Pressure adjusting device and filtering system

Abstract

The utility model relates to the technical field of filtering, and discloses a pressure adjusting device and a filtering system.The pressure adjusting device is used for adjusting the pressure of liquid in an infusion tube and comprises a fixing piece, a first containing cavity and a second containing cavity are formed in the fixing piece, and the infusion tube is fixed in the first containing cavity; the adjusting part is movably arranged in the second accommodating cavity; the driving part is connected with the adjusting part and used for driving the adjusting part to move in the second containing cavity to extrude the infusion tube so as to adjust the pressure of the liquid. The infusion tube is fixed in the first containing cavity, the driving piece drives the adjusting piece to move in the second containing cavity to extrude the infusion tube, the liquid pressure in the infusion tube can be adjusted, when the infusion tube is applied to a tangential flow filtering system, the liquid pressure can be stabilized, membrane holes of a filtering membrane are prevented from being blocked by pollutants, and the filtering effect is improved. The tangential flow filtering system reduces the filtering efficiency, prevents the filtering membrane from being broken or damaged and reduces the filtering quality, and can prolong the service life of the tangential flow filtering system.

Description

Technical Field

[0001] This utility model relates to the field of filtration technology, specifically to a pressure regulating device and a filtration system. Background Technology

[0002] In a tangential flow filtration system, the feed solution enters the filter from the storage tank via a circulation pump. The solution that passes through the filter membrane enters the collection tank, while the solution that does not pass through the filter membrane is returned to the storage tank. Tangential flow filtration means that in the filter, the feed solution flows parallel to the surface of the filter membrane. Feed solutions smaller than the pore size of the filter membrane pass through and flow out perpendicular to the flow direction, while feed solutions larger than the pore size are intercepted on the filter membrane surface and continue to flow in the same direction. Tangential flow filtration is widely used in cell perfusion culture, harvesting, clarification of lysate, purification and concentration of recombinant proteins, viruses, and other target products, washing / filtering of target products, and rinsing of drug carriers such as liposomes and nanoparticles.

[0003] However, in tangential flow filtration systems, if the liquid pressure of the feed solution is unstable, it can cause contaminants to accumulate and clog the membrane pores, resulting in decreased filtration efficiency. The organisms in the feed solution may also agglomerate and lose their activity. Furthermore, if the filter membrane is ruptured or damaged, the impurity content in the filtered liquid will increase, the filtration quality will decrease, and the normal operation and service life of the equipment will be affected. Utility Model Content

[0004] In view of this, the present invention provides a pressure regulating device and a filtration system to solve the problem that the liquid pressure of the feed liquid in the existing tangential flow filtration system is unstable, which leads to the accumulation of pollutants and blockage of the membrane pores of the filter membrane, as well as the rupture or damage of the filter membrane.

[0005] In a first aspect, this utility model provides a pressure regulating device for regulating the pressure of liquid in an infusion tube, comprising:

[0006] The fixing component has a first receiving cavity and a second receiving cavity, which are arranged at an angle. Both ends of the first receiving cavity are connected to the outside, and one end of the second receiving cavity is connected to the first receiving cavity and the other end is connected to the outside. The infusion tube is fixed in the first receiving cavity.

[0007] The adjusting member is movably disposed within the second receiving cavity;

[0008] A driving member, connected to the adjusting member, is used to drive the adjusting member to move within the second receiving cavity to squeeze the infusion tube, thereby adjusting the pressure of the liquid.

[0009] Beneficial effects: By fixing the infusion tube in the first receiving cavity and driving the adjusting member to move in the second receiving cavity to squeeze the infusion tube, the liquid pressure in the infusion tube can be adjusted. When the infusion tube is used in a tangential flow filtration system, the liquid pressure can be stabilized, thereby avoiding contaminants from clogging the membrane pores of the filter membrane and reducing the filtration efficiency, as well as avoiding the rupture or damage of the filter membrane and reducing the filtration quality, thus improving the service life of the tangential flow filtration system.

[0010] In one alternative embodiment, the fastener is provided with a groove to form the first receiving cavity;

[0011] And / or, the fastener is provided with a blind hole to form the second receiving cavity.

[0012] In one optional embodiment, the extension length direction of the first receiving cavity is perpendicular to the extension length direction of the second receiving cavity;

[0013] And / or, the first receiving cavity is provided along a direction perpendicular to the extension length of the fixing member;

[0014] And / or, the second receiving cavity is provided along the extension length direction parallel to the fixing member.

[0015] Beneficial effects: By setting the first and second receiving cavities perpendicularly, it is easier for the adjusting component to squeeze the infusion tube, and the squeezing effect is good.

[0016] In one alternative embodiment, the first receiving cavity is disposed near the end of the fixing member.

