Low-temperature human tissue sample collecting and processing equipment
By designing a low-temperature human tissue sample collection and processing device and constructing a low-temperature environment, the problem of poor quality and activity of human tissue samples at room temperature was solved, thus achieving high-quality scientific research and accurate research results.
Patent Information
- Application Number
- CN202520541323.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-03-26
- Publication Date
- 2026-02-13
- Estimated Expiration
- 2035-03-26
AI Technical Summary
In existing technologies, when human tissue samples are collected, stored, and transported at room temperature, there are problems such as microbial growth and reproduction, sample degradation, and poor quality and activity, which affect the quality of scientific research and the progress of disease research.
Design a low-temperature human tissue sample collection and processing device, including a cabinet with a refrigeration structure, a sterile chamber, a sample processing structure, and a low-temperature cryopreservation structure to create a low-temperature environment and ensure the quality and activity of the samples.
By constructing a low-temperature environment, the quality and viability of human tissue samples can be guaranteed, ensuring the accuracy of high-quality scientific research and research results, and avoiding false negatives or false positives that could affect clinical interpretation and scientific progress.
Smart Images
Figure CN223900110U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to medical instrument technical field more specifically, especially, particularly relates to a low temperature formula human tissue sample collection processing equipment. BACKGROUND
[0002] In biomedical, the collection processing of human tissue sample is a vital link. In order to guarantee the quality of human tissue sample to ensure its stability and biological activity, usually human tissue sample should be quickly transferred to proper storage conditions after collection to prevent its necrosis or change.
[0003] However, the current hospital clinical collection processing mode of human tissue sample, common is the collection and storage transportation of human tissue sample under normal temperature environment, and this sample processing mode has some obvious problems in practical application: first, under normal temperature environment, the sample pollution caused by the growth and reproduction of microorganism in human tissue sample, and then the quality of sample and certain biological safety risk are influenced;Second, under normal temperature environment, human tissue sample is easy to be degraded and influence the biological activity of sample;Then, under normal temperature environment, the quality and activity of human tissue sample are poor due to the pollution and degradation, indirectly influence the quality of subsequent scientific research, hinder the progress of related disease research.
[0004] How to solve the above-mentioned problems becomes a technical problem to be solved. UTILITY MODEL CONTENT
[0005] The utility model solves the technical problem in providing a low temperature formula human tissue sample collection processing equipment that can refrigerate to build a low temperature environment for implementing the collection processing and storage of human tissue sample, effectively guarantee the quality and activity of sample to ensure the subsequent high quality scientific research.
[0006] To achieve the above object, the utility model adopts the following technical scheme:
[0007] A low temperature formula human tissue sample collection processing equipment, including the car cabinet body with universal wheel;The top of the car cabinet body is equipped with a sterile warehouse, and a sample processing structure for medical staff to implement the collection processing of external human tissue sample is arranged in the sterile warehouse;Still include the refrigeration structure for the sample processing structure refrigeration to build a low temperature environment in the coverage area of the sample processing structure for medical staff to safely handle human tissue sample is arranged on the car cabinet body;Still be equipped with a low temperature cryopreservation structure for implementing low temperature collection of research tissue sample to ensure its quality and activity in the left lower side of the front side of the car cabinet body.
[0008] Preferably, the sterile cabin comprises a cover body arranged on the top of the vehicle cabinet body and cooperated with the vehicle cabinet body to form a closed cavity, wherein the sample processing structure is arranged on the top of the vehicle cabinet body and located in the cover body, a cabin door is arranged on the front side wall of the cover body for the access of external human tissue samples and the sample collection operation of medical staff, and an illumination filtering structure is arranged on the top of the cover body.
[0009] Preferably, the illumination filtering structure comprises an exhaust fan arranged on the top of the cover body for discharging air in the cavity of the cover body to the external environment, a HEPA filter arranged at the inlet end of the exhaust fan and located in the cavity of the cover body for purifying and filtering the discharged air, and an illumination lamp and an ultraviolet lamp arranged on the top of the cover body and located at the front and back ends of the HEPA filter respectively for illumination and sterilization and disinfection, wherein the exhaust fan, the illumination lamp and the ultraviolet lamp are electrically connected with the control panel arranged on the top of the front side of the vehicle cabinet body.
[0010] Preferably, the sample processing structure comprises a sample shearing table arranged on the top of the vehicle cabinet body and located at the front end of the cover body, and a disposable tray and a non-woven fabric detachably arranged on the top of the sample shearing table, a scale for measuring the size of the sample is arranged on the sample shearing table, a sample collection table for spacing a plurality of external collection tubes to implement sample collection and packaging is arranged in the cover body and located at the rear end of the sample shearing table, a refrigeration tank for temporarily refrigerating and storing the collection tubes with samples is arranged in the cover body and located at one side end of the sample collection table, and a waste liquid collection device for collecting waste liquid generated in the process of sample collection and cleaning is arranged in the cover body and located at the other side away from the refrigeration tank, wherein the refrigeration structure is connected with the sample shearing table, the sample collection table and the refrigeration tank to implement refrigeration operation.
