Crystallizing tank for producing fructose diphosphate sodium bulk drug
By employing a multi-dimensional stirring and automatic venting mechanism in the fructose diphosphate sodium crystallization equipment, the problems of uneven stirring and crystal adhesion to the wall were solved, thereby improving the crystallization quality and the safety and continuity of equipment operation.
Patent Information
- Application Number
- CN202520527293.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-03-25
- Publication Date
- 2026-02-17
- Estimated Expiration
- 2035-03-25
AI Technical Summary
Existing fructose diphosphate sodium crystallization equipment suffers from problems such as uneven stirring, severe crystal adhesion to the wall, and untimely gas pressure regulation, which affect crystallization efficiency and product purity.
It adopts a stirring mechanism with a square rod and sleeve sliding cooperation, combined with the linkage design of swashplate and upper and lower rollers, and is equipped with anti-stick components and automatic venting mechanism to achieve multi-dimensional stirring and automatic air pressure adjustment.
It improves the uniformity of stirring, reduces crystal adhesion to the wall, enhances the crystallization quality and the continuity and safety of equipment operation, and avoids equipment damage and safety risks.
Smart Images
Figure CN223914724U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of pharmaceutical and chemical equipment, and in particular to a crystallization tank for the production of fructose diphosphate sodium raw material. Background Technology
[0002] Sodium fructose diphosphate is a pharmaceutical intermediate with high clinical value, widely used in the research and preparation of drugs for cardiovascular and cerebrovascular diseases, metabolic regulation, and cellular energy supplementation. One of the key steps in its production process is crystallization, which directly affects the purity, particle size distribution, and yield of the product. The crystallizer, as the core equipment for this process, typically needs to have multiple functions including heating, temperature control, stirring, and sealing to ensure that the material crystallizes fully in an ideal environment, achieving high-quality separation and purification.
[0003] In existing technologies, commonly used crystallization equipment mostly adopts a single rotary stirring structure, resulting in a relatively simple stirring method. The stirring shaft is usually at a fixed height, lacking vertical disturbance, which makes it easy for blind spots to appear in the vertical direction of the material, leading to uneven crystallization. In addition, some equipment lacks an effective anti-adhesion structure, which easily causes crystals to adhere to the tank wall, affecting heat exchange and cleaning, and even causing problems such as reduced crystallization efficiency and unstable product purity, thus limiting its application in continuous, high-quality production.
[0004] Therefore, a crystallization tank for the production of fructose diphosphate sodium raw material is proposed to solve the above problems. Utility Model Content
[0005] To overcome the above shortcomings, this utility model provides a crystallization tank for the production of fructose diphosphate sodium raw material, which aims to improve the problems of uneven stirring, severe crystal adhesion to the wall, and untimely gas pressure regulation in existing equipment.
[0006] To achieve the above objectives, the present invention adopts the following technical solution: a crystallization tank for the production of fructose diphosphate sodium raw material, comprising an outer tank, an inner tank fixedly connected inside the outer tank, a stirring mechanism provided inside the inner tank, a sealing cover provided at the top of the inner tank, an exhaust mechanism provided at the top of the sealing cover, a feed pipe fixedly connected to the outside of the sealing cover, and a discharge pipe fixedly connected to the bottom of the outer tank and penetrating the bottom of the inner tank;
[0007] The stirring mechanism includes a motor, which is fixedly connected to the middle of the sealing cover. A square rod is fixedly connected to the output end of the motor. A sleeve is slidably connected to the outside of the square rod. A swash plate is fixedly connected to the outside of the sleeve. Multiple stirring rods are fixedly connected to the outside of the sleeve. An anti-sticking component is provided at the end of the stirring rod away from the sleeve. A fixing rod is fixedly connected to the inner top wall of the sealing cover. An upper roller and a lower roller are fixedly connected to the fixing rod from top to bottom.
[0008] As a further description of the above technical solution:
[0009] The exhaust mechanism includes an L-shaped tube, which is fixedly connected to the top of the sealing cover. A piston is slidably connected in the horizontal direction inside the L-shaped tube. A telescopic rod is provided inside the L-shaped tube, and a spring is sleeved on the outside of the telescopic rod. An exhaust pipe is fixedly connected to the top of the L-shaped tube.