[0017] Beneficial effects: By placing the first receiving cavity close to the end of the fixing member, the fixing member can be made smaller, thereby reducing the space occupied by the pressure regulating device and making it more flexible to use.

[0018] In one alternative embodiment, the end of the adjusting member near the first receiving cavity is a pointed tip, which is angled to the infusion tube.

[0019] Beneficial effect: By setting the end of the adjusting element to a pointed tip, the pressure adjustment of the liquid in the infusion tube is more sensitive.

[0020] In one alternative implementation, the tip has a "V" shaped cross-section.

[0021] In one optional embodiment, the pressure regulating device includes:

[0022] A connector is fixedly disposed within the first receiving cavity, and the connector is disposed on the side of the infusion tube away from the adjusting member. The connector is disposed opposite to the tip and is used to squeeze the infusion tube.

[0023] Beneficial effect: By setting up a connector, a supporting surface can be provided for the infusion tube when the tip of the adjusting member squeezes the infusion tube, thereby improving the squeezing effect.

[0024] In one optional embodiment, a first limiting member is provided in the second receiving cavity, and a second limiting member is provided on the adjusting member corresponding to the first limiting member, for limiting the direction of the adjusting member.

[0025] Beneficial effects: By setting the first and second limiting components, the direction of movement of the adjusting component can be restricted, preventing the tip of the adjusting component from being parallel to the infusion tube and thus preventing the liquid from being squeezed.

[0026] In one optional embodiment, the end of the adjusting member away from the first receiving cavity is provided with a recess, and the output end of the driving member extends into the recess to drive the adjusting member to move.

[0027] Beneficial effects: By setting the recessed part, the contact position between the output end of the drive component and the adjustment component can be limited, avoiding the output end from abutting against the end of the adjustment component, causing the position to shift, or even the output end to break.

[0028] Secondly, this utility model also provides a filtration system, comprising:

[0029] Liquid storage tanks are used to store liquids;

[0030] A collection tank for collecting the filtered liquid;

[0031] The filter element has an inlet end, a first outlet end and a second outlet end. The inlet end is connected to the storage tank, the first outlet end is connected to the collection tank, and the second outlet end is connected to the storage tank.

[0032] The pressure regulating device described above is located between the second liquid outlet and the liquid storage tank, and is used to regulate the pressure of the liquid.

[0033] Beneficial effects: Since the filtration system includes a pressure regulating device, it has the same effect as the pressure regulating device, which will not be elaborated here. Attached Figure Description

[0034] To more clearly illustrate the specific embodiments of this utility model or the technical solutions in the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this utility model. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0035] Figure 1 This is a schematic diagram of the structure of a pressure regulating device according to an embodiment of the present utility model;

[0036] Figure 2 for Figure 1 A cross-sectional view of the pressure regulating device shown;

[0037] Figure 3 for Figure 1 A first-view structural schematic diagram of the fixture of the pressure regulating device shown;

[0038] Figure 4 for Figure 1 A structural schematic diagram of the fixture of the pressure regulating device shown from a second perspective;

[0039] Figure 5 for Figure 1 The diagram shows the structure of the regulating component of the pressure regulating device.

[0040] Figure 6 for Figure 1 The diagram shows the structural schematic of the drive component of the pressure regulating device.

[0041] Figure 7 This is a schematic diagram of the structure of a filtration system according to an embodiment of the present invention.

[0042] Explanation of reference numerals in the attached figures:

[0043] 1. Fixing component; 11. Groove; 12. Blind hole; 13. First limiting component; 2. Adjusting component; 21. Second limiting component; 22. Recessed part; 3. Driving component; 31. Output end; 4. Connecting component; 5. Liquid storage tank; 6. Collection tank; 7. Filter component; 71. Liquid inlet end; 72. First liquid outlet end; 73. Second liquid outlet end. Detailed Implementation

[0044] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this utility model.

[0045] The following is combined Figures 1 to 7 The following describes embodiments of the present invention.

[0046] According to an embodiment of the present invention, a pressure regulating device is provided for regulating the pressure of liquid in an infusion tube, comprising: a fixing member 1, having a first receiving cavity and a second receiving cavity, the first receiving cavity and the second receiving cavity being arranged at an angle, the two ends of the first receiving cavity being connected to the outside, one end of the second receiving cavity being connected to the first receiving cavity, and the other end being connected to the outside, the infusion tube being fixed in the first receiving cavity; an adjusting member 2, movably disposed in the second receiving cavity; and a driving member 3, connected to the adjusting member 2, for driving the adjusting member 2 to move in the second receiving cavity to squeeze the infusion tube, thereby regulating the pressure of the liquid.