[0011] Preferably, the waste liquid collection device comprises a waste liquid tank arranged in the cover body and located at the other side away from the refrigeration tank, and the outlet end of the waste liquid tank penetrates the top of the vehicle cabinet body, a fixed box arranged on the top end of the inside of the vehicle cabinet body and located directly below the waste liquid tank, and the fixed box is in sealed communication with the waste liquid tank, a push-pull box with an open top arranged on the fixed box for collecting the waste liquid delivered by the waste liquid tank, and the push-pull box can be pushed and pulled out from the side end of the fixed box.
[0012] Preferably, the refrigeration structure comprises a heat dissipation fin embedded on the outer wall of the vehicle cabinet body away from the control panel end by a heat dissipation fan, a metal conductor is arranged on the end of the heat dissipation fin away from the heat dissipation fan, and ceramic sleeve bodies are respectively arranged on the sample shearing table, the sample receiving table and the refrigeration tank, and the bottoms of the ceramic sleeve bodies extend into the inside of the vehicle cabinet body and are connected to each other, and a P-type semiconductor and an N-type semiconductor are arranged between the metal conductor and the ceramic sleeve bodies in a spaced manner, wherein the metal conductor is electrically connected to a refrigeration temperature controller arranged on the outer wall of the vehicle cabinet body and close to the end of the control panel by a conductive wire bundle.
[0013] Preferably, the low-temperature cryopreservation structure comprises a sample drawer arranged on the other side of the vehicle cabinet body away from the control panel and at the lower end, an internal liquid nitrogen tank filled with liquid nitrogen is arranged at the bottom end of the inside of the sample drawer through a limiting seat, a top of the liquid nitrogen tank is safely sealed by a cover with a snap lock, and a storage cavity for placing a research tissue sample is detachably arranged in the liquid nitrogen tank to realize low-temperature collection of human tissue samples to ensure the quality and activity of the samples for subsequent high-quality scientific research. For example, the research tissue sample is a tissue sample for molecular biology or immunohistochemistry and fluorescence or proteomics detection.
[0014] Preferably, a sample information management structure for collecting information of the shape and sample receiving operation of the human tissue sample in the cover body is arranged on the vehicle cabinet body.
[0015] Preferably, the sample information management structure comprises a camera arranged on the inside of the cover body and at the upper end of one side and the upper end of the rear side for collecting information of the shape of the human tissue sample and the sample receiving operation of the medical staff, information collection and storage are facilitated to implement subsequent sample spatial omics research and traceability of research results, the camera is electrically connected to a touch screen controller arranged on the other side of the vehicle cabinet body away from the control panel by a conductive wire bundle, and a code scanner for scanning the bar code of the collection tube for sample receiving to record sample processing information is arranged in the cover body and in front of the waste tank and electrically connected to the touch screen controller by a conductive wire bundle.
[0016] Preferably, a plurality of normal-temperature storage drawers for placing corresponding conventional medical consumables are arranged on the front side wall of the vehicle cabinet body, a garbage can for centralized collection of garbage generated in the sample receiving process to facilitate timely cleaning and disinfection by external disinfection equipment is arranged on a side wall of the vehicle cabinet body, a handle for pushing the vehicle cabinet body to a designated place by the medical staff is arranged on both sides of the top of the vehicle cabinet body, and the door and the part of the cover body above the door are made of PMMA transparent material.
[0017] Due to the adoption of the above structure, the utility model has the beneficial effects as follows:
[0018] 1. In the utility model, under the guidance of the universal wheel, the medical staff can push the cabinet body to drive the sterile bin together with the sample processing structure, the refrigeration structure and the low-temperature frozen storage structure to the designated place, the external sterile small dish is used to obtain the human tissue from the external operating table and is transported to the sample processing structure in the sterile bin, under the low-temperature environment of the refrigeration structure to the sample processing structure, the medical staff can safely process the human tissue to cut it into several parts, a part is packaged in the external collection tube and is moved to the refrigeration space of the sample processing structure to carry out short-term refrigeration to implement pathological detection, another part is packed in the predetermined organoid special storage liquid and is marked with a serial number and is placed in the refrigeration space to carry out short-term refrigeration for extracting the organoid, and another part is directly sealed in the external frozen storage tube, is input into the low-temperature frozen storage structure to carry out freezing after scanning and inputting information into the information system to carry out subsequent high-quality scientific research, which is beneficial to accurately implementing the scientific research of related diseases, thereby the low-temperature environment is constructed to implement the sample collection and storage processing of the human tissue, the quality and activity of the human tissue sample can be guaranteed, and then the high-quality scientific research is ensured to accurately implement the scientific research of related diseases, therefore, the utility model has the advantages that the refrigeration can be implemented to construct a low-temperature environment to implement the sample collection and storage processing of the human tissue, the quality and activity of the sample are effectively guaranteed to ensure the subsequent high-quality scientific research, at the same time, the accuracy of the subsequent test results, clinical pathological diagnosis results and scientific research results can be ensured, and the problem that the sample quality and activity are poor to cause the above-mentioned results to be false negative or false positive to influence the clinical interpretation results and hinder the progress of the scientific research of related diseases is avoided.
