Organ storage and transfer box for lung transplantation
By using paraffin phase change materials and a single-cycle compressor refrigeration system, the temperature during lung transport is controlled, solving the problem of temperature fluctuations during transport, extending the preservation time of the lungs, reducing hypothermic ischemia damage, and improving the success rate of transplantation.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-03-26
- Publication Date
- 2026-03-03
AI Technical Summary
Existing technologies cannot maintain a constant temperature of 10 degrees Celsius during lung transport, which can damage lung viability and affect transplant outcomes.
By using paraffin phase change material combined with a single-cycle compressor refrigeration system, the temperature inside the central container is controlled at around 10°C through heat exchange pipelines, thus extending the preservation time of the lungs.
This method achieves stable temperature control during lung transport, extends lung preservation time, reduces hypothermic ischemia damage, and improves transplant success rate.
Smart Images
Figure CN223958240U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of auxiliary medical device technology, and more specifically to an organ preservation and transport box for lung transplantation. Background Technology
[0002] In emergency departments, organ failure is a very serious condition, usually requiring an organ transplant that matches the patient. During organ transplantation, after obtaining the donor's organ, it may need to be transported over a long period or distance before being transplanted into the patient. Temperature control is crucial during organ transport; maintaining a constant low temperature is essential for preserving organ viability. Currently, organ transport involves placing dry ice in a standard transport box for cooling before placing the organ inside. While the initial temperature inside the box can reach the organ's preservation temperature, it cannot be guaranteed to remain constant within this range after a certain period. Therefore, it is difficult to ensure the organ's viability during transport.
[0003] The lungs are susceptible to damage from various physical and chemical factors, including air pressure, temperature, and humidity. Among these, the lungs are particularly sensitive to temperature changes. Low temperatures can reduce cellular metabolic activity, decrease cellular ATP consumption, and slow down cell death, but they can also lead to mitochondrial stress and reactive oxygen species (ROS) production, resulting in cellular peroxidation and aseptic inflammation. Because lung transport requires oxygenation, the lungs experience hypothermic ischemia damage more quickly than other organs, which is a major cause of post-transplant lung dysfunction.
[0004] Studies have shown that a sub-hypothermic level of 10 degrees Celsius can slow down the process of cold blood injury in the lungs, further prolonging lung preservation time and reducing postoperative primary graft failure. However, there is currently a lack of a preservation device that can achieve stable preservation at 10 degrees Celsius in clinical practice. Therefore, how to provide an organ preservation and transport device that can prolong lung preservation time is a problem that urgently needs to be solved by those skilled in the art. Utility Model Content
[0005] In view of this, the present invention provides an organ preservation and transport box for lung transplantation, which extends the preservation time of the lungs and enables long-distance transportation of the lungs. To achieve the above objectives, the present invention adopts the following technical solution:
[0006] This utility model provides an organ preservation and transport box for lung transplantation, comprising:
[0007] The box has a lid at the top, and there are interlayers inside the box and on the inner wall of the lid. The interlayers inside the box and on the lid enclose a closed central container for placing the lung to be transplanted. Paraffin phase change material is placed inside each of the interlayers.
[0008] Furthermore, a refrigeration system is provided inside the housing. The refrigeration system includes a single-cycle compressor and a heat exchange pipeline. The input and output ends of the single-cycle compressor are both connected to the heat exchange pipeline. The single-cycle compressor cools the medium in the heat exchange pipeline, and the heat exchange pipeline cools the paraffin phase change material in the interlayer.
[0009] Furthermore, a temperature sensor is installed inside the central container, and a temperature recorder is installed on the lid of the container. The temperature sensor is electrically connected to the temperature recorder.
[0010] Furthermore, a location recorder is installed on the box to remotely track the geographical location of the organ.
[0011] Furthermore, the bottom of the box is rotatably connected to an axle, and both ends of the axle are provided with rollers. A telescopic pull rod is provided on the box.
[0012] Furthermore, the refrigeration system also includes a battery pack, which is electrically connected to the single-cycle compressor.
