Freezing module for paraffin-embedded pathological tissue section pretreatment
By designing a pathological tissue section pretreatment device with an aluminum alloy square tube freezing module filled with refrigerant, the shortcomings of existing technologies such as cold stages and ice blocks are solved, realizing low-cost, high-efficiency, and low-energy-consumption pathological tissue freezing, and improving section quality and ease of use.
Patent Information
- Application Number
- CN202520050148.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-01-09
- Publication Date
- 2026-02-17
- Estimated Expiration
- 2035-01-09
AI Technical Summary
In current pathological tissue section pretreatment, the use of cold stages is costly, cumbersome, and energy-intensive, while the use of ice is inconvenient and ineffective, resulting in low freezing efficiency of pathological tissues and the risk of contamination.
A cryogenic module for pretreatment of paraffin-embedded pathological tissue sections is designed. It is made of aluminum alloy square tube and filled with refrigerant. The structure is flat and can be spliced. It is equipped with valves for replenishment and venting, ensuring uniform temperature and convenient use.
It achieves low-cost, low-energy, and uniform low-temperature freezing of pathological tissues, reduces the risk of contamination, shortens pretreatment time, and improves section quality and ease of use.
Smart Images
Figure CN223926121U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of pathological sectioning technology, specifically a freezing module for pretreatment of paraffin-embedded pathological tissue sections. Background Technology
[0002] In medical examinations, the results obtained preoperatively through auxiliary examinations such as X-rays, CT scans, and MRI are generally insufficient to definitively determine the nature of tissue. Only after extensive surgical excision or a pathological examination of a localized tissue sample can its nature be determined. Surgically removed tissues such as moles, lipomas, hemangiomas, and malignant tumors require further pathological examination to confirm the accuracy of the preoperative diagnosis and guide further treatment. During medical examinations, surgically removed tissues requiring definitive characterization undergo pathological examination. Because the tissue must be embedded in paraffin before sectioning and testing, the tissue section is also called a paraffin section, and the pathology report is also called a paraffin report. In fact, the full name is a paraffin section pathology report, which is the pathology result.
[0003] In the process of preparing pathological tissue sections, pre-treatment by freezing is required before sectioning paraffin tissue to increase the hardness of the tissue and ensure the quality of the sections. Furthermore, the blades used for sectioning require high-quality blades. After several sections, the microstructure of the blade can become damaged, making it impossible to cut smooth sections and affecting the accuracy of the analysis. Freezing the tissue can also increase the number of times the blades can be used.
[0004] In existing technologies, pathological tissue sections require the use of cold stage products for freezing. However, in reality, the promotion and use of cold stages for pathological tissue section pretreatment has not been very effective. On the one hand, cold stages use semiconductor refrigeration, which makes the products relatively expensive, and many medical institutions are unwilling to purchase and use cold stages for freezing pathological tissue sections. On the other hand, cold stages are relatively cumbersome to use. They require pre-conditioning before each use, and the pre-conditioning time ranges from 30 minutes to several hours. The pre-conditioning time is relatively long, and if a doctor needs to prepare pathological sections as soon as he starts work, he cannot use them in time. In addition, cold stages have high energy consumption and are prone to frost formation, which is inconvenient.
[0005] Therefore, a less-than-standard but relatively useful method has emerged: using ice cubes instead of a cold table to freeze pathological tissues. This method is favored by many doctors. While disposable ice cubes are relatively convenient, they need to be prepared a day in advance. If ice is forgotten, there will be no ice available for pre-processing pathological tissue sections. The surface of the ice cubes is not smooth enough, resulting in large temperature differences and poor freezing effects. The ice cube temperature is not low enough, leading to prolonged pre-processing time. Ice cubes melt easily, have a short lifespan, and the melting process generates water, posing a risk of tissue contamination. These methods are inconvenient and have shortcomings. Utility Model Content
[0006] To address the shortcomings of existing technologies, this utility model provides a freezing module for pre-processing paraffin-embedded pathological tissue sections, which solves the problem of inconvenience in using cold stages and ice blocks for pre-processing paraffin-embedded pathological tissues in existing technologies.