[0019] 2. Since the bin door and the part of the cover body above the bin door are transparent and visualized, when in use, the bin door is pushed and pulled upward to open to the minimum opening position suitable for operation to enable the hands of the medical staff and the human tissue sample to be inserted into the inside, when cutting the sample, under the transparent and visualized part of the cover body above the bin door for the medical staff to view and operate, the medical staff only need to insert the hands into the cavity formed by the cover body to implement the cutting and packaging operation of the sample, so that the problem that a large area of tissue liquid is splashed to the outside or even directly contacts the body surface of the medical staff to cause pollution when cutting the sample can be minimized, thereby achieving the use purpose of the safety cabinet. BRIEF DESCRIPTION OF DRAWINGS
[0020] In order to more clearly illustrate the technical scheme in the embodiments of the utility model, the drawings needed to be used in the embodiments or the prior art description will be briefly introduced below, obviously, the drawings in the following description are only some embodiments of the utility model, and for those skilled in the art, other drawings can also be obtained without creative labor.
[0021] Fig. 1 It is the internal structure schematic view of low temperature type human tissue sample collection and processing equipment of the utility model;
[0022] Fig. 2 It is the external structure schematic view of low temperature type human tissue sample collection and processing equipment of the utility model;
[0023] Fig. 3 It is the refrigeration structure schematic view of low temperature type human tissue sample collection and processing equipment of the utility model;
[0024] Fig. 4 It is the circuit connection block diagram of low temperature type human tissue sample collection and processing equipment of the utility model.
[0025] The figure mark explanation: 1, universal wheel, 2, car cabinet body, 3, sterile warehouse, 31, cover body, 32, warehouse door, 33, illumination filtering structure, 331, exhaust fan, 332, HEPA filter, 333, illuminating lamp, 334, ultraviolet lamp, 335, control panel, 4, sample processing structure, 41, sample shearing table, 42, disposable tray, 43, non-woven fabric, 44, scale, 45, sample collection table, 46, refrigeration tank, 47, waste liquid collection device, 471, waste liquid tank, 472, fixed box, 473, push-pull box, 5, refrigeration structure, 51, heat dissipation fan, 52, heat sink, 53, metal conductor, 54, ceramic sleeve, 55, P-type semiconductor, 56, N-type semiconductor, 57, refrigeration temperature controller, 6, low temperature cryopreservation structure, 61, sample drawer, 62, limit seat, 63, liquid nitrogen tank, 64, storage cavity, 65, hasp lock, 66, lid, 7, sample information management structure, 71, camera, 72, touch screen controller, 73, code scanner, 8, normal temperature storage drawer, 9, garbage can, 10, handle. DETAILED DESCRIPTION
[0026] The technical solutions in the embodiments of the utility model will be clearly and completely described below with reference to the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, rather than all the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by those skilled in the art without creative labor fall within the protection scope of the utility model.
[0027] Please refer to Figs. 1 to 4As shown, a low-temperature human tissue sample collection and processing device includes a cabinet body 2 with universal wheels 1; a sterile bin 3 is provided on the top of the cabinet body 2, and a sample processing structure 4 for medical staff to collect and process external human tissue samples is arranged in the sterile bin 3; further comprising a refrigeration structure 5 arranged on the cabinet body 2 for refrigerating the sample processing structure 4 to build a low-temperature environment in the coverage area of the sample processing structure 4 for medical staff to safely process human tissue samples; and a low-temperature cryopreservation structure 6 is further arranged on the front left lower side of the cabinet body 2 for low-temperature collection of tissue samples for scientific research to ensure their quality and activity. In use, the cabinet body 2 is pushed by medical staff under the guidance of the universal wheels 1 to drive the sterile bin 3 together with the sample processing structure 4, the refrigeration structure 5 and the low-temperature cryopreservation structure 6 to move to the designated place, then the external sterile small dishes are used to obtain human tissue from the external operating table and deliver it to the sample processing structure 4 in the sterile bin 3, under the low-temperature environment built by the refrigeration structure 5 on the sample processing structure 4, the human tissue is safely processed by medical staff to be cut into several parts, a part is packaged in an external collection tube and then moved to the refrigeration space of the sample processing structure 4 for short-term refrigeration for subsequent transfer to the pathology site for pathological detection, a part is filled with a predetermined organoid special preservation liquid and marked with a serial number, then placed in the refrigeration space of the sample processing structure 4 for short-term refrigeration for extraction of organoids; another part of human tissue for scientific research is directly sealed in an external cryopreservation tube, after scanning and entering the information system, it is put into the low-temperature cryopreservation structure 6 for low-temperature freezing collection and storage for subsequent high-quality scientific research, which is conducive to accurately carrying out scientific research and research on related diseases, thereby building a low-temperature environment for collecting and storing human tissue samples, which can ensure the quality and activity of human tissue samples, and further ensure high-quality scientific research to accurately implement scientific research and research on related diseases, avoid false negative or false positive results due to poor quality and activity of samples, and hinder the progress of related disease research.
