Electroencephalogram closed-loop phase interference stimulation system

Abstract

The utility model discloses an electroencephalogram closed-loop phase interference stimulation system, which comprises an electroencephalogram acquisition module, a signal processing and analyzing module, a phase interference control module and a stimulation output module which are sequentially connected, and is characterized in that the electroencephalogram acquisition module is used for acquiring electroencephalogram signals of a subject; the signal processing and analyzing module is used for receiving the electroencephalogram signals of the electroencephalogram acquisition module and processing and analyzing the electroencephalogram signals; the phase interference control module is used for receiving the electroencephalogram data of the signal processing and analyzing module, performing phase analysis on the electroencephalogram data and generating a stimulation control signal; and the stimulation output module is used for receiving the stimulation control signal of the phase interference module, generating and outputting a stimulation signal and stimulating a subject through an electrode slice. Real-time monitoring and analysis of electroencephalogram signals are achieved, the brain is stimulated, and brain diseases are improved. Through the combination of phase interference and closed-loop control, the system can adjust stimulation parameters according to real-time electroencephalogram signals, and the optimal stimulation effect and treatment effect are achieved.

Description

TECHNICAL FIELD

[0001] The utility model relates to electroencephalogram stimulation technical field, especially a kind of electroencephalogram closed-loop phase interference stimulation system. BACKGROUND

[0002] Phase interference electric field stimulation is a low-frequency envelope wave stimulation, which forms a low-frequency envelope stimulation electric field by two high-frequency alternating currents with small difference frequency. Existing brain stimulation technology often uses open-loop control mode, lacks real-time monitoring and adjustment ability of stimulation effect. Although part of the equipment has electroencephalogram monitoring function, effective closed-loop control and application of phase interference technology cannot be realized, resulting in unstable treatment effect. Therefore, it is of great significance to develop a device that can adjust stimulation parameters according to real-time electroencephalogram signals. SUMMARY

[0003] The utility model aims at providing a kind of electroencephalogram closed-loop phase interference stimulation system, realizes the closed-loop system of electroencephalogram signal real-time monitoring, analysis and stimulation control.

[0004] The utility model achieves the purpose by the following technical solutions:

[0005] A kind of electroencephalogram closed-loop phase interference stimulation system, it includes brain electric acquisition module, signal processing analysis module, phase interference module, stimulation output module connected in sequence, wherein:

[0006] The brain electric acquisition module is used to obtain the electroencephalogram signal of subject;

[0007] The signal processing analysis module is used to accept the electroencephalogram signal of brain electric acquisition module, and process and analyze electroencephalogram signal;

[0008] The phase interference control module is used to receive the electroencephalogram data of signal processing analysis module, and carry out phase analysis to electroencephalogram data and generate stimulation control signal;

[0009] The stimulation output module is used to receive the stimulation control signal of phase interference module, generate and output stimulation signal, and stimulate subject through electrode sheet.

[0010] Further, the brain electric acquisition module includes multi-lead electrode module, signal amplification module and analog-digital conversion module connected in sequence, the analog-digital conversion module is connected with the signal processing analysis module, the multi-lead electrode module has multiple independently configured signal acquisition channels, and the connected electrode sheet is Ag / AgCl.

[0011] Further, the signal processing analysis module comprises a real-time filtering unit, a feature extraction unit and an electroencephalogram rhythm analysis unit, the real-time filtering unit pre-processes the received electroencephalogram signals, the feature extraction unit extracts time-frequency characteristic parameters of the electroencephalogram signals, and the electroencephalogram rhythm analysis unit separates and analyzes electroencephalogram rhythms of different frequency bands.

[0012] Further, the phase interference control module comprises a phase detection unit, an interference mode calculation unit, a parameter optimization unit and a feedback control unit, the phase detection unit performs real-time phase extraction on the electroencephalogram data, the interference mode calculation unit calculates a stimulation mode based on the phase extraction information, and the parameter optimization unit optimizes and adjusts stimulation parameters of the stimulation mode.

[0013] Further, the stimulation output module comprises a waveform generator, a waveform synthesizer and an ADC converter, the ADC converter generates analog signals based on the stimulation parameters, and the waveform synthesizer is used for synthesizing multiple analog signals and generating a stimulation signal waveform through the waveform generator.

