Filtering device for antibody production

Abstract

The utility model relates to the technical field of antibody production, and discloses a filtering device for antibody production, which comprises a filtering barrel component, the filter barrel assembly comprises: a barrel body; the barrel cover is clamped at the top of the barrel body; supporting legs are arranged at the bottom of the filtering barrel assembly; a feeding assembly is arranged at the top of the filter vat assembly, and a drain valve is arranged at the bottom of the filter vat assembly; a driving motor is mounted at the bottom of the filtering barrel assembly, and a filtering assembly is arranged in the filtering barrel assembly; a driving motor and a filtering assembly are arranged, the filtering assembly adopts three filtering covers to form a three-layer filtering cylinder, when an antibody stock solution is filtered, the antibody stock solution enters from the filtering cover on the innermost layer, then the driving motor drives the three-layer filtering cylinder to rotate, and the three-layer filtering cylinder sequentially filters the antibody stock solution from inside to outside; according to the filtering mode, the stock solution is filtered by utilizing centrifugal force, so that the filtering speed of the antibody stock solution can be greatly improved.

Description

Technical Field

[0001] This utility model relates to the field of antibody production technology, specifically a filtration device for antibody production. Background Technology

[0002] Antibodies are a class of immunoglobulins that specifically bind to antigens. Antibodies are classified according to their reaction form into agglutinins, precipitins, antitoxins, lysins, opsonins, neutralizing antibodies, complement-fixing antibodies, etc. They are also classified according to their origin into normal antibodies (natural antibodies), such as anti-A and anti-B antibodies in blood group ABO typing, and immune antibodies, such as antimicrobial antibodies. Furthermore, they are classified according to the source of the antigen they react with into heterologous antibodies, heterophilic antibodies, alloantibodies, and autoantibodies. Antibodies have a wide range of applications in medical practice, such as in disease prevention and diagnosis. It has certain roles in both diagnosis and treatment. Clinically, gamma globulin is used to prevent viral hepatitis, measles, rubella, etc. Internationally, anti-Rh immunoglobulin is used to prevent hemolytic disease caused by Rh blood type incompatibility. In diagnosis, rheumatoid factor is used for rheumatoid arthritis, antinuclear antibody (ANA) and anti-DNA antibody are used for systemic lupus erythematosus, and antisperm antibody is used for the diagnosis of primary infertility. In treatment, it is used for antitoxic treatment of toxin poisoning and for the treatment of immunodeficiency diseases. When preparing antibodies, they need to be filtered and purified.

[0003] For example, Chinese utility model patent CN216778153U proposes a filtration device for antibody production, including a main body and a filtration component for purifying antibody stock solution. The filtration component includes an inlet pipe at the top of the main body, a connecting pipe at the bottom of the inlet pipe, a filter box located inside the main body and at the bottom of the connecting pipe, multiple filter plates evenly arranged inside the filter box, two support frames at the bottom of the main body, fixed frames located at the bottom of the main body and on both sides of the support frames, movable through holes on both sides of the main body, fixed blocks on both sides of the filter box, a rotating shaft on one side of the main body, two cams sleeved on the outside of the rotating shaft, a motor at one end of the rotating shaft, an outlet pipe on one side of the filter box, and a discharge through hole on the other side of the main body. The connecting pipe is a corrugated pipe, the fixed blocks are slidably connected to the movable through holes, and the diameter of the filter holes of the multiple filter plates decreases from top to bottom.

[0004] In existing technologies, multiple filter plates are used to filter the antibody stock solution. The stock solution passes through different filter plates from top to bottom under the action of gravity. This filtration method has low filtration efficiency and cannot quickly filter the stock solution. Summary of the Invention

[0005] (a) Technical problems to be solved

[0006] To address the shortcomings of existing technologies, this invention provides a filtration device for antibody production, which has the advantages of solving the problems of low filtration efficiency and inability to quickly filter the original solution.

