Chromatographic column

Abstract

The chromatographic column comprises a column tube, a plunger rod arranged in the column tube in a sliding mode and a limiting structure used for limiting ascending of the plunger rod, the limiting structure comprises a locking block and a locking rod, the locking rod is arranged on the column tube, the height of the locking rod is adjustable, the locking block is used for connecting the plunger rod and the locking rod, and a clamping opening correspondingly matched with the locking rod is formed in the locking block. The utility model has the advantages that the lock rod does not need to be disassembled frequently and the plunger rod is convenient to disassemble and assemble.

Description

TECHNICAL FIELD

[0001] The utility model relates to food, medicine packing technical field, concretely relates to a chromatographic column. BACKGROUND

[0002] When using the chromatographic column, the hydraulic pump needs to fix the position of the plunger rod 1 after pushing it to the appropriate process position to avoid affecting the chromatographic effect when the chromatographic process is carried out. Figure 1 and Figure 2 The existing technology generally uses a limiting structure as shown in the drawings to limit the position of the plunger rod 1, which specifically includes a screw rod 2 and a locking block 3. When limiting, the plunger rod 1 is first inserted into the locking block 3, and the two sides of the locking block 3 are then fixed with the screw rod 2. This fixing method is very cumbersome because the screw rod 2 hinders the plunger rod 1 from being inserted into and taken out of the locking block 3. In addition, the existing chromatographic column has the following two shortcomings: first, there is no safety protection device. The plunger rod 1 distributor 4 is driven to the appropriate position by the pump providing hydraulic power. If the pump is not stopped in time, the upper screen 5 on the distributor 4 will hit the lower screen 6, thereby damaging the precise screen and causing overpressure damage to the chromatographic column or the pump, resulting in huge losses and safety problems. Moreover, the upper screen 5 is welded to the distributor 4, and the screen is a consumable. Replacing the screen requires reprocessing the distributor 4, which is difficult to process and expensive. Second, the column bed height cannot be quickly known and needs to be temporarily measured with a tape measure, which is inefficient. SUMMARY

[0003] The technical problem to be solved by the utility model is to overcome the shortcomings of the prior art and provide a chromatographic column that does not need to be frequently disassembled and assembled.

[0004] To solve the above technical problems, the utility model adopts the following technical scheme:

[0005] A chromatographic column includes a column pipe, a plunger rod slidingly arranged in the column pipe, and a limiting structure for limiting the upward movement of the plunger rod. The limiting structure includes a locking block and a locking rod. The locking rod is arranged on the column pipe and has an adjustable height. The locking block is used to connect the plunger rod and the locking rod. A bayonet on the locking block corresponds to and matches the locking rod.

[0006] As a further improvement of the above technical scheme:

[0007] The locking block includes a first sub-locking block and a second sub-locking block. The second sub-locking block is detachably connected to the first sub-locking block. The first sub-locking block and the second sub-locking block each have a limiting port for forming a limiting channel. The plunger rod has a limiting recess. The limiting recess is located in the limiting channel. The bayonet is arranged on the first sub-locking block.

[0008] The lock rod is threadedly connected with lock rods on both sides, the limiting channel is rotatable relative to the limiting recess, and the lock block is provided with a bayonet on both sides.

[0009] The top of the column pipe is further provided with a limiting block for limiting the downward position of the plunger rod, the plunger rod is arranged in the limiting block, and the diameter of the limiting block is greater than that of the limiting channel.

[0010] One end of the plunger rod is detachably connected with a product inlet joint, and the other end is connected with a distributor, the distributor is detachably connected with an upper screen mesh, and the product inlet joint, the plunger rod and the distributor are sequentially communicated.

[0011] The upper screen mesh is connected with a screen mesh outer ring, a sealing gasket is arranged between the top of the screen mesh outer ring and the distributor, a first sealing ring is arranged between the inner side of the screen mesh outer ring and the distributor, the distributor is threadedly connected with the screen mesh outer ring through the sealing gasket and the connecting piece, and the bottom of the distributor abuts against the upper screen mesh.

