Fluorescent temperature measurement closed-loop control device and laser instrument

Abstract

The embodiment of the utility model discloses a fluorescence temperature measurement closed-loop control device and a laser instrument, belongs to the technical field of laser medicine, and can automatically control the transmitting power of a laser according to hyperplasia tissue temperature measurement data. The device comprises: a semiconductor laser module for irradiating the hyperplasia tissue with a first wavelength laser; the fluorescent temperature measurement module is used for collecting a fluorescent afterglow signal of the hyperplasia tissue in a temperature environment through the fluorescent probe; and the main control module is connected with the semiconductor laser module and the fluorescence temperature measurement module, and is used for receiving a feedback signal sent by the fluorescence temperature measurement module and sending a control signal carrying the emission power information of the first wavelength laser to the semiconductor laser module.

Description

Technical Field

[0001] This document relates to the field of laser medical technology, and in particular to a fluorescence temperature measurement closed-loop control device and laser instrument. Background Technology

[0002] In recent years, lasers have shown positive therapeutic effects in trials and research on oncology. Many experiments mainly involve irradiating hyperplastic tissue with lasers, where the light energy is absorbed and converted into heat energy, raising the tissue temperature for a certain period of time. The laser generates a photothermal effect in the tissue, thermally destroying abnormally growing cells, achieving cell killing and inhibition. This can produce certain therapeutic effects on primary tumors and metastatic tumors, and has advantages such as low systemic toxicity and short treatment time.

[0003] Currently, laser instruments can be used to irradiate proliferating tissue. During instrument operation, the laser irradiation time and power need to be intermittently limited, and the surface temperature rise of the proliferating tissue needs to be judged based on experience and temperature measuring equipment. However, this approach prolongs the treatment cycle and results in low equipment efficiency. Furthermore, if there is insufficient experience and misjudgment occurs, failure to limit the laser emission power in time can easily lead to thermal runaway, causing irreversible thermal damage to normal cells in the proliferating tissue. Conversely, excessively reducing the laser power can weaken its killing effect on abnormally growing cells, making it difficult to achieve therapeutic efficacy. Therefore, there are still significant challenges in applying laser instruments to the production of medical equipment for inhibiting proliferative tissue growth. Summary of the Invention

[0004] The purpose of this specification is to provide a fluorescent thermometry closed-loop control device and laser instrument that requires temperature measurement of proliferating tissue. This is to avoid the risk of thermal runaway or insufficient lethality caused by the inaccuracy of surface thermometry technology used in existing medical laser equipment, which makes it difficult to control the laser emission power. The fluorescent thermometry closed-loop control device and instrument realizes automatic control of laser emission power based on the temperature measurement data of proliferating tissue, accurately controls the temperature of proliferating tissue, has better thermal protection, improves temperature measurement accuracy and equipment working efficiency, and is easier to use.

[0005] To achieve the above objectives, the embodiments in this specification adopt the following solutions:

[0006] In a first aspect, a closed-loop control device for fluorescence temperature measurement is provided, comprising:

[0007] A semiconductor laser module, corresponding to the location region of the proliferating tissue, is used to irradiate the proliferating tissue with a first wavelength laser.

[0008] A fluorescence thermometry module is provided, which is equipped with a fluorescence probe that corresponds to the location area of ​​the proliferating tissue. The probe is used to collect the fluorescence afterglow signal of the proliferating tissue under temperature conditions and to determine the temperature information of the proliferating tissue based on the fluorescence afterglow signal.

[0009] The main control module is connected to the semiconductor laser module and also to the fluorescence thermometry module. It is used to receive a feedback signal carrying the temperature information of the proliferating tissue sent by the fluorescence thermometry module, and to send a control signal carrying the emission power information of the first wavelength laser to the semiconductor laser module.

[0010] Secondly, a laser instrument is provided, comprising:

[0011] The aforementioned fluorescence temperature measurement closed-loop control device;

[0012] A human-computer interaction device is connected to the fluorescence temperature measurement closed-loop control device and is used to input configuration information to the fluorescence temperature measurement closed-loop control device in response to user operation; and the human-computer interaction device is also used to display the status information of the fluorescence temperature measurement closed-loop control device.

[0013] In the embodiments of this specification, a first wavelength laser, corresponding to the location region of the proliferating tissue, is used in a semiconductor laser module to irradiate the proliferating tissue. This causes the temperature of the proliferating tissue to rise in the initial stage of irradiation, providing a basis for adjusting the controlled laser power emitted during continuous irradiation, based on the temperature information of the proliferating tissue obtained by the fluorescence thermometer module and the main control module. During laser irradiation of the proliferating tissue, the temperature information of the proliferating tissue can be obtained through the fluorescence probe of the fluorescence thermometer module, which also corresponds to the location region of the proliferating tissue. The response to temperature changes caused by laser irradiation of the proliferating tissue is rapid and the measurement accuracy is high, exhibiting real-time characteristics. This provides the main control module with the temperature information basis for adjusting the laser emission power, ensuring that the maximum temperature of the proliferating tissue is lower than the configured preset temperature but higher than the normal temperature of the proliferating tissue, and optimally, it can support stability at the specified target operating temperature point. During irradiation, the main control module, together with the semiconductor laser module and the fluorescence thermometry module, achieves closed-loop control of laser emission power based on temperature information feedback. This allows the device to adjust the emission power in real time in response to the temperature of the proliferating tissue, matching the laser emission power with the target operating temperature required for the treatment of the proliferating tissue, preventing the risk of thermal runaway and avoiding insufficient lethality.

