Immune cell separation high-speed centrifugal machine

Abstract

The utility model discloses an immune cell separation high-speed centrifugal machine, and relates to the technical field of centrifugal machines, the immune cell separation high-speed centrifugal machine comprises a separator main body, the bottom of the separator main body is provided with a mounting groove, the middle of the bottom of the mounting groove is provided with a driving shaft, the top of the driving shaft is provided with a protruding block, and the top of the separator main body abuts against a supporting plate; a centrifugal bin used for being connected to the mounting groove in a sleeving mode is formed in the middle of the bottom of the supporting plate, a driving column movably penetrates through the middle of the bottom of the centrifugal bin, a connecting groove matched with the protruding block for use is formed in the bottom end of the driving column, and the horizontal rotor and the angle rotor are both installed at the top end of the driving column. By means of the design that the rotors can be switched according to needs, the function application range of the centrifugal machine is greatly expanded, separation of different solutions can be flexibly coped with, the defect that when a single rotor is used, the function is single is effectively overcome, and the diversified requirements for different characteristics and separation requirements of various immune cell solutions are met.

Description

TECHNICAL FIELD

[0001] The application relates to the technical field of centrifuges, in particular to an immune cell separation high-speed centrifuge. BACKGROUND

[0002] A centrifuge is a machine that uses centrifugal force to accelerate the separation of different materials that need to be separated. The core principle of the centrifuge is to generate strong centrifugal force through high-speed rotation, thereby accelerating the settling speed of particles in the liquid, and separating substances with different settling coefficients and buoyant densities in the sample.

[0003] In addition, the existing Chinese patent No. CN214262343U discloses a biological cell separation device. However, the device has the following disadvantages in actual use:

[0004] The above device has multiple test tube boxes, resulting in a high overall separation device height that is not compatible with existing separation equipment. In addition, when the centrifuge rotates at high speed, the high device height can cause uneven distribution of centrifugal force on the internal sample, thereby affecting the sample separation effect. Existing high-speed centrifuges need to be used with rotors, and each rotor has a horizontal rotor, an angle rotor, and a vertical rotor. Each rotor can achieve different effects during use. Generally, a centrifuge is used with a rotor, and its function is greatly limited. Therefore, the present application provides an immune cell separation high-speed centrifuge. CONTENT OF THE UTILITY MODEL

[0005] In order to improve the problem that the centrifuge is generally used with only one rotor and its function is greatly limited, the application provides an immune cell separation high-speed centrifuge.

[0006] The immune cell separation high-speed centrifuge provided by the application adopts the following technical scheme:

[0007] An immune cell separation high-speed centrifuge includes a separator main body, a horizontal rotor, and an angle rotor. The separator main body has a heat dissipation hole on one side, and an installation groove is formed in the bottom of the separator main body. A drive shaft is arranged in the middle of the bottom of the installation groove, and a protruding block is installed on the top of the drive shaft. A support plate is abutted to the top of the separator main body, and a centrifuge chamber for sleeving on the installation groove is formed in the middle of the bottom of the support plate. A drive column is movably penetrated into the bottom of the centrifuge chamber, and a connecting groove adapted to the protruding block is formed in the bottom end of the drive column. The horizontal rotor and the angle rotor are both installed on the top end of the drive column.

[0008] By adopting the above technical scheme, the design of the double centrifuge chamber allows the horizontal rotor and the angle rotor to be installed in the centrifuge chamber, so that different rotors can be selected for use according to the needs, thereby improving the functionality of the centrifuge.

[0009] Preferably, a limiting groove is symmetrically arranged on the top of the separator body, and a positioning hole is arranged at the end of the limiting groove on the two sides of the top of the separator body.

[0010] By adopting the above technical scheme, the limiting groove and the positioning hole can play an auxiliary positioning role.

[0011] Preferably, a side plate is symmetrically and fixedly connected to one side of the separator body, and a limiting hole is arranged on the side plate.

[0012] By adopting the above technical scheme, the limiting hole on the side plate can make the device installed on the side plate rotatable.

[0013] Preferably, a vertical shaft is movably penetrated through the side plate, a limiting vertical groove is arranged on the outer circumferential surface of the vertical shaft, and a connecting column is inserted into the vertical shaft.

