Centrifugal chromatographic column for separating metabolite of sulfur tire compound

Abstract

The utility model provides a centrifugal chromatographic column for separating sulfur tire compound metabolites, which comprises a column body, a cover body inserted into the column body is arranged at the top of the column body, a discharge pipe is arranged at the bottom of the column body, a driven shaft is fixedly connected to the bottom surface of the cover body, and a moving ring is in threaded connection with the driven shaft. The cleaning device has the advantages that when the inner wall of the cylinder needs to be cleaned, the driving shaft is driven by the driving assembly to rotate, the driven shaft is driven by the driving shaft through the transmission assembly to rotate, and the moving ring and the cleaning ring are driven by the driven shaft to move vertically. Meanwhile, a driving shaft drives a driving column to rotate, the driving column drives an inner gear ring to rotate through a transmission wheel, and then a cleaning ring and a cleaning brush are driven to rotate, so that the cleaning brush synchronously rotates and vertically moves, and the inner wall of the column body is cleaned. The operation is simple and convenient, the inner wall of the column body can be quickly cleaned, and the device is more suitable for separation work of metabolite of sulfur tire compounds.

Description

Technical Field

[0001] This utility model relates to the field of chromatography column technology, and in particular to a centrifugal chromatography column for separating the metabolites of sulfur-containing compounds. Background Technology

[0002] Centrifugal chromatography is a rapid chromatographic method that places a small chromatography column in a centrifuge tube, using centrifugal force instead of gravity to perform chromatography on small samples. Its principle is based on the different partition coefficients of each component in the sample mixture between the stationary and mobile phases, separating the components through repeated partitioning.

[0003] Sulfate compounds can produce various metabolites such as sulfates, thiol sulfones, and sulfoxides after metabolism.

[0004] In existing technologies, centrifugal chromatography columns are generally used for the separation of sulfur-containing compound metabolites. However, due to the corrosive nature of the metabolites, the chromatography column needs to be cleaned after separation. Existing chromatography columns do not allow for convenient cleaning of their inner walls after use, affecting efficiency. Therefore, an improved centrifugal chromatography column for the separation of sulfur-containing compound metabolites is proposed. Utility Model Content

[0005] The purpose of this invention is to at least solve one of the aforementioned technical defects.

[0006] Therefore, one objective of this invention is to provide a centrifugal chromatography column for separating the metabolites of sulfur-containing compounds, in order to solve the problems mentioned in the background art and overcome the shortcomings of the existing technology.

[0007] To achieve the above objectives, one embodiment of this utility model provides a centrifugal chromatography column for separating sulfur-containing compound metabolites, comprising a column body, a cap inserted into the column body at the top, a discharge pipe at the bottom of the column body, a driven shaft fixedly connected to the bottom surface of the cap, a movable ring threadedly connected to the driven shaft, a connecting plate fixedly connected to the movable ring, a transmission wheel rotatably connected to the connecting plate, a cleaning ring rotatably connected inside the movable ring, a cleaning brush provided on the outer side of the cleaning ring, and an internal toothed ring fixedly connected to the inner side of the cleaning ring, the internal toothed ring meshing with the transmission wheel; a drive shaft rotatably connected to the bottom surface of the cap, a transmission assembly provided between the drive shaft and the driven shaft, a drive assembly capable of driving the drive shaft to rotate provided on the cap, and a drive column meshing with the transmission wheel fixedly connected to the bottom end of the drive shaft.

[0008] Preferably, of any of the above embodiments, a handle is fixedly connected to the cover, and a control valve is provided on the discharge pipe.

[0009] The above technical solution employs the following: the column provides a space to contain metabolites, and the cap seals the column to prevent spillage. A handle is provided on the cap for easy removal. A discharge pipe is used to discharge the separated product from the column. A control valve is installed on the pipe for easy control of its opening and closing.

[0010] Preferably, of any of the above embodiments, there are several driven shafts evenly arranged on the cover, and the inner side of the moving ring is fixedly connected with a drive lug that is threadedly connected to the driven shaft.

[0011] The above technical solution employs a driven shaft to drive the moving ring in vertical displacement. Several driven shafts are evenly arranged on the cover, driving the moving ring from multiple positions, making the movement of the moving ring more balanced and stable. The vertical displacement of the moving ring can drive the cleaning ring above it to also move vertically, thus allowing the cleaning ring to clean different positions within the cylinder.

