In-vivo reflection type confocal microscope objective lens three-dimensional support

Abstract

The utility model provides an in-vivo reflection type confocal microscope objective lens three-dimensional support, which comprises an adjusting plate I, an adjusting plate II, a substrate, an axial adjusting mechanism and an objective lens, and is characterized in that the adjusting plate I, the adjusting plate II and the substrate are sequentially arranged in parallel; the axial adjusting mechanism is arranged on the substrate and comprises a groove drum, an objective lens supporting cylinder, a driving block, a worm gear, a worm and a driver. Therefore, the overall occupied volume can be reduced, the overall volume of the objective lens of the reflective confocal microscope is reduced, meanwhile, the axial acquisition precision is improved, and the image acquisition quality is ensured.

Description

TECHNICAL FIELD

[0001] The utility model relates to the field of confocal microscope imaging control technology, especially to a three-dimensional support of in vivo reflection confocal microscope objective. BACKGROUND

[0002] In vivo reflection confocal microscopy (RCM) can non-invasively image skin lesions at the cellular level and ultra-high resolution, and is based on the different gray images of light refractive index of microstructure in skin tissue. Since the characteristics of its cross-sectional imaging can realize layer-by-layer scanning of skin from shallow to deep, similar to the scanning of CT, it is also called "skin CT" figuratively.

[0003] The biggest difficulty of the three-dimensional imaging function of in vivo reflection confocal microscopy on the skin is the high-precision tomographic detection imaging of the maximum field of view, wherein the control accuracy of the z-axis is extremely high. The control mechanism for confocal microscope three-dimensional imaging disclosed in the application number 201910398167.0 sets a linear drive mechanism and a guide mechanism to drive the objective lens to reciprocate linearly in the axial direction. However, since the linear drive mechanism and the guide mechanism are perpendicular to the entire support, the axial length of the support is too large, the overall volume is increased, which affects the setting of the confocal microscope barrel lens, and further affects the actual imaging effect. In addition, the linear drive mechanism is used to control the movement of the objective lens, which reduces the axial collection accuracy. SUMMARY

[0004] The utility model aims to solve one of the technical problems in the related art to at least some extent.

[0005] Therefore, the utility model aims to provide an in vivo reflection confocal microscope objective three-dimensional support, which can reduce the overall occupied volume, reduce the overall volume of the reflection confocal microscope objective, improve the axial collection accuracy, and ensure the image collection quality.

[0006] To achieve the above objectives, this utility model proposes a three-dimensional support for an in vivo reflective confocal microscope objective, comprising an adjustment plate one, an adjustment plate two, a base plate, an axial adjustment mechanism, and an objective lens. The adjustment plate one, adjustment plate two, and base plate are arranged in parallel. The axial adjustment mechanism is mounted on the base plate and includes a slotted cylinder, an objective lens support cylinder, a drive block, a worm gear, a worm, and a drive seat. The slotted cylinder is rotatably mounted on the base plate, with a guide groove at its top. The objective lens support cylinder is inserted into the slotted cylinder. The drive block is located at the top of the objective lens support cylinder and within the guide groove. The objective lens is inserted into the objective lens support cylinder. The worm gear is sleeved on the slotted cylinder, and the worm is located on one side of the worm gear and meshes with it. The drive seat is mounted on the base plate and connected to the worm. A fixing cylinder is mounted on the base plate, sleeved on the slotted cylinder and the objective lens support cylinder, and slidably connected to the fixing cylinder.

[0007] In addition, the three-dimensional support for the in vivo reflective confocal microscope objective proposed in the application may also have the following additional technical features:

[0008] Specifically, a nasal tube is provided on the adjustment plate, and the objective lens is located inside the nasal tube.

[0009] Specifically, the substrate is provided with a horizontal and vertical adjustment mechanism, which is connected to the first adjustment plate and the second adjustment plate.

[0010] Specifically, the drive seat includes a bracket and a first driver, wherein the bracket is disposed on the base plate and rotatably connected to the worm gear, and the first driver is disposed on one side of the bracket and connected to the worm gear.

[0011] Specifically, the horizontal and vertical adjustment mechanism includes a horizontal adjustment structure and a vertical adjustment structure. The horizontal adjustment structure is disposed on the second adjustment plate and connected to the first adjustment plate, and the vertical adjustment structure is disposed on the base plate and connected to the second adjustment plate.

[0012] Specifically, the lateral adjustment structure includes two sets of lateral guide rails, a connecting frame one, and a second driver. The two sets of lateral guide rails are respectively disposed on the second adjustment plate and connected to the first adjustment plate. The first connecting frame one is disposed on the top of the first adjustment plate, and the second driver one is disposed on one side of the second adjustment plate and connected to the first connecting frame one.