[0014] By adopting the above technical scheme, the combination of the vertical shaft and the connecting column can play a role of lifting.

[0015] Preferably, a sliding block for cooperating with the limiting vertical groove is fixedly connected to the bottom end of the connecting column, and a limiting block fixedly connected with the supporting plate is fixedly connected to the top end of the connecting column.

[0016] By adopting the above technical scheme, the cooperation of the sliding block and the limiting vertical groove can play a role of stable lifting.

[0017] Preferably, a limiting rod for being inserted into the positioning hole is fixedly connected to the side of the bottom of the supporting plate close to the limiting block, and the bottom end of the limiting rod is slidably connected with the limiting groove.

[0018] By adopting the above technical scheme, the installation of the limiting rod can play a role of positioning.

[0019] Preferably, a cover plate is hingedly connected to one side of the supporting plate, and a sealing ring for being sleeved on the top end of the centrifugal bin is arranged in the middle of the inner side of the cover plate.

[0020] By adopting the above technical scheme, the installation of the cover plate and the sealing ring can play a role of sealing.

[0021] Preferably, the top end of the driving column is in a semispherical shape, the top end of the driving column is rotatably connected with the sealing ring, and a limiting ring rotatably connected with the middle of the bottom of the centrifugal bin is fixedly connected to the outer circumferential surface of the driving column.

[0022] By adopting the above technical scheme, the rotatable connection of the driving column and the sealing ring can make the centrifuge stable when rotating.

[0023] In summary, the present application has at least one of the following beneficial technical effects:

[0024] 1. The horizontal rotor or the angular rotor can be selected according to the needs, and the design capable of switching the rotor on demand greatly expands the functional application range of the centrifuge, can flexibly cope with the separation of different solutions, effectively makes up for the defect of single function of single rotor, and meets the diversified needs of different characteristics and separation requirements of various immune cell solutions.

[0025] 2. Through simple and easy-to-operate actions such as lifting and rotating the supporting plate, the centrifuge chamber can be accurately positioned to the appropriate position by the cooperation of the limiting rod and the positioning hole, so that the whole operation process is clear and convenient, which not only facilitates the user operation, but also guarantees the efficient subsequent cell solution centrifugal separation work. BRIEF DESCRIPTION OF DRAWINGS

[0026] Figure 1 It is the overall structural schematic diagram of the present application file;

[0027] Figure 2 It is the main structure schematic diagram of the separator of the present application file;

[0028] Figure 3 It is the overall sectional structure schematic diagram of the present application file;

[0029] Figure 4 It is the horizontal rotor structure schematic diagram of the present application file;

[0030] Figure 5 It is the angular rotor structure schematic diagram of the present application file;

[0031] Figure 6 It is the local structure schematic diagram of the present application file;

[0032] Figure 7 It is the local structure schematic diagram of the present application file.

[0033] Figures: 1, separator main body; 101, mounting groove; 102, driving shaft; 1020, protruding block; 103, heat dissipation hole; 104, limiting groove; 105, positioning hole; 106, side plate; 107, limiting hole;

[0034] 2, vertical shaft; 3, limiting vertical groove; 4, connecting column; 401, sliding block; 5, limiting block; 6, supporting plate; 7, centrifuge chamber; 8, driving column; 801, limiting ring; 802, connecting groove;

[0035] 9, horizontal rotor; 10, angular rotor; 11, cover plate; 1101, sealing ring; 12, limiting rod. DETAILED DESCRIPTION

[0036] The following will be combined with the drawings Figures 1-7 The present application is further described in detail.

[0037] The "up, down, left, right" perspective of the device is based on Figure 1 The direction of the drawing is the reference

[0038] The embodiment of the application discloses an immune cell separation high-speed centrifuge.

