .1 : 0.9 to 1 .1 : 0.9 to 1 .1 , glucose, sorbitol and fructose, preferably with a molar ratio of 0.7 to 1 .3 : 0.7 to 1 .5 : 0.7 to 1 .5, more preferably 0.9 to 1 .1 : 0.8 to 1 .2 : 0.8 to 1 .2, betaine, sucrose and proline, preferably with a molar ratio of 0.8 to 10 : 0.5 to 5 : 0.5 to 5, more preferably 1 to 8 : 1 to 5 : 1 to 5, most preferably 1 .5 to 3 : 0.8 to 2 : 0.8 to 2, 202300151 Foreign Filing 6 glycerol, sucrose and proline, preferably with a molar ratio of 2 to 20 : 0.5 to 8 : 0.5 to 8, more preferably 4 to 10 : 1 to 5 : 1 to 5, glycerol, xylitol and fructose, preferably with a molar ratio of 5 to 15 : 0.5 to 4 : 0.5 to 4, more preferably 6 to 10 : 1 to 3 : 1 to 3, malic acid, glucose and fructose, preferably with a molar ratio of 0.5 to 3 : 0.5 to 2 : 0.5 to 2, malic acid, proline and choline chloride, preferably with a molar ratio of 0.5 to 4 : 0.5 to 4 : 1 to 10, urea, glucose and citric acid, preferably with a molar ratio of 1 to 14 : 0.5 to 8 : 0.5 to 8, and urea, glucose and fructose, preferably with a molar ratio of 2 to 20 : 0.5 to 8 : 0.5 to 8.

[0040] A preferred composition according to the instant invention is characterized in that said combination

[0041] I is selected from betaine and ascorbic acid, preferably with a molar ratio of 1 :1 to 3:1 , and additionally comprising at least one member of the subgroup h consisting of ethanol, diols and triols with 6 or less carbon atoms, preferably 1 ,3- propanediol, butylene glycol, glycerol and hexanediol, with glycerol and 1 ,3-propanediol being most preferred.

[0042] A preferred composition according to the instant invention is characterized in that said combination

[0043] II additionally comprising water is is selected from citric acid and lactic acid, preferably with a molar ratio of 1 :4 to 1 :3, lactic acid and glycerol, preferably with a molar ratio of 1 :4 to 1 :3, lactic acid and citric acid, preferably with a molar ratio of 1 :4 to 1 :3, alternatively preferably with a molar ratio of 2:1 to 8:1 , glycerol and lactic acid, preferably with a molar ratio of 1 :4 to 1 :3, alternatively preferably with a molar ratio of 1 :2 to 2:1 , glycerol and transcutol, preferably with a molar ratio of 1 :4 to 1 :3, lactic acid and transcutol, preferably with a molar ratio of 1 :4 to 1 :3, transcutol and lactic acid, preferably with a molar ratio of 1 :4 to 1 :3, lactic acid and glycine, preferably with a molar ratio of 1 :4 to 1 :3, alternatively preferably with a molar ratio of 4:1 to 6:1 tetrabutylammonium bromide and oleic acid, preferably with a molar ratio of 1 :4 to 1 :3, more preferably 1 :2, tetrabutylammonium bromide and capric acid, preferably with a molar ratio of 1 :4 to 1 :3, more preferably 1 :2, and wherein glycerol and transcutol, lactic acid and transcutol, and glycerol and maleic acid are especially preferred. 202300151 Foreign Filing 7

[0044] A preferred composition according to the instant invention is characterized in that said combination

[0045] III is selected from thymol and caprylic acid, preferably with a molar ratio of 4:1 to 1 :3, more preferably 1 :2, thymol and pelargonic acid, preferably with a molar ratio of 4:1 to 1 :3, more preferably 1 :2, thymol and capric acid, preferably with a molar ratio of 4:1 to 1 :3, more preferably 1 :2 thymol and 10-undecelenic acid, preferably with a molar ratio of 2:1 to 1 :2, thymol and undecanoic acid, preferably with a molar ratio of 3:1 to 1 :1 , thymol and lauric acid, preferably with a molar ratio of 3:1 to 1 :1 , more preferably 2:1 , thymol and sodium caproyl / lauroyl lactylate preferably with a molar ratio of 5:1 to 1 :2, more preferably 2:1 , menthol and caprylic acid, preferably with a molar ratio of 4:1 to 1 :3, more preferably 1 :2, menthol and pelargonic acid, preferably with a molar ratio of 4:1 to 1 :3, more preferably 1 :2, menthol and capric acid, preferably with a molar ratio of 4:1 to 1 :3, more preferably 1 :2 menthol and 10-undecelenic acid, preferably with a molar ratio of 2:1 to 1 :2, menthol and undecanoic acid, preferably with a molar ratio of 3:1 to 1 :1 , menthol and lauric acid, preferably with a molar ratio of 3:1 to 1 :1 , more preferably 2:1 , menthol and myristic acid, preferably with a molar ratio of 3:1 to 1 :1 , more preferably 2:1 menthol and sodium caproyl / lauroyl lactylate preferably with a molar ratio of 5:1 to 1 :2, more preferably 2:1 , panthenol and caprylic acid, preferably with a molar ratio of 5:1 to 1 :3, more preferably 2:1 , panthenol and pelargonic acid, preferably with a molar ratio of 5:1 to 1 :3, more preferably 2:1 , panthenol and capric acid, preferably with a molar ratio of 5:1 to 1 :3, more preferably 2:1 , panthenol and 10-undecelenic acid, preferably with a molar ratio of 5:1 to 1 :3, more preferably 3:1 , panthenol and undecanoic acid, preferably with a molar ratio of 5:1 to 1 :3, preferably 3:1 , panthenol and lauric acid, preferably with a molar ratio of 4:1 to 1 :2, more preferably 3:1 , panthenol and sodium caproyl / lauroyl lactylate preferably with a molar ratio of 4:1 to 1 :4, more preferably 3:1 , eugenol and pelargonic acid, preferably with a molar ratio of 1 :1 , eugenol and lauric acid, preferably with a molar ratio of 1 :1 , eugenol and myristic acid, preferably with a molar ratio of 1 :1 , linanol and capric acid, preferably with a molar ratio of 1 :1 , linanol and myristic acid, preferably with a molar ratio of 1 :1 , linanol and palmitic acid, preferably with a molar ratio of 1 :1 , and linanol and stearic acid, preferably with a molar ratio of 1 :1 .