[0012] The outer side of the distributor is provided with a second sealing ring, and the second sealing ring is used for sealing the upper screen mesh and the column pipe.

[0013] The distributor is internally provided with a main flow channel and a plurality of inclined branch flow channels, the plurality of inclined branch flow channels are arranged in a circumferential direction along the main flow channel, and output ends of the plurality of inclined branch flow channels all face the upper screen mesh.

[0014] The top of the column pipe is provided with a hydraulic inlet and a safety valve, the bottom of the column pipe is provided with a product outlet, a lower screen mesh is arranged above the product outlet, a process cavity is formed between one side of the upper screen mesh and the lower screen mesh, a hydraulic cavity is formed between the other side of the upper screen mesh and the column pipe, and the hydraulic inlet and the safety valve are both in communication with the hydraulic cavity.

[0015] A scale is arranged on the lock rod.

[0016] Compared with the prior art, the chromatography column has the following advantages:

[0017] The chromatography column disclosed by the utility model is limited by the limiting structure when the plunger rod goes up, the lock block connects the lock rod and the plunger rod when the plunger rod reaches the specified position, the position of the plunger rod is fixed, the plunger rod cannot move upward in the subsequent chromatography process, the chromatography effect is guaranteed, the position of the lock rod on the column pipe is adjustable, the position can be adjusted according to the process requirement, the lock block is clamped on the lock rod through the bayonet, when the plunger rod needs to be disassembled or replaced, the lock rod can be removed from the bayonet by disassembling the lock block, the plunger rod cannot be hindered during disassembly, and the disassembly is simple and convenient. BRIEF DESCRIPTION OF DRAWINGS

[0018] Figure 1 It is a sectional structure schematic view of the chromatography column of the prior art.

[0019] Figure 2It is a schematic diagram of the three-dimensional structure of the chromatography column of the prior art.

[0020] Figure 3 It is a schematic diagram of the three-dimensional structure of the chromatography column of the present application.

[0021] Figure 4 It is Figure 3 It is an enlarged structural schematic diagram of position A in the middle.

[0022] Figure 5 It is a schematic diagram of the cross-sectional structure of the chromatography column of the present application.

[0023] Figure 6 It is a schematic diagram of the three-dimensional structure of the plunger rod in the present application.

[0024] Figure 7 It is a schematic diagram of the three-dimensional structure of the lock block in the present application.

[0025] Figure 8 It is a schematic diagram of the front structure of the top structure of the present application.

[0026] Figure 9 It is a schematic diagram of the cross-sectional structure of the distributor and the upper screen mesh in the present application.

[0027] The various reference numerals in the figure represent: 1, plunger rod; 2, screw rod; 3, locking block; 4, distributor; 41, main flow channel; 42, oblique sub-flow channel; 5, upper screen mesh; 51, screen mesh outer ring; 6, lower screen mesh; 7, column pipe; 71, hydraulic inlet; 72, safety valve; 73, product outlet; 74, limiting block; 8, lock block; 81, first sub-lock block; 82, second sub-lock block; 83, limiting passage; 84, limiting port; 9, lock rod; 91, scale; 10, bayonet; 11, limiting recess; 12, product inlet connector; 13, sealing gasket; 14, first sealing ring; 15, second sealing ring; 16, process cavity; 17, hydraulic cavity. DETAILED DESCRIPTION

[0028] The present application will be further described in detail below in conjunction with the accompanying drawings and specific examples.

[0029] In the description of the present application, it should be understood that the terms "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and therefore cannot be understood as indicating or implying that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the present application.

[0030] In addition, the terms "first", "second" are only for descriptive purposes and cannot be understood as indicating or implying relative importance or implicitly indicating the number of indicated technical features. Therefore, the features defined as "first", "second" can explicitly or implicitly include one or more of the features. In the description of the present application, the meaning of "multiple" is two or more than two, unless otherwise explicitly specified and limited.