[0007] To solve the above-mentioned technical problems, this utility model provides the following technical solution:
[0008] A freezing module for pretreatment of paraffin-embedded pathological tissue sections includes an outer square tube, horizontal square tubes disposed at both ends inside the outer square tube, and several vertical square tubes disposed between the two horizontal square tubes. One of the horizontal square tubes has a structural plate disposed on the side opposite to the vertical square tubes, and the other horizontal square tube has a decorative plate disposed on the side opposite to the vertical square tubes. The horizontal square tubes have through holes at positions corresponding to the vertical square tubes. The opposite surfaces of the horizontal square tubes and the structural plate are provided with two clearance holes, and valves are installed in the two clearance holes of the horizontal square tubes.
[0009] Sealant is applied between the horizontal square tube and the vertical square tube, and between the outer square tube and the horizontal and vertical tubes. Sealant and structural adhesive are also applied between the structural plate and the decorative plate and the horizontal square tube and the outer square tube.
[0010] The horizontal and vertical square tubes are filled with refrigerant.
[0011] Preferably, the horizontal square tube, the vertical square tube, and the outer square tube are all aluminum alloy square tubes, and the overall thickness and wall thickness of the horizontal and vertical square tubes are equal.
[0012] Preferably, the inner and outer walls of the horizontal square tube, the inner and outer walls of the vertical square tube, and the inner and outer walls of the outer square tube are all provided with anti-corrosion coatings.
[0013] Preferably, a partition plate is provided between the horizontal square tube and the vertical square tube, and a through hole is also provided at the corresponding position on the partition plate, and the sealant between the horizontal square tube and the vertical square tube is applied to the surface of the partition plate.
[0014] Preferably, the partition plate and the structural plate are both plastic plates, the decorative plate is a glass plate, and the decorative plate is flush with one end of the outer square tube.
[0015] Preferably, sealing rings are installed between the inner and outer walls of the horizontal square tube and the valve stem, and a sealing cap is also installed outside the valve stem, wherein the end face of the sealing cap does not exceed the end face of the outer square tube.
[0016] Preferably, the structural adhesive is applied to the outside of the sealant.
[0017] Compared with the prior art, the present invention has the following beneficial effects:
[0018] (1) This utility model is simple to manufacture and has low manufacturing and usage costs by filling the refrigeration module made of aluminum alloy square tube with refrigerant.
[0019] (2) After the refrigerant freezes, the low temperature is transferred to the outside through the aluminum alloy square tube, the temperature transfer is uniform, and the freezing effect is good.
[0020] (3) The surface structure of the freezing module is flat, the temperature difference between different parts of the pathological tissue is small, and the pretreatment effect of the pathological tissue is good.
[0021] (4) The refrigerant is protected by layers of aluminum alloy square tubes, which slows down the melting speed after the refrigerant freezes, and can be used for a long time.
[0022] (5) Both the aluminum alloy square tube freezing module and the brine refrigerant have a cooling effect after freezing. Compared with direct ice block cooling, the temperature is lower and can effectively shorten the pretreatment time of pathological tissues.
[0023] (6) The refrigerant melts inside the refrigeration module and does not come into contact with the outside. After melting, there is no water stains, the frost thickness is small, and there is no risk of contaminating pathological tissues.
[0024] (7) The cryo-module has a rectangular structure and a standard shape. Multiple cryo-modules can be modularly spliced together and used in combination. Multiple pathological tissues can be pre-treated at the same time, which is highly practical.
[0025] (8) A valve is installed on the refrigeration module. The refrigerant inside the refrigeration module is not fully filled. Refrigerant can be added and vented regularly to prevent bulging and ensure quality.