[0014] Other features and advantages of the embodiments described herein will be described in detail in the following detailed description section. Attached Figure Description

[0015] The accompanying drawings, which are included to provide a further understanding of this specification and form part of this specification, illustrate this disclosure by way of example rather than limitation, and in particular should not be construed as the sole limitation or undue limitation of this specification. In the drawings:

[0016] Figure 1 This is a schematic diagram of the main modules of an exemplary fluorescence temperature measurement closed-loop control device according to an embodiment of this specification.

[0017] Figure 2 This is a schematic diagram of an exemplary semiconductor laser module according to an embodiment of this specification;

[0018] Figure 3 This is a schematic diagram illustrating the construction of an exemplary fluorescence thermometer module according to an embodiment of this specification.

[0019] Figure 4 This is a schematic diagram of an exemplary fluorescence thermometry module structure according to an embodiment of this specification;

[0020] Figure 5 This is a schematic diagram of an exemplary closed-loop control architecture for a fluorescence temperature measurement closed-loop control device according to an embodiment of this specification.

[0021] Figure 6 This is a schematic diagram of the power supply architecture of an exemplary fluorescent temperature measurement closed-loop control device according to an embodiment of this specification.

[0022] Figure 7 This is a schematic diagram illustrating an exemplary use scenario of a laser instrument as described in this specification. Detailed Implementation

[0023] To make the objectives, technical solutions, and advantages of this specification clearer, the technical solutions of this specification will be clearly and completely described below in conjunction with specific embodiments and corresponding drawings. It is understood that the described embodiments are only a part of the embodiments of this specification, and not all of them. Based on the embodiments in this specification, any modifications, equivalent substitutions, improvements, etc., made by those skilled in the art without departing from this disclosure, and all other embodiments obtained should fall within the scope of protection of this document.

[0024] As mentioned earlier, conventional thermometers are insufficient for accurately and reliably capturing real-time temperature changes in proliferating tissue. While thermocouples and resistance thermometers can be used for surface / implanted temperature measurement, thermocouples suffer from poor stability and weak interference resistance, while resistance thermometers have slow response times and are costly to achieve high-precision measurements. Furthermore, to achieve selectivity by ensuring different responses to a specific laser between normal and abnormally growing cells in the proliferating tissue, the tissue needs to carry an injected drug. Based on one possible mechanism of action, laser irradiation could raise the normal cell temperature to the target operating temperature corresponding to the drug's effectiveness or kill optimum (killing as many abnormally growing cells as possible while killing as few normal cells as possible). However, continuous, uncontrolled laser irradiation would further increase the cell temperature, leading to drug inactivation and thermal runaway. Furthermore, using intermittent irradiation (not emitting laser or emitting low-power laser during non-irradiation cycles) will cause temperature fluctuations, making it difficult to match the target operating temperature corresponding to the optimal point of photosensitive agent effectiveness or kill. The effect of the same dose of photosensitive agent is reduced and it is easily metabolized, resulting in low instrument efficiency.

[0025] Attempts to apply the aforementioned temperature measuring devices, such as thermocouples or resistance temperature detectors, to medical laser equipment have resulted in low temperature measurement stability and reliability, high latency, and difficulty in consistently matching the laser's emission power with the target operating temperature required for treating hyperplastic tissue. This makes it difficult for the equipment to adjust its emission power in real time in response to the temperature of the hyperplastic tissue, and there will still be risks of thermal runaway or insufficient lethality.

[0026] In addition, an experimental semiconductor laser therapy system can be used. This system incorporates a control system for the semiconductor laser therapy device, which may include a semiconductor laser, a temperature control module, and a circuit control module. The circuit control system is connected to the semiconductor laser module, outputting a constant current to control its operation and coupling the laser output via fiber optics. The circuit control system is also connected to the temperature control system to maintain a constant laser temperature and ensure stable operation. Specifically, a microcontroller (MCU) monitors the laser temperature; if the temperature control system fails, the laser output is immediately stopped to protect the laser. The MCU monitors the laser's operating current; if the operating current exceeds 110% of the laser's rated current, a self-locking circuit automatically cuts off the current output, and the MCU shuts down the laser's main power supply and issues an alarm. However, the laser temperature does not reflect the temperature of the proliferating tissue. The temperature detection and control in this system cannot capture the temperature of the proliferating tissue, making it difficult for the device to adjust its emission power in real time in response to the tissue temperature. This makes it challenging to match the laser's emission power with the target operating temperature required for treating the proliferating tissue. Therefore, this semiconductor laser therapy system solution is difficult to precisely control the laser emission power, which will still lead to the risk of thermal runaway or insufficient lethality.