[0031] In the present application, unless otherwise explicitly specified and limited, the terms "assembly", "connection", "connection", "fixing" and the like should be broadly understood, for example, it can be fixedly connected, or it can be detachably connected, or it can be integrated; it can be mechanically connected, or it can be electrically connected; it can be directly connected, or it can be indirectly connected through an intermediate medium; it can be the internal communication of two elements or the interaction relationship between two elements. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0032] Figures 1 to 9 An embodiment of the chromatography column of the present application is shown, the chromatography column of the embodiment includes a column tube 7, a plunger rod 1 slidingly arranged in the column tube 7, and a limiting structure for limiting the upward movement of the plunger rod 1, the limiting structure includes a locking block 8 and a locking rod 9, the locking rod 9 is arranged on the column tube 7 and is height-adjustable, the locking block 8 is used for connecting the plunger rod 1 and the locking rod 9, and the locking block 8 is provided with a bayonet 10 corresponding to the locking rod 9.

[0033] The chromatography column limits the upward movement of the plunger rod 1 through the limiting structure, when the plunger rod 1 reaches the specified position, the locking block 8 connects the locking rod 9 and the plunger rod 1, fixes the position of the plunger rod 1, so that it does not move upward during subsequent chromatography process, ensures the chromatography effect, the position of the locking rod 9 on the column tube 7 is adjustable, which can be adjusted according to process requirements, and since the locking block 8 is clamped to the locking rod 9 through the bayonet 10, when the plunger rod 1 needs to be disassembled or replaced, the locking rod 9 can be removed from the bayonet 10 by disassembling the locking block 8, which does not hinder the disassembly of the plunger rod 1, and the disassembly is simple and convenient.

[0034] Further, in the embodiment, the lock block 8 comprises a first sub-lock block 81 and a second sub-lock block 82, the second sub-lock block 82 is detachably connected with the first sub-lock block 81, the first sub-lock block 81 and the second sub-lock block 82 are both provided with a limiting opening 84 for forming a limiting channel 83, the plunger rod 1 is provided with a limiting recess 11, the limiting recess 11 is located in the limiting channel 83, and the bayonet 10 is arranged on the first sub-lock block 81. The second sub-lock block 82 is detached from the first sub-lock block 81, the limiting recess 11 of the plunger rod 1 is placed in one of the limiting openings 84, and then the second sub-lock block 82 is installed with the first sub-lock block 81, so that the limiting recess 11 is located in the limiting channel 83. At this time, the relative movement between the plunger rod 1 and the lock block 8 is limited, and the lifting of the plunger rod 1 can be limited by limiting the lifting of the lock block 8.

[0035] Further, in the embodiment, the lock block 8 comprises a first sub-lock block 81 and a second sub-lock block 82, the second sub-lock block 82 is detachably connected with the first sub-lock block 81, the first sub-lock block 81 and the second sub-lock block 82 are both provided with a limiting opening 84 for forming a limiting channel 83, the plunger rod 1 is provided with a limiting recess 11, the limiting recess 11 is located in the limiting channel 83, and the bayonet 10 is arranged on the first sub-lock block 81. The second sub-lock block 82 is detached from the first sub-lock block 81, the limiting recess 11 of the plunger rod 1 is placed in one of the limiting openings 84, and then the second sub-lock block 82 is installed with the first sub-lock block 81, so that the limiting recess 11 is located in the limiting channel 83. At this time, the relative movement between the plunger rod 1 and the lock block 8 is limited, and the lifting of the plunger rod 1 can be limited by limiting the lifting of the lock block 8.

[0036] Further, in the embodiment, the top of the column tube 7 is further provided with a limiting block 74 for limiting the downward position of the plunger rod 1, the plunger rod 1 is arranged in the limiting block 74, and the diameter of the limiting block 74 is greater than that of the limiting channel 83. When the lock block 8 is lowered to abut against the limiting block 74, the plunger rod 1 cannot continue to descend, and the collision between the plunger rod 1 and the column tube 7 can be avoided.