[0026] (9) The freezing module can be frozen for a long time, and there is no need to prepare the freezing module temporarily when pre-processing pathological tissues, which is convenient to use. Attached Figure Description
[0027] Figure 1 This is a front view of the present utility model;
[0028] Figure 2 This is a rear view of the present invention;
[0029] Figure 3 This is a top view of the present invention;
[0030] Figure 4 This is a top view of the internal structure of the outer sleeve of this utility model;
[0031] Figure 5 This is a top cross-sectional view of the position corresponding to the through hole in this utility model.
[0032] In the diagram: 1. Outer square tube; 2. Horizontal square tube; 3. Vertical square tube; 4. Structural plate; 5. Decorative plate; 6. Clearance hole; 7. Valve nozzle; 8. Sealant; 9. Structural adhesive; 10. Anti-corrosion coating; 11. Partition plate; 12. Sealing cap; 13. Through hole. Detailed Implementation
[0033] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.
[0034] like Figure 1-5 As shown, this utility model provides a technical solution: a cryogenic module for pretreatment of paraffin-embedded pathological tissue sections, including an outer square tube 1, horizontal square tubes 2 disposed at both ends inside the outer square tube 1, and a plurality of vertical square tubes 3 disposed between the two horizontal square tubes 2. The outer square tube 1 has an external dimension of 80*40*18mm. The horizontal square tubes 2, vertical square tubes 3 and the outer square tube 1 are all aluminum alloy square tubes, and the overall thickness and wall thickness of the horizontal square tubes 2 and the vertical square tubes 3 are equal, which is conducive to uniformly transferring low-temperature energy outward.
[0035] The horizontal square tube 2 and the vertical square tube 3 are filled with refrigerant, which is brine and environmentally friendly. The brine refrigerant in the horizontal square tube 2 and the vertical square tube 3 is not fully filled, and 310ml of brine with a concentration of 5%-6% is filled. The inner and outer walls of the horizontal square tube 2, the inner and outer walls of the vertical square tube 3, and the inner and outer walls of the outer square tube 1 are all provided with anti-corrosion coating 10 to prevent corrosion caused by internal brine and external condensate.
[0036] A partition plate 11 is also provided between the horizontal square tube 2 and the vertical square tube 3. The partition plate 11 can reduce the speed of internal energy transfer to the outside and extend the freezing time. A through hole 13 is also provided at the corresponding position on the partition plate 11. The sealant 8 between the horizontal square tube 2 and the vertical square tube 3 is coated on the surface of the partition plate 11.
[0037] The partition plate 11 and the structural plate 4 are both plastic plates, and the decorative plate 5 is a colored glass plate, which is beautiful and elegant, and can be screen-printed with relevant markings and symbols. The decorative plate 5 is flush with one end of the outer square tube 1. The inner and outer walls of the horizontal square tube 2 are equipped with sealing rings between them and the valve 7. A sealing cap 12 is also installed outside the valve 7. The end face of the sealing cap 12 does not exceed the end face of the outer square tube 1.
[0038] One of the horizontal square tubes 2 has a structural plate 4 on the side opposite to the vertical square tube 3, and the other horizontal square tube 2 has a decorative plate 5 on the side opposite to the vertical square tube 3. A through hole 13 is provided at the position of the horizontal square tube 2 corresponding to the vertical square tube 3. Two clearance holes 6 are provided on the opposite sides of the horizontal square tube 2 and the structural plate 4. A valve 7 is installed in each of the two clearance holes 6 of the horizontal square tube 2.
[0039] Sealant 8 is applied between the horizontal square tube 2 and the vertical square tube 3, and between the outer square tube 1 and the horizontal square tube 2 and the vertical square tube 3. Sealant 8 and structural adhesive 9 are also applied between the structural plate 4 and the decorative plate 5 and the horizontal square tube 2 and the outer square tube 1. The structural adhesive 9 is applied to the outside of the sealant 8, which has good structural stability and seals layer by layer to prevent refrigerant from overflowing.