[0028] In the embodiment, the sterile cabin 3 comprises a cover 31 arranged on the top of the cabinet body 2 and cooperated with the cabinet body 2 to form a closed cavity, wherein the sample processing structure 4 is arranged on the top of the cabinet body 2 and located in the cover 31, a cabin door 32 for the external human tissue sample to enter and exit and for the medical staff to perform the sample collection operation is arranged on the front side wall of the cover 31, and an illumination filtering structure 33 is arranged on the top of the cover 31. The illumination filtering structure 33 comprises an exhaust fan 331 arranged on the top of the cover 31 for discharging the air in the cavity of the cover 31 to the external environment, a HEPA filter 332 arranged at the inlet end of the exhaust fan 331 and located in the cavity of the cover 31 for performing the purification filtering treatment on the discharged air, an illumination lamp 333 and an ultraviolet lamp 334 arranged on the top of the cover 31 and located at the front and rear ends of the HEPA filter 332 respectively for illumination and sterilization and disinfection, wherein the exhaust fan 331, the illumination lamp 333 and the ultraviolet lamp 334 are all electrically connected with a control panel 335 arranged on the top of the front side of the cabinet body 2. In use, the exhaust fan 331 is started to work by the control panel 335 of the illumination filtering structure 33 to perform the air exhaust and ventilation treatment on the closed cavity formed by the cover 31 of the sterile cabin 3 and the cabinet body 2, in this process, the HEPA filter 332 is used to perform the filtering and cleaning treatment on the discharged air to avoid the pollution source in the closed cavity to be discharged to the outside to cause the environmental pollution, and the ultraviolet lamp 334 is started to perform the sterilization and disinfection treatment to form a sterile closed cavity; the cabin door 32 of the sterile cabin 3 is opened and the illumination lamp 333 is started to work, the external sterile small dish is used to obtain the human tissue from the external operating table and deliver to the sample processing structure 4 in the closed cavity of the sterile cabin 3 to perform the low-temperature sample collection treatment and storage, thereby the sample collection safety can be effectively improved by performing the sample collection treatment and storage of the human tissue sample under the sterile condition.
[0029] In the present embodiment, the sample processing structure 4 comprises a sample cutting table 41 arranged at the top of the vehicle cabinet body 2 and located at the front end of the cover body 31, and the top of the sample cutting table 41 is detachably placed with a disposable tray 42 and a non-woven fabric 43, a scale 44 for measuring the size of the sample is arranged on the sample cutting table 41, and a sample collection table 45 for spacing a plurality of external collection tubes to implement sample collection and packaging is arranged at the rear end of the sample cutting table 41 in the cover body 31, a refrigeration tank 46 for temporarily storing the collection tube with the sample is arranged at one side end of the sample collection table 45 in the cover body 31, and a waste liquid collection device 47 for collecting the waste liquid generated in the process of implementing sample collection and cleaning treatment is arranged at the other side of the cover body 31 away from the refrigeration tank 46, wherein the refrigeration structure 5 is connected with the sample cutting table 41, the sample collection table 45, and the refrigeration tank 46 to implement refrigeration operation. The waste liquid collection device 47 comprises a waste liquid tank 471 arranged in the cover body 31 away from the other side of the refrigeration tank 46, and the outlet end of the waste liquid tank 471 penetrates the top of the vehicle cabinet body 2, and a fixed box 472 is arranged at the top end inside the vehicle cabinet body 2 and located directly below the waste liquid tank 471, and the fixed box 472 is in sealed communication with the waste liquid tank 471, a push-pull box 473 is arranged on the fixed box 472 and is used to collect the waste liquid transported by the waste liquid tank 471, and the push-pull box 473 can be pulled out from the side end of the fixed box 472. In use, the disposable tray 42 and the non-woven fabric 43 of the sample processing structure 4 are sequentially placed on the sample cutting table 41 from bottom to top, and the human tissue obtained from the external operating table by using an external sterile dish is placed on the non-woven fabric 43, so as to avoid cross infection of the human tissue and the sample cutting table 41 caused by accidental factors, under the low-temperature environment of the refrigeration structure 5 for implementing refrigeration construction of the sample cutting table 41, the sample collection table 45, and the refrigeration tank 46, the medical staff safely cuts the human tissue into a plurality of human tissue samples under the guidance of the scale 44, a part of the human tissue samples is packaged in the external collection tube pre-placed on the sample collection table 45 and then moved to the refrigeration tank 46 for short-term refrigeration for subsequent transfer to a pathological site for pathological detection, a part of the human tissue samples is packed in a predetermined organoid special storage liquid and is marked with a serial number and then is placed in the refrigeration tank 46 for short-term refrigeration for subsequent extraction of the organoid. Another part of the sample is packed in an external cryopreservation tube, is input into the low-temperature refrigeration structure 6 after scanning and entering the information system, and is implemented for refrigeration.When the sample processing of the human tissue sample is completed, if there are more blood stains in the tissue, the internal space of the cover body 31 needs to be flushed several times with external PBS or physiological saline, and the sample processing structure 4 needs to be cleaned and disinfected with external cleaning and disinfecting liquid. The waste liquid generated by flushing and cleaning and disinfecting is drained to the push-pull box 473 on the fixed box 472 through the waste liquid tank 471 of the waste liquid collecting device 47 for centralized collection, thereby facilitating subsequent discharge treatment and effectively improving the convenience of use. By constructing a low-temperature environment for sample collection and storage of human tissue, the quality and activity of the human tissue sample can be guaranteed, thereby ensuring subsequent high-quality scientific research and ensuring the accuracy of the test results and clinical pathological diagnosis results of clinical tests, avoiding false negative or false positive results caused by poor sample quality and activity, which affects clinical interpretation results and hinders the progress of related disease research.