[0037] Further, in the embodiment, one end of the plunger rod 1 is detachably connected with a product inlet joint 12, the other end is connected with a distributor 4, the distributor 4 is detachably connected with an upper screen 5, and the product inlet joint 12, the plunger rod 1 and the distributor 4 are sequentially communicated. The liquid for chromatography process is input from the product inlet joint 12, transported through the plunger rod 1 and then enters the distributor 4, the distributor 4 distributes the liquid to each part of the upper screen 5, and the chromatography process begins; the upper screen 5 is detachably connected with the distributor 4, which facilitates the replacement of the upper screen 5. If only the upper screen 5 is damaged, the detachable design can avoid the replacement of the complex distributor 4, thereby saving costs.

[0038] Further, in the embodiment, the upper screen 5 is connected with a screen outer ring 51 on the side, a sealing gasket 13 is arranged between the top of the screen outer ring 51 and the distributor 4, a first sealing ring 14 is arranged between the inner side of the screen outer ring 51 and the distributor 4, the distributor 4 is screwed with the screen outer ring 51 through the sealing gasket 13 by a connecting piece, and the bottom of the distributor 4 abuts against the upper screen 5. The device is convenient to disassemble, has good sealing performance, and the bottom of the distributor 4 abuts against the upper screen 5 to prevent the upper screen 5 from deforming under pressure.

[0039] Further, in the embodiment, a second sealing ring 15 is arranged on the outer side of the distributor 4, and the second sealing ring 15 is used to seal the upper screen 5 and the column tube 7. The sealing performance between the distributor 4 and the column tube 7 is improved to ensure the chromatography effect.

[0040] Further, in the embodiment, the distributor 4 is internally provided with a main flow channel 41 and a plurality of oblique branch flow channels 42, the plurality of oblique branch flow channels 42 are arranged in a circumferential direction of the main flow channel 41 at intervals, and the output ends of the plurality of oblique branch flow channels 42 all face the upper screen 5. Liquid flows into the main flow channel 41 and is distributed to each part of the side of the upper screen 5 through each oblique branch flow channel 42, so that the uniformity and efficiency of chromatography are improved.

[0041] Further, in the embodiment, the top of the column tube 7 is provided with a hydraulic inlet 71 and a safety valve 72, the bottom of the column tube 7 is provided with a product outlet 73, the product outlet 73 is provided with the lower screen 6 above, the process cavity 16 is formed between one side of the upper screen 5 and the lower screen 6, the hydraulic cavity 17 is formed between the other side of the upper screen 5 and the column tube 7, and the hydraulic inlet 71 and the safety valve 72 are both in communication with the hydraulic cavity 17. The specific chromatography process is as follows: 1) slightly loosen the locking rod 9, unscrew the locking block 8, connect the pump to the product outlet 73, and use purified water to push the distributor 4, the plunger rod 1 and the locking block 8 out of the column tube 7; 2) disconnect the pump, discharge the purified water in the column tube 7, and connect the pump to the hydraulic inlet 71; 3) pour the filler into the column tube 7, put the plunger rod 1 and the distributor 4, the upper screen 5 and the like into the column tube 7, and lock the locking rod 9; 4) open the pump to push the distributor 4 downward, adjust the locking rod 9, screw the locking block 8 back after the process column bed height is reached, and make the plunger rod 1 unable to move upward by the clamping of the clamping opening 10 and the locking rod 9, and then disconnect the pump; and 5) connect the pump to the product inlet connector 12 to transport product liquid for chromatography process. In fact, the limiting block 74 is used to avoid the collision between the upper screen 5 and the lower screen 6 to improve the service life of the screen. In addition, the safety valve 72 is used to automatically release pressure protection when the pressure exceeds the set pressure.

[0042] Further, in the embodiment, a scale 91 is arranged on the locking rod 9. The column bed height can be more intuitively and quickly reflected, and the adjustment of the column bed height is facilitated.