[0013] Furthermore, the refrigeration system also includes a power socket, which is electrically connected to the single-cycle compressor and connected to an external power source, thereby enabling the external power source to supply power to the single-cycle compressor.
[0014] As can be seen from the above technical solution, compared with the prior art, this utility model discloses an organ preservation and transport box for lung transplantation. During the lung transportation process, the temperature inside the central container is reduced by the heat absorption of paraffin phase change material, so that the temperature inside the central container is about 10°C, thus extending the preservation time of the lung. Attached Figure Description
[0015] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on the provided drawings without creative effort.
[0016] Figure 1 A schematic diagram of the organ preservation and transport box for lung transplantation provided by this utility model;
[0017] Figure 2 This is a time-temperature diagram illustrating the lung transport process.
[0018] In the diagram: 1. Power socket; 2. Battery pack; 3. Single-cycle compressor; 4. Heat exchange pipeline; 5. Cover; 6. Temperature recorder; 7. Position recorder; 8. Central container; 9. Interlayer; 10. Axle; 11. Telescopic rod. Detailed Implementation
[0019] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.
[0020] See Figure 1 This utility model discloses an organ preservation and transport box for lung transplantation, comprising:
[0021] The box has a lid 5 at the top. There are interlayers 9 inside the box and on the inner wall of the lid 5. The interlayers 9 inside the box and the interlayers on the lid 5 enclose a closed central container 8. The central container 8 is used to place the lung to be transplanted. Paraffin phase change material is placed inside the interlayers 9.
[0022] The paraffin phase change material absorbs heat during the melting process, which lowers the temperature inside the central container, keeping it at around 10°C and extending the preservation time of the lungs.
[0023] In some embodiments, a refrigeration system is provided inside the housing. The refrigeration system includes a single-cycle compressor 3 and a heat exchange pipeline 4. The input and output ends of the single-cycle compressor 3 are both connected to the heat exchange pipeline 4. The single-cycle compressor 3 cools the medium in the heat exchange pipeline 4, and the heat exchange pipeline 4 cools the paraffin phase change material in the interlayer 9.
[0024] Pre-cooling and temperature control of the central container 8 are achieved by adjusting the refrigeration temperature of the single-cycle compressor 3.
[0025] The single-cycle compressor 3 is set to a temperature of 2°C and the paraffin phase change material is kept warm for 3 hours to completely solidify the paraffin phase change material in the interlayer 9. At this time, the filling liquid can be stored in the central container 8, and the filling liquid can be pre-cooled or stored.
[0026] Before the lung is placed into the central container 8, the temperature of the single-cycle compressor 3 is set to 10°C. The medium in the heat exchange pipeline 4 is cooled by the single-cycle compressor 3. The cold medium enters the heat exchange pipeline 4 from the single-cycle compressor 3. The cold medium in the heat exchange pipeline 4 exchanges heat with the paraffin phase change material in the interlayer 9. The temperature of the paraffin phase change material fluctuates between 8-12°C. The temperature range of the paraffin phase change material is at the critical temperature of the paraffin phase change material. At this time, the temperature in the central container 8 is maintained at 10°C. The cold medium in the heat exchange pipeline 4 becomes a hot medium after heat exchange. The hot medium enters the single-cycle compressor 3 from the input end of the single-cycle compressor 3. The hot medium is cooled again by the single-cycle compressor 3.
[0027] When it is necessary to place the lungs into the central container 8, the packaged lungs are placed into the central container 8 and the single-cycle compressor 3 is turned off. At this time, the paraffin phase change material melts and absorbs a large amount of heat, keeping the temperature of the lungs in the central container 8 at about 10°C, thereby extending the storage time of the lungs and realizing long-distance transportation of the lungs.
[0028] In some embodiments, the interlayer 9 is a polytetrafluoroethylene shell.
[0029] In some embodiments, a temperature sensor is provided inside the central container 8, and a temperature recorder 6 is provided on the lid 5. The temperature sensor and the temperature recorder 6 are electrically connected.
[0030] The temperature inside the central container 8 is measured by a temperature sensor, and the temperature measured by the temperature sensor is recorded by a temperature recorder 6.