[0010] As a further description of the above technical solution:
[0011] The anti-sticking component includes a housing, which is fixedly connected to the end of the stirring rod away from the sleeve. Multiple springs are provided inside the housing, and a limiting plate is slidably connected inside the housing. A scraper is fixedly connected to the outside of the limiting plate.
[0012] As a further description of the above technical solution:
[0013] The swashplate is slidably connected between the upper roller and the lower roller, a thermometer is installed on the outside of the sealing cover, and a heating wire is installed between the outer tank and the inner tank.
[0014] As a further description of the above technical solution:
[0015] One end of the telescopic rod is fixedly connected to the inner wall of the L-shaped tube, and the other end of the telescopic rod is fixedly connected to one side of the piston.
[0016] As a further description of the above technical solution:
[0017] The piston is located directly below the air outlet pipe. One end of the second spring is fixedly connected to one side of the piston, and the other end of the second spring abuts against the inner wall of the L-shaped tube.
[0018] As a further description of the above technical solution:
[0019] The scraper passes through the outer shell and is slidably connected inside the outer shell, and the scraper abuts against the inner wall of the inner tank.
[0020] As a further description of the above technical solution:
[0021] One end of the spring is fixedly connected to the side of the limiting plate away from the scraper, and the other end of the spring abuts against the inner wall of the outer casing.
[0022] This utility model has the following beneficial effects:
[0023] 1. This utility model employs a structure with a square rod and sleeve slidingly engaged, combined with a linkage design between the swashplate and upper and lower rollers, enabling the stirring mechanism to achieve reciprocating motion while rotating, forming a multi-dimensional stirring path. With the anti-sticking component located at the end of the stirring rod, the scraper, under the action of a spring, always adheres to the inner wall of the tank and can automatically fine-tune according to changes in operating conditions. Compared to the shortcomings of existing single-horizontal stirring methods, which suffer from uneven mixing and crystal adhesion to the wall, this structure improves stirring uniformity, further enhancing crystallization quality and the continuity of equipment operation.
[0024] 2. In this utility model, by setting an exhaust mechanism with a piston, spring, and telescopic rod on the top of the sealing cap, the system can automatically open the exhaust channel when the gas pressure inside the tank is too high, without manual intervention, thus avoiding equipment damage or safety risks caused by abnormal pressure. Compared with the previous method of controlling exhaust by manual mechanical operation or external sensors, the structure is more compact, the response is more direct, and the safety and automation of the system operation are also improved. Attached Figure Description
[0025] Figure 1 This is a three-dimensional schematic diagram of the crystallization tank for the production of fructose diphosphate raw material proposed in this utility model;
[0026] Figure 2 This is a schematic diagram of the cross-section of the crystallization tank for the production of fructose diphosphate raw material proposed in this utility model;
[0027] Figure 3 This is a schematic diagram of the stirring mechanism of the crystallization tank for the production of fructose diphosphate raw material proposed in this utility model;
[0028] Figure 4 for Figure 3 Enlarged view of point A in the middle;
[0029] Figure 5 for Figure 3 Enlarged view of point B in the middle;
[0030] Figure 6 This is a schematic diagram of the exhaust mechanism of the crystallization tank for the production of fructose diphosphate sodium raw material proposed in this utility model.
[0031] Legend:
[0032] 1. Motor; 2. Thermometer; 3. Sealing cap; 4. Discharge pipe; 5. Outer tank; 6. Feed pipe; 7. L-shaped tube; 8. Heating wire; 9. Inner tank; 10. Square rod; 11. Swash plate; 12. Scraper; 13. Outer shell; 14. Stirring rod; 15. Sleeve; 16. Spring 1; 17. Limiting plate; 18. Upper roller; 19. Lower roller; 20. Fixing rod; 21. Telescopic rod; 22. Spring 2; 23. Air outlet pipe; 24. Piston. Detailed Implementation
[0033] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.
