Positioning sample feeding device and dissolution tester

Abstract

The utility model provides a positioning sample feeding device and a dissolution tester, and belongs to the technical field of medicine dissolution equipment. The positioning sample feeding device comprises a telescopic sample feeding pipe, a telescopic sample feeding pipe lifting control system and a fixator, the telescopic sample feeding pipe comprises an inner pipe and an outer pipe arranged on the outer side of the inner pipe in a sealing and sleeving mode, the inner pipe is fixed to a panel of the dissolution tester through the fixator, and the telescopic sample feeding pipe lifting control system controls the outer pipe to axially stretch out and draw back relative to the inner pipe. The telescopic lofting pipe lifting control system controls the outer pipe of the telescopic lofting pipe to axially move, the outer pipe moves to the bottom of the dissolution cup before a sample is put, the outer pipe of the telescopic lofting pipe moves to the top of the dissolution cup after the sample is put, and the sample naturally falls into the bottom of each dissolution cup along the inner wall of the telescopic lofting pipe in the process of falling into the dissolution cup, so that the sample is completely put into the dissolution cup. The effect of accurate positioning sample feeding is achieved, and the accuracy and the stability of the dissolution tester for detecting the drug dissolution rate are improved.

Description

Technical Field

[0001] This utility model relates to the field of dissolution equipment technology, specifically to a positioning and sampling device and a dissolution tester. Background Technology

[0002] A dissolution tester is a pharmaceutical testing instrument specifically designed to detect the dissolution rate of oral solid dosage forms (such as tablets, capsules, and granules). It simulates the human gastrointestinal environment and digestive process, serving as an in vitro testing device for controlling the dissolution of pharmaceutical preparations. It is widely used in drug research, production, and testing. With increasing demands for accuracy, dissolution testers are often equipped with a positioning sample delivery device to prevent the influence of sample drop differences at the bottom of the dissolution vessel on the test results.

[0003] Currently, dissolution testers on the market are equipped with different sampling devices. However, in general, the existing dissolution testers only complete the sampling above the dissolution cup. There is no positioning sampling device inside the dissolution cup. Because the angle at which the sample falls into the dissolution cup is different, the dissolution liquid will change the trajectory of the sample, thus failing to achieve the effect of positioning sampling. The difference in the flow rate of the dissolution liquid between the bottom and the side bottom of the dissolution cup leads to a large difference in the test results.

[0004] Therefore, there is an urgent need to develop a positioning and dissolution testing device and a dissolution tester that can ensure that the sample achieves the desired positioning and dissolution effect. Utility Model Content

[0005] The technical problem to be solved by this application is to address the shortcomings of the existing technology by providing a positioning and sampling device and a dissolution tester. The positioning and sampling device can accurately position and sample, thereby improving the accuracy and stability of the dissolution tester in detecting the dissolution of drugs.

[0006] This application addresses the problems of the related technologies from at least the following aspects:

[0007] Therefore, the first aspect of this application provides a positioning and sampling device, including a telescopic sampling tube, a telescopic sampling tube lifting control system, and a fixer, wherein the telescopic sampling tube includes an inner tube and an outer tube sealed outside the inner tube, the inner tube is fixed to the panel of the dissolution tester by the fixer, and the telescopic sampling tube lifting control system controls the axial extension and retraction of the outer tube relative to the inner tube.

[0008] Furthermore, the telescopic sampling tube lifting control system of the positioning sampling device includes a lifting control panel and a gear electrically connected to the lifting control panel, and a rack connected to the gear teeth. The rack is located on the top of the outer tube side wall. The lifting control panel controls the movement of the outer tube by controlling the rotation of the gear to drive the movement of the rack.

[0009] Furthermore, the rack in the positioning and sampling device extends axially along the outer tube; the top of the outer tube sidewall is serrated, or the rack is installed on the top of the outer tube sidewall.

[0010] Furthermore, the lifting control panel and gears of the positioning and sampling device are located on the panel of the dissolution apparatus.

[0011] Furthermore, the telescopic sampling tube of the positioning and sampling device also includes a sealing cap with an opening at the top of the inner tube.

[0012] Furthermore, the top end of the inner tube of the telescopic sampling tube of the positioning sampling device passes through the top wall of the dissolution apparatus panel and is fixed to the panel by a fixture, and the bottom end of the inner tube extends downward into the outer tube.

[0013] Furthermore, the inner and outer tubes of the telescopic sampling tube of the positioning sampling device are connected by a sealing ring, which is fitted on the outside of the inner tube.

[0014] Furthermore, a groove is formed at the bottom end of the side wall of the inner tube of the telescopic sampling tube of the positioning sampling device, and a sealing ring is placed in the groove.

[0015] Furthermore, the inner diameter of the telescopic sampling tube of the positioning sampling device is 24.5mm-25.5mm; the outer diameter of the telescopic sampling tube is 25.5mm-26.5mm; and the difference between the outer and inner diameters of the telescopic sampling tube is 0.1-0.5mm.