[0027] Therefore, this specification provides a fluorescence thermometry closed-loop control device and laser instrument. It can irradiate the proliferating tissue with a first wavelength laser corresponding to the location region of the proliferating tissue, set by the semiconductor laser module. This causes the temperature of the proliferating tissue to rise in the initial stage of irradiation, providing a basis for adjusting the controlled laser power emitted during continuous irradiation by coordinating the fluorescence thermometry module and the main control module with the temperature information of the proliferating tissue. During laser irradiation of the proliferating tissue, the temperature information of the proliferating tissue can be obtained through the fluorescence probe of the fluorescence thermometry module, which also corresponds to the location region of the proliferating tissue. The response to temperature changes caused by laser irradiation of the proliferating tissue is rapid and the measurement accuracy is high, exhibiting real-time characteristics. This provides the main control module with the temperature information basis for adjusting the laser emission power, ensuring that the maximum temperature of the proliferating tissue is lower than the configured preset temperature but higher than the normal temperature of the proliferating tissue, and optimally, it can support stability at the specified target operating temperature point. During irradiation, the main control module, together with the semiconductor laser module and the fluorescence temperature measurement module, achieves closed-loop control of laser emission power based on temperature information feedback. This allows the device to adjust the emission power in real time in response to the temperature of the proliferating tissue, matching the laser emission power with the target working temperature required for the treatment of the proliferating tissue. This prevents the risk of thermal runaway and avoids insufficient lethality, precisely controls the temperature of the proliferating tissue, provides better thermal protection, improves temperature measurement accuracy and equipment efficiency, and makes the device easier to use.

[0028] The technical solutions provided in the various embodiments of this specification are described in detail below with reference to the accompanying drawings.

[0029] One embodiment of this specification provides a closed-loop control device for fluorescence thermometry. Please refer to [link / reference]. Figure 1 It can include:

[0030] The semiconductor laser module 101 corresponds to the location region of the proliferating tissue 103 and is used to irradiate the proliferating tissue 103 with a first wavelength laser.

[0031] In the embodiments of this specification, proliferating tissue can be tissue carrying abnormally growing (proliferating) cells such as abnormal cells (constituting nodules), cancer cells, and metastatic cancer cells at various stages. For example, tissue carrying nodules or tumors may include, exemplarily, tissue carrying solid tumors such as pancreatic cancer, breast cancer, head and neck tumors (thyroid cancer, intracranial tumors such as glioma, esophageal cancer, etc.), colorectal cancer, liver cancer, lung cancer, cervical cancer, kidney cancer, bone cancer, and (skin) melanoma, as well as tissue carrying abnormally growing cells in the process of carcinogenesis.

[0032] The aforementioned semiconductor laser module can be a laser emission module in which the emission power is controlled by a control signal corresponding to the temperature information of the proliferating tissue.

[0033] Among some possible implementations, please combine Figure 1 and Figure 2 The aforementioned semiconductor laser module 101 may include a constant current drive circuit 111, a semiconductor laser 112, and a medical optical fiber and laser output window 113.

[0034] In some possible examples, the aforementioned semiconductor laser 112 can be connected to a medical optical fiber 113 to emit a first wavelength laser to the location region of the proliferating tissue 103. This first wavelength laser is output from the laser output window of the semiconductor laser module. The aforementioned semiconductor laser 112 can emit near-infrared laser and can at least support the emission of a first wavelength laser, for example, a laser with a primary wavelength of 808 nm. Understandably, other wavelength lasers can be selected based on the medication and actual needs.

[0035] The aforementioned constant current drive circuit 111 can be connected to the semiconductor laser 112 and also to the main control module 104. It is used to receive the control signal sent by the main control module 104 and adjust the emission power of the semiconductor laser 112. The constant current drive circuit 111 can convert the control signal into a current signal, thereby adjusting the emission power of the semiconductor laser 112 in real time.

[0036] For example, the constant current drive circuit may include components such as an operational amplifier and a field-effect transistor (FET). The operational amplifier can be connected to the main control module and can also be connected to the semiconductor laser via the FET. A control signal (e.g., a voltage signal) corresponding to the current real-time temperature information of the proliferating tissue output from the main control module can be input to the input terminal of the operational amplifier, thereby adjusting the output current of the operational amplifier according to the control signal. The adjusted output current of the operational amplifier can be input to the semiconductor laser (e.g., the positive electrode) through the FET (e.g., the drain), thereby enabling real-time adjustment of the emission power of the semiconductor laser. The input terminal of the operational amplifier can, for example, be connected to the circuit containing the laser via a sampling resistor to construct a feedback loop, which can make the current more stable. Other feedback loops can also be constructed and tested as needed.

[0037] In addition to using operational amplifiers and field-effect transistors, the constant current drive circuit can also be implemented using an integrated circuit chip with constant current drive functionality. After configuring the parameters of this integrated circuit chip, the main control module and the semiconductor laser can be connected to the chip's pins accordingly, thus offering advantages such as lower hardware costs, higher stability and reliability, and higher integration. Understandably, the implementation method can also be selected and designed based on the overall integrated chip and circuit resources of the product, actual needs, and sample test results, rather than being limited to the implementation methods described above.