[0034] Reference Figure 1 - Figure 6 An embodiment of this utility model provides a crystallization tank for the production of fructose diphosphate sodium raw material, including an outer tank 5, an inner tank 9 fixedly connected inside the outer tank 5, a stirring mechanism inside the inner tank 9, a sealing cover 3 on the top of the inner tank 9, an exhaust mechanism on the top of the sealing cover 3, a feed pipe 6 fixedly connected to the outside of the sealing cover 3, and a discharge pipe 4 fixedly connected to the bottom of the outer tank 5 and penetrating the bottom of the inner tank 9.
[0035] The stirring mechanism includes a motor 1, which is fixedly connected to the middle of the sealing cover 3. A square rod 10 is fixedly connected to the output end of the motor 1. A sleeve 15 is slidably connected to the outside of the square rod 10. A swash plate 11 is fixedly connected to the outside of the sleeve 15. Multiple stirring rods 14 are fixedly connected to the outside of the sleeve 15. An anti-sticking component is provided at the end of the stirring rod 14 away from the sleeve 15. A fixing rod 20 is fixedly connected to the inner top wall of the sealing cover 3. An upper roller 18 and a lower roller 19 are fixedly connected to the fixing rod 20 from top to bottom. The swash plate 11 is slidably connected between the upper roller 18 and the lower roller 19. A thermometer 2 is installed on the outside of the sealing cover 3. A heating wire 8 is installed between the outer tank 5 and the inner tank 9.
[0036] The outer tank 5 is the main container of the crystallization tank, serving to protect and support the inner tank 9, while also withstanding the internal working pressure and temperature. The inner tank 9 is located inside the outer tank 5 and is fixedly connected within it. Its main function is to contain the solution for the crystallization process of sodium fructose diphosphate. The inner tank 9 provides the crystallization zone and aids in the precipitation of the solute through stirring and heating. The sealing cap 3 is located on top of the inner tank 9 to seal the crystallization tank, preventing solution spillage or environmental contamination. The sealing cap 3 also features a venting mechanism to facilitate the discharge of gases generated during crystallization, ensuring stable internal system pressure. The venting mechanism, located on top of the sealing cap 3, is used to discharge gases generated during crystallization, preventing excessive pressure buildup inside the inner tank 9. The feed pipe 6 is fixedly connected to the outside of the sealing cap 3, used to input the solution or raw materials into the inner tank 9, facilitating the addition of the sodium fructose diphosphate solution. The discharge pipe 4 is fixedly connected to the bottom of the outer tank 5 and extends through the bottom of the inner tank 9, serving as a discharge channel for the crystallized product, ensuring smooth discharge of the crystallized solution. Both the feed pipe 6 and the discharge pipe 4 are equipped with valves. Thermometer 2 is installed on the outside of the sealing cover 3 to monitor the temperature of the solution inside the crystallization tank in real time, ensuring that the temperature during the crystallization process is within the ideal range. Heating wire 8 is installed between the outer tank 5 and the inner tank 9 to heat the solution in the inner tank 9, regulate the solution temperature, promote the crystallization process, and ensure the precipitation of crystalline substances. Heating wire 8 works in conjunction with thermometer 2; it automatically starts working when the temperature is lower than the set temperature. Motor 1 is the power source for the stirring mechanism, driving the square rod 10 to rotate, which in turn drives the stirring rod 14 to rotate. The stirring rod 14 is fixed to the outside of the sleeve 15 and is responsible for the actual stirring work, agitating the substances in the solution and promoting the crystallization process. Swashplate 11 slides between the upper roller 18 and the lower roller 19. When the square rod 10 rotates, due to its square design, it also rotates the sleeve 15 along with it. Therefore, swashplate 11 slides between the upper roller 18 and the lower roller 19. Due to its sloping design, the sleeve 15 also slides up and down on the square rod 10 while rotating, achieving vertical stirring and making the stirring more uniform. The anti-stick component is used to prevent crystals from adhering to the inner wall of the inner tank 9, thus preventing resource waste.