[0047] By fixing the infusion tube in the first receiving cavity, the driving member 3 drives the adjusting member 2 to move in the second receiving cavity to squeeze the infusion tube, which can regulate the liquid pressure in the infusion tube. When the infusion tube is used in a tangential flow filtration system, it can stabilize the liquid pressure, thereby preventing contaminants from clogging the membrane pores of the filter membrane and reducing the filtration efficiency, as well as preventing the filter membrane from breaking or being damaged and reducing the filtration quality, thus improving the service life of the tangential flow filtration system.

[0048] like Figures 1-4 As shown, in one embodiment, the fixing member 1 has a groove 11 to form a first receiving cavity; the fixing member 1 also has a blind hole 12 to form a second receiving cavity. The groove 11 is used to fix an infusion tube with an inner diameter of 4.8mm-14.6mm. Alternatively, the fixing member 1 may have a through hole to form the first receiving cavity. Alternatively, the fixing member 1 may have a groove to form the second receiving cavity. Alternatively, the groove 11 may also be used to fix an infusion tube with an inner diameter of 4.7mm or 14.7mm.

[0049] like Figures 3-4 As shown, in one embodiment, the extension direction of the first receiving cavity is perpendicular to the extension direction of the second receiving cavity. Specifically, the first receiving cavity is arranged perpendicular to the extension direction of the fixing member 1; the second receiving cavity is arranged parallel to the extension direction of the fixing member 1. By arranging the first and second receiving cavities perpendicularly, it is convenient for the adjusting member 2 to squeeze the infusion tube, and the squeezing effect is good. As an alternative implementation, the first and second receiving cavities can also be arranged at an angle, as long as they are not parallel. As an alternative implementation, the first receiving cavity can also be arranged at an angle to the fixing member 1, and the second receiving cavity can also be arranged at an angle to the fixing member 1, as long as both ends of the first receiving cavity are connected to the outside, one end of the second receiving cavity is connected to the first receiving cavity, and the other end is connected to the outside.

[0050] like Figures 3-4As shown, in one embodiment, the first receiving cavity is disposed near the end of the fixing member 1. By disposing the first receiving cavity near the end of the fixing member 1, the fixing member 1 can be made smaller, thereby reducing the space occupied by the pressure regulating device and making it more flexible in use. As an alternative implementation, the first receiving cavity may also be disposed near the middle of the fixing member 1, without further limitation.

[0051] like Figure 5 As shown, in one embodiment, the end of the adjusting member 2 near the first receiving cavity is a pointed tip, which is angled to the infusion tube. The tip has a V-shaped cross-section. By making the end of the adjusting member 2 a pointed tip, the pressure adjustment of the liquid inside the infusion tube is more sensitive. As an alternative implementation, the end of the adjusting member 2 near the first receiving cavity can also be flat. As an alternative implementation, the cross-section of the tip can also be trapezoidal or arc-shaped; no further limitations are imposed here.

[0052] In one embodiment, the drive element 3 is a motor. As an alternative implementation, the drive element 3 may also be a manual button or a cylinder.

[0053] like Figures 1-2 As shown, in one embodiment, the pressure regulating device includes a connector 4, fixedly disposed within the first receiving cavity, and located on the side of the infusion tube away from the regulating member 2. The connector 4 is positioned opposite to the tip and is used to squeeze the infusion tube. The connector 4 is a connecting rod. By providing the connector 4, a supporting surface is provided for the infusion tube when the tip of the regulating member 2 squeezes it, thereby improving the squeezing effect. Alternatively, the connector 4 may not be provided in any other embodiment.

[0054] like Figures 4-5 As shown, in one embodiment, a first limiting member 13 is provided in the second receiving cavity, and a second limiting member 21 corresponding to the first limiting member 13 is provided on the adjusting member 2 to limit the direction of the adjusting member 2. The first limiting member 13 is a groove, and the second limiting member 21 is a protrusion. By providing the first limiting member 13 and the second limiting member 21, the direction of movement of the adjusting member 2 can be restricted, preventing the tip of the adjusting member 2 from being parallel to the infusion tube, thus preventing the liquid from being squeezed. Alternatively, the first limiting member 13 can be a protrusion, and the second limiting member 21 can be a groove.

[0055] like Figures 5-6As shown, in one embodiment, the end of the adjusting member 2 furthest from the first receiving cavity has a recess 22, and the output end 31 of the driving member 3 extends into the recess 22 to drive the adjusting member 2 to move. By providing the recess 22, the contact position between the output end 31 of the driving member 3 and the adjusting member 2 can be limited, preventing the output end 31 from abutting against the end of the adjusting member 2 and causing positional movement, or even breakage of the output end 31. As an alternative implementation, when the cross-sectional size of the output end 31 is large, the adjusting member 2 may not have the recess 22.