[0014] Further, the system further comprises a safety monitoring module, the safety monitoring module comprises a current detection unit, an impedance detection unit and an abnormality control unit, the current detection unit is connected with the waveform generator, and the impedance detection unit is connected with the electroencephalogram rhythm analysis unit.

[0015] Further, the system further comprises a data storage unit and a display and input module, the data storage unit is connected with the signal processing analysis module, and the display and input module is connected with the signal processing analysis module and the phase interference control module.

[0016] The utility model has the following advantages:

[0017] 1, this system realizes the real -time monitoring, analysis and to brain stimulation of electroencephalogram, improves the brain disease.

[0018] 2, through the combination of phase interference and closed loop control, the system can adjust stimulation parameters according to real-time electroencephalogram signals, and realizes the best stimulation effect and treatment effect. BRIEF DESCRIPTION OF DRAWINGS

[0019] Fig. 1 It is the structural schematic diagram of the utility model.

[0020] Fig. 2 It is the schematic diagram of phase interference principle.

[0021] Fig. 3 It is the schematic diagram of the system operation process. DETAILED DESCRIPTION

[0022] In order to make the purpose, technical scheme and advantages of the embodiments of the present application clearer, the technical scheme of the embodiments of the present application will be described clearly and completely below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are some of the embodiments of the present application, rather than all the embodiments of the present application. The components of the embodiments of the present application described and shown in the drawings herein can be arranged and designed in various different configurations.

[0023] Therefore, the following detailed description of the embodiments of the present application provided in the drawings is not intended to limit the scope of the claimed present application, but only represents selected embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative labor fall within the scope of protection of the present application.

[0024] It should be noted that the embodiments in the present application and the features in the embodiments can be combined with each other without conflict.

[0025] It should be noted that: similar reference numerals and letters represent similar items in the following drawings, therefore, once an item is defined in one drawing, it does not need to be further defined and explained in subsequent drawings.

[0026] In the description of the present application, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, or the orientation or positional relationship commonly placed when the product of the present application is used, or the orientation or positional relationship commonly understood by those skilled in the art, and are only for the convenience of describing the present application and simplifying the description, and therefore cannot be understood as indicating or implying that the indicated device or element must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the present application. In addition, the terms "first", "second" and the like are only used to distinguish the description and cannot be understood as indicating or implying relative importance.

[0027] In the description of the present application, it should also be noted that, unless otherwise explicitly specified and limited, the terms "set", "mount", "connected", "connected" should be understood broadly, for example, it can be fixedly connected, or it can be detachably connected, or integrally connected; it can be mechanically connected, or it can be electrically connected; it can be directly connected, or it can be indirectly connected through an intermediate medium, or it can be the communication inside two elements. For those of ordinary skill in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0028] Reference Figs. 1-3As shown, one embodiment of the utility model provides

[0029] A brain electric closed loop phase interference stimulation system, including brain electric collection module, signal processing analysis module, phase interference module, stimulation output module that connect gradually, wherein:

[0030] The brain electric collection module is used for obtaining the brain electric signal of the subject.

[0031] The signal processing analysis module is used for receiving the brain electric signal of the brain electric collection module and processing and analyzing the brain electric signal.

[0032] The phase interference control module is used for receiving the brain electric data of the signal processing analysis module, performing phase analysis on the brain electric data and generating stimulation control signal.

[0033] The stimulation output module is used for receiving the stimulation control signal of the phase interference module, generating and outputting stimulation signal and stimulating the subject through the electrode sheet.

[0034] Specifically, the brain electric collection module includes multi-lead electrode module, signal amplification module and analog-digital conversion module that connect gradually, the analog-digital conversion module is connected with the signal processing analysis module, the multi-lead electrode module has a plurality of independently configured signal acquisition channels, and the connected electrode sheet is Ag / AgCl.

[0035] The electrode sheet is equipped with an electrode holder with impedance detection function and adopts a quick connection and anti-falling structure.

[0036] The signal amplification module specifically includes preamplifier, intermediate amplifier and post-amplifier: the preamplifier adopts an instrument amplifier AD8420, the common-mode rejection ratio is greater than 100dB, the input impedance is greater than 100MΩ, and the input noise is less than 1uV peak-to-peak value. The intermediate amplifier adopts a programmable gain amplifier, the gain range is 10-1000 times adjustable, the bandwidth range is 0.1Hz-100Hz, and the intermediate amplifier has a direct current bias compensation function. The post-amplifier adopts a precision operational amplifier, has an overload protection function, is provided with a gain fine-tuning circuit, and is provided with an output buffer stage.