[0013] Specifically, the longitudinal adjustment structure includes two sets of longitudinal guide rails, a second connecting frame, and a third driver. The two sets of longitudinal guide rails are respectively disposed on the base plate and connected to the second adjusting plate. The second connecting frame is disposed on one side of the second adjusting plate, and the third driver is disposed at the bottom of the base plate and connected to the second connecting frame.

[0014] Compared with the prior art, this utility model has the following advantages: 1. It adopts a worm gear transmission method, which has a large transmission ratio, can reduce the layer cutting distance of each step, and improve the acquisition accuracy in the axial direction.

[0015] 2. The use of a worm gear drive avoids the need for a linear motor to be installed perpendicular to the objective lens holder, thus reducing the overall size and compressing the objective lens holder volume.

[0016] Additional aspects and advantages of this invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. Attached Figure Description

[0017] The above and / or additional aspects and advantages of this utility model will become apparent and readily understood from the following description of the embodiments taken in conjunction with the accompanying drawings, in which:

[0018] Figure 1 This is a schematic diagram of the three-dimensional support structure of the in vivo reflective confocal microscope objective lens of this utility model;

[0019] Figure 2 This is a cross-sectional view of the three-dimensional support for the objective lens of the in vivo reflective confocal microscope of this invention;

[0020] Figure 3 This is a bottom cross-sectional view of the three-dimensional support for the objective lens of the in vivo reflective confocal microscope of this invention.

[0021] As shown in the figure: 1. Adjustment plate one; 2. Adjustment plate two; 3. Base plate; 4. Axial adjustment mechanism; 41. Groove cylinder; 42. Objective lens support cylinder; 43. Drive block; 44. Worm gear; 45. Worm; 46. Drive seat; 461. Bracket; 462. First driver; 47. Fixing cylinder; 5. Objective lens; 6. Nose tube; 7. Horizontal and longitudinal adjustment mechanism; 71. Horizontal adjustment structure; 711. Horizontal guide rail assembly; 712. Connecting frame one; 713. Second driver; 72. Longitudinal adjustment structure; 721. Longitudinal guide rail assembly; 722. Connecting frame two; 723. Third driver. Detailed Implementation

[0022] The embodiments of this utility model are described in detail below. Examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and intended to explain this utility model, and should not be construed as limiting this utility model. Rather, the embodiments of this utility model include all variations, modifications, and equivalents falling within the spirit and scope of the appended claims.

[0023] The following description, in conjunction with the accompanying drawings, describes a three-dimensional support for an in vivo reflective confocal microscope objective lens according to an embodiment of the present invention.

[0024] like Figures 1-3 As shown, the in vivo reflective confocal microscope objective lens three-dimensional support of this utility model embodiment includes an adjustment plate 1, an adjustment plate 2, a base plate 3, an axial adjustment mechanism 4, and an objective lens 5.

[0025] Among them, adjustment plate 1, adjustment plate 2 and base plate 3 are arranged side by side in sequence.

[0026] It should be noted that adjustment plate 1, adjustment plate 2, and base plate 3 are arranged sequentially with gaps between them to facilitate adjustment between the plates.

[0027] The axial adjustment mechanism 4 is mounted on the substrate 3. The axial adjustment mechanism 4 includes a slotted cylinder 41, an objective lens support cylinder 42, a drive block 43, a worm gear 44, a worm 45, and a drive seat 46. The slotted cylinder 41 is rotatably mounted on the substrate 3. A guide groove is provided at the top of the slotted cylinder 41. The objective lens support cylinder 42 is inserted into the slotted cylinder 41. The drive block 43 is located at the top of the objective lens support cylinder 42 and is located in the guide groove. The objective lens 5 is inserted into the objective lens support cylinder 42.

[0028] The worm gear 44 is sleeved on the grooved cylinder 41, the worm 45 is disposed on one side of the worm gear 44 and meshes with it, the drive seat 46 is disposed on the base plate 3 and is connected to the worm 45, the base plate 3 is provided with a fixing cylinder 47, the fixing cylinder 47 is sleeved on the grooved cylinder 41 and the objective lens support cylinder 42, and the objective lens support cylinder 42 is slidably connected to the fixing cylinder 47.

[0029] It should be noted that a guide groove is provided at the top of the groove cylinder 41, the drive block 43 is located in the guide groove and connected to the objective lens support cylinder 42, and the objective lens support cylinder 42 is slidably mounted on the fixed cylinder 47 and cannot rotate. The objective lens support cylinder 42 is connected to the objective lens 5. When the groove cylinder 41 rotates, it drives the drive block 43 and the objective lens support cylinder 42 to achieve axial adjustment through the guide groove.