[0046] A preferred composition according to the instant invention is characterized in that said combination

[0047] IV is selected from pelargonic acid and capric acid / lauric acid, preferably in a molar ratio of 6:6:1 to 3:0:3, more preferably 3:2:1 to 3:1 :2, 202300151 Foreign Filing 8 caprylic acid and lauric acid, preferably in a molar ratio of 5:1 to 1 :4, more preferably 3:2 to 2:3, caprylic acid and myristic acid, preferably in a molar ratio of 5:1 to 1 :3, more preferably 3:1 to 1 :1 , caprylic acid and palmitic acid, preferably in a molar ratio of 3:1 to 1 :2, more preferably 2:1 to 1 :1 , and pelargonic acid and lauric acid, preferably in a molar ratio of 15:1 to 1 :5, more preferably 10:1 to 1 :4, most preferably from 4:1 to 1 :2.

[0048] A preferred composition according to the instant invention is characterized in that said combination V is selected from lactic acid and nicotinamide, preferably in a molar ratio of 10:1 to 1 :3, more preferably 5:1 to 1 :2, most preferably 3:1 to 1 :1 , lactic acid and creatine, preferably in a molar ratio of 9:1 to 1 :2, more preferably 6:1 to 1 :1 , citric acid and creatine, preferably in a molar ratio of 5:1 to 1 :2, more preferably 3:1 to 1 :1 , lactic acid and betaine, preferably in a molar ratio of 14:1 to 1 :3, more preferably 5:1 to 1 :2, lactic acid and glycine, preferably in a molar ratio of 15:1 to 1 :4, more preferably 10:1 to 5:1 , salicylic acid and betaine, preferably in a molar ratio of 3:1 to 1 :3, more preferably 2:1 to 1 :2, and para-toluenesulofnic acid and choline chloride in a molar ratio of 3:1 to 1 :3, more preferably 1 :1 to 1 :2.

[0049] Preferred compositions according to the invention are characterized in that component B) is comprised in an amount of from 50.0 wt-% to 99.95 wt-%, preferably from 60.0 wt-% to 99.5 wt-%, more preferably from 80.0 wt-% to 99.0 wt-%, where the percentages by weight refer to the total composition.

[0050] Preferred compositions according to the invention are characterized in that component A) is comprised in an amount of from 0.05 wt-% to 10 wt-%, preferably from 0.5 wt-% to 5.0 wt-%, more preferably from 1 .0 wt-% to 3.0 wt-%, wherein the percentages by weight refer to the total composition.

[0051] Preferred compositions according to the invention are characterized in that component A) is comprised in an amount of from from 1 .0 wt-% to 3.0 wt-%, and component B) is comprised in an amount of from from 80.0 wt-% to 99.0 wt-%, wherein the percentages by weight refer to the total composition. 202300151 Foreign Filing 9

[0052] Preferred compositions according to the invention are characterized in that they comprise at least one ceramide.

[0053] It is preferred in accordance with the invention that the composition according to the invention is characterized in that said at least one ceramide is selected from the group consisting of ceramide NP, ceramide AP, ceramide EOP, ceramide OP, ceramide NDS, ceramide ADS, ceramide EODS, ceramide NS, ceramide AS, ceramide EOS, ceramide OS, ceramide NH, ceramide AH, ceramide EOH, and ceramide OH, preferably selected from the group comprising ceramide NP, ceramide AP, ceramide NDS, most preferably ceramide NP.

[0054] A preferred composition according to the invention is characterized in that said composition comprises at least two ceramides, preferably at least three ceramides, particularly preferably precisely three ceramides.

[0055] Preferred compositions according to the invention are characterized in that they comprise at least one sphingoid base selected from sphingosine, sphinganine, 6-hydroxysphingosine and phytosphingosine, preferably phytosphingosine.

[0056] Preferred compositions according to the invention are characterized in that they comprise at least one pseudo-ceramide, in which the fatty acid joined by an amide bond, is substituted by a non-fatty carboxylic acid selected from salicylic acid, succinic acid, gluconic acid, lactobionic acid, cinnamic acid, mandelic acid, glycolic acid, malic acid, tartaric acid, hydroxy cinnamic acid, citric acid, vanillic acid and benzoic acid, more preferable salicylic acid, succinic acid, gluconic acid and lactobionic acid, most preferably salicylic acid.

[0057] The most preferred pseudo-ceramide in this context is salicyloyl phytosphingosine.

[0058] Preferred compositions according to the invention are characterized in that they comprise at least one ceramide and at least one sphingoid base.

[0059] In this context, the ceramides and sphingoid bases described above to be preferably comprised, are also preferably comprised in here.

[0060] A composition according to the invention is preferably characterized in that it comprises

[0061] C) cholesterol and / or at least one cholesterol derivative selected from the group comprising, preferably consisting of, cholesterol sulfate, cholesterol hydrogen succinate and 7- dehydrocholesterol, most preferably cholesterol. 202300151 Foreign Filing 10

[0062] Preferably component C) is comprised in an amount of from 0.05 wt-% to 3.0 wt-%, preferably from 0.1 wt-% to 2.0 wt-%, more preferably from 0.2 wt-% to 1 .0 wt-%, wherein the percentages by weight refer to the total composition.