[0043] Although the utility model has disclosed as above with preferable embodiments, however, is not used to limit the utility model. Any skilled person in the art, without departing from the utility model technical scheme range, can utilize the above disclosed technical content to make many possible changes and modifications to the utility model technical scheme, or modify as equivalent variation equivalent embodiment. Therefore, any simple modification, equivalent change and modification made to the above embodiments according to the technical essence of the utility model, which does not deviate from the content of the utility model technical scheme, should fall within the scope of protection of the utility model technical scheme.

Claims

1. A chromatographic column comprising a column tube (7), a plunger rod (1) slidingly arranged in the column tube (7) and a stop structure for limiting the upward movement of the plunger rod (1), characterized in that: The limiting structure comprises a locking block (8) and a locking rod (9), the locking rod (9) is arranged on the column pipe (7) and is adjustable in height, the locking block (8) is used for connecting the plunger rod (1) and the locking rod (9), and the locking block (8) is provided with a bayonet (10) corresponding to the locking rod (9).

2. The chromatography column of claim 1, wherein: The locking block (8) comprises a first sub-locking block (81) and a second sub-locking block (82), the second sub-locking block (82) is detachably connected with the first sub-locking block (81), the first sub-locking block (81) and the second sub-locking block (82) are both provided with a limiting port (84) for forming a limiting channel (83), the plunger rod (1) is provided with a limiting recess (11), the limiting recess (11) is located in the limiting channel (83), and the bayonet (10) is arranged on the first sub-locking block (81).

3. The chromatography column of claim 2, wherein: The locking rod (9) is threadedly connected with the locking rod (9) on both sides, the limiting channel (83) can rotate relative to the limiting recess (11), and the locking block (8) is provided with the bayonet (10) on both sides.

4. The chromatography column of claim 2, wherein: The column pipe (7) is further provided with a limiting block (74) at the top for limiting the downward position of the plunger rod (1), the plunger rod (1) is arranged in the limiting block (74), and the diameter of the limiting block (74) is greater than that of the limiting channel (83).

5. The chromatography column of claim 1, wherein: One end of the plunger rod (1) is detachably connected with a product inlet connector (12), the other end is connected with a distributor (4), the distributor (4) is detachably connected with an upper screen (5), and the product inlet connector (12), the plunger rod (1) and the distributor (4) are sequentially communicated.

6. The chromatography column of claim 5, wherein: The upper screen (5) is connected with a screen outer ring (51) on the side, the top of the screen outer ring (51) and the distributor (4) are provided with a sealing gasket (13), the inner side and the distributor (4) are provided with a first sealing ring (14), the distributor (4) is threadedly connected with the screen outer ring (51) through the connecting piece and the sealing gasket (13), and the bottom of the distributor (4) abuts against the upper screen (5).

7. The chromatography column of claim 6, wherein: The outer side of the distributor (4) is provided with a second sealing ring (15), and the second sealing ring (15) is used for sealing the upper screen (5) and the column pipe (7).

8. The chromatography column of claim 5, wherein: The distributor (4) is provided with a main flow channel (41) and a plurality of inclined branch flow channels (42), the plurality of inclined branch flow channels (42) are arranged along the main flow channel (41) in a circumferential direction, and the output ends of the plurality of inclined branch flow channels (42) all face the upper screen (5).

9. The chromatography column of claim 5, wherein: The top of the column pipe (7) is provided with a hydraulic inlet (71) and a safety valve (72), the bottom of the column pipe (7) is provided with a product outlet (73), the upper side of the product outlet (73) is provided with a lower screen (6), one side of the upper screen (5) and the lower screen (6) form a process cavity (16), the other side of the upper screen (5) and the column pipe (7) form a hydraulic cavity (17), and the hydraulic inlet (71) and the safety valve (72) are both communicated with the hydraulic cavity (17).

10. The chromatography column of any one of claims 1-9, wherein: The locking rod (9) is provided with a scale ruler (91).

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