[0030] In the present embodiment, the refrigeration structure 5 includes a heat sink 52 embedded on the outer wall of the vehicle cabinet body 2 away from the control panel 335 by a heat dissipation fan 51, a metal conductor 53 is provided on the end of the heat sink 52 away from the heat dissipation fan 51, and ceramic sleeves 54 are respectively sleeved on the sample shearing table 41, the sample collection table 45, and the refrigeration tank 46, and the bottoms of the ceramic sleeves 54 extend into the interior of the vehicle cabinet body 2 and are connected to each other. A P-type semiconductor 55 and an N-type semiconductor 56 are arranged in a spaced manner between the metal conductor 53 and the ceramic sleeves 54, and the metal conductor 53 is electrically connected to a refrigeration temperature controller 57 arranged on the outer wall of the vehicle cabinet body 2 and close to one end of the control panel 335 by a conductive wire bundle. In use, the refrigeration temperature controller 57 of the refrigeration structure 5 starts the P-type semiconductor 55 and the N-type semiconductor 56 to work by the metal conductor 53. When the low electron potential of the N-type semiconductor 56 moves to the high electron potential of the P-type semiconductor 55, the ceramic sleeves 54 absorb the heat of the sample shearing table 41, the sample collection table 45, and the refrigeration tank 46 as heat energy to provide power for the movement of the low electron potential to the high electron potential, thereby realizing refrigeration operation of the sample shearing table 41, the sample collection table 45, and the refrigeration tank 46 to form a low-temperature environment. At the same time, by starting the heat dissipation fan 51 to work, the heat dissipation fan 51 discharges the exchanged heat of the heat sink 52 to the external environment under the heat exchange of the P-type semiconductor 55 and the N-type semiconductor 56, thereby realizing heat exchange circulation to meet the refrigeration of the sample shearing table 41, the sample collection table 45, and the refrigeration tank 46 to form a low-temperature environment for medical staff to safely perform human tissue sample collection and storage work, thereby effectively improving the safety and convenience of use.
[0031] In the present embodiment, the low-temperature cryopreservation structure 6 comprises a sample drawer 61 arranged on the vehicle cabinet body 2 away from the lower end of the other side of the control panel 335, an internal bottom end of the sample drawer 61 is provided with a limited seat 62, an internal liquid nitrogen tank 63 filled with liquid nitrogen is arranged in the limited seat 62, and the top of the liquid nitrogen tank 63 is safely sealed by a lid 66 with a snap lock 65, and a storage cavity 64 for placing tissue samples for scientific research is detachably arranged in the liquid nitrogen tank 63 to achieve low-temperature collection of human tissue samples to ensure their quality and activity for subsequent high-quality scientific research. In use, the human tissue used for scientific research is directly sealed in the external cryopreservation tube and entered into the information system after scanning the code and entering the storage, and at the same time, the sample drawer 61 of the low-temperature cryopreservation structure 6 is opened, the snap lock 65 is opened and the lid 66 is lifted to open the top opening of the liquid nitrogen tank 63 under the safe limitation of the limited seat 62 to the liquid nitrogen tank 63, the marked human tissue sample is placed on the storage cavity 64 and then moved into the liquid nitrogen tank 63, the lid 66 is closed and the snap lock 65 is locked, so as to safely close the opening end of the liquid nitrogen tank 63 to prevent the liquid nitrogen in the liquid nitrogen tank 63 from overflowing outside and causing personnel frostbite or frozen goods, thereby realizing the closed low-temperature collection and storage of the human tissue sample, effectively ensuring its quality and activity for subsequent high-quality scientific research, and facilitating accurate implementation of scientific research and research on related diseases.
[0032] In the embodiment, a sample information management structure 7 is arranged on the cabinet body 2 for collecting the shape of the human tissue sample in the cover body 31 and the sample collection operation information of the medical staff to facilitate traceability management. The sample information management structure 7 includes a camera 71 arranged on the inner side of the cover body 31 at the upper end and the rear upper end for collecting the shape of the human tissue sample and the sample collection operation information of the medical staff, and the camera 71 is electrically connected to a touch screen controller 72 arranged on the other side of the control panel 335 of the cabinet body 2 through a conductive wire harness. The sample information management structure 7 also includes a code scanner 73 arranged in the cover body 31 in front of the waste tank 471 and electrically connected to the touch screen controller 72 through a conductive wire harness for scanning the bar code of the collection tube to record the sample processing information. In use, under the power supply of the external power supply, the camera 71 and the code scanner 73 are started to work by the touch screen controller 72 of the sample information management structure 7, the shape of the human tissue sample and the sample collection operation information of the medical staff are collected by the camera 71 and stored in the touch screen controller 72, and a part of the human tissue sample is placed in the external collection tube placed on the sample collection table 45, packaged and labeled, and then scanned by the code scanner 73 to record the sample information into the touch screen controller 72, and then moved to the refrigeration tank 46 for short-term refrigeration for subsequent transfer to the pathology site for pathological detection. A part of it is filled with a predetermined organoid special preservation liquid and marked with a serial number, and then scanned by the code scanner 73 to record the sample information into the touch screen controller 72, and then moved to the refrigeration tank 46 for short-term refrigeration for subsequent extraction of the organoid. The human tissue used for scientific research is directly sealed in an external cryopreservation tube and marked with a serial number, and then scanned by the code scanner 73 to record the sample information into the touch screen controller 72, and then placed in the low-temperature storage structure 6 for low-temperature collection and storage for subsequent high-quality scientific research, which is conducive to accurately carrying out scientific research on related diseases. Then, the touch screen controller 72 interacts with the external hospital HIS system information to synchronize the shape of the human tissue sample and the sample collection operation information of the medical staff and the completed record information to the hospital HIS system for subsequent traceability management.