[0037] The analog-digital conversion module adopts a 24-bit sigma-delta type ADC converter, the sampling rate range is 250Hz-1kHz adjustable, the signal-to-noise ratio is greater than 100dB, the effective bit number is not less than 20 bits, and the analog-digital conversion module has a multi-channel synchronous sampling function.

[0038] The system adopts anti-interference design, adopts multi-layer PCB design, realizes separation of analog and digital, key signals adopt differential transmission, and sets metal shielding shell. On the filter system, the power supply end is configured with LC low-pass filter, the signal channel is configured with 50Hz notch filter; 0.1Hz high-pass filter is provided; 100Hz low-pass filter is provided, so as to ensure that the system has high precision, high reliability and good anti-interference ability.

[0039] The EEG acquisition module acquires the EEG signal of the target brain area through the electrode piece connected by the multi-lead electrode module arranged on the scalp surface, the acquired signal is amplified through the signal amplification module, and then the analog signal is converted into a digital signal through a 24-bit high-precision analog-to-digital converter and transmitted to the signal processing and analysis module.

[0040] The signal processing and analysis module includes a real-time filtering unit, a feature extraction unit and an EEG rhythm analysis unit. The real-time filtering unit includes a digital filter group: FIR band-pass filter, IIR notch filter and adaptive filter. The real-time filtering unit pre-processes the received EEG signal, including power frequency interference suppression, baseline drift correction and high-frequency noise removal. Then, the feature extraction unit extracts the time-frequency feature parameters of the EEG signal, which can be extracted by using the mathematical tool of Hilbert transform, including: time domain feature extraction: mean value calculation; variance analysis; zero-crossing rate detection. Frequency domain feature extraction: power spectral density estimation; frequency band energy calculation; phase feature extraction. Finally, the EEG rhythm analysis unit separates and analyzes the EEG rhythms of different frequency bands such as δ, θ, α, β and γ through wavelet analysis and other methods, so as to provide basic data for the subsequent phase interference control module.

[0041] The phase interference control module includes a phase detection unit, an interference mode calculation unit, a parameter optimization unit and a feedback control unit. The phase detection unit extracts the real-time phase of the EEG data, which includes: real-time phase calculation: Hilbert transform; instantaneous phase extraction; phase synchronization analysis. Phase tracking system: phase-locked loop design; phase prediction algorithm; phase correction mechanism. Then, the interference mode calculation unit calculates the stimulation mode that can produce the best interference effect based on the phase extraction information and the theory of neural oscillation and the principle of phase synchronization, and obtains the specific stimulation parameters, which include: interference mode generation: single-frequency interference mode; multi-frequency interference mode; adaptive interference mode. In this process, the system continuously monitors the neural activity state and phase synchronization degree of the target brain area by real-time acquisition and analysis of the EEG signal of the subject, and optimizes and adjusts the stimulation parameters of the stimulation mode based on the monitoring results through the parameter optimization unit, including stimulation intensity, frequency and phase, which include: real-time optimization strategy: gradient descent method; genetic algorithm; particle swarm optimization. Performance evaluation index: phase synchronization degree; energy efficiency; stability evaluation.

[0042] The stimulation output module includes a waveform generator, a waveform synthesizer, and an ADC converter, which generates analog signals based on stimulation parameters including stimulation waveform, frequency, phase, amplitude, and other parameters. The waveform synthesizer is used to synthesize multiple analog signals and generate a stimulation signal waveform through the waveform generator, and act on the subject through the electrode sheet connected by the stimulation output channel.

[0043] The specific parameters of the stimulation output system include: output current range of 0-2mA, accuracy better than 0.1mA; frequency range of 0.1-100Hz, adjustable step of 0.1Hz; phase adjustment range of 0-360°, accuracy better than 1°; multiple output waveforms such as sine wave, square wave, and triangular wave; output channel number of 8-16, which can be independently controlled; overcurrent protection function, response time less than 1ms.