[0012] Preferably, in any of the above embodiments, the movable ring includes an upper ring and a lower ring, the upper ring and the lower ring are fixedly connected by a drive ear, and the cleaning ring is disposed between the upper ring and the lower ring.

[0013] The above technical solution provides installation space for the cleaning ring by including an upper ring and a lower ring. The moving ring is connected to the driven shaft through a drive ear, providing installation space for the internal toothed ring inside the cleaning ring, thus avoiding interference between the driven shaft and the internal toothed ring.

[0014] Preferably, in any of the above schemes, there are two connecting plates, which are respectively fixedly connected to the upper ring and the lower ring of the moving ring, and the cleaning ring adopts a T-shaped cross section.

[0015] The above technical solution employs the following: the connecting plate provides a mounting platform for the transmission wheel, which is used to transmit power between the drive column and the internal gear ring. The cleaning ring provides a mounting platform for the cleaning brush and can drive the cleaning brush to move, allowing the cleaning brush to clean the inner wall of the column.

[0016] Preferably, in any of the above embodiments, the drive shaft is located at the center of the cover, and the transmission assembly consists of gears meshing with each other on the drive shaft and the driven shaft.

[0017] The above technical solution utilizes a drive assembly to rotate the drive shaft, which in turn drives the driven shaft to rotate via a transmission assembly. The driven shaft then drives the moving ring and cleaning ring to move vertically. Simultaneously, the drive shaft drives the drive column to rotate, which in turn drives the internal gear ring to rotate via a transmission wheel. This, in turn, drives the cleaning ring and cleaning brush to rotate, allowing the cleaning brush to rotate and move vertically in sync, thus cleaning the inner wall of the column.

[0018] Preferably, in any of the above embodiments, the length of the drive column is not less than the length of the driven shaft, and an end plate is fixedly connected to the bottom end of the driven shaft.

[0019] By adopting the above technical solution, the length of the drive column can be controlled to ensure that the cleaning brush is rotating throughout the entire process, thus guaranteeing the cleaning effect. An end plate is installed at the end of the driven shaft to prevent the moving ring from completely detaching from it.

[0020] Compared with the prior art, the advantages and beneficial effects of this utility model are as follows:

[0021] 1. This centrifugal chromatography column for separating sulfur-containing compound metabolites comprises a cap, driven shaft, moving ring, transmission wheel, cleaning ring, cleaning brush, internal toothed ring, drive shaft, and drive column. When cleaning of the column inner wall is required, the drive assembly rotates the drive shaft, which in turn drives the driven shaft via the transmission assembly. The driven shaft then moves the moving ring and cleaning ring vertically. Simultaneously, the drive shaft rotates the drive column, which in turn drives the internal toothed ring via the transmission wheel, which in turn rotates the cleaning ring and cleaning brush. This synchronized rotation and vertical displacement of the cleaning brush effectively cleans the inner wall of the column. The operation is simple and convenient, enabling rapid cleaning of the column inner wall and making it well-suited for the separation of sulfur-containing compound metabolites.

[0022] 2. This centrifugal chromatography column for separating sulfur-containing compound metabolites features a handle on the cap for easy removal. Several driven shafts are evenly distributed on the cap, driving the moving ring from multiple positions to ensure more balanced and stable movement. By controlling the length of the drive column, the cleaning brush is ensured to rotate throughout the entire process, guaranteeing effective cleaning. End plates are provided at the ends of the driven shafts to prevent the moving ring from completely detaching.

[0023] Additional aspects and advantages of this invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. Attached Figure Description

[0024] The above and / or additional aspects and advantages of this utility model will become apparent and readily understood from the description of the embodiments taken in conjunction with the following drawings, in which:

[0025] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0026] Figure 2 This is a cross-sectional view of the moving ring of this utility model;

[0027] Figure 3 This is a schematic diagram of the structure of the moving ring and the cleaning ring combined according to this utility model;

[0028] Figure 4 This is a schematic diagram of the cleaning ring of this utility model.

[0029] In the diagram: 1-Column, 2-Cover, 3-Discharge pipe, 4-Driven shaft, 5-Moving ring, 6-Drive ear, 7-Connecting plate, 8-Transmission wheel, 9-Cleaning ring, 10-Cleaning brush, 11-Internal toothed ring, 12-Drive shaft, 13-Transmission assembly, 14-Drive assembly, 15-Drive column. Detailed Implementation

[0030] The embodiments of this utility model are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and intended to explain this utility model, and should not be construed as limiting this utility model.