[0038] In the aforementioned semiconductor laser module example, the semiconductor laser can be connected to the laser output window via a medical optical fiber, which extends the laser's effective distance and facilitates aligning the laser output window with the location of proliferating tissue, thus meeting the needs of various products and application scenarios. Understandably, in some examples, the medical optical fiber and the laser output window can be integrated, with the end of the medical optical fiber serving as the laser output window, and the input connector of the medical optical fiber connecting to the semiconductor laser. The end of the medical optical fiber can also be equipped with a structural layer that alters the optical path and / or a protective layer that allows light transmission, to adapt to various scenarios and product requirements.

[0039] In the embodiments of this specification, in order to obtain the temperature information of the proliferating tissue irradiated by the first wavelength laser, fluorescence thermometry can be performed on the proliferating tissue to ensure that the obtained temperature information is real-time, highly accurate, stable, and reliable. Please refer to... Figure 1 and Figure 3 The fluorescence temperature measurement closed-loop control device may further include:

[0040] The fluorescence thermometry module 102 is equipped with a fluorescence probe 124, which corresponds to the location area of ​​the proliferating tissue 103. The fluorescence probe 124 is used to irradiate the proliferating tissue 103 with fluorescence output through the fluorescence probe 124, and to collect the fluorescence afterglow signal of the proliferating tissue 103 under temperature conditions through the fluorescence probe 124.

[0041] The aforementioned fluorescence temperature measurement module can be a module that provides temperature information as a basis for the main control module to adjust the transmission power.

[0042] In some possible implementations, the aforementioned fluorescence temperature measurement module 102 may include a fluorescence light source 121, a demodulation module 122, a temperature measurement fiber optic cable 123, and a fluorescence probe 124.

[0043] In some possible examples, the aforementioned fluorescent light source 121 can be connected to the fluorescent probe 124 to emit excitation light to the fluorescent probe 124. The fluorescence afterglow signal can be generated by the excitation light emitted by the fluorescent thermometry module.

[0044] Excitation light can pass through the fluorescence probe to irradiate the proliferating tissue 103. The fluorescent material in the fluorescence probe generates fluorescence under the action of the excitation light. The fluorescence temperature measurement module 102 can obtain the temperature information of the proliferating tissue 103 by detecting the fluorescence afterglow signal.

[0045] For example, the excitation light may be a second wavelength laser, and the fluorescence probe 124 is provided with a fluorescent material layer / coating structure excited by the second wavelength laser; the wavelength of the second wavelength laser may be different from the wavelength of the first wavelength laser.

[0046] The aforementioned fluorescent light source 121 can be a light source for exciting the fluorescent material on the fluorescent material layer, and is preferably a semiconductor laser, solid-state laser, etc. The wavelength of the second wavelength laser can include 365nm, 488nm, etc., and can be selected to be different from the wavelength of the first wavelength laser, thereby avoiding interference. Furthermore, by setting the aforementioned locations, the fluorescent probe 124 can be prevented from being irradiated by the first wavelength laser; in this case, a fluorescent excitation light wavelength that is the same as, similar to, or different from the first wavelength laser can be used. In addition, the excitation light can also be the emitted light of an LED light source. The light source can be designed and selected according to the material and product requirements of the fluorescent probe.

[0047] The aforementioned fluorescent probe can be called a fluorescent sensor. It can be a multi-layered probe, which may include a fluorescent material layer and a protective layer. The protective layer can be located outside the fluorescent material layer. The protective layer is transparent and thermally conductive, and can directly contact the surface / internal environment of the proliferating tissue to prevent the external environment from damaging the fluorescent material layer. Understandably, when the diameter of the fluorescent probe is smaller than a specified diameter, the fluorescent probe can also be called a fluorescent probe probe.

[0048] In a preferred example of a temperature-sensing fiber optic cable and fluorescence probe, please refer to... Figure 3 and Figure 4 A fluorescence probe 124 and a jumper connector (not shown) can be respectively disposed at both ends of a temperature-sensing optical fiber 123, the middle section of which is an optical fiber cable. The optical fiber cable of the temperature-sensing optical fiber 123 is a partial structure that conducts the excitation light (long dashed arrow) and the fluorescence afterglow signal (short dashed arrow). The internal structure is preferably quartz optical fiber, which may have a coating and cladding layer, with the outermost layer being a Teflon protective sleeve. One end of the temperature-sensing optical fiber 123 with a jumper connector is connected to the fluorescence light source 121 and the demodulation module 122 via corresponding jumper connectors to irradiate the excitation light and acquire the fluorescence afterglow signal, thereby measuring the temperature information of the proliferating tissue in real time. The fluorescence probe can be coupled to the end of the temperature-sensing optical fiber. The fluorescence probe 124 may include the aforementioned fluorescent material layer or may include an end-covering structure formed of fluorescent material, serving as the end-sensing temperature-sensing end of the temperature-sensing optical fiber 123, corresponding to the location region of the proliferating tissue, to sense temperature changes in the temperature environment of the proliferating tissue through the end-sensing temperature-sensing end.

[0049] The aforementioned demodulation module 122 can be connected to the fluorescence probe 124 and also to the main control module 104. It is used to receive the fluorescence afterglow signal of the proliferating tissue 103 under temperature environment collected by the fluorescence probe 124, and determine the temperature information of the proliferating tissue 103 based on the fluorescence afterglow signal. It is also used to send a feedback signal carrying the temperature information of the proliferating tissue 103 to the main control module 104.