[0007] (II) Technical Solution

[0008] To achieve the above objectives, this utility model provides the following technical solution: a filtration device for antibody production, comprising a filter barrel assembly; the filter barrel assembly includes a barrel body; and a barrel lid, which is snapped onto the top of the barrel body;

[0009] The bottom of the filter barrel assembly is provided with support legs;

[0010] The top of the filter barrel assembly is provided with a feeding assembly, and the bottom of the filter barrel assembly is provided with a drain valve;

[0011] A drive motor is installed at the bottom of the filter barrel assembly. A filter assembly is provided inside the filter barrel assembly. The filter assembly includes a centrifugal filter shaft, which is located at the bottom of the barrel body and has one end fixedly connected to the output shaft of the drive motor; a first filter screen, which is fixedly connected to the top of the centrifugal filter shaft; a second filter screen, which is fitted on the outside of the first filter screen; and a third filter screen, which is fitted on the outside of the second filter screen.

[0012] Preferably, the filter bucket assembly further includes a sealing ring disposed on the inner side wall of the bucket lid.

[0013] Preferably, the feeding assembly includes a feeding seat fixedly connected to the top of the barrel cover; a feeding hopper fixedly connected to the top of the feeding seat; and an extension tube disposed at the bottom of the feeding seat.

[0014] Preferably, the bottom end of the extension tube extends into the interior of the filter screen.

[0015] Preferably, the feeding assembly further includes a sealing seat disposed at the connection between the feeding hopper and the extension tube.

[0016] Preferably, the centrifugal filter shaft includes a rotary bearing, the outer ring of which is fixedly connected to the inner bottom of the barrel; a centrifugal shaft body, which is rotatably connected to the inner side wall of the rotary bearing, and one end of which is fixedly connected to the output shaft of the drive motor; and a fixing bolt, which is threadedly connected to the top end of the centrifugal shaft body.

[0017] Preferably, the first filter screen, the second filter screen, and the third filter screen are all cylindrical in structure and are arranged sequentially from the inside to the outside.

[0018] (III) Beneficial Effects

[0019] Compared with the prior art, the present invention provides a filtration device for antibody production, which has the following beneficial effects:

[0020] 1. This filtration device for antibody production, by setting up a drive motor and a filtration assembly, consists of three filter covers forming a three-layer filter cylinder. When filtering antibody stock solution, the antibody stock solution enters through the innermost filter cover, and then the drive motor drives the three-layer filter cylinder to rotate, so that the three-layer filter cylinder filters the antibody stock solution sequentially from the inside out. This filtration method uses centrifugal force to filter the stock solution, which can significantly improve the filtration speed of antibody stock solution.

[0021] 2. The filtration device for antibody production has a centrifugal filter shaft. The three-layer filter cylinder is fixed to the centrifugal shaft by fixing bolts on the centrifugal filter shaft. After filtration, the three-layer filter cylinder can be disassembled directly by unscrewing the fixing bolts, so that the three-layer filter cylinder can be quickly disassembled for cleaning. This allows the device to be quickly disassembled and cleaned. Attached Figure Description

[0022] Figure 1 This is a schematic diagram of the structure of this utility model;

[0023] Figure 2 This is a cross-sectional view of the filter barrel in this utility model;

[0024] Figure 3 This is a schematic diagram of the feeding assembly in this utility model;

[0025] Figure 4 In this utility model Figure 2 Enlarged view of point A.

[0026] In the picture:

[0027] 10. Filter canister assembly; 11. Canister body; 12. Canister lid; 13. Sealing ring;

[0028] 20. Supporting leg;

[0029] 30. Feeding assembly; 31. Feeding seat; 32. Feeding hopper; 33. Extension tube; 34. Sealing seat;

[0030] 40. Drain valve;

[0031] 50. Drive motor;

[0032] 60. Filter assembly; 61. Centrifugal filter shaft; 611. Rotary bearing; 612. Centrifugal shaft body; 613. Fixing bolt; 62. Filter screen cover one; 63. Filter screen cover two; 64. Filter screen cover three. Detailed Implementation

[0033] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of this application, and not all of the embodiments. Based on the embodiments of this application, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of this application.

[0034] It should be noted that all directional indications in the embodiments of this application are only used to explain the relative positional relationship and movement of each component in a specific posture. If the specific posture changes, the directional indications will also change accordingly.

[0035] In this application, unless otherwise expressly specified and limited, the terms "connection," "fixed," etc., should be interpreted broadly. For example, "fixed" can mean a fixed connection, a detachable connection, or an integral part; it can mean a mechanical connection or an electrical connection; it can mean a direct connection or an indirect connection through an intermediate medium; it can mean the internal communication of two components or the interaction between two components, unless otherwise expressly limited. Those skilled in the art can understand the specific meaning of the above terms in this application according to the specific circumstances.