[0031] In this utility model, unless otherwise explicitly specified and limited, the terms "installation," "connection," "linking," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0032] like Figures 1-4 As shown, this utility model includes a column 1, a cover 2 inserted into the top of the column 1, a discharge pipe 3 at the bottom of the column 1, a driven shaft 4 fixedly connected to the bottom surface of the cover 2, a moving ring 5 threadedly connected to the driven shaft 4, a connecting plate 7 fixedly connected to the moving ring 5, a transmission wheel 8 rotatably connected to the connecting plate 7, a cleaning ring 9 rotatably connected inside the moving ring 5, a cleaning brush 10 on the outer side of the cleaning ring 9, and an internal toothed ring 11 fixedly connected to the inner side of the cleaning ring 9, the internal toothed ring 11 meshing with the transmission wheel 8; a drive shaft 12 rotatably connected to the bottom surface of the cover 2, a transmission assembly 13 between the drive shaft 12 and the driven shaft 4, a drive assembly 14 on the cover 2 capable of driving the drive shaft 12 to rotate, and a drive column 15 meshing with the transmission wheel 8 fixedly connected to the bottom end of the drive shaft 12.

[0033] Example 1: A handle is fixedly connected to the cover 2, and a control valve is installed on the discharge pipe 3. The column 1 provides a space to contain metabolic products, and the cover 2 seals the column 1 to prevent the metabolic products from spilling out. The handle on the cover 2 facilitates its removal. The discharge pipe 3 is used to discharge the separated products from the column 1. A control valve is installed on it for easy control of its opening and closing.

[0034] Several driven shafts 4 are evenly arranged on the cover 2. A drive lug 6, threadedly connected to the driven shaft 4, is fixedly connected to the inner side of the moving ring 5. The driven shafts 4 drive the moving ring 5 to make vertical displacement. The several driven shafts 4 evenly arranged on the cover 2 drive the moving ring 5 from multiple positions, making the movement of the moving ring 5 more balanced and stable. The vertical displacement of the moving ring 5 drives the cleaning ring 9 on it to also move vertically, thus allowing the cleaning ring 9 to clean different positions inside the column 1.

[0035] Example 2: The movable ring 5 includes an upper ring and a lower ring, which are fixedly connected by a drive ear 6. The cleaning ring 9 is disposed between the upper ring and the lower ring. The movable ring 5, including the upper ring and the lower ring, provides installation space for the cleaning ring 9. The movable ring 5 is connected to the driven shaft 4 through the drive ear, providing installation space for the internal gear ring 11 inside the cleaning ring 9, thus avoiding interference between the driven shaft 4 and the internal gear ring 11.

[0036] There are two connecting plates 7, which are fixedly connected to the upper and lower rings of the moving ring 5, respectively. The cleaning ring 9 has a T-shaped cross-section. The connecting plate 7 provides a mounting platform for the transmission wheel 8, which is used to transmit power between the drive column 15 and the internal gear ring 11. The cleaning ring 9 provides a mounting platform for the cleaning brush 10 and can drive the cleaning brush 10 to move, so that the cleaning brush 10 can clean the inner wall of the column 1.

[0037] Example 3: The drive shaft 12 is located at the center of the cover 2. The transmission assembly 13 consists of gears meshing on the drive shaft 12 and the driven shaft 4. The drive assembly 14 drives the drive shaft 12 to rotate, which in turn drives the driven shaft 4 to rotate via the transmission assembly 13. The driven shaft 4 then drives the moving ring 5 and the cleaning ring 9 to move vertically. Simultaneously, the drive shaft 12 drives the drive column 15 to rotate, which in turn drives the internal gear ring 11 to rotate via the transmission wheel 8. This, in turn, drives the cleaning ring 9 and the cleaning brush 10 to rotate, causing the cleaning brush 10 to rotate and move vertically in sync, thus cleaning the inner wall of the column 1.

[0038] The length of the drive column 15 is not less than the length of the driven shaft 4, and an end plate is fixedly connected to the bottom end of the driven shaft 4. By controlling the length of the drive column 15, it can be ensured that the cleaning brush 10 is in a rotating state throughout the entire process, thus ensuring the cleaning effect. The end plate at the end of the driven shaft 4 can prevent the moving ring 5 from completely detaching from it.

[0039] The working principle of this utility model is as follows:

[0040] S1. When it is necessary to clean the inner wall of the column 1, the drive assembly 14 drives the drive shaft 12 to rotate. The drive shaft 12 drives the driven shaft 4 to rotate through the transmission assembly 13. The driven shaft 4 drives the moving ring