[0016] The second aspect of this application provides a dissolution apparatus including the positioning and sampling device of the first aspect, comprising a positioning and sampling device, a panel, a panel operating system, and a dissolution cup. The positioning and sampling device is disposed above the dissolution cup, and the telescopic sampling tube lifting and controlling system is capable of controlling the movement of the outer tube along the axial direction of the dissolution cup.

[0017] Compared with the prior art, the beneficial effects of this application include:

[0018] The positioning and sampling device of this application includes a telescopic sampling tube, a telescopic sampling tube lifting and control system, and a fixer. The telescopic sampling tube includes an inner tube and an outer tube sealed outside the inner tube. The inner tube is fixed to the panel of the dissolution tester by the fixer. The outer tube is controlled by the telescopic sampling tube lifting and control system to move axially relative to the inner tube. Before sample delivery, the outer tube of the telescopic sampling tube moves axially to the bottom of the dissolution cup of the dissolution tester under the control of the telescopic sampling tube lifting and control system. After sample delivery, the telescopic sampling tube moves axially to the top of the dissolution cup under the control of the telescopic sampling tube lifting and control system. During the falling process of the sample in each sampling tube in the dissolution cup, it falls naturally into the bottom of each dissolution cup along the inner wall of the telescopic sampling tube, achieving the effect of accurate positioning and sampling.

[0019] The dissolution tester of this application has high accuracy and good stability in detecting drug dissolution. Attached Figure Description

[0020] Figure 1 This is a schematic diagram of the dissolution test apparatus of this application;

[0021] Figure 2 This is a schematic diagram of the positioning and sampling device for this application.

[0022] The reference numerals in the attached figures are for illustrative purposes only.

[0023] In the diagram: 1-Telescopic casting tube, 11-Inner tube, 12-Outer tube, 13-Sealing cap; 2-Telescopic casting tube lifting control system, 21-Lifting control panel, 22-Gear, 23-Rack; 3-Fixer; 4-Panel; 5-Panel operating system; 6-Dissolution cup. Detailed Implementation

[0024] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0025] In this utility model, unless otherwise explicitly specified and limited, the terms "assembly," "fixing," etc., should be interpreted broadly. For example, "fixing" can mean a fixed connection, a detachable connection, or an integral part; unless otherwise explicitly limited. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0026] If the dissolution tester positioning and sampling device of this application is not used, the existing dissolution tester sampling devices only complete the sampling above the dissolution cup. There is no positioning and sampling device inside the dissolution cup. Because the sample falls into the dissolution cup at different angles, the dissolving liquid will change the sample's trajectory, thus failing to achieve the effect of positioning and sampling. Furthermore, the difference in flow rate of the dissolving liquid between the bottom and side bottom of the dissolution cup leads to significant differences in the test results. Using the dissolution tester positioning and sampling device described in this application will achieve the effect of positioning the sample and make the test simpler and easier to perform. To make the technical solution of this application clearer, the following will describe the technical solution of this application clearly and completely with examples. A schematic diagram of the dissolution tester positioning and sampling device is shown below. Figure 2As shown, it includes a telescopic sampling tube 1, a telescopic sampling tube lifting control system 2, and a fixture 3. The telescopic sampling tube 1 includes an inner tube 11, an outer tube 12, and a sealing cap 13. The telescopic sampling tube lifting control system 2 includes a lifting control panel 21, a gear 22, and a rack 23. The fixture 3 fixes the inner tube 11 to the panel 4 of the dissolution apparatus.

[0027] This application is mainly achieved through the following technical solution: a schematic diagram of a dissolution tester is shown below. Figure 1 As shown, the system includes a positioning and sampling device, a panel 4, a panel operating system 5, and a dissolution vessel 6. The positioning and sampling device is positioned above the dissolution vessel 6. A schematic diagram of the positioning and sampling device is shown below. Figure 2 As shown, the system includes a telescopic layout tube 1, a telescopic layout tube lifting control system 2, and a fixing device 3. The telescopic layout tube 1 includes an inner tube 11 and an outer tube 12 sealed around the inner tube 11, as well as a sealing cap 13 located at the top opening of the inner tube 11. The top end of the inner tube 11 passes through the top wall of the panel 4 and is fixed to the panel 4 by the fixing device 3. The bottom end of the inner tube 11 extends downward into the outer tube 12. The inner tube 11 and the outer tube 12 are sealed together by a sealing ring, which is fitted around the outside of the inner tube 11. A groove is formed at the bottom end of the side wall of the inner tube 11, and the sealing ring is disposed within the groove. Furthermore, the diameter of the inner tube 11 can range from 24.5mm to 25.5mm, and the diameter of the outer tube 12 can range from 25.5mm to 26.5mm. The diameter difference between the outer tube 12 and the inner tube 11 is 0.1-0.5mm, ensuring that the outer tube 12 can move axially. The telescopic sampling tube lifting control system 2 includes a lifting control panel 21, a gear 22 electrically connected to the lifting control panel 21, and a rack 23 toothedly connected to the gear 22. The lifting control panel 21 and the gear 22 are mounted on the panel 4, and the rack 23 is mounted on the top of the side wall of the outer tube 12 and extends along the axial direction of the outer tube 12. The lifting control panel 21 controls the movement of the rack 23 by controlling the rotation of the gear 22, thereby controlling the axial telescopic movement of the outer tube 12 along the dissolution cup 6. The top of the side wall of the outer tube 12 is serrated, or the rack 23 is mounted on the top of the outer wall of the outer tube 12.