[0050] The aforementioned demodulation module can be a module with signal processing capabilities, including a processor and memory, or it can include other commercially available logic circuit modules or integrated circuit chips with the same functions. The aforementioned demodulation module can acquire the detection intensity of the fluorescence afterglow signal under the temperature environment of proliferating tissue, and can preferably determine the temperature information corresponding to the detected fluorescence afterglow signal at the current moment based on the detection intensity of the fluorescence afterglow signal under the temperature environment of proliferating tissue and the decay time since the last detection when the detection intensity is reached. The processor can solve for the temperature value in real time using the afterglow decay time constant and a configured function. Furthermore, the numerical correspondence between calibrated fluorescence afterglow signal parameter values ​​(detection intensity during decay, decay time) and temperature information can be pre-recorded using registers, flash memory, or other memory. For example, this correspondence information can be represented as a table showing the numerical relationship between all possible decay parameters and temperature values. Then, during detection, the processor queries to determine the real-time temperature information. The processor can transmit a feedback signal carrying the temperature information to the main control module via a designated pin or communication module. The demodulation module can preferably be a modulation and demodulation module, and can also provide modulation functionality for the emission of a second wavelength laser from the fluorescence light source. In addition, fluorescent light sources can also use other independent light source modulation modules, which can be selected and designed according to product needs.

[0051] Both the fluorescent light source 121 and the demodulation module 122 are connected to the fluorescent probe 124 via a temperature-sensing optical fiber 123, thereby extending the operating distance of the fluorescent probe 124 and facilitating matching the position of the irradiation area of ​​the semiconductor laser. The aforementioned fluorescent temperature measurement module is easy to implement, has high detection accuracy, and is stable and reliable.

[0052] In some exemplary fluorescent material probe applications, after the fluorescent material layer in the aforementioned fluorescent probe is excited and irradiated by the aforementioned second wavelength laser, it absorbs light energy, and electrons in the fluorescent material transition from a low energy level to a high energy level, thereby emitting fluorescence during the decay process of returning to a low energy level. The intensity and decay time of the fluorescence afterglow signal of the aforementioned proliferating tissue under temperature environment collected by the fluorescent probe are closely related to the real-time temperature of the aforementioned temperature environment. The higher the real-time temperature in the temperature environment, the shorter the time required for the fluorescence signal generated by the fluorescent material caused by the excitation light to decay to the same intensity value. Thus, the fluorescence temperature measurement module (wherein the demodulation module) can determine the temperature information expressing the real-time temperature of the aforementioned proliferating tissue under temperature environment based on the fluorescence afterglow signal collected under the aforementioned temperature environment.

[0053] It should be further clarified that the temperature environment of the aforementioned proliferative tissue can be either the surface or internal temperature environment of the proliferative tissue. The proliferative tissue irradiated by the semiconductor laser module and the proliferative tissue detected by the fluorescence thermometry module are the same proliferative tissue. The location of the proliferative tissue can be determined by the user, such as the location of a pigmented tumor on the surface of skin tissue, or the location of a nodule or tumor outside / inside an organ or tissue.

[0054] In the embodiments of this specification, the location region of the proliferating tissue can be a region where abnormal growth characteristics are to be eliminated and inhibited. The location region of the proliferating tissue may include an abnormally growing cell region and a normal cell region near the boundary of the abnormally growing cell region. In some other possible examples, the proliferating tissue may be tumor tissue, in which case the location region of the proliferating tissue may be a region composed of abnormally growing cells. There may be one or more such locations within the proliferating tissue. Depending on different window and probe sizes, these regions can be simultaneously irradiated by the first wavelength laser emitted by the semiconductor laser module, or irradiated one by one or several at a time. Normal cell regions outside the boundary of the abnormally growing cell region that are less than a distance threshold (which may be two-dimensional / three-dimensional coordinates) can be considered as nearby normal cell regions. These nearby normal cell regions may be irradiated by the first wavelength laser, but due to the selectivity of the agent, the temperature they can be heated will not exceed the temperature of the abnormally growing cells, and they will be almost unaffected by the agent and the first wavelength laser.

[0055] For each of the aforementioned location regions, the laser output direction of the aforementioned semiconductor laser module is aligned with the selected center point of the proliferating tissue, so as to set the optical path of the first wavelength laser output through the medical optical fiber and the laser output window to pass through the location region of the proliferating tissue.

[0056] Depending on the selection of different window and probe sizes, and the size of the abnormally growing cell region within the location area of ​​the proliferating tissue, a point (e.g., the geometric center point) can be selected from the abnormally growing cell region as the aforementioned selected center point. The laser output window can be positioned at a certain distance from the surface of the proliferating tissue, aligned with this selected center point, so that the extended straight line of the laser output window passes through this selected center point, maximizing the irradiation of the abnormally growing cell region and minimizing adverse effects on normal cells. Alternatively, the first wavelength laser output from the laser output window of the semiconductor laser module can cover the location area of ​​the proliferating tissue, which is suitable for situations where the proliferating tissue has multiple location areas, increasing the number of abnormally growing cell regions covered in a single irradiation, improving equipment efficiency, and reducing adverse effects on normal cells. The fluorescence probe of the fluorescence thermometry module is attached to the area of ​​the proliferating tissue irradiated by the first wavelength laser output from the laser output window. The fluorescence probe can directly contact the surface of the proliferating tissue, where the temperature changes fastest, enabling more timely transmission of the current temperature information of the proliferating tissue to the main control module. The fluorescence light source of the fluorescence temperature measurement module can be a light source with a wavelength different from that of the first wavelength laser, which can reduce mutual interference.