[0063] Preferred compositions according to the invention are characterized in that component A) is comprised in an amount of from from 1 .0 wt-% to 3.0 wt-%, component B) is comprised in an amount of from from 80.0 wt-% to 99.0 wt-%, and component C) is comprised in an amount of from 0.2 wt-% to 1 .0 wt-% .wherein the percentages by weight refer to the total composition.

[0064] A composition according to the invention is preferably characterized in that it comprises D) at least one polyglycerol and / or polyglycerol ester.

[0065] Preferably component D) of the composition of the instant invention comprises at least one polyglycerol ester.

[0066] Preferably the weight ratio between component B) and component D) is in the range of from 99 to 1 , preferably from 50 to 1 , more preferably from 10 to 1 .

[0067] Preferred compositions according to the invention are characterized in that component A) is comprised in an amount of from from 1 .0 wt-% to 3.0 wt-%, component B) is comprised in an amount of from from 80.0 wt-% to 99.0 wt-%, component C) is comprised in an amount of from 0.2 wt-% to 1 .0 wt-%, wherein the percentages by weight refer to the total composition, and the weight ratio between component B) and component D) is in the range of from 10 to 1.

[0068] It is preferred in accordance with the invention that the composition according to the invention is characterized in that said composition has a pH in the range of 1 .5 to 7.5, preferably 2.0 to 6.5, particularly preferably 2.5 to 4.5, most preferably 3.1 to 3.9.

[0069] The present invention further relates to a process for producing a cosmetic or pharmaceutical formulation comprising at least one selected from ceramides, sphingoid bases and pseudoceramides, the latter being ceramides, in which the fatty acid joined by an amide bond, is substituted by a non-fatty carboxylic acid, comprising the process steps of: a) providing a composition according to the instant invention; 202300151 Foreign Filing 11 b) mixing the composition with at least one cosmetically and / or pharmaceutically acceptable carrier and at least one selected from cosmetical and pharmaceutical active components.

[0070] Said at least one cosmetically and / or pharmaceutically acceptable carrier is preferably selected from cosmetic oils, cosmetic waxes and water, preferably water.

[0071] The cosmetical and pharmaceutical active components of step b) are, of course different from any component A) to D) comprised in the composition of the instant invention.

[0072] Preferred compositions according to the instant invention are preferably used in the context of the process according to the instant invention.

[0073] A preferred process according to the instant invention is characterized in that said process comprises c) emulsification of the formulation.

[0074] In consequence, cosmetic or pharmaceutical formulation produced by the process according to the instant invention preferably is an emulsion, in particular an oil-in-water emulsion.

[0075] To facilitate the emulsification step c) of the process according to the instant invention it is preferred in accordance with the invention that the at least one emulsifier is present in process step c).

[0076] The term "emulsifier" in the context of the present invention is understood to mean organic substances having surface-active properties which may have the ability to lower the surface tension of water at 20°C and at a concentration of 0.5% by weight, based on the total composition, to less than 45 mN / m, and for which there is no pH between 2 and 12, in which at 20°C, at least 50 mol% of the molecules are ionically charged. Thus, these substances are overall mostly uncharged from the outside at all pH values between 2 and 12.

[0077] The surface tension is determined here by the ring method in accordance with du Nouy at 20°C. Emulsifiers preferably present are selected from the group of acyl lactylates (especially sodium lauroyl lactylate), ethoxylated fatty alcohols (especially ceteareth-25), ethoxylated fatty acids (especially PEG_100 stearates), polyglycerol esters (especially polyglyceryl-3 methylglucose distearate, polyglyceryl-6 stearate, polyglyceryl-6 behenate, polyglyceryl-10 stearate), glycerol esters, (especially glyceryl stearate citrate), ethoxylated sorbitan esters, lecithin, hydrogenated lecithin, phosphatidylcholin and hydrogenated phosphatidylcholin.

[0078] The term "acyl lactylate" in the context of the present invention is understood to mean salt-form reaction products of fatty acid with lactic acid and / or polylactic acid. 202300151 Foreign Filing 12

[0079] A preferred process according to the instant invention is characterized in that said process comprises d) adjusting the pH of the formulation to a range of 4.0 to 8.0, preferably 4.5 to 7.4 particularly preferably 5.0 to 12.

[0080] The formulations prepared by the process according to the instant invention are in particular physically stable formulations. In the context of the present invention, the term "physically stable formulations containing at least one ceramide and / or sphingoid base " is understood in particular to mean formulations which in particular do not exhibit any crystallization of the ceramide and no separation or inhomogeneity after six months of storage at 25°C.

[0081] The present invention further relates to the use of at least one of the component B) as defined above for any composition according to the instant invention for physical stabilization of a composition comprising at least one selected from ceramides, sphingoid bases and pseudoceramides, the latter being ceramides, in which the fatty acid joined by an amide bond, is substituted by a non-fatty carboxylic acid, in particular with regard to homogeneity, and / or for preventing crystallization of at least one ceramide and / or pseudo-ceramide, the latter being a ceramide, in which the fatty acid joined by an amide bond, is substituted by a non-fatty carboxylic acid, in a composition

[0082] In the context of the use according to the instant invention the compositions comprising at least one selected from ceramides, sphingoid bases and pseudo-ceramides, the latter being ceramides, in which the fatty acid joined by an amide bond, is substituted by a non-fatty carboxylic acid, are preferably equal to the preferred compositions according to the instant invention, especially regarding component A), and the component B) preferably used is preferably equal to the preferred component B) of the preferred compositions according to the instant invention.

[0083] The examples adduced hereinafter describe the present invention by way of example, without any intention that the invention, the scope of application of which is apparent from the entirety of the description and the claims, be restricted to the embodiments specified in the examples.