[0031] During transportation, the temperature recorder 6 records the temperature data measured by the temperature sensor every minute. The temperature recorder 6 enables remote monitoring of the temperature inside the central container 8.
[0032] In some embodiments, a location recorder 7 is provided on the housing to remotely track the geographical location of the organ.
[0033] During transportation, location information and temperature information are recorded synchronously and stored in the memory cards of the location recorder 7 and the temperature recorder 6, respectively. The contents recorded in the memory cards can be exported via Bluetooth or by directly reading them.
[0034] In some embodiments, a wheel axle 10 is rotatably connected to the bottom of the housing, and rollers are provided at both ends of the wheel axle 10. A telescopic pull rod 11 is provided on the housing.
[0035] The transfer box is easily moved by rollers and telescopic rod 11 to meet transportation requirements.
[0036] In some embodiments, the refrigeration system further includes a battery pack 2, which is electrically connected to a single-cycle compressor 3.
[0037] The single-cycle compressor 3 is powered by the battery pack 2, which enables the single-cycle compressor 3 to cool the paraffin phase change material during transportation, thus ensuring the temperature inside the central container 8.
[0038] In some embodiments, the refrigeration system further includes a power socket 1, which is electrically connected to the single-cycle compressor 3, and connects the power socket 1 to an external power source, thereby enabling the external power source to supply power to the single-cycle compressor 3.
[0039] During transportation, the power socket 1 is connected to the power supply on the vehicle to supply power to the single-cycle compressor 3.
[0040] In some embodiments, a battery pack socket is also provided, which is electrically connected to the battery pack 2. The battery pack socket is connected to an external power source to provide power to the battery pack 2 and store the power in the battery pack 2.
[0041] While waiting for the transplant at the transplant hospital, the single-cycle compressor 3 was powered by the operating room power supply.
[0042] In some embodiments, the capacity of battery pack 2 is within 100Wh to meet civil aviation transport regulations.
[0043] The various embodiments in this specification are described in a progressive manner, with each embodiment focusing on its differences from other embodiments. Similar or identical parts between embodiments can be referred to interchangeably. For the apparatus disclosed in the embodiments, since they correspond to the methods disclosed in the embodiments, the description is relatively simple; relevant parts can be referred to the method section.
[0044] The above description of the disclosed embodiments enables those skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims
1. An organ preservation and transport box for lung transplantation, characterized in that, include: The box has a lid at the top, and there are interlayers inside the box and on the inner wall of the lid. The interlayers inside the box and on the lid enclose a closed central container for placing the lung to be transplanted. Paraffin phase change material is placed inside each of the interlayers.
2. The organ preservation and transport box for lung transplantation according to claim 1, characterized in that, The housing is equipped with a refrigeration system, which includes a single-cycle compressor and a heat exchange pipeline. The input and output ends of the single-cycle compressor are both connected to the heat exchange pipeline. The single-cycle compressor cools the medium in the heat exchange pipeline, and the heat exchange pipeline cools the paraffin phase change material in the interlayer.
3. The organ preservation and transport box for lung transplantation according to claim 1, characterized in that, A temperature sensor is installed inside the central container, and a temperature recorder is installed on the lid. The temperature sensor is electrically connected to the temperature recorder.
4. The organ preservation and transport box for lung transplantation according to claim 1, characterized in that, The enclosure is equipped with a location recorder, which enables remote tracking of the organ's geographical location.
5. The organ preservation and transport box for lung transplantation according to claim 1, characterized in that, The bottom of the box is rotatably connected to an axle, and both ends of the axle are equipped with rollers. The box is also equipped with a telescopic rod.
6. The organ preservation and transport box for lung transplantation according to claim 2, characterized in that, The refrigeration system also includes a battery pack, which is electrically connected to the single-cycle compressor.
7. The organ preservation and transport box for lung transplantation according to claim 2, characterized in that, The refrigeration system also includes a power socket, which is electrically connected to the single-cycle compressor. The power socket is connected to an external power source, allowing the external power source to supply power to the single-cycle compressor.