[0030] The worm gear 45 is driven and controlled by the drive seat 46. The worm gear 45 drives the worm wheel 44 with a large transmission ratio, which can reduce the layer cutting distance at each step and effectively improve the acquisition accuracy in the axial direction.

[0031] Specifically, when using an in vivo reflective confocal microscope, it is necessary to ensure contact with the patient's skin. Therefore, during actual use, the nasal tube 6 is placed against the patient's lesion on the skin. The drive seat 46 controls the worm gear 45 to drive the worm wheel 44. The worm wheel 44 drives the groove cylinder 41 to rotate, which in turn drives the objective lens support cylinder 42 and the objective lens 5 to adjust axially, ensuring clear imaging.

[0032] In one embodiment of this utility model, such as Figure 1 and Figure 2 As shown, a nasal tube 6 is provided on the adjustment plate 1, and the objective lens 5 is located inside the nasal tube 6.

[0033] It should be noted that the nasal tube 6 serves as the outer cover of the objective lens 5, and is used to contact the patient's skin to protect the objective lens 5.

[0034] In one embodiment of this utility model, such as Figure 1 As shown, the drive base 46 includes a bracket 461 and a first driver 462.

[0035] The bracket 461 is mounted on the base plate 3 and is rotatably connected to the worm gear 45. The first driver 462 is mounted on one side of the bracket 461 and is connected to the worm gear 45.

[0036] It should be noted that the first driver 462 can be an electric motor, which is mounted and fixed on the base plate 3 by the bracket 461. The first driver 462 is connected to the worm gear 45 and controls the rotation of the worm gear 45.

[0037] Specifically, when adjusting the objective lens 5 axially, the relevant personnel can drive the worm gear 45 to rotate by operating the first driver 462, and then control the axial adjustment of the objective lens 5 according to the subsequent transmission components.

[0038] In one embodiment of this utility model, such as Figure 1 , Figure 2 and Figure 3 As shown, a horizontal and vertical adjustment mechanism 7 is provided on the substrate 3. The horizontal and vertical adjustment mechanism 7 is connected to the adjustment plate 1 and the adjustment plate 2. The horizontal and vertical adjustment mechanism 7 includes a horizontal adjustment structure 71 and a vertical adjustment structure 72.

[0039] The horizontal adjustment structure 71 is disposed on the second adjustment plate 2 and connected to the first adjustment plate 1, and the vertical adjustment structure 72 is disposed on the base plate 3 and connected to the second adjustment plate 2.

[0040] It should be noted that the lateral adjustment structure 71 is used to control the lateral movement between the second adjustment plate 2 and the first adjustment plate 1 relative to the x-axis, and the longitudinal adjustment structure 72 is used to control the longitudinal movement between the second adjustment plate 2 and the base plate 3 relative to the y-axis.

[0041] To clearly illustrate the previous embodiment, in one embodiment of this application, such as Figure 1 and Figure 2 As shown, the lateral adjustment structure 71 includes two sets of lateral guide rails 711, a connecting frame 712, and a second driver 713.

[0042] Two sets of transverse guide rails 711 are respectively set on the second adjustment plate 2 and connected to the first adjustment plate 1. The first connecting frame 712 is set on the top of the first adjustment plate 1. The second driver 713 is set on one side of the second adjustment plate 2 and connected to the first connecting frame 712.

[0043] It should be noted that the second driver 713 can be a linear motor, and its telescopic section is connected to the connecting frame 712. The connecting frame 712 is connected to the adjusting plate 1. The transverse guide rail assembly 711 can be composed of rails and guide blocks to ensure that the adjusting plate 1 and the adjusting plate 2 can only move laterally relative to each other, and to ensure that the two are set in parallel.

[0044] A spring connection can be provided between adjustment plate 1 and adjustment plate 2, so that the positions of adjustment plate 1 and adjustment plate 2 can be easily adjusted and then reset via the spring.

[0045] To clearly illustrate the previous embodiment, in one embodiment of this application, such as Figure 2 and Figure 3 As shown, the longitudinal adjustment structure 72 includes two sets of longitudinal guide rails 721, a connecting frame 722, and a third driver 723.

[0046] Two sets of longitudinal guide rails 721 are respectively mounted on the base plate 3 and connected to the second adjustment plate 2. The second connecting frame 722 is mounted on one side of the second adjustment plate 2. The third driver 723 is mounted on the bottom of the base plate 3 and connected to the second connecting frame 722.