[0056] According to an embodiment of the present invention, another aspect provides a filtration system, comprising: a storage tank 5 for storing liquid; a collection tank 6 for collecting filtered liquid; a filter element 7 having an inlet end 71, a first outlet end 72, and a second outlet end 73, wherein the inlet end 71 is connected to the storage tank 5, the first outlet end 72 is connected to the collection tank 6, and the second outlet end 73 is connected to the storage tank 5; and the aforementioned pressure regulating device is disposed between the second outlet end 73 and the storage tank 5 for regulating the pressure of the liquid.

[0057] like Figure 7 As shown, in one embodiment, pressure sensors are provided between the inlet end 71 and the storage tank 5, between the first outlet end 72 and the collection tank 6, and between the second outlet end 73 and the storage tank 5, for detecting liquid pressure.

[0058] like Figure 7 As shown, in one embodiment, the filtration system includes a replenishment tank connected to a storage tank 5 for replenishing liquid into the storage tank 5.

[0059] like Figure 7 As shown, in one embodiment, a drive structure is provided between the liquid storage tank 5 and the liquid inlet 71, and between the replenishment tank and the liquid storage tank 5, for adjusting the liquid pressure. The drive structure is a circulating pump. As an alternative implementation, the drive structure can also be a centrifugal pump or a self-priming pump, or other drive structures; no further limitations are imposed here.

[0060] In one embodiment, when the filtration system is in use, when the liquid pressure is less than the set value, the drive 3 stops working and the regulator 2 moves away from the infusion tube; when the liquid pressure is greater than the set value, the drive 3 starts working and drives the regulator 2 to squeeze the infusion tube.

[0061] Although embodiments of the present invention have been described in conjunction with the accompanying drawings, those skilled in the art can make various modifications and variations without departing from the spirit and scope of the present invention, and such modifications and variations all fall within the scope defined by the appended claims.

Claims

1. A pressure regulating device for regulating the pressure of liquid in an infusion tube, characterized in that, include: The fixing member (1) is provided with a first receiving cavity and a second receiving cavity. The first receiving cavity and the second receiving cavity are arranged at an angle. Both ends of the first receiving cavity are connected to the outside. One end of the second receiving cavity is connected to the first receiving cavity and the other end is connected to the outside. The infusion tube is fixed in the first receiving cavity. Adjustment member (2) is movably disposed within the second receiving cavity; A drive member (3), connected to the adjusting member (2), is used to drive the adjusting member (2) to move within the second receiving cavity to squeeze the infusion tube in order to adjust the pressure of the liquid.

2. The pressure regulating device according to claim 1, characterized in that, The fastener (1) is provided with a groove (11) to form the first receiving cavity; And / or, the fastener (1) is provided with a blind hole (12) to form the second receiving cavity.

3. The pressure regulating device according to claim 1, characterized in that, The extension direction of the first receiving cavity is perpendicular to the extension direction of the second receiving cavity; And / or, the first receiving cavity is provided along the extension length direction perpendicular to the fixing member (1); And / or, the second receiving cavity is provided along the extension length direction parallel to the fixing member (1).

4. The pressure regulating device according to claim 1, characterized in that, The first receiving cavity is located near the end of the fixing member (1).

5. The pressure regulating device according to any one of claims 1 to 4, characterized in that, The end of the adjusting member (2) near the first receiving cavity is a pointed tip, and the pointed tip is set at an angle to the infusion tube.

6. The pressure regulating device according to claim 5, characterized in that, The tip has a V-shaped cross-section.

7. The pressure regulating device according to claim 5, characterized in that, The pressure regulating device includes: The connector (4) is fixedly disposed in the first receiving cavity, and the connector (4) is disposed on the side of the infusion tube away from the adjusting member (2). The connector (4) is disposed opposite to the tip and is used to squeeze the infusion tube.

8. The pressure regulating device according to any one of claims 1 to 4, characterized in that, The second receiving cavity is provided with a first limiting member (13), and the adjusting member (2) is provided with a second limiting member (21) corresponding to the first limiting member (13), which is used to limit the direction of the adjusting member (2).

9. The pressure regulating device according to any one of claims 1 to 4, characterized in that, The adjusting member (2) has a recess (22) at the end away from the first receiving cavity, and the output end (31) of the driving member (3) extends into the recess (22) to drive the adjusting member (2) to move.

10. A filtration system, characterized in that, include: Storage tank (5), used for storing liquid; Collection tank (6) for collecting the filtered liquid; The filter element (7) is provided with an inlet end (71), a first outlet end (72) and a second outlet end (73). The inlet end (71) is connected to the storage tank (5), the first outlet end (72) is connected to the collection tank (6), and the second outlet end (73) is connected to the storage tank (5). The pressure regulating device according to any one of claims 1 to 9 is disposed between the second liquid outlet (73) and the liquid storage tank (5) for regulating the pressure of the liquid.

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