[0036] Furthermore, the use of terms such as "first" and "second" in this application is for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include at least one of those features. Additionally, the technical solutions of the various embodiments can be combined with each other, but only on the basis of being achievable by those skilled in the art. If the combination of technical solutions is contradictory or impossible to implement, such a combination of technical solutions should be considered non-existent and not within the scope of protection claimed in this application.

[0037] In related technologies, multiple filter plates are used to filter the antibody stock solution. The stock solution passes through different filter plates from top to bottom under the action of gravity. This filtration method has low filtration efficiency and cannot quickly filter the stock solution.

[0038] To address some of the problems in related technologies, this application provides a filtration device for antibody production. By incorporating a drive motor and a filtration assembly, the filtration assembly consists of three filter housings forming a three-layer filter cylinder. During antibody filtration, the antibody stock solution enters through the innermost filter housing, and the drive motor rotates the three-layer filter cylinder, causing it to filter the antibody stock solution sequentially from the inside out. This filtration method utilizes centrifugal force to filter the stock solution, significantly increasing the filtration speed. A centrifugal filter shaft is incorporated, and the three-layer filter cylinder is fixed to the centrifugal shaft using bolts. After filtration, the three-layer filter cylinder can be easily disassembled by loosening the bolts, allowing for quick disassembly and cleaning. This enables the device to be rapidly assembled, disassembled, and cleaned.

[0039] This application is described below with reference to the accompanying drawings and specific embodiments:

[0040] Combination Figures 1-4 This application provides a filtration device for antibody production, including a filter barrel assembly 10; the filter barrel assembly 10 includes a barrel body 11; a barrel cover 12, which is snapped onto the top of the barrel body 11; and a support leg 20 is provided at the bottom of the filter barrel assembly 10.

[0041] The filter barrel consists of a barrel body 11, a barrel cover 12, and support legs 20;

[0042] The top of the filter barrel assembly 10 is provided with a feeding assembly 30, and the bottom of the filter barrel assembly 10 is provided with a drain valve 40;

[0043] The antibody stock solution enters the tank 11 through the feed assembly 30 and is discharged through the drain valve 40 after filtration.

[0044] A drive motor 50 is installed at the bottom of the filter barrel assembly 10. A filter assembly 60 is provided inside the filter barrel assembly 10. The filter assembly 60 includes a centrifugal filter shaft 61, which is located at the bottom of the barrel body 11. One end of the shaft is fixedly connected to the output shaft of the drive motor 50. A filter screen cover 62 is fixedly connected to the top of the centrifugal filter shaft 61. A filter screen cover 63 is fitted on the outside of the filter screen cover 62. A filter screen cover 64 is fitted on the outside of the filter screen cover 63.

[0045] The drive motor 50 is installed at the bottom of the barrel 11, and the filter assembly 60 is installed at the bottom inside the barrel 11. The output shaft of the drive motor 50 is connected to the bottom of the filter assembly 60. The filter assembly 60 is composed of filter screen 1 62, filter screen 2 63, and filter screen 3 64 arranged sequentially from the inside to the outside. The aperture of filter screen 1 62, filter screen 2 63, and filter screen 3 64 decreases sequentially from the inside to the outside, so that filter screen 1 62, filter screen 2 63, and filter screen 3 64 perform three-stage filtration of the antibody stock solution. During the filtration of the original solution, the drive motor 50 is started, which drives the centrifugal filter shaft 61 to rotate. The centrifugal filter shaft 61 then drives the filter screen 62, filter screen 63, and filter screen 64 to rotate synchronously. When the antibody original solution enters the inner layer of filter screen 62, the rotating filter screen 62 drives the antibody original solution to centrifugal motion, so that the antibody original solution quickly passes through filter screen 62, filter screen 63, and filter screen 64 in sequence under the action of centrifugal force for three-stage filtration.

[0046] In some embodiments, the filter canister assembly 10 further includes a sealing ring 13 disposed on the inner side wall of the canister cover 12. By providing the sealing ring 13, leakage can be prevented.

[0047] In some embodiments, the feeding assembly 30 includes a feeding seat 31, which is fixedly connected to the top of the barrel cover 12; a feeding hopper 32, which is fixedly connected to the top of the feeding seat 31; and an extension tube 33, which is disposed at the bottom of the feeding seat 31. The antibody stock solution enters the extension tube 33 from the feeding hopper 32 and then enters the filter screen 62 from the extension tube 33.