[0033] In the embodiment, a plurality of normal-temperature storage drawers 8 for placing corresponding conventional medical consumables are arranged on the front side wall of the cabinet body 2; a garbage can 9 for collecting garbage generated during sample collection is arranged on one side wall of the cabinet body 2 to facilitate timely cleaning and disinfection by external disinfection equipment; a handle 10 for pushing the cabinet body 2 to the designated place is arranged on both sides of the top of the cabinet body 2; and the warehouse door 32 and the part of the cover body 31 above the warehouse door 32 are made of PMMA transparent material.
[0034] In the present embodiment, since the door 32 and the portion of the cover 31 above the door 32 are transparent, in use, the door 32 is pushed up and pulled to open to a minimum opening position suitable for operation, so that the human tissue sample and the hands of the medical staff can be inserted into the inside, and in the process of cutting the sample, the transparent door 32 and the portion of the cover 31 above the door 32 provide the medical staff with a view of the operation, so that the medical staff only need to insert their hands into the cavity formed by the cover 31 to implement the sample cutting and packaging operation, thereby minimizing the problem of large-area spattering of tissue fluid to the outside or even directly contacting the body surface of the medical staff during sample cutting, thereby achieving the purpose of using a safety cabinet.
[0035] In use, first, the medical staff pushes the handle 10 under the guidance of the universal wheel 1 to drive the cabinet body 2 to move the sterile cabin 3 together with the sample processing structure 4, the refrigeration structure 5, the low-temperature frozen storage structure 6, the sample information management structure 7, the normal-temperature storage drawer 8 with conventional medical consumables, and the garbage can 9 to the designated place; the control panel 335 of the lighting filter structure 33 is used to start the exhaust fan 331 to work to implement the air exhaust and ventilation treatment on the closed cavity formed by the cover body 31 of the sterile cabin 3 and the cabinet body 2, in the process, the HEPA filter 332 is used to filter and clean the discharged air to avoid the pollution source in the closed cavity to be discharged to the outside to cause environmental pollution, and the ultraviolet lamp 334 is started to implement the sterilization and disinfection treatment to form a sterile closed cavity; the door 32 of the sterile cabin 3 is opened and the lighting lamp 333 is started to work, the external sterile small dish is used to obtain the human tissue from the external operating table and deliver it to the sample processing structure 4 in the closed cavity of the sterile cabin 3 to implement the low-temperature sample collection treatment, thereby the sample collection safety is effectively improved by implementing the sample collection treatment of the human tissue sample under the sterile condition; secondly, the disposable tray 42 and the non-woven fabric 43 of the sample processing structure 4 are placed on the sample shearing table 41 from bottom to top, the human tissue obtained from the external operating table by the external sterile small dish is placed on the non-woven fabric 43, thereby avoiding the contact between the human tissue and the sample shearing table 41 to cause the cross infection due to accidental factors, the refrigeration temperature controller 57 of the refrigeration structure 5 is used to start the P-type semiconductor 55 and the N-type semiconductor 56 to work by the metal conductor 53, when the low electron potential of the N-type semiconductor 56 moves to the high electron potential of the P-type semiconductor 55, the ceramic sleeve 54 absorbs the heat of the sample shearing table 41, the sample collection table 45, and the cold storage tank 46 as heat energy to provide power for the movement of the low electron potential to the high electron potential, thereby the refrigeration operation is implemented on the sample shearing table 41, the sample collection table 45, and the cold storage tank 46 to form a low-temperature environment, at the same time, the heat dissipation fan 51 is started to work under the heat exchange of the heat dissipation fin 52 to the P-type semiconductor 55 and the N-type semiconductor 56, the heat dissipation fan 51 is used to discharge the exchanged heat of the heat dissipation fin 52 to the external environment, thereby the heat exchange circulation is realized to meet the refrigeration of the sample shearing table 41, the sample collection table 45, and the cold storage tank 46 to form a low-temperature environment for the medical staff to safely implement the sample collection treatment of the human tissue sample, and the safety and convenience of use are effectively improved; under the low-temperature environment formed by the refrigeration of the sample shearing table 41, the sample collection table 45, and the cold storage tank 46 by the refrigeration structure 5, the medical staff safely cuts the human tissue into several human tissue samples under the guidance of the scale 44.Then, under the power supply of the external power supply, the camera 71 and the code scanner 73 are started by the touch screen controller 72 of the sample information management structure 7, the morphological information of the human tissue sample and the sample collection operation information of the medical staff are collected by the camera 71 and stored in the touch screen controller 72, a part of the human tissue sample is placed in the external collection tube placed on the sample collection table 45, and after packaging and labeling, the collection tube is scanned by the code scanner 73 to enter the sample information into the touch screen controller 72 and then moved to the cold storage tank 46 for short-term cold storage for subsequent pathological detection in the pathology department, a part of the sample is placed in the predetermined organoid special storage liquid and marked with a serial number, and then scanned by the code scanner 73 to enter the sample information into the touch screen controller 72, and then moved to the cold storage tank 46 for short-term cold storage for subsequent extraction of organoids, and the other part of the human tissue used for scientific research is directly sealed in the external cryopreservation tube and marked with a serial number, and then scanned by the code scanner 73 to enter the sample information into the touch screen controller 72, and then the sample drawer 61 of the low-temperature freezing structure 6 is opened, the safety limit of the liquid nitrogen