[0040] Working principle:
[0041] The inner and outer walls of the horizontal square tube 2, the vertical square tube 3, and the outer square tube 1 are all coated with an anti-corrosion coating 10, which effectively prevents corrosion caused by brine refrigerant and external condensate, protecting the freezing module. The horizontal square tube 2 and the vertical square tube 3 are fixed inside the outer square tube 1 with sealant 8, and a partition plate 11 is installed between the horizontal square tube 2 and the vertical square tube 3 to delay the transfer of cold energy of the internal freezing refrigerant to the outside and extend the service life. On the basis of sealant 8, structural adhesive 9 is used to increase structural strength and fix structural plate 4 and decorative plate 5. The brine refrigerant is injected into the horizontal square tube 2 and the vertical square tube 3 through the valve 7 using a syringe. The refrigerant is not fully filled to prevent the freezing module from deforming due to the increase in the volume of the refrigerant freezing. The refrigerant is replenished regularly and excess air is released regularly through the valve 7, which can effectively protect the freezing module from deformation and ensure normal freezing use. After freezing, the surface temperature of the freezing module can be kept below 0°C at room temperature for up to half a day, which is sufficient for the pretreatment of pathological tissue sections. The structure is simple and easy to use.
[0042] It should be noted that, in this document, terms such as “comprising,” “including,” or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.
[0043] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.
Claims
1. A freezing module for pretreatment of paraffin-embedded pathological tissue sections, characterized in that: It includes an outer square tube (1), horizontal square tubes (2) set at both ends inside the outer square tube (1), and several vertical square tubes (3) set between the two horizontal square tubes (2). One of the horizontal square tubes (2) has a structural plate (4) on the side away from the vertical square tubes (3), and the other horizontal square tube (2) has a decorative plate (5) on the side away from the vertical square tubes (3). The horizontal square tube (2) has a through hole (13) at the position corresponding to the vertical square tube (3). The opposite sides of the horizontal square tube (2) and the structural plate (4) are provided with two clearance holes (6). The two clearance holes (6) of the horizontal square tube (2) are each installed with a valve (7). The horizontal square tube (2) and the vertical square tube (3) are coated with sealant (8), and the outer square tube (1) is coated with sealant (8) and the horizontal square tube (2) and the vertical square tube (3). The structural plate (4) and the decorative plate (5) are also coated with sealant (8) and structural adhesive (9) with the horizontal square tube (2) and the outer square tube (1). The horizontal square tube (2) and the vertical square tube (3) are filled with refrigerant.
2. The freezing module for pretreatment of paraffin-embedded pathological tissue sections according to claim 1, characterized in that: The horizontal square tube (2), the vertical square tube (3) and the outer square tube (1) are all aluminum alloy square tubes, and the overall thickness and wall thickness of the horizontal square tube (2) and the vertical square tube (3) are equal.
3. The freezing module for pretreatment of paraffin-embedded pathological tissue sections according to claim 2, characterized in that: The inner and outer walls of the horizontal square tube (2), the inner and outer walls of the vertical square tube (3), and the inner and outer walls of the outer square tube (1) are all provided with anti-corrosion coatings (10).
4. The freezing module for pretreatment of paraffin-embedded pathological tissue sections according to claim 1, characterized in that: A partition plate (11) is provided between the horizontal square tube (2) and the vertical square tube (3), and a through hole (13) is also provided at the corresponding position on the partition plate (11). The sealant (8) between the horizontal square tube (2) and the vertical square tube (3) is coated on the surface of the partition plate (11).
5. A freezing module for pretreatment of paraffin-embedded pathological tissue sections according to claim 4, characterized in that: The partition plate (11) and the structural plate (4) are both plastic plates, and the decorative plate (5) is a glass plate, and the decorative plate (5) is flush with one end of the outer square tube (1).
6. The freezing module for pretreatment of paraffin-embedded pathological tissue sections according to claim 1, characterized in that: A sealing ring is installed between the inner and outer walls of the horizontal square tube (2) and the valve (7). A sealing cap (12) is also installed outside the valve (7). The end face of the sealing cap (12) does not exceed the end face of the outer square tube (1).
7. A freezing module for pretreatment of paraffin-embedded pathological tissue sections according to claim 1, characterized in that: The structural adhesive (9) is applied to the outside of the sealant (8).