[0037] Reference Figure 1 , Figure 2 and Figure 6The exhaust mechanism includes an L-shaped pipe 7, which is fixedly connected to the top of the sealing cover 3. A piston 24 is horizontally slidably connected inside the L-shaped pipe 7. A telescopic rod 21 is installed inside the L-shaped pipe 7, and a spring 22 is sleeved on the outside of the telescopic rod 21. An exhaust pipe 23 is fixedly connected to the top of the L-shaped pipe 7. One end of the telescopic rod 21 is fixedly connected to the inner wall of the L-shaped pipe 7, and the other end is fixedly connected to one side of the piston 24. The piston 24 is located directly below the exhaust pipe 23. One end of the spring 22 is fixedly connected to one side of the piston 24, and the other end abuts against the inner wall of the L-shaped pipe 7. The L-shaped pipe 7 is the basic connection of the exhaust mechanism, carrying all the internal components and ensuring the normal operation of the exhaust mechanism. When the internal air pressure of the inner tank 9 is normal, the piston 24 closes the outlet of the exhaust pipe 23. When the air pressure exceeds a safe value, the piston 24 is forced open, and the spring 22 is compressed. Spring 22 is used to control the air pressure level based on its own elasticity. When spring 22 is compressed, piston 24 moves, opening the outlet of air pipe 23 to release gas. Telescopic rod 21 assists in the movement of piston 24. When the air pressure returns to normal, piston 24 returns to its original position, closing the outlet of air pipe 23.
[0038] Reference Figure 1 - Figure 4 The anti-stick component includes a housing 13, which is fixedly connected to the end of the stirring rod 14 away from the sleeve 15. Multiple springs 16 are provided inside the housing 13. A limiting plate 17 is slidably connected inside the housing 13. A scraper 12 is fixedly connected to the outside of the limiting plate 17. The scraper 12 passes through the housing 13 and is slidably connected inside the housing 13. The scraper 12 abuts against the inner wall of the inner tank 9. One end of the spring 16 is fixedly connected to the side of the limiting plate 17 away from the scraper 12, and the other end of the spring 16 abuts against the inner wall of the housing 13.
[0039] The outer casing 13 supports the internal components and ensures the normal operation of the anti-sticking assembly. Spring 16 keeps the scraper 12 in constant contact with the inner wall of the inner tank 9 and allows it to slide within the outer casing 13 for fine-tuning. A limiting plate 17 allows the scraper 12 to slide freely within the outer casing 13. The scraper 12 contacts the inner wall of the inner tank 9 to scrape away crystals, preventing them from adhering to the inner wall and ensuring a smooth crystallization process. The design of the scraper 12 effectively prevents solute from adhering to the inner wall, maintaining solution homogeneity and efficient stirring.
[0040] Working principle: When using this equipment, first open the valve on the feed pipe 6 to inject the solution or raw material into the inner tank 9 through the feed pipe 6. After injection, close the valve. During the crystallization process, if the gas pressure inside the inner tank 9 rises above the safe value, the piston 24 is pushed open under the action of gas pressure, and the gas outlet pipe 23 opens, allowing gas to be discharged through the gas outlet pipe 23. After the gas pressure returns to the normal range, under the combined action of the spring 22 and the telescopic rod 21, the piston 24 resets, and the gas outlet pipe 23 closes again.
[0041] During the stirring process, motor 1 starts and drives square rod 10 to rotate, causing sleeve 15, swashplate 11, and stirring rod 14 to move synchronously. With the combined action of swashplate 11, upper roller 18, and lower roller 19, sleeve 15 slides up and down along square rod 10, enhancing the vertical movement of the stirring shaft and accelerating the mixing of substances in the solution. Stirring rod 14 remains in continuous contact with the solution during rotation, ensuring a uniform mixture and promoting the crystallization reaction of sodium fructose diphosphate. Simultaneously, scraper 12 rotates with stirring rod 14, running close to the inner wall of inner tank 9 under the continuous thrust of spring 16, continuously scraping away crystals adhering to the inner wall surface to prevent accumulation and maintain crystallization efficiency. Scraper 12 can slide within outer shell 13 during operation, allowing for adaptive fine-tuning to meet operational needs under different stirring conditions.
[0042] During the crystallization process, the solution temperature gradually decreases, and thermometer 2 monitors the temperature change inside the inner tank 9 in real time. If the temperature falls below the set value, heating wire 8 starts working to raise the solution temperature through heat transfer, maintain the stability of the crystallization environment, and ensure the continuous crystallization reaction.