tank 63 in the limited seat 62 is opened, the hasp lock 65 is opened and the cover 66 is opened to open the top opening of the liquid nitrogen tank 63, the marked human tissue sample is placed on the storage cavity 64 and then moved to the liquid nitrogen tank 63, the cover 66 is closed and the hasp lock 65 is locked, so that the opening end of the liquid nitrogen tank 63 is safely closed to prevent the liquid nitrogen in the liquid nitrogen tank 63 from overflowing outside during movement and causing personnel frostbite or frozen goods, thereby collecting and storing the human tissue sample for subsequent high-quality scientific research, which is conducive to accurately conducting scientific research on related diseases, thereby realizing the closed and low-temperature collection and storage of the human tissue sample, which can effectively ensure the quality and activity of the human tissue sample for subsequent testing and extraction of organoids for scientific research, and then the touch screen controller 72 interacts with the external hospital HIS system information to synchronize the morphological information of the human tissue sample and the sample collection operation information of the medical staff and the sample completion record information to the hospital HIS system for subsequent traceability management; in addition, during the sample collection process, the garbage produced is collected by the garbage can 9 for centralized collection and timely cleaning and disinfection by the external disinfection equipment.Finally, when the sample collection and processing of the human tissue sample is completed, if there are more blood stains in the tissue, the sample processing structure 4 needs to be cleaned and disinfected by external PBS or physiological saline flushing several times, and the waste liquid generated by flushing and cleaning and disinfecting is drained to the push-pull box 473 on the fixed box 472 through the waste liquid tank 471 of the waste liquid collection device 47 for centralized collection, so as to facilitate subsequent discharge treatment, effectively improve the convenience of use, and thus by constructing a low-temperature environment for sample collection and storage of human tissue, the quality and activity of the human tissue sample can be guaranteed, thereby ensuring the accuracy of subsequent test results and clinical pathological diagnosis results, avoiding false negative or false positive of the above results due to poor quality and activity of the sample, affecting clinical interpretation results and hindering the progress of related disease research.
[0036] In summary, the utility model has the advantages of being able to refrigerate to build a low-temperature environment for sample collection and storage of human tissue samples, effectively guaranteeing the quality and activity of the samples to ensure subsequent high-quality scientific research; being able to ensure the accuracy of subsequent test results, clinical pathological diagnosis results and scientific research results, and avoiding false negative or false positive of the above results due to poor quality and activity of the sample, affecting clinical interpretation results and hindering the progress of related disease research.
[0037] The preferred embodiments of the utility model are described above. It should be understood that the utility model is not limited to the above specific embodiments, and the devices and structures not described in detail should be understood as being implemented in the ordinary way in the art; any person skilled in the art can make many possible changes and modifications to the technical solutions of the utility model or modify them into equivalent embodiments with equivalent changes without departing from the scope of the technical solutions of the utility model, which does not affect the essential content of the utility model. Therefore, any simple modification, equivalent change and modification of the above embodiments made according to the technical essence of the utility model, without departing from the content of the technical solutions of the utility model, still belongs to the scope of protection of the technical solutions of the utility model.
Claims
1. A low-temperature human tissue sample collecting and processing device, comprising a cabinet body (2) with universal wheels (1); characterized in that: The sterile cabin (3) is arranged on the top of the cabinet body (2), and a sample processing structure (4) for medical staff to collect and process external human tissue samples is arranged in the sterile cabin (3); the refrigeration structure (5) for refrigerating the sample processing structure (4) to build a low-temperature environment in the coverage area of the sample processing structure (4) for medical staff to safely process human tissue samples is arranged on the cabinet body (2); and the low-temperature cryopreservation structure (6) for collecting and processing tissue samples for scientific research to ensure the quality and activity of the tissue samples is arranged on the front lower left side of the cabinet body (2).
2. The low-temperature human tissue sample receiving and processing apparatus according to claim 1, characterized by: The sterile cabin (3) includes a cover body (31) arranged on the top of the cabinet body (2) and cooperating with the cabinet body (2) to form a closed cavity, wherein the sample processing structure (4) is arranged on the top of the cabinet body (2) and located in the cover body (31), a cabin door (32) for the external human tissue samples to enter and exit and for the medical staff to collect and process the samples is arranged on the front side wall of the cover body (31), and an illumination filtering structure (33) is arranged on the top of the cover body (31).
3. The low-temperature human tissue sample receiving and processing apparatus according to claim 2, characterized by: The illumination filtering structure (33) includes an exhaust fan (331) arranged on the top of the cover body (31) and used for discharging air in the cavity of the cover body (31) to the external environment, a HEPA filter (332) arranged at the inlet end of the exhaust fan (331) and located in the cavity of the cover body (31) and used for purifying and filtering the discharged air, and an illuminating lamp (333) and an ultraviolet lamp (334) arranged on the top of the cover body (31) and located at the front and rear ends of the HEPA filter (332) respectively and used for illumination and sterilization and disinfection, wherein the exhaust fan (331), the illuminating lamp (333) and the ultraviolet lamp (334) are all electrically connected with a control panel (335) arranged on the top of the front side of the cabinet body (2).