[0057] Furthermore, the aforementioned semiconductor laser module is connected to one end of a medical optical fiber, and the other end of the medical optical fiber can be implanted into the proliferating tissue. This allows the first wavelength laser output through the laser output window to irradiate the proliferating tissue, adapting to areas where abnormally growing cells are located at a certain depth within the proliferating tissue, thus reducing damage to surrounding normal cells. The fluorescence probe of the fluorescence thermometry module can also be implanted into the proliferating tissue, and the distance between the implanted fluorescence probe and the implanted laser output window is less than a preset distance. That is, the implanted fluorescence probe is located near the implanted laser output window (i.e., the end / other end of the aforementioned medical optical fiber), thereby transmitting the current temperature information of the proliferating tissue to the main control module more accurately and promptly.

[0058] Understandably, the corresponding settings of each of the aforementioned location areas can be designed, adjusted, or changed according to user needs and test results, without being limited to the corresponding settings of the aforementioned location areas. For example, external irradiation with a first wavelength laser can be used without implanting a laser output window, and a fluorescence probe can be implanted into the abnormally growing cell area in the location area of ​​the proliferating tissue, so as to transmit the current temperature information of the proliferating tissue to the main control module more accurately and in a more timely manner.

[0059] In the embodiments described in this specification, in order to realize the feedback signal carrying the temperature information of the irradiated proliferating tissue acquired by the fluorescence thermometry module, the emission power of the first wavelength laser output by the semiconductor laser module through the laser output window is controlled in a closed loop. Please refer to [reference needed]. Figure 5 The fluorescence temperature measurement closed-loop control device may further include:

[0060] The main control module 104 is connected to the semiconductor laser module 101 and also to the fluorescence thermometry module 102. It is used to receive a feedback signal carrying the temperature information of the proliferating tissue sent by the fluorescence thermometry module 102, and to send a control signal carrying the emission power information of the first wavelength laser to the semiconductor laser module 101.

[0061] The aforementioned main control module 104 can be a module that selectively outputs corresponding control signals based on the aforementioned feedback signals. It can be a PID closed-loop control module with PID control logic.

[0062] In some possible implementations, the aforementioned main control module may include a computing module and a control module.

[0063] In some possible examples, the computing module can be connected to the fluorescence thermometry module to receive a feedback signal carrying temperature information of the proliferating tissue sent by the fluorescence thermometry module, and to determine the emission power information of the first wavelength laser.

[0064] The aforementioned computing module may include a processor and a memory. The memory may be configured with a proportional-integral-derivative (PID) controller program. The PID controller program can take temperature information as input and output a voltage or current value corresponding to the target emission power information. It can transmit an electrical signal (voltage signal or a current signal corresponding to the voltage signal) carrying the voltage or current value corresponding to the target emission power information to the control module, so as to adjust the emission power of the first wavelength laser output by the semiconductor laser module through the laser output window. The computing module can communicate with the fluorescence temperature measurement module. Depending on the selection of the computing module and the fluorescence temperature measurement module, communication can be achieved through the transmission of CAN bus signals or pin voltage signals, etc.

[0065] The control module can be connected to the computing module and also to the semiconductor laser module. It is used to convert electrical signals into control signals and send control signals carrying emission power information of the first wavelength laser to the semiconductor laser module. The electrical signals carry emission power information of the first wavelength laser determined by the computing module.

[0066] The control module can be matched with the constant current drive circuit in the semiconductor laser module. The electrical signal can be converted into a control signal corresponding to the input terminal of the constant current drive circuit, thereby applying the voltage or current value corresponding to the target emission power information to the constant current drive circuit to adjust the emission power of the first wavelength laser. This allows the laser power to be matched with the target working temperature of the proliferating tissue in real time, avoiding the risk of thermal runaway due to excessively high temperature or insufficient lethality due to excessively low power (insufficient thermal lethality or inability to fully activate the agent). The control module can be a controller chip with digital-to-analog conversion function or a circuit implemented through digital-to-analog converters, resistors, transistors, and logic elements. Preferably, the aforementioned computing module and control module can be implemented on an integrated circuit chip, such as an MCU or a system-on-a-chip (SoC) chip. This implementation method is low-cost and operates stably and reliably.

[0067] Furthermore, the aforementioned computational module does not require a PID controller program and can be connected to a PID peripheral circuit. The PID control circuit can be implemented using an operational amplifier and multiple resistors, comparators, and capacitors to achieve proportional, integral, and derivative control. The operational amplifier, provided by the computational module, can receive a feedback signal carrying temperature information of the proliferating tissue. This feedback signal provides a voltage / current value corresponding to the temperature value, causing the PID control circuit to output a voltage / current value corresponding to the transmission power information. Multiple resistors, comparators, and capacitors can constitute the PID peripheral circuit. The design of this PID control circuit can refer to examples of PID control circuits in commercially available controllers, or the combination of the aforementioned components can be selected based on test results to form a PID control circuit. This implementation method supports customized requirements, further improving the circuit system's anti-interference capability and increasing the stability of the control logic. The aforementioned computational module can be equipped with PID control logic implemented in software, hardware, or a combination thereof, depending on product needs and test results.