[0043] After crystallization, the product is concentrated at the bottom of the inner tank 9. By opening the discharge pipe 4, the crystals are smoothly discharged to the outside, completing the entire crystallization operation process.
[0044] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.
Claims
1. Crystallization tank for the production of sodium fructose diphosphate bulk drug substance, comprising an outer tank (5), characterized in that: The outer tank (5) is fixedly connected with an inner tank (9) inside, the inner tank (9) is provided with a stirring mechanism inside, the top of the inner tank (9) is provided with a sealing cover (3), the top of the sealing cover (3) is provided with an exhaust mechanism, the outer side of the sealing cover (3) is fixedly connected with a feeding pipe (6), and the bottom of the outer tank (5) is fixedly connected with a discharging pipe (4) and penetrates the bottom of the inner tank (9); The stirring mechanism comprises a motor (1), the motor (1) is fixedly connected in the middle of the sealing cover (3), the output end of the motor (1) is fixedly connected with a square rod (10), the outer side of the square rod (10) is slidably connected with a sleeve (15), the outer side of the sleeve (15) is fixedly connected with a swash plate (11), the outer side of the sleeve (15) is fixedly connected with a plurality of stirring rods (14), the end of the stirring rod (14) away from the sleeve (15) is provided with an anti-sticking component, the inner top wall of the sealing cover (3) is fixedly connected with a fixed rod (20), and the fixed rod (20) is sequentially fixedly connected with an upper roller (18) and a lower roller (19) from top to bottom.
2. The crystallization tank for producing sodium fructose diphosphate raw material medicine according to claim 1, characterized in that: The exhaust mechanism comprises an L-shaped pipe (7), the L-shaped pipe (7) is fixedly connected at the top of the sealing cover (3), the piston (24) is slidably connected in the L-shaped pipe (7) in the horizontal direction, the L-shaped pipe (7) is provided with a telescopic rod (21) inside, the telescopic rod (21) is sleeved with a spring (22) outside, and the top of the L-shaped pipe (7) is fixedly connected with an air outlet pipe (23).
3. The crystallization tank for producing sodium fructose diphosphate raw material medicine according to claim 1, characterized in that: The anti-sticking component comprises an outer shell (13), the outer shell (13) is fixedly connected at the end of the stirring rod (14) away from the sleeve (15), the inner tank (9) is provided with a plurality of springs (16) inside, the inner tank (9) is slidably connected with a limiting plate (17) inside, and the outer side of the limiting plate (17) is fixedly connected with a scraper (12).
4. The crystallization tank for producing sodium fructose diphosphate raw material medicine according to claim 1, characterized in that: The swash plate (11) is slidably connected between the upper roller (18) and the lower roller (19), a thermometer (2) is installed on the outer side of the sealing cover (3), and a heating wire (8) is installed between the outer tank (5) and the inner tank (9).
5. The crystallization tank for producing sodium fructose diphosphate raw material medicine according to claim 2, characterized in that: One end of the telescopic rod (21) is fixedly connected to the inner wall of the L-shaped pipe (7), and the other end of the telescopic rod (21) is fixedly connected to one side of the piston (24).
6. The crystallization tank for producing sodium fructose diphosphate raw material medicine according to claim 2, characterized in that: The piston (24) is located directly below the air outlet pipe (23), one end of the spring (22) is fixedly connected to one side of the piston (24), and the other end of the spring (22) abuts against the inner wall of the L-shaped pipe (7).
7. The crystallization tank for producing sodium fructose diphosphate raw material medicine according to claim 3, characterized in that: The scraper (12) penetrates the outer shell (13) and is slidably connected inside the outer shell (13), and the scraper (12) abuts against the inner wall of the inner tank (9).
8. The crystallization tank for producing sodium fructose diphosphate raw material medicine according to claim 3, characterized in that: One end of the spring (16) is fixedly connected to the side of the limiting plate (17) away from the scraper (12), and the other end of the spring (16) abuts against the inner wall of the outer shell (13).