[0044] The system continuously monitors the neural activity state and phase synchronization degree of the target brain area through the feedback control unit of the phase interference control module, and based on the monitoring results, uses the PID adaptive control algorithm to adjust the stimulation parameters in real time to realize closed-loop control. In addition, it also evaluates the stimulation effect by calculating quantitative indicators such as phase-locked value (PLV), and based on the evaluation results, uses machine learning algorithm to continuously optimize the control strategy to achieve the best stimulation effect and treatment effect.

[0045] In this embodiment, the system also includes a data storage unit, a display and input module, the data storage unit is connected with the signal processing and analysis module, and the display and input module is connected with the signal processing and analysis module and the phase interference control module.

[0046] The interactive display and operation module is used to complete the operation command, and can display operation information, stimulation remaining time, stimulation mode, and resistance value and other information.

[0047] The system also includes a safety monitoring module, which includes a current detection unit, an impedance detection unit, and an abnormality control unit. The current detection unit is connected with the waveform generator, and the impedance detection unit is connected with the electroencephalogram rhythm analysis unit.

[0048] The safety monitoring module is set to ensure the safety of system operation. The current detection unit detects the current of the waveform generator, and when it exceeds the set threshold, it immediately cuts off the output of the stimulation output module through the abnormality control unit. The impedance detection unit monitors the electrode-skin impedance in real time through the small signal injection method, and triggers the protection mechanism when the impedance exceeds the threshold or the change rate exceeds 50% / s.

[0049] Although the utility model has been explained in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions recorded in the foregoing embodiments or make equivalent replacement to part of the technical features, and any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the utility model shall be included in the protection scope of the utility model.

Claims

1. A closed-loop phase interference stimulation system for electroencephalography, characterized in that: It includes, in sequence, an EEG acquisition module, a signal processing and analysis module, a phase interference control module, and a stimulus output module, wherein: The EEG acquisition module is used to acquire the subject's EEG signals; The signal processing and analysis module is used to receive the EEG signals from the EEG acquisition module and to process and analyze the EEG signals. The phase interference control module is used to receive the EEG data from the signal processing and analysis module, perform phase analysis on the EEG data, and generate stimulation control signals. The stimulation output module is used to receive the stimulation control signal from the phase interference module, generate and output stimulation signals, and stimulate the subject through electrode pads.

2. The EEG closed-loop phase interference stimulation system according to claim 1, characterized in that: The EEG acquisition module includes a multi-lead electrode module, a signal amplification module, and an analog-to-digital conversion module connected in sequence. The analog-to-digital conversion module is connected to the signal processing and analysis module. The multi-lead electrode module has multiple independently configured signal acquisition channels, and the connected electrode pads are Ag / AgCl.

3. The EEG closed-loop phase interference stimulation system according to claim 2, characterized in that: The signal processing and analysis module includes a real-time filtering unit, a feature extraction unit, and an EEG rhythm analysis unit. The real-time filtering unit preprocesses the received EEG signals, the feature extraction unit extracts the time-frequency feature parameters of the EEG signals, and the EEG rhythm analysis unit separates and analyzes EEG rhythms in different frequency bands.

4. The EEG closed-loop phase interference stimulation system according to claim 3, characterized in that: The phase interference control module includes a phase detection unit, an interference mode calculation unit, a parameter optimization unit, and a feedback control unit. The phase detection unit performs real-time phase extraction on the EEG data, the interference mode calculation unit calculates the stimulation mode based on the phase extraction information, and the parameter optimization unit optimizes and adjusts the stimulation parameters of the stimulation mode.

5. The EEG closed-loop phase interference stimulation system according to claim 4, characterized in that: The stimulus output module includes a waveform generator, a waveform synthesizer, and an ADC converter. The ADC converter generates an analog signal based on stimulus parameters, and the waveform synthesizer is used to synthesize multiple analog signals and generate a stimulus signal waveform through the waveform generator.

6. The EEG closed-loop phase interference stimulation system according to claim 5, characterized in that: The system also includes a safety monitoring module, which includes a current detection unit, an impedance detection unit, and an abnormal control unit. The current detection unit is connected to the waveform generator, and the impedance detection unit is connected to the EEG rhythm analysis unit.

7. The EEG closed-loop phase interference stimulation system according to claim 1, characterized in that: The system also includes a data storage unit and a display and input module. The data storage unit is connected to the signal processing and analysis module, and the display and input module is connected to the signal processing and analysis module and the phase interference control module.

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