Quantitative protein sampling device for mass spectrometric detection

Abstract

The utility model discloses a quantitative protein sampling device for mass spectrum detection, which is characterized by comprising a top fixing plate, and a metal fixing plate is elaborately designed and mounted below the top fixing plate. A precise parallel type pneumatic chuck is further arranged below the metal fixing plate, and the parallel type pneumatic chuck can ensure the stability and the accuracy during protein sampling. Besides, the quantitative precision of the protein sample is improved below the parallel pneumatic chuck, and the conveying amount of the protein on the material conveying belt can be more accurately controlled through accurate control of the first movable baffle and the second movable baffle, so that the quantitative precision of the protein sample is improved. And through the design of the threaded connection holes in the top fixing plate, different types of sample treatment devices can be conveniently installed and replaced, and the operation process is simplified. And by means of the design of the auxiliary frame, the stability of the device is improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to the technical field of biochemical analysis, and specifically to a protein quantitative sampling device for mass spectrum detection. BACKGROUND

[0002] In biochemical and molecular biology research, mass spectrum detection is an important analysis technology for identifying and quantifying biological macromolecules such as proteins. In order to improve the accuracy and repeatability of mass spectrum detection, accurate quantitative sampling of protein samples is required. Traditional protein quantitative sampling methods usually rely on manual operation, which not only consumes time but also introduces operational errors, affecting the reliability of experimental results. In addition, sample loss and contamination during manual sampling are difficult to avoid, which to some extent limits the application and development of mass spectrum detection technology. SUMMARY

[0003] The utility model aims at providing a protein quantitative sampling device for mass spectrum detection to solve the problems raised in the background.

[0004] To achieve the above-mentioned purpose, the utility model provides the following technical scheme: a protein quantitative sampling device for mass spectrum detection, characterized by comprising a top fixed plate, a metal fixed plate is designed and installed below the top fixed plate. A precise parallel pneumatic chuck is further provided below the metal fixed plate, which can ensure the stability and accuracy of protein sampling. In addition, two flexible first and second moving arms are specially designed below the parallel pneumatic chuck, which can work together to realize accurate control and positioning of protein samples.

[0005] In the utility model, the first and second moving arms are designed to move towards each other or in opposite directions. Specifically, a first moving baffle is installed below the first moving arm, and a second moving baffle is installed below the second moving arm. The two moving baffles are configured to abut against the belt surface of the material conveying belt, thereby realizing accurate control of the protein conveying amount on the material conveying belt. Through this design, the position of the baffle can be adjusted as needed, thereby controlling the flow of protein and ensuring uniform distribution and appropriate conveying of protein during transmission.

[0006] More specifically, a large number of threaded connection holes are arranged on the top fixed plate in a ring array around the longitudinal center axis of the top fixed plate, ensuring the stability of the structure and the reliability of the connection.

[0007] In more detail, we can see that the metal fixing plate is specially designed with auxiliary frames below, which is designed to provide additional support and stability. Specifically, the number of auxiliary frames is set to two, which are precisely placed on the feeding side and discharging side of the parallel pneumatic chuck, which ensures the balance and uniform stress of the whole device during operation. In addition, in order to further enhance its function, the lower end face of the auxiliary frame is designed to be at the same horizontal level as the lower end face of the first and second movable baffle, which not only makes the whole device look more tidy, but also improves the convenience and safety of operation in actual use.

[0008] Further, the side wall of the material conveying belt is ingeniously installed with a baffle, which is mainly designed to prevent the scattering of materials during transmission, thereby ensuring the safe and accurate delivery of materials to the designated location. The baffle not only plays a protective role, but also has a through slot specially designed on it, which is set to facilitate the movement of the first or second movable baffle, so that the baffle can be flexibly adjusted in position without affecting the material conveying. This thoughtful design not only ensures the continuity of material conveying, but also improves the operating efficiency of the whole system.

[0009] Compared with the prior art, the beneficial effects of the present application are: improving the quantitative accuracy of protein samples, through the precise control of the first and second movable baffles, the delivery amount of protein on the material conveying belt can be more accurately controlled, thereby improving the quantitative accuracy of protein samples.