[0068] In the embodiments described in this specification, please refer to Figure 6 The aforementioned fluorescence temperature measurement closed-loop control device may also include a power supply module 105, which can be connected to the main control module 104 and the constant current drive circuit 111 and semiconductor laser 112 in the semiconductor laser module. The fluorescence temperature measurement module 102 (which requires less emission power for the second wavelength laser) can be powered by the main control module 104.

[0069] The aforementioned fluorescence thermometry closed-loop control device features an accurate temperature measurement module with high resolution, fast dynamic response, and strong anti-electromagnetic interference performance. The main control module, based on feedback signals from the fluorescence thermometry module carrying temperature information of the irradiated proliferating tissue, controls the emission power of the semiconductor laser module through a feedback closed-loop control method, exhibiting high stability, accuracy, and measurement and control response speed. In a preferred example of the fluorescence thermometry closed-loop control device, the temperature measurement range is 5℃~78℃, and the measurement accuracy is ±1.0℃. The feedback closed-loop design maintains a constant temperature error of ±1℃ within the set temperature range of 45℃~70℃ (the aforementioned preset temperature can be 70℃). The peak wavelength of the semiconductor laser module is 808nm, and the deviation between its measured value and nominal value is ±5nm within 2 hours of continuous operation. The laser output power can be adjusted via emission power information, with an adjustment range of 0.10W~20.0W, and step intervals of 0.1W, 0.5W, or 1.0W selectable. The deviation between its measured value and the set value should be ±10%.

[0070] This specification also provides laser instruments based on the same inventive concept as the foregoing embodiments, which can be applied to medical devices for inhibiting hyperplasia. Please refer to [link / reference]. Figure 7 The instrument 200 may include:

[0071] The aforementioned fluorescence temperature measurement closed-loop control device;

[0072] The human-computer interaction device 201 is connected to the fluorescence temperature measurement closed-loop control device and is used to input configuration information to the fluorescence temperature measurement closed-loop control device in response to user operation; and the human-computer interaction device is also used to present the status information of the fluorescence temperature measurement closed-loop control device.

[0073] In the embodiments of this specification, the human-machine interface device 201 may include a touch screen and / or display screen, a keyboard and buttons 202 (function buttons for starting / stopping irradiation and temperature measurement functions, emergency disconnection, etc.), and other input / output elements. The human-machine interface device can be powered by the power module or main control module in the fluorescence temperature measurement closed-loop control device. It can be used to receive preset temperature and optional parameter configuration information from the user, as well as to display the status information of the therapeutic instrument (laser, emergency disconnection, etc.) and the measured temperature information, etc. The laser instrument 200 may also include an instrument housing. The human-machine interface device 201 may be disposed on the instrument housing, and the fluorescence temperature measurement closed-loop control device may be disposed inside the instrument housing. The instrument housing may be provided with a connector area 203 for the fluorescence temperature measurement closed-loop control device. The medical optical fiber and laser output window 204 connected to the connector area 203 of the fluorescence temperature measurement closed-loop control device can irradiate the location area of ​​the proliferating tissue (the grid-filled circular area). The temperature-measuring optical fiber and fluorescence probe 205 connected to the connector area 203 of the fluorescence temperature measurement closed-loop control device can detect the temperature information of the location area of ​​the proliferating tissue. Therefore, the fluorescence temperature measurement closed-loop control device can be used to adjust the laser power emitted by the fluorescence temperature measurement closed-loop control device 203 through the medical optical fiber and laser output window 204. Preferably, the semiconductor laser instrument 200 may also include an active cooling device. The active cooling device (e.g., a chassis fan) can be installed inside the instrument housing and ventilated through corresponding through-holes on the instrument housing to reduce the temperature of the semiconductor laser module in the fluorescence temperature measurement closed-loop control device.

[0074] It should also be noted that the aforementioned terms such as "first" and "second" are used only for distinguishing description and do not indicate limitations such as order or importance. The terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that includes elements of this disclosure includes not only those elements but also combinations of other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0075] In implementation, each step of the above method can be completed by integrated logic circuits in the processor or by instructions in software. The processor can be an integrated circuit chip with signal processing capabilities. It can also be a general-purpose processor, including a Central Processing Unit (CPU), a Network Processor (NP), etc.; or a Digital Signal Processor (DSP), Application Specific Integrated Circuit (ASIC), Field-Programmable Gate Array (FPGA), or other programmable logic devices, discrete gate or transistor logic devices, or discrete hardware components. It can implement or execute the methods, steps, and logic block diagrams disclosed in the embodiments of this specification. The general-purpose processor can be a microprocessor or any conventional processor. The steps of the methods disclosed in the embodiments of this specification can be directly implemented by a hardware decoding processor, or by a combination of hardware and software modules in the decoding processor. The software modules can reside in random access memory, flash memory, read-only memory, programmable read-only memory, electrically erasable programmable memory, registers, or other mature storage media in the art. The storage medium is located in the memory, and the processor reads the information in the memory and, in conjunction with its hardware, completes the steps of the above method.