[0084] Examples:

[0085] Example 1: Preparation of component B) 202300151 Foreign Filing 13

[0086] The substances comprised in component B) were weighed into a container, if the case water was added. This composition was mixed in a “Speedmixer” (Hausschild, Germany) for 2 minutes at 3000 rpm. After mixing, the mixture became a clear, homogenous liquid. The liquid was transferred into glass containers to re-check if any solids remained.

[0087] Example 2: Preparation of component B) and component A)

[0088] Components B) prepared as described in example 1 were mixed with ceramides at room temperature. The mixture was allowed to be stirred for 24 hours at room temperature, the mixture was checked for homogeneity by eye. Mixtures which did not form homogeneous mixtures with ceramides are saturated.

[0089] The following tables are showing different combination of component B) and their groups l-V. Each subgroup Xi and X2 and if the case X3 with X = I to V of the following group

[0090] 202300151 Foreign Filing 14 202300151 Foreign Filing 15

[0091] The following tables are showing examples of combinations component B) with component A), component C) and / or component D)

[0092] Mix_l: example 1-10 202300151 Foreign Filing 16

[0093] Mix_l: example 11-20

[0094] Mix_l: example 21-30

[0095] Mix_l: example 31-40 202300151 Foreign Filing 17

[0096] Mix_ll: example 1-10

[0097] Mix_ll: example 11-20 202300151 Foreign Filing 18

[0098] Mix_lll: example 1-10

[0099] Mix_lll: example 11-20

[0100] Mix_IV: example 1-10 202300151 Foreign Filing 19

[0101] Mix_IV: example 11-20

[0102] Mix_V: example 1-10 202300151 Foreign Filing 20 Turbid, stable, no crystals

[0103] Mix_V: example 11-20

[0104] Mix_water: example 1-10 Example 3: Combination of more than one component B)

[0105] Combinations of CBs were also prepared, e.g. a combination of CB 3, CB 8 and CB 45 in mass ratio 1 :1 :1 resulted also in a clear liquid which was used to prepare a dispersion of ceramides 202300151 Foreign Filing 21

[0106] Example 4: Commercial Ceramide blends in different water concentrations in component B)

[0107] A systematic variation of a mixture of component B) based on sorbitol and betaine with water was conducted.

[0108] The amounts of Polyglyceryl ester (Polyglyceryl-10 Stearate; Polyglyceryl-6 Behenate), Hairflux® and Bodyflux® were always 5 %, 5 % and 2 %, all formulations were physically stable.

[0109] The formulations were stored in open containers located in the lab on the lab bench and optically inspected with respect to microbially contamination for 26 weeks.

[0110] Hairflux® (Olea Europaea (Olive) Fruit Oil; Ricinus Communis (Castor) Seed Oil; Ceramide NDS) and Bodyflux® (Ceramide NP)

[0111] Example 4b: Commercial Ceramide blends in different water concentrations in component B)

[0112] Systematic variations of mixture of component B) with water were conducted.

[0113] The amounts of Hairflux® and Bodyflux® were always 5 % and 2 %, all formulations were physically stable.

[0114] The formulations were stored in open containers located in the lab on the lab bench and optically inspected with respect to microbially contamination for 26 weeks. 202300151 Foreign Filing 22

[0115] X w = contamination after W week(s), nc = no comtamination, solid = precipitate 202300151 Foreign Filing 23

[0116] Example 5: Commercial Ceramide blends in component B) plus surfactants

[0117] In another set of experiments, different emulsifiers were tested for their usability in the compositions according to the instant invention.

[0118] Component B) was based on 36,17 % Sorbitol, 26,83 % TMG and 25 % water. All formulations contained 5 % emulsifier / surfactant (as listed in the table below), 2 % Bodyflux® and 5 % Hairflux®.

[0119] Rhamnolipids (Tego® Rheance One) of Evonik which has an active matter of 50 % was added by 10 % to the formulation, the amount of water was reduced by 5 % from 25 % to 20 % water.

[0120] Example 6: Example formulations

[0121] Each of the formulations below was produced while incorporating each of the 120 examples “1-40 of MixJ”, “1-20 of MixJI”, “1-20 of MixJII”, “1-20 of MixJV” and “1-20 of Mix_V” into examples formulations listed; the 120 examples are depicted as “No. X” below.

[0122] Face cream 202300151 Foreign Filing 24

[0123] Preparation: Heat phase A and B to 85 °C. Add phase A to B with stirring. Homogenize. Cool down while stirring to 40 °C. Add phase C, D and E. Cool down while stirring to 30 °C. Face cream 202300151 Foreign Filing 25

[0124] Preparation: Heat phase A and B to 85 °C. Add phase A to B with stirring. Homogenize. Cool down while stirring to 40 °C. Add phase C, D and E. Cool down while stirring to 30 °C. Face cream III 202300151 Foreign Filing 26

[0125] Preparation: Heat phase A and B to 85 °C. Add phase A to B with stirring. Homogenise. Cool down while stirring to 40 °C. Add phase C and D. Cool down while stirring to 30 °C. O / W Night Cream

[0126] Preparation: Heat phase A and phase B to approx. 80°C. Add phase A to phase B with stirring. Homogenize. Cool down to approx. 60°C with gentle stirring. Add phase C and homogenize for a short while. Cool down to room temperature, adjust the pH with phase D. Add phase E and phase Z, stir well.

[0127] O / W lotion, moisturizing skin fluid 202300151 Foreign Filing 27

[0128] Preparation:

[0129] Heat phase A and B to 85 °C. Add phase A to B with stirring. Homogenise. Cool with gentle stirring to approx. 40 °C and add phase C. Homogenise for a short time. Add phase D, E and F step by step.

[0130] Sunscreen SPF 50 202300151 Foreign Filing 28

[0131] Preparation:

[0132] Heat phase A and B separately to approx. 85 °C. Add phase A to B. Homogenize. Cool with gentle stirring to approx. 50 °C, then add phase C. Homogenise. Cool with gentle stirring to approx. 35 °C, then add phase D, E, F and G.