[0010] Simplify the operation process, through the design of the threaded connection hole on the top fixing plate, different types of sample processing devices can be conveniently installed and replaced, simplifying the operation process.

[0011] Enhance the stability of the equipment, the design of the auxiliary frame increases the stability of the device, ensuring the stable operation of the equipment during operation.

[0012] Prevent material scattering, the design of the baffle can effectively prevent the scattering of materials during transmission, ensuring the integrity of the sample.

[0013] Improve the operation flexibility, the movement direction of the first and second movable baffles can be adjacent or opposite, providing greater operation flexibility to adapt to different experimental needs. BRIEF DESCRIPTION OF DRAWINGS

[0014] Fig. 1 is a front view of the present application;

[0015] Fig. 2 is a side view of the present application.

[0016] In the figure: 1, top fixed plate; 2, metal fixed plate; 3, parallel pneumatic chuck; 4, first moving arm; 5, second moving arm; 6, first moving baffle; 7, second moving baffle; 8, material conveying belt; 9, threaded connection hole; 10, auxiliary frame; 11, material blocking plate. DETAILED DESCRIPTION

[0017] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0018] Please refer to Figs. 1-2 The present application provides a technical solution: a protein quantitative sampling device for mass spectrometry, characterized in that it comprises a top fixed plate 1, and a metal fixed plate 2 is carefully designed and installed below the top fixed plate 1. A precise parallel pneumatic chuck 3 is further provided below the metal fixed plate 2, which can ensure the stability and accuracy during protein sampling. In addition, below the parallel pneumatic chuck 3, the device is specially designed with two flexible first moving arms 4 and second moving arms 5, which can work cooperatively to realize accurate manipulation and positioning of the protein sample.

[0019] In the present application, the first moving arm 4 and the second moving arm 5 are designed to move towards each other or in opposite directions. Specifically, a first moving baffle 6 is installed at the lower position of the first moving arm 4, and a second moving baffle 7 is installed at the lower position of the second moving arm 5. The two moving baffles 6 and 7 are configured to abut against the belt surface of the material conveying belt 8, thereby realizing accurate control of the protein conveying amount on the material conveying belt 8. Through this design, the position of the baffle can be adjusted as needed, thereby controlling the flow of protein and ensuring uniform distribution and appropriate conveying of protein during the conveying process.

[0020] More specifically, a large number of threaded connection holes 9 are provided on the top fixed plate 1, which are carefully arranged in a ring array around the longitudinal center axis of the top fixed plate 1, ensuring the stability of the structure and the reliability of the connection.

[0021] In more detail, we can see that the lower part of the metal fixed plate 2 is specially designed with auxiliary frames 10, which are designed to provide additional support and stability. Specifically, the number of auxiliary frames 10 is set to two, which are precisely placed on the feeding side and the discharging side of the parallel pneumatic chuck 3, which ensures the balance and uniform stress of the entire device during operation. In addition, in order to further enhance its function, the lower end face of the auxiliary frame 10 is designed to be at the same horizontal level as the lower end face of the first movable baffle 6 and the second movable baffle 7, which not only makes the entire device look more tidy, but also improves the convenience and safety of operation in actual use.

[0022] Further, the side wall of the material conveying belt 8 is ingeniously installed with a baffle plate 11, which is mainly designed to prevent the scattering of materials during transmission, so as to ensure that the materials can be safely and accurately conveyed to the designated position. The baffle plate 11 not only plays a protective role, but also is specially designed with through grooves on it, which are arranged to facilitate the movement of the first movable baffle 6 or the second movable baffle 7, so that the baffle can be flexibly adjusted in position without affecting the material transmission. This design is thoughtful, which not only ensures the continuity of material transmission, but also improves the operation efficiency of the entire system.

[0023] Working principle: when the utility model works, the top fixed plate 1 serves as the uppermost structure of the device, providing a stable platform.

[0024] The metal fixed plate 2 is installed below the top fixed plate 1, providing additional structural strength and stability to the device.

[0025] The parallel pneumatic chuck 3 is located below the metal fixed plate 2, which is used to clamp and fix the protein sample for precise sampling and transfer.