[0048] In some embodiments, the bottom end of the extension tube 33 extends into the interior of the filter screen 62. In order to ensure that the antibody stock solution enters the inner layer of the filter screen 62, the bottom end of the extension tube 33 is extended into the filter screen 62.

[0049] In some embodiments, the feeding assembly 30 further includes a sealing seat 34 disposed at the connection between the feeding hopper 32 and the extension tube 33, thereby improving the sealing performance during feeding.

[0050] In some embodiments, the centrifugal filter shaft 61 includes a rotating bearing 611, the outer ring of which is fixedly connected to the inner bottom of the barrel 11; a centrifugal shaft 612, which is rotatably connected to the inner side wall of the rotating bearing 611, and one end of which is fixedly connected to the output shaft of the drive motor 50; and a fixing bolt 613, which is threadedly connected to the top end of the centrifugal shaft 612. Filter screen cover 1 62, filter screen cover 2 63 and filter screen cover 3 64 are all fixed to the centrifugal shaft 612 by the fixing bolt 613, which facilitates the disassembly, assembly and cleaning of the filter mechanism.

[0051] In some embodiments, filter screen 62, filter screen 63 and filter screen 64 are all cylindrical structures, arranged sequentially from the inside to the outside.

[0052] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of this application. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. In addition, those skilled in the art can combine and integrate the different embodiments or examples described in this specification.

[0053] Furthermore, the technical solutions of the various embodiments can be combined with each other, but only if they are based on the ability of those skilled in the art to implement them. When the combination of technical solutions is contradictory or cannot be implemented, it should be considered that such combination of technical solutions does not exist and is not within the scope of protection claimed in this application.

[0054] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A filtration apparatus for antibody production, comprising a filter cartridge assembly (10); the filter cartridge assembly (10) comprising: Barrel body (11); The lid (12) is snapped onto the top of the barrel body (11); The bottom of the filter barrel assembly (10) is provided with support legs (20); The filter barrel assembly (10) is characterized in that: a feeding assembly (30) is provided at the top of the filter barrel assembly (10), and a drain valve (40) is provided at the bottom of the filter barrel assembly (10). A drive motor (50) is installed at the bottom of the filter barrel assembly (10), and a filter assembly (60) is provided inside the filter barrel assembly (10). The filter assembly (60) includes: Centrifugal filter shaft (61) is located at the bottom of the inside of the barrel (11), and one end is fixedly connected to the output shaft of the drive motor (50); A filter screen cover (62) is fixedly connected to the top end of the centrifugal filter shaft (61); Filter screen cover two (63) is fitted on the outside of filter screen cover one (62); Filter cover three (64) is fitted on the outside of filter cover two (63).

2. The filtration device for antibody production according to claim 1, characterized in that: The filter cartridge assembly (10) also includes: A sealing ring (13) is provided on the inner side wall of the bucket lid (12).

3. The filtration device for antibody production according to claim 1, characterized in that: The feeding assembly (30) includes: The feed seat (31) is fixedly connected to the top of the barrel cover (12); The feed hopper (32) is fixedly connected to the top of the feed seat (31); An extension tube (33) is disposed at the bottom of the feed seat (31).

4. The filtration device for antibody production according to claim 3, characterized in that: The bottom end of the extension tube (33) extends into the interior of the filter screen (62).

5. A filtration device for antibody production according to claim 3, characterized in that: The feeding assembly (30) further includes: A sealing seat (34) is provided at the connection between the feed hopper (32) and the extension tube (33).

6. The filtration device for antibody production according to claim 1, characterized in that: The centrifugal filter shaft (61) includes: A rotating bearing (611) has its outer ring fixedly connected to the inner bottom of the barrel body (11); The centrifugal shaft (612) is rotatably connected to the inner wall of the rotating bearing (611), and one end is fixedly connected to the output shaft of the drive motor (50). A fixing bolt (613) is threaded onto the top of the centrifugal shaft (612).

7. A filtration device for antibody production according to claim 1, characterized in that: The filter screen cover one (62), the filter screen cover two (63) and the filter screen cover three (64) are all cylindrical structures, and they are arranged sequentially from the inside to the outside.

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