[0133] 202300151 Foreign Filing 29

[0134] Face Care SPF 50

[0135] Preparation:

[0136] Heat phase A and B separately to approx. 80 °C. Add phase B to A without stirring. Homogenize.

[0137] Cool down to 60 °C and add phase C. Homogenize. Cool with gentle stirring and add phase D below 40°C. Stir well until uniform.

[0138] Microemulsion 202300151 Foreign Filing 30

[0139] Preparation:

[0140] Add phase B to phase A slowly while stirring. Add phase C, D, E and F step by step. Adjust pH with phase G to pH 5-5.5.

[0141] Facial Cleanser

[0142] Preparation

[0143] Heat phase A up to 85 °and stirr until it is clear. Add phase B to A slowly with gentle stirring. Cool down to 30 °C. Add phase C. Adjust pH with phase D between 5.0-5.5.

[0144] Shampoo 202300151 Foreign Filing 31

[0145] Preparation:

[0146] Mix Sodium Laureth Sulfate, dermofeel® sensolv MB, dermofeel® G10 LW 70 MB until the solution is clear, heat if necessary. Add the other ingredients step by step in the given order. Cool down while stirring to 30 °C.

[0147] Oral Care (Mouth Wash)

[0148] Preparation

[0149] Dissolve the flavour in RHEANCE One. Add the water slowly while stirring, then add the remaining ingredients in the given order.

[0150] Toothpaste

[0151] Preparation 202300151 Foreign Filing 32

[0152] Phase A: Disperse the Blanose into the water. Swelling time: 30-45 min. After swelling process, humectants are dispersed.

[0153] Phase B: Components of Phase B are added while mixing, using vacuum if necessary. Mixing time: 5-10 min.

[0154] Phase C: Components of C are added to the premixed disperision by using low mixing speed. After that, mixing speed is increased. During mixing process vacuum is started. Mixing time: approx. 15- 20 min.

[0155] Phase D: During mixing process, oils are added.

[0156] Phase E: Components of E are added by using low mixing speed. After that, the whole mixture must be dispersed by using vacuum for about 10 min.

[0157] Finished toothpaste can be filled into tubes.

[0158] Deo Roll-On

[0159] Preparation

[0160] Heat phase A up to 80 °C and disperse phase B in A. Heat phase C up to 85 °C separately. Add phase C into phae A / B. Cool down to 35 °C and add phase D in the given order under slowly stirring. Add phase E to adjust the pH value. 202300151 Foreign Filing 33

[0161] Clear Deo Spray

[0162] Preparation

[0163] Premix phase A and make sure that all ingredients are solved. Premix phase B under stirring and add slowly into phase A while stirring. Adjust the pH value.

[0164] Shower Gel

[0165] Preparation

[0166] Mix the ingredients slowly step by step in the given order while stirring. 202300151 Foreign Filing 34

[0167] Facial Mask

[0168] Preparation Heat phase A and B to 85 °C. Add phase A to B with stirring. Homogenize. Cool with gentle stirring to 50 °C. Add phase C at about 50 °C. Homogenize again for a short time. Cool with gentle stirring to appr. 35 °C. Prepare phase D. Add phase D with stirring. Add phase E. Adjust pH with phase F to 4.0-5.0.

[0169] Hair Conditioner 202300151 Foreign Filing 35

[0170] Preparation

[0171] Heat phase A and B to 85 °C. Add phase B to phase A without stirring. Homogenize. Cool down to 30 °C while stirring. Add phase C and D.

[0172] W / O Soft Cream

[0173] Preparation

[0174] Heat phase A to approx. 85 °C. Add phase B (80 °C or room temperature) slowly while stirring.

[0175] Homogenise for a short time. Cool with gentle stirring below 30 °C and add phase C. homogenise again for a short time.

[0176] Moisturizing W / O Lotion (cold-processable) 202300151 Foreign Filing 36

[0177] Preparation

[0178] Disperse phase A with Ultra Thurrax. Add phase B to phase A while stirring. Add phase C.

[0179] Homogenize.

[0180] Beard Oil

[0181] Preparation

[0182] 1 . Mix ingredients of phase A and heat to approx. 35 °C.

[0183] 2. Stir well until all ingredients are dissolved.

[0184] Lip Balm 202300151 Foreign Filing 37

[0185] Preparation

[0186] 1 . Mix ingredients one after the other and heat up to 65°C under medium stirring until a clear solution is obtained.

[0187] 2. Start to cool down under medium stirring and stir until a turbid oil solution is obtained (point of turbidity approx. 36°C).

[0188] 3. Homogenize for 1 min. using an Ultra Turrax.

[0189] 4. Leave batch untouched until a homogeneous gel is obtained and fill in containers. Skin Lift Serum

[0190] Preparation

[0191] Add phase A ingredients one by one with stirring. Predissolve the transparent xanthan gum with glycerin and add it to the rest. Check that the gel has formed without lumps left undissolved Add phase B to phase A. Adjust pH if is necessary

[0192] Oil Infused Micellar Water 202300151 Foreign Filing 38

[0193] Preparation

[0194] Blend phases A and B separately in the given order. Add B to A while stirring. Adjust pH to 6.0. Daily Wear SPF Foundation 202300151 Foreign Filing 39

[0195] Preparation

[0196] Heat phase A up to 60°C while stirring. Heat phase B up to 85°C. Make sure Phytosphingosine is completely dissolved. Blend ingredients of phase C and add to phase B. Homogenize. Slowly add phase A to phase B / C while stirring and homogenize using an Ultra Turrax. Cool down to room temperature and add ingredients of phase D below 40°C.

[0197] Hair Treatment

[0198] Preparation Heat phase A and B to 85°C. Add phase B to phase A without stirring. Homogenize. Cool slowly with stirring and add phase Z when less than 40°C.