[0028] During dissolution testing, after the dissolution apparatus is ready and the dissolution medium is preheated to the required temperature, the telescopic sampling tube lifting control system 2 is controlled via the panel operating system 5. The telescopic sampling tube lifting control system 2 controls the axial telescopic movement of the outer tube 12 in the telescopic sampling tube 1 via the lifting control panel 21. The inner tube 11 and outer tube 12 of the telescopic sampling tube 1 are sealed together by a sealing ring, which is fitted into a groove at the bottom of the side wall of the inner tube 11, thus ensuring the axial movement of the outer tube 12 outside the inner tube 11. The telescopic sampling tube lifting control system 2 includes the lifting control panel 21, a gear 22 electrically connected to the lifting control panel 21, and a rack 23 connected to the gear 22. The lifting control panel 21 controls the rotation of the gear 22, which in turn drives the rack 23 to move, thereby controlling the axial extension and retraction of the outer tube 12 along the dissolution cup 6. This lowers the outer tube 12 into the dissolution medium within the dissolution cup 6. The sealing cap 13 on the telescopic sampling tube 1 is used to mark different samples for identification. Samples are placed above the inner tube 11 of different telescopic sampling tubes 1, and the samples naturally fall along the inner wall of the telescopic sampling tube 1 into the bottom of each dissolution cup 6, achieving the effect of targeted sample placement. Subsequently, the lifting control panel 21 in the telescopic sampling tube lifting control system 2 is controlled by the panel operating system 5. This control, through the rotation of the gear 22, drives the rack 23 to move, thereby controlling the axial extension and retraction of the outer tube 12 along the dissolution cup 6. The outer tube 12 rises above the dissolution medium in the dissolution cup 6 and returns to its original position, completing the sample placement. After sample placement, the dissolution apparatus is controlled by the panel operating system 5 to operate, and then sample collection and testing are performed according to preset time points and preset plans.

[0029] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A positioning and sampling device, characterized in that: The instrument includes a telescopic sampling tube (1), a telescopic sampling tube lifting control system (2), and a fixture (3). The telescopic sampling tube (1) includes an inner tube (11) and an outer tube (12) that is sealed outside the inner tube (11). The inner tube (11) is fixed to the panel (4) of the dissolution tester by the fixture (3). The telescopic sampling tube lifting control system (2) controls the outer tube (12) to extend and retract axially relative to the inner tube (11). The telescopic layout tube lifting control system (2) includes a lifting control panel (21), a gear (22) electrically connected to the lifting control panel (21), and a rack (23) connected to the gear (22). The rack (23) is located on the top of the side wall of the outer tube (12). The lifting control panel (21) controls the movement of the outer tube (12) by controlling the rotation of the gear (22) to drive the movement of the rack (23).

2. The positioning and sampling device according to claim 1, characterized in that: The rack (23) extends along the axial direction of the outer tube (12); the top of the side wall of the outer tube (12) is provided in a sawtooth shape, or the rack (23) is installed on the top of the outer wall of the outer tube (12).

3. The positioning and sampling device according to claim 1, characterized in that: The lifting control panel (21) and gear (22) are located on the panel (4).

4. The positioning and sampling device according to claim 1, characterized in that: The telescopic layout tube (1) also includes a sealing cap (13) with an opening at the top of the inner tube (11).

5. The positioning and sampling device according to claim 4, characterized in that: The top end of the inner tube (11) passes through the top wall of the panel (4) and is fixed to the panel (4) by the fastener (3), and the bottom end of the inner tube (11) extends downward into the outer tube (12).

6. The positioning and sampling device according to any one of claims 1-5, characterized in that: The inner tube (11) and the outer tube (12) are connected by a sealing ring, which is sleeved on the outside of the inner tube (11).

7. The positioning and sampling device according to claim 6, characterized in that: The inner tube (11) has a groove formed at the bottom of its side wall, and the sealing ring is disposed in the groove.

8. The positioning and sampling device according to any one of claims 1-5, characterized in that: The inner tube (11) of the telescopic laying tube (1) has a diameter of 24.5mm-25.5mm; the outer tube (12) of the telescopic laying tube (1) has a diameter of 25.5mm-26.5mm; the diameter difference between the outer tube (12) and the inner tube (11) of the telescopic laying tube (1) is 0.1-0.5mm.

9. A dissolution tester, characterized in that, It includes a positioning and sampling device, a panel (4), a panel operating system (5), and a dissolution cup (6) as described in any one of claims 1-8. The positioning and sampling device is disposed above the dissolution cup (6), and the telescopic sampling tube lifting control system (2) is capable of controlling the outer tube (12) to move along the axial direction of the dissolution cup (6).

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