4. The low-temperature human tissue sample receiving and processing apparatus according to claim 3, characterized by: The sample processing structure (4) includes a sample shearing table (41) arranged on the top of the cabinet body (2) and located at the front end of the cover body (31), and a disposable tray (42) and a non-woven fabric (43) are detachably arranged on the top of the sample shearing table (41), a scale (44) for measuring the size of the sample is arranged on the sample shearing table (41), a sample collecting table (45) for spacing and arranging a plurality of external collection tubes to collect and package the samples is arranged in the cover body (31) and located at the rear end of the sample shearing table (41), a cold storage tank (46) for temporarily storing the collection tubes with the samples is arranged in the cover body (31) and located at one side end of the sample collecting table (45), and a waste liquid collecting device (47) for collecting waste liquid generated in the process of collecting and processing the samples and cleaning is arranged in the cover body (31) and located at the other side away from the cold storage tank (46), wherein the refrigeration structure (5) is connected with the sample shearing table (41), the sample collecting table (45) and the cold storage tank (46) to perform refrigeration operation.
5. The low-temperature human tissue sample receiving and processing apparatus according to claim 4, characterized by: The waste liquid collecting device (47) comprises a waste liquid tank (471) arranged in the cover body (31) away from the other side of the refrigeration tank (46), and the outlet end of the waste liquid tank (471) penetrates the top of the vehicle cabinet body (2), and further comprises a fixed box (472) arranged at the top end inside the vehicle cabinet body (2) and located directly below the waste liquid tank (471), and the fixed box (472) is in sealed communication with the waste liquid tank (471), and a top open port is arranged on the fixed box (472) for collecting the waste liquid pushed and pulled box (473) of the waste liquid tank (471), and the waste liquid pushed and pulled box (473) can be pushed and pulled out from the side end of the fixed box (472).
6. The low-temperature human tissue sample receiving and processing apparatus according to claim 5, characterized by: The refrigeration structure (5) comprises a heat dissipation fin (52) embedded on the outer wall of the vehicle cabinet body (2) away from the control panel (335) by a heat dissipation fan (51), a metal conductor (53) is arranged on one end of the heat dissipation fin (52) away from the heat dissipation fan (51), and further comprises a ceramic sleeve body (54) respectively sleeved on the sample shearing table (41), the sample receiving table (45) and the refrigeration tank (46), and the bottom of the ceramic sleeve body (54) extends into the inside of the vehicle cabinet body (2) and is connected with each other, and a P-type semiconductor (55) and an N-type semiconductor (56) are arranged between the metal conductor (53) and the ceramic sleeve body (54) and are spaced from each other, wherein the metal conductor (53) is electrically connected with a refrigeration temperature controller (57) arranged on the outer wall of the vehicle cabinet body (2) and close to one end of the control panel (335) through a conductive wire bundle.
7. The low-temperature human tissue sample receiving and processing apparatus according to claim 6, characterized by: The low-temperature freezing structure (6) comprises a sample drawer (61) arranged on the vehicle cabinet body (2) away from the other side of the control panel (335) at the lower end, an internal liquid nitrogen tank (63) filled with liquid nitrogen is arranged at the inside bottom end of the sample drawer (61) through a limiting seat (62), and the top of the liquid nitrogen tank (63) is safely sealed by a cover (66) with a snap lock (65), and a storage cavity (64) for placing research tissue samples is detachably arranged in the liquid nitrogen tank (63) to realize low-temperature collection of human tissue samples to ensure the quality and activity of the samples for subsequent high-quality scientific research.
8. The low-temperature human tissue sample receiving and processing apparatus according to claim 7, characterized by: A sample information management structure (7) is arranged on the vehicle cabinet body (2) for collecting information of the shape and sample collection of the human tissue samples in the cover body (31) to facilitate traceable management.
9. The low-temperature human tissue sample receiving and processing apparatus according to claim 8, characterized by: The sample information management structure (7) includes a camera (71) arranged at the upper end of the inner side and the upper end of the rear side of the cover body (31) for collecting the shape of the human tissue sample and the sample collection operation information of the medical staff, and the camera (71) is electrically connected with a touch screen controller (72) arranged on the other side of the control panel (335) of the cabinet body (2) through a conductive wire harness, and further includes a code scanner (73) arranged in the cover body (31) and located in front of the waste liquid tank (471) and electrically connected with the touch screen controller (72) through a conductive wire harness for scanning the code of the collected tube to record the sample processing information.
10. The low-temperature human tissue sample receiving and processing apparatus according to any one of claims 2 to 9, characterized in that: A plurality of normal temperature storage drawers (8) for classifying and placing corresponding conventional medical consumables are arranged on the front side wall of the cabinet body (2); a garbage can (9) for centralized collection of garbage generated in the sample collection process is arranged on a side wall of the cabinet body (2) to facilitate timely cleaning and disinfection by external disinfection equipment; a handle (10) for medical staff to push the cabinet body (2) to the designated place is arranged on both sides of the top of the cabinet body (2); the cabinet door (32) and the part above the cabinet door (32) of the cover body (31) are made of PMMA transparent material.