[0199] Hair Detangling Spray 202300151 Foreign Filing 40

[0200] Preparation

[0201] Blend all ingredients in given order and heat up to 80 C. Adjust pH if needed.

Claims

202300151 Foreign Filing 41Claims1 . A composition comprisingA) at least one selected from ceramides, sphingoid bases and pseudo-ceramides, the latter being ceramides, in which the fatty acid joined by an amide bond, is substituted by a non-fatty carboxylic acid, andB) at least one combination of at least one different member of each subgroup Xi and X2 and if the case optionally X3 with X = I to V of the following group combination I selected from the subgroup I1 consisting of betaine, choline chloride, citric acid, creatine, creatinine, ectoine, fructose, glucose, glycerol, glycine, malic acid, maltose, mannose, proline, rhamnose, sophorose, sorbitol, sucrose, tetraalkylammonium halogenide, trehalose, urea, xylitol and zinc(ll)chloride, the subgroup h consisting of ascorbic acid, betaine, choline chloride, citric acid, erythritol, ethylene glycol, fructose, glucose, glycerol, isomaltose, malic acid, maltose, mannitol, mannose, proline, rhamnose, sophorose, sorbitol, sucrose, threitol, trehalose, urea, xylitol and zinc(ll)chloride, the subgroup I3 consisting of betaine, choline chloride, citric acid, erythritol, ethylene glycol, fructose, glucose, glycerol, isomaltose, malic acid, maltose, mannitol, mannose, proline, rhamnose, sophorose, sorbitol, sucrose, threitol, trehalose, urea, xylitol and zinc(ll)chloride, combination II selected from the subgroup Hi consisting of citric acid, glycerol, lactic acid, maleic acid, malic acid and tetraalkyllammonium halogenide, and the subgroup II2 consisting of capric acid, caprylic acid, citric acid, diethylenglycolmonoethylether, glycerol, glycine, lactic acid, oleic acid, perlargonic acid, pyroglutamic acid, transcutol and undecelynic acid, combination III selected from the subgroup Illi consisting of beta-citronellol, camphor, carvacrol, carvone, eugenol, fenchone, geraniol, linalool, menthol, panthenol and thymol, and the subgroup III2 consisting of arachic acid, arachidonic acid, behenic acid, capric acid, caproic acid, caprylic acid, docosahexaenoic acid, eicosapentaenoic acid, elaidic acid, erucic acid, gadoleic acid, isostearic acid, lauric acid, linoleic acid, linolenic acid, myristic acid, oleic acid, palmitic acid, palmitoleic acid, pelargonic acid, petroselinic acid, sodium lauryl lactylate, stearic acid and undecylenic acid, preferably capric acid, pelargonic acid and sodium lauryl lactylate,202300151 Foreign Filing 42 combination IV selected from the subgroup IVi consisting of fatty acids, preferably selected from the group consisting of arachic acid, arachidonic acid, behenic acid, capric acid, caproic acid, caprylic acid, docosahexaenoic acid, eicosapentaenoic acid, elaidic acid, erucic acid, gadoleic acid, isostearic acid, lauric acid, linoleic acid, linolenic acid, myristic acid, oleic acid, palmitic acid, palmitoleic acid, pelargonic acid, petroselinic acid, stearic acid and undecylenic acid, with capric acid, caproic acid, caprylic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, palmitoleic acid, perlagonic acid and undecylenic acid being preferred, with caproic acid, caprylic acid, capric acid, perlagonic acid and undecylenic acid being especially preferred, and the subgroup IV2 consisting of fatty acids as named in IV1, and combination V selected from the subgroup Vi consisting of anisic acid, benzoic acid, cinnamic acid, citric acid, lactic acid, m-cresol, o-cresol, para-toluenesulfonic acid, p-cresol, phenol, phenylacetic acid and salicylic acids, and the subgroup V2 consisting of benzoic alcohol, betaine, choline chloride, creatine, creatinine, ectoine, glycine, niacin, nicotinamide, proline and tetraalkyllammonium halogenide.

2. Composition according to claim 1 , characterized in that said combination I, II or V additionally comprises water, preferably in an amount of from 6.0 wt.-% to 60 wt.%, wherein the weight percentages refer to the total sum of respective Xi and respective X2 and water.

3. Composition according to claim 1 or 2, characterized in that said combination I is selected from betaine and ascorbic acid, preferably with a molar ratio of 1 :1 to 3:1 , betaine and glucose, preferably with a molar ratio of 3:1 to 5:1 , alternatively preferably with a molar ratio of 1 :2 to 2:1 , betaine and glycerol, preferably with a molar ratio of 1 :1 .5 to 2:1 , betaine and glycerol, preferably with a molar ratio of 1 :2 to 1 :5, more preferably 1 :3 to 1 :4, betaine and malic acid, preferably with a molar ratio of 1 :2 to 2:1 , betaine and sorbitol, preferably with a molar ratio of 1 :2 to 2:1 , betaine and trehalose, preferably with a molar ratio of 3:1 to 5:1 , betaine and urea, preferably with a molar ratio of 2:1 to 1 :1 , choline chloride and glucose, preferably with a molar ratio of 1 :3 to 1 :5, choline chloride and urea, preferably with a molar ratio of 1 :1 to 1 :3, glycerol and glycine, preferably with a molar ratio of 2:1 to 4:1 glycerol and citric acid, preferably with a molar ratio of 1 :1 to 3:1 ,202300151 Foreign Filing 43 urea and choline chloride, preferably with a molar ratio of 1 :1 to 3:1 , proline and urea, preferably with a molar ratio of 1 :1 to 1 :3, more preferably 1 :1 to 1 :2, and proline and sorbitol, preferably with a molar ratio of 1 :2 to 2:1 .