[0026] The first movable arm 4 and the second movable arm 5 are respectively located on both sides of the parallel pneumatic chuck 3, which can move towards adjacent or opposite directions to realize precise manipulation of the protein sample.

[0027] The first movable baffle 6 and the second movable baffle 7 are respectively located below the first movable arm 4 and the second movable arm 5, which can move to the belt surface of the material conveying belt 8 to control the delivery amount of the protein sample.

[0028] The material conveying belt 8 is responsible for conveying the protein sample, and the baffle plate 11 on the side wall prevents the scattering of materials, and the baffle plate is provided with through grooves to facilitate the movement of the movable baffle.

[0029] The auxiliary frame 10 is located below the metal fixing plate 2, and there is one on the feeding side and the discharging side of the parallel pneumatic chuck 3 respectively, and the lower end faces of the auxiliary frame 10 are located at the same height with the lower end face of the moving baffle, so as to ensure the stability of the protein sample during the transmission.

[0030] The whole device realizes quantitative sampling and conveying of the protein sample by accurately controlling the movement of the moving arm and the baffle, and ensures the accuracy and repeatability of the sample during the mass spectrum detection.

[0031] In the description of the utility model, unless there is definite and limited provision and limitation, the terms "mounting", "connecting", "connecting", "fixing" should be understood broadly, for example, it can be fixed connection, or can be detachable connection, or be integrated; it can be mechanical connection, or electrical connection; it can be directly connected, or indirectly connected through intermediate medium, it can be the communication of two elements or the interaction of two elements. For ordinary skilled in the art, the specific meaning of the above terms in the utility model can be understood according to the specific circumstances.

[0032] The standard parts used in the utility model can be purchased from the market, and the special-shaped parts can be ordered according to the description and the drawings, and the specific connection mode of each part adopts the conventional means such as bolt, rivet and welding in the prior art, and the machinery, parts and equipment adopt the conventional type in the prior art, and the circuit connection adopts the conventional connection mode in the prior art, which will not be described in detail here.

[0033] Although the embodiments of the utility model have been shown and described, those skilled in the art can understand that various changes, modifications, replacements and variations can be made to the embodiments without departing from the principles and spirits of the utility model, and the scope of the utility model is defined by the appended claims and their equivalents.

Claims

1. A protein quantification sampling device for mass spectrometric detection, characterized by: Including top fixed plate (1), the lower portion of top fixed plate (1) is equipped with metal fixed plate (2), the lower portion of metal fixed plate (2) is equipped with parallel pneumatic chuck (3), the lower portion of parallel pneumatic chuck (3) is equipped with first mobile arm (4) and second mobile arm (5); First mobile arm (4) and second mobile arm (5) move to adjacent or opposite direction, the lower portion of first mobile arm (4) is equipped with first mobile baffle (6), the lower portion of second mobile arm (5) is equipped with second mobile baffle (7), the lower portion of first mobile baffle (6) and second mobile baffle (7) is located on the belt surface of material conveying belt (8), control the delivery amount of protein on material conveying belt (8).

2. The protein quantification sampling device for mass spectrometry detection according to claim 1, characterized in that: The upper portion of top fixed plate (1) is equipped with threaded connection hole (9), the number of threaded connection hole (9) is several, several threaded connection hole (9) is arranged in annular array with the longitudinal axis of top fixed plate (1).

3. The protein quantification sampling device for mass spectrometry detection according to claim 1, characterized in that: The lower portion of metal fixed plate (2) is equipped with auxiliary frame (10), the number of auxiliary frame (10) is 2, respectively located on the feeding side and discharging side of parallel pneumatic chuck (3), the lower end surface of auxiliary frame (10) is located at the same height with the lower end surface of first mobile baffle (6) and second mobile baffle (7).

4. The protein quantification sampling device for mass spectrometry detection according to claim 1, characterized in that: The sidewall of material conveying belt (8) is equipped with baffle (11), prevent material scattering, at the same time, the baffle (11) is equipped with through slot for the movement of first mobile baffle (6) or second mobile baffle (7).

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