[0076] Examples of memory include, but are not limited to, phase-change memory (PRAM), static random-access memory (SRAM), dynamic random-access memory (DRAM), other types of random-access memory (RAM), read-only memory (ROM), electrically erasable programmable read-only memory (EEPROM), flash memory or other memory technologies, CD-ROM, digital versatile optical disc (DVD) or other optical storage, magnetic tape, magnetic tape, disk storage or other magnetic storage devices, or any other non-transfer medium that can be used to store information that can be accessed by a computing device. As defined herein, computer-readable media does not include transient computer-readable media, such as modulated data signals and carrier waves.

Claims

1. A fluorescent temperature measurement closed loop control device, characterized by, The application relates to a fluorescence temperature measurement closed-loop control device. The device comprises: a semiconductor laser module corresponding to a position area of hyperplastic tissue, used for irradiating first wavelength laser on the hyperplastic tissue; a fluorescence temperature measurement module provided with a fluorescence probe corresponding to the position area of the hyperplastic tissue, used for collecting fluorescence afterglow signals of the hyperplastic tissue under a temperature environment through the fluorescence probe, and determining temperature information of the hyperplastic tissue according to the fluorescence afterglow signals; and a main control module connected with the semiconductor laser module and also connected with the fluorescence temperature measurement module, used for receiving feedback signals carrying the temperature information of the hyperplastic tissue sent by the fluorescence temperature measurement module, and sending control signals carrying emission power information of the first wavelength laser to the semiconductor laser module.

2. The fluorescence temperature measurement closed-loop control device according to claim 1, wherein the laser output direction of the semiconductor laser module is aligned with a selected center point of the hyperplastic tissue; or the first wavelength laser covers and irradiates the position area of the hyperplastic tissue.

3. The fluorescence temperature measurement closed-loop control device according to claim 2, wherein the fluorescence probe of the fluorescence temperature measurement module is attached to an area irradiated by the first wavelength laser in the position area of the hyperplastic tissue.

4. The fluorescence temperature measurement closed-loop control device according to claim 1, wherein the semiconductor laser module is connected with one end of a medical optical fiber, and the other end of the medical optical fiber is implanted into the hyperplastic tissue to irradiate the position area of the hyperplastic tissue through the first wavelength laser; the fluorescence probe of the fluorescence temperature measurement module is implanted into the hyperplastic tissue, and the distance between the implanted fluorescence probe and the other end of the implanted medical optical fiber is less than a preset distance. The semiconductor laser module comprises: a semiconductor laser connected with the medical optical fiber, used for emitting first wavelength laser to the position area of the hyperplastic tissue, wherein the first wavelength laser is output from a laser output window of the semiconductor laser module; and a constant current driving circuit connected with the semiconductor laser and also connected with the main control module, used for receiving the control signals sent by the main control module, and adjusting the emission power of the semiconductor laser. The fluorescence temperature measurement module comprises: a fluorescence light source connected with the fluorescence probe, used for emitting excitation light to the fluorescence probe; a demodulation module connected with the fluorescence probe and also connected with the main control module, used for receiving the fluorescence afterglow signals of the hyperplastic tissue under a temperature environment collected by the fluorescence probe, and determining the temperature information of the hyperplastic tissue according to the fluorescence afterglow signals; and the demodulation module is also used for sending feedback signals carrying the temperature information of the hyperplastic tissue to the main control module.

7. The fluorescence temperature measurement closed-loop control device according to claim 6, wherein the fluorescence light source and the demodulation module are both connected with the fluorescence probe through a temperature measurement optical fiber.

8. The fluorescence temperature measurement closed-loop control device according to claim 7, wherein ​ ​ ​ 5. The fluorescence thermometry closed loop control device of claim 1, wherein, ​ ​ ​ 6. The fluorescence thermometry closed loop control device of claim 1, wherein, ​ ​ ​ ​ ​ ​ ​ The fluorescent probe is arranged at one end of the temperature measuring fiber, and the other end of the temperature measuring fiber is further provided with a jumper connector, each jumper connector is connected with the demodulation module and the fluorescent light source respectively.

9. The fluorescence thermometry closed loop control device of claim 1, wherein, The main control module comprises: An operation module connected with the fluorescent temperature measuring module, configured to receive the feedback signal carrying the temperature information of the hyperplastic tissue sent by the fluorescent temperature measuring module, and determine the emission power information of the first wavelength laser; A control module connected with the operation module and further connected with the semiconductor laser module, configured to convert an electric signal into a control signal, and send the control signal carrying the emission power information of the first wavelength laser to the semiconductor laser module; the electric signal carries the emission power information of the first wavelength laser determined by the operation module.

10. A laser instrument, characterized by, The application further provides a fluorescent temperature measuring closed-loop control device comprising: The fluorescent temperature measuring closed-loop control device according to any one of claims 1 to 9; A human-computer interaction device connected with the fluorescent temperature measuring closed-loop control device, configured to input configuration information to the fluorescent temperature measuring closed-loop control device in response to user operation; and the human-computer interaction device is further configured to present state information of the fluorescent temperature measuring closed-loop control device.

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