4. Composition according to claim 1 or 2, characterized in that said combination I is selected from glucose, sucrose and fructose, preferably with a molar ratio of 0.8 to 1 .5 : 0.8 to1 .5 : 0.8 to 1 .5, more preferably 0.9 to 1 .1 : 0.9 to 1 .1 : 0.9 to 1 .1 , glucose, xylitol and fructose, preferably with a molar ratio of 0.7 to 1 .4 : 0.7 to 1 .4 : 0.7 to 1 .4, more preferably 0.9 to 1 .1 : 0.9 to 1 .1 : 0.9 to 1 .1 , glucose, sorbitol and fructose, preferably with a molar ratio of 0.7 to 1 .3 : 0.7 to 1 .5 : 0.7 to 1 .5, more preferably 0.9 to 1 .1 : 0.8 to 1 .2 : 0.8 to 1 .2, betaine, sucrose and proline, preferably with a molar ratio of 0.8 to 10 : 0.5 to 5 : 0.5 to 5, more preferably 1 to 8 : 1 to 5 : 1 to 5, most preferably 1 .5 to 3 : 0.8 to 2 : 0.8 to 2, glycerol, sucrose and proline, preferably with a molar ratio of 2 to 20 : 0.5 to 8 : 0.5 to 8, more preferably 4 to 10 : 1 to 5 : 1 to 5, glycerol, xylitol and fructose, preferably with a molar ratio of 5 to 15 : 0.5 to 4 : 0.5 to 4, more preferably 6 to 10 : 1 to 3 : 1 to 3, malic acid, glucose and fructose, preferably with a molar ratio of 0.5 to 3 : 0.5 to 2 : 0.5 to 2, malic acid, proline and choline chloride, preferably with a molar ratio of 0.5 to 4 : 0.5 to 4 : 1 to 10, urea, glucose and citric acid, preferably with a molar ratio of 1 to 14 : 0.5 to 8 : 0.5 to 8, and urea, glucose and fructose, preferably with a molar ratio of 2 to 20 : 0.5 to 8 : 0.5 to 8.

5. Composition according to claim 1 or 2, characterized in that said combination I is selected from betaine and glucose, preferably with a molar ratio of 3:1 to 5:1 , betaine and glycerol, preferably with a molar ratio of 1 :1 .5 to 2:1 , betaine and malic acid, preferably with a molar ratio of 1 :2 to 2:1 , betaine and sorbitol, preferably with a molar ratio of 1 :2 to 2:1 , betaine and trehalose, preferably with a molar ratio of 3:1 to 5:1 , betaine and urea, preferably with a molar ratio of 2:1 to 1 :1 , most preferably betaine and sorbitol, preferably with a molar ratio of 1 :2 to 2:1 .

6. Composition according to claim 1 or 2, characterized in that said combination II is selected from citric acid and lactic acid, preferably with a molar ratio of 1 :4 to 1 :3, lactic acid and glycerol, preferably with a molar ratio of 1 :4 to 1 :3,202300151 Foreign Filing 44 lactic acid and citric acid, preferably with a molar ratio of 1 :4 to 1 :3, alternatively preferably with a molar ratio of 2:1 to 8:1 , glycerol and lactic acid, preferably with a molar ratio of 1 :4 to 1 :3, alternatively preferably with a molar ratio of 1 :2 to 2:1 , glycerol and transcutol, preferably with a molar ratio of 1 :4 to 1 :3, lactic acid and transcutol, preferably with a molar ratio of 1 :4 to 1 :3, transcutol and lactic acid, preferably with a molar ratio of 1 :4 to 1 :3, lactic acid and glycine, preferably with a molar ratio of 1 :4 to 1 :3, alternatively preferably with a molar ratio of 4:1 to 6:1 tetrabutylammonium bromide and oleic acid, preferably with a molar ratio of 1 :4 to 1 :3, more preferably 1 :2, tetrabutylammonium bromide and capric acid, preferably with a molar ratio of 1 :4 to 1 :3, more preferably 1 :2, and wherein glycerol and transcutol, lactic acid and transcutol, and glycerol and maleic acid are especially preferred.

7. Composition according to claim 1 or 2, characterized in that said combination III is selected from thymol and caprylic acid, preferably with a molar ratio of 4:1 to 1 :3, more preferably 1 :2, thymol and pelargonic acid, preferably with a molar ratio of 4:1 to 1 :3, more preferably 1 :2, thymol and capric acid, preferably with a molar ratio of 4:1 to 1 :3, more preferably 1 :2 thymol and 10-undecelenic acid, preferably with a molar ratio of 2:1 to 1 :2, thymol and undecanoic acid, preferably with a molar ratio of 3:1 to 1 :1 , thymol and lauric acid, preferably with a molar ratio of 3:1 to 1 :1 , more preferably 2:1 , thymol and sodium caproyl / lauroyl lactylate preferably with a molar ratio of 5:1 to 1 :2, more preferably 2:1 , menthol and caprylic acid, preferably with a molar ratio of 4:1 to 1 :3, more preferably 1 :2, menthol and pelargonic acid, preferably with a molar ratio of 4:1 to 1 :3, more preferably 1 :2, menthol and capric acid, preferably with a molar ratio of 4:1 to 1 :3, more preferably 1 :2 menthol and 10-undecelenic acid, preferably with a molar ratio of 2:1 to 1 :2, menthol and undecanoic acid, preferably with a molar ratio of 3:1 to 1 :1 , menthol and lauric acid, preferably with a molar ratio of 3:1 to 1 :1 , more preferably 2:1 , menthol and myristic acid, preferably with a molar ratio of 3:1 to 1 :1 , more preferably 2:1 menthol and sodium caproyl / lauroyl lactylate preferably with a molar ratio of 5:1 to 1 :2, more preferably 2:1 , panthenol and caprylic acid, preferably with a molar ratio of 5:1 to 1 :3, more preferably 2:1 , panthenol and pelargonic acid, preferably with a molar ratio of 5:1 to 1 :3, more preferably2:1 , panthenol and capric acid, preferably with a molar ratio of 5:1 to 1 :3, more preferably 2:1 ,202300151 Foreign Filing 45 panthenol and 10-undecelenic acid, preferably with a molar ratio of 5:1 to 1 :3, more preferably 3:1 , panthenol and undecanoic acid, preferably with a molar ratio of 5:1 to 1 :3, preferably 3:1 , panthenol and lauric acid, preferably with a molar ratio of 4:1 to 1 :2, more preferably 3:1 , panthenol and sodium caproyl / lauroyl lactylate preferably with a molar ratio of 4:1 to 1 :4, more preferably 3:1 , eugenol and pelargonic acid, preferably with a molar ratio of 1 :1 , eugenol and lauric acid, preferably with a molar ratio of 1 :1 , eugenol and myristic acid, preferably with a molar ratio of 1 :1 , linanol and capric acid, preferably with a molar ratio of 1 :1 , linanol and myristic acid, preferably with a molar ratio of 1 :1 , linanol and palmitic acid, preferably with a molar ratio of 1 :1 , and linanol and stearic acid, preferably with a molar ratio of 1 :1 .

8. Composition according to claim 1 or 2, characterized in that said combination IV is selected from pelargonic acid and capric acid / lauric acid, preferably in a molar ratio of 6:6:1 to 3:0:3, more preferably 3:2:1 to 3:1 :2, caprylic acid and lauric acid, preferably in a molar ratio of 5:1 to 1 :4, more preferably 3:2 to 2:3, caprylic acid and myristic acid, preferably in a molar ratio of 5:1 to 1 :3, more preferably 3:1 to 1 :1 , caprylic acid and palmitic acid, preferably in a molar ratio of 3:1 to 1 :2, more preferably 2:1 to 1 :1 , and pelargonic acid and lauric acid, preferably in a molar ratio of 15:1 to 1 :5, more preferably 10:1 to 1 :4, most preferably from 4:1 to 1 :2.

9. Composition according to claim 1 or 2, characterized in that said combination V is selected from lactic acid and nicotinamide, preferably in a molar ratio of 10:1 to 1 :3, more preferably 5:1 to1 :2, most preferably 3:1 to 1 :1 , lactic acid and creatine, preferably in a molar ratio of 9:1 to 1 :2, more preferably 6:1 to 1 :1 , citric acid and creatine, preferably in a molar ratio of 5:1 to 1 :2, more preferably 3:1 to 1 :1 , lactic acid and betaine, preferably in a molar ratio of 14:1 to 1 :3, more preferably 5:1 to 1 :2, lactic acid and glycine, preferably in a molar ratio of 15:1 to 1 :4, more preferably 10:1 to 5:1 , salicylic acid and betaine, preferably in a molar ratio of 3:1 to 1 :3, more preferably 2:1 to 1 :2, and para-toluenesulofnic acid and choline chloride in a molar ratio of 3:1 to 1 :3, more preferably 1 :1 to 1 :2.202300151 Foreign Filing 4610. Composition according to at least one of the preceding claims, characterised in that component B) is comprised in an amount of from 50.0 wt-% to 99.95 wt-%, preferably from 60.0 wt-% to 99.5 wt-%, more preferably from 80.0 wt-% to 99.0 wt-%, where the percentages by weight refer to the total composition.

11. Composition according to at least one of the preceding claims, characterized in that component A) is comprised in an amount of from 0.05 wt-% to 10 wt-%, preferably from 0.5 wt-% to 5.0 wt-%, more preferably from 1 .0 wt-% to 3.0 wt-%, wherein the percentages by weight refer to the total composition.

12. Composition according to at least one of the preceding claims, characterized in that component A) is selected from the group consisting of ceramide NP, ceramide AP, ceramide EOP, ceramide OP, ceramide NDS, ceramide ADS, ceramide EODS, ceramide NS, ceramide AS, ceramide EOS, ceramide OS, ceramide NH, ceramide AH, ceramide EOH, ceramide OH, sphingosine, sphinganine, 6-hydroxysphingosine and phytosphingosine, salicyloyl phytosphingosine preferably selected from the group consisting of ceramide NP, ceramide AP, ceramide NDS, phytosphingosine and salicyloyl phytosphingosine, most preferably ceramide NP.

13. Composition according to at least one of the preceding claims, characterized in that it comprisesC) cholesterol and / or at least one cholesterol derivative selected from the group comprising cholesterol sulfate, cholesterol hydrogen succinate and 7- dehydrocholesterol, wherein preferably component C) is comprised in an amount of from 0.05 wt-% to 3.0 wt-%, preferably from 0.1 wt-% to 2.0 wt-%, more preferably from 0.2 wt-% to 1 .0 wt-%, wherein the percentages by weight refer to the total composition.

14. Process for producing a cosmetic or pharmaceutical formulation comprising at least one selected from ceramides, sphingoid bases and pseudo-ceramides, the latter being ceramides, in which the fatty acid joined by an amide bond, is substituted by a non-fatty carboxylic acid, comprising the process steps of: a) providing a composition according to at least one of the claims 1 to 13; b) mixing the composition with at least one cosmetically and / or pharmaceutically acceptable carrier and at least one selected from cosmetical and pharmaceutical active components.

15. Use of at least one of the component B) as defined in any of the claims 1 to 13 for physical stabilization of a composition comprising at least one selected from ceramides, sphingoid bases and pseudo-ceramides, the latter being ceramides, in which the fatty acid joined by an202300151 Foreign Filing 47 amide bond, is substituted by a non-fatty carboxylic acid, in particular with regard to homogeneity, and / or for preventing crystallization of at least one ceramide and / or pseudoceramide, the latter being a ceramide, in which the fatty acid joined by an amide bond, is substituted by a non-fatty carboxylic acid, in a composition.

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