[0047] It should be noted that the third driver 723 can be a linear motor, and its telescopic section is connected to the second connecting frame 722. The second connecting frame 722 is connected to the second adjusting plate 2. The longitudinal guide rail assembly 721 can be composed of a track and a guide block to ensure that the second adjusting plate 2 and the base plate 3 can only move longitudinally relative to each other, and to ensure that the two are set in parallel.

[0048] A spring connection can be provided between the adjustment plate 2 and the base plate 3, so that the position of the adjustment plate 2 and the base plate 3 can be easily adjusted and then reset through the spring.

[0049] Specifically, when the position of the objective lens 5 needs to be adjusted, the third actuator 723 pushes the adjustment plate 1 relative to the adjustment plate 2 via the connecting frame 1 712 to achieve lateral movement along the x-axis through the lateral guide rail assembly 711. The third actuator 723 pushes the adjustment plate 2 relative to the substrate 3 via the connecting frame 2 722 to achieve longitudinal movement along the y-axis through the longitudinal guide rail assembly 721, thereby changing the position of the objective lens 5 relative to the nose tube 6.

[0050] In the description of this specification, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this utility model, "a plurality of" means at least two, such as two, three, etc., unless otherwise explicitly specified.

[0051] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of different embodiments or examples.

[0052] Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those skilled in the art can make changes, modifications, substitutions and variations to the above embodiments within the scope of the present invention.

Claims

1. A three-dimensional support for an in vivo reflective confocal microscope objective, characterized in that, It includes adjustment plate one, adjustment plate two, base plate, axial adjustment mechanism and objective lens, wherein, The first adjustment plate, the second adjustment plate, and the base plate are arranged side by side in sequence; The axial adjustment mechanism is disposed on the substrate, and the axial adjustment mechanism includes a grooved cylinder, an objective lens support cylinder, a drive block, a worm gear, a worm, and a drive seat, wherein... The slotted tube is rotatably mounted on the substrate. A guide groove is provided at the top of the slotted tube. The objective lens support tube is inserted into the slotted tube. The driving block is located at the top of the objective lens support tube and within the guide groove. The objective lens is inserted into the objective lens support tube. The worm gear is sleeved on the grooved cylinder, the worm is disposed on one side of the worm gear and meshes with it, the drive seat is disposed on the base plate and is connected to the worm, a fixed cylinder is disposed on the base plate, the fixed cylinder is sleeved on the grooved cylinder and the objective lens support cylinder, and the objective lens support cylinder is slidably connected to the fixed cylinder.

2. The three-dimensional support for the in vivo reflective confocal microscope objective lens according to claim 1, characterized in that, A nasal tube is provided on the adjustment plate, and the objective lens is located inside the nasal tube.

3. The three-dimensional support for the in vivo reflective confocal microscope objective lens according to claim 1, characterized in that, The substrate is provided with a horizontal and vertical adjustment mechanism, which is connected to the first adjustment plate and the second adjustment plate.

4. The three-dimensional support for the in vivo reflective confocal microscope objective lens according to claim 1, characterized in that, The drive base includes a bracket and a first driver, wherein the bracket is disposed on the base plate and rotatably connected to the worm gear, and the first driver is disposed on one side of the bracket and connected to the worm gear.

5. The three-dimensional support for the in vivo reflective confocal microscope objective lens according to claim 3, characterized in that, The horizontal and vertical adjustment mechanism includes a horizontal adjustment structure and a vertical adjustment structure. The horizontal adjustment structure is disposed on the second adjustment plate and connected to the first adjustment plate, and the vertical adjustment structure is disposed on the base plate and connected to the second adjustment plate.

6. The three-dimensional support for the in vivo reflective confocal microscope objective lens according to claim 5, characterized in that, The lateral adjustment structure includes two sets of lateral guide rails, a connecting frame one, and a second driver. The two sets of lateral guide rails are respectively disposed on the second adjustment plate and connected to the first adjustment plate. The first connecting frame one is disposed on the top of the first adjustment plate, and the second driver one is disposed on one side of the second adjustment plate and connected to the first connecting frame one.

7. The three-dimensional support for the in vivo reflective confocal microscope objective lens according to claim 5, characterized in that, The longitudinal adjustment structure includes two sets of longitudinal guide rails, a second connecting frame, and a third driver. The two sets of longitudinal guide rails are respectively disposed on the base plate and connected to the second adjusting plate. The second connecting frame is disposed on one side of the second adjusting plate, and the third driver is disposed at the bottom of the base plate and connected to the second connecting frame.

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