[0039] Referring to Figure 1 、 Figure 5 、 Figure 7 , an immune cell separation high-speed centrifuge, comprising a separator main body 1 and a horizontal rotor 9 and an angle rotor 10, a heat dissipation hole 103 is formed on one side of the separator main body 1, a vertical downward circular mounting groove 101 is formed in the middle of the bottom of the separator main body 1, a driving shaft 102 is rotatably connected to the middle of the bottom of the mounting groove 101, a hexagonal protruding block 1020 is formed on the top end of the driving shaft 102, a support plate 6 with a side surface flush with the side surface of the separator main body 1 is abutted to the top of the separator main body 1, a centrifuge chamber 7 with an outer surface matched with the inner side of the circular mounting groove 101 is formed in the middle of the bottom of the support plate 6, the centrifuge chamber 7 is sleeved with the mounting groove 101, a circular hole is formed in the middle of the bottom of the centrifuge chamber 7, a driving column 8 is movably penetrated through the circular hole, a connecting groove 802 is formed in the bottom end of the driving column 8, the connecting groove 802 is connected with the protruding block 1020, the horizontal rotor 9 and the angle rotor 10 are fixedly installed on the top end of the driving column 8, and the top end is lower than the top surface of the support plate 6.

[0040] First, according to the requirements, the required horizontal rotor 9 or angle rotor 10 is selected, then the immune cell solution to be separated is installed on the required rotor, then the support plate 6 is installed on the top of the separator main body 1, so that the centrifuge chamber 7 is sleeved in the mounting groove 101 in the middle of the top of the separator main body 1, so that the connecting groove 802 at the bottom end of the driving column 8 is connected with the upper hexagonal protruding block 1020 on the driving shaft 102, when the driving shaft 102 rotates, it can drive the driving column 8 and the rotor installed on the driving column 8 to rotate, thereby improving the separation efficiency and separation effect.

[0041] It should be noted that a cavity is formed in the inside of the separator main body 1, a driving motor and a gear set for driving the driving shaft 102 to rotate are installed in the cavity, the driving motor and the gear set are prior art, which will not be described in detail here.

[0042] Referring to Figures 2-4 、 Figure 6As shown, the top of the separator body 1 is symmetrically provided with an arc-shaped limiting groove 104 on both sides, and the end of the limiting groove 104 is provided with a vertical downward positioning hole 105. The side of the separator body 1 close to the positioning hole 105 is symmetrically fixedly connected with a side plate 106 which is provided with a limiting hole 107 in the middle. A vertical shaft 2 which is provided with a cylindrical cavity in the inside is movably penetrated at the limiting hole 107. The outer circumferential surface of the vertical shaft 2 is provided with a vertical upward limiting vertical groove 3. A connecting column 4 is inserted into the cylindrical cavity in the vertical shaft 2. The bottom end of the connecting column 4 is fixedly connected with a sliding block 401 which is in sliding connection with the limiting vertical groove 3. The top end of the connecting column 4 is fixedly connected with a limiting block 5 which is fixedly connected with a supporting plate 6. The bottom of the supporting plate 6 close to the limiting block 5 is fixedly connected with a limiting rod 12 which is inserted into the positioning hole 105 and is in sliding connection with the limiting groove 104 at the bottom end. The side of the supporting plate 6 is hingedly connected with a cover plate 11 which is flush with the side of the supporting plate 6. The inner side of the cover plate 11 is fixedly installed with a sealing ring 1101 which is rotatably connected with the top end of a driving column 8. The top end of the driving column 8 is in the shape of a hemisphere. The outer circumferential surface of the driving column 8 is fixedly connected with a limiting ring 801 which is rotatably connected with the bottom middle of the centrifugal bin 7.

[0043] The separated cell solution needed to be used is placed on the rotor needed to be used. Taking the angular rotor 10 as an example, when needed to be used, the supporting plate 6 is lifted to lift the limiting block 5 and the connecting column 4, so that the sliding block 401 slides in the limiting vertical groove 3, so that the bottom of the centrifugal bin 7 is lifted above the top of the separator body 1. Then the supporting plate 6 is rotated to drive the connecting column 4 and the vertical shaft 2 to rotate on the side plate 106. At the same time, the bottom end of the limiting rod 12 is first abutted to the limiting groove 104 and then moved on the limiting groove 104. When the limiting rod 12 moves to the positioning hole 105, the centrifugal bin 7 is located vertically above the mounting groove 101 at this time. Then the supporting plate 6 is loosened, so that the centrifugal bin 7 is sleeved on the mounting groove 101, and the limiting rod 12 is inserted into the positioning hole 105.

[0044] The implementation principle of the immune cell separation high-speed centrifuge according to an embodiment of the present application is as follows: first, a horizontal rotor 9 or an angle rotor 10 is selected according to requirements, and the immune cell solution to be separated is placed on the selected rotor, then the support plate 6 is rotated to drive the connecting column 4 and the vertical shaft 2 to rotate on the side plate 106, in this process, the support plate 6 drives the bottom end of the limiting rod 12 to abut against the limiting groove 104 first, then moves on the limiting groove 104, until the limiting rod 12 moves to the positioning hole 105, at this time, the centrifugal chamber 7 is vertically above the mounting groove 101, then the support plate 6 is loosened, the centrifugal chamber 7 is sleeved on the mounting groove 101, and the limiting rod 12 is inserted in the positioning hole 105, the centrifugal chamber 7 is sleeved in the mounting groove 101 in the middle of the top of the separator main body 1, so that the connecting groove 802 at the bottom end of the drive column 8 is connected with the upper hexagonal protruding block 1020 on the drive shaft 102, in this way, when the drive shaft 102 rotates, the drive column 8 and the rotor can be driven to rotate.

[0045] The above is only an optional embodiment of the present disclosure, and is not used to limit the present disclosure. For those skilled in the art, the present disclosure can have various modifications and changes. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present disclosure shall be included in the protection scope of the present disclosure.

Claims

1. An immune cell separation high-speed centrifuge, comprising a separator main body (1) and a horizontal rotor (9) and an angle rotor (10), one side of the separator main body (1) is provided with a heat dissipation hole (103), characterized in that: The bottom of the separator body (1) is provided with a mounting groove (101), and the bottom of the mounting groove (101) is provided with a driving shaft (102), and the top of the driving shaft (102) is provided with a protruding block (1020). The top of the separator body (1) is provided with a supporting plate (6), and the bottom of the supporting plate (6) is provided with a centrifugal chamber (7) for sleeving on the mounting groove (101), and the bottom of the centrifugal chamber (7) is movably penetrated by a driving column (8), and the bottom end of the driving column (8) is provided with a connecting groove (802) matched with the protruding block (1020), and the horizontal rotor (9) and the angle rotor (10) are both installed on the top end of the driving column (8).

2. The immune cell isolation high-speed centrifuge according to claim 1, characterized in that: The top of the separator body (1) is provided with a limiting groove (104) symmetrically arranged on both sides, and the top of the separator body (1) is provided with a positioning hole (105) on both sides of the limiting groove (104).

3. The immune cell isolation high-speed centrifuge of claim 1, wherein: The side plate (106) is symmetrically fixed on one side of the separator body (1), and the limiting hole (107) is arranged on the side plate (106).

4. The immune cell isolation high-speed centrifuge of claim 3, wherein: The vertical shaft (2) movably penetrates the side plate (106), and the limiting vertical groove (3) is arranged on the outer circumferential surface of the vertical shaft (2).

5. The immune cell isolation high-speed centrifuge of claim 4, wherein: The connecting column (4) is inserted into the limiting vertical groove (3).

6. The immune cell isolation high-speed centrifuge of claim 1, wherein: The bottom end of the connecting column (4) is fixedly connected with the sliding block (401) matched with the limiting vertical groove (3), and the top end of the connecting column (4) is fixedly connected with the limiting block (5) fixedly connected with the supporting plate (6).

7. The immune cell isolation high-speed centrifuge of claim 1, wherein: The bottom of the supporting plate (6) is fixedly connected with the limiting rod (12) matched with the positioning hole (105) on one side close to the limiting block (5), and the bottom end of the limiting rod (12) is slidably connected with the limiting groove (104).

8. The immune cell isolation high-speed centrifuge of claim 1, wherein: The side of the supporting plate (6) is hingedly connected with the cover plate (11), and the inner side of the cover plate (11) is movably penetrated by the sealing ring (1101) matched with the top end of the centrifugal chamber (7). The top end of the driving column (8) is a semispherical surface, and the top end of the driving column (8) is rotatably connected with the sealing ring (1101), and the outer circumferential surface of the driving column (8) is fixedly connected with the limiting ring (801) rotatably connected with the bottom of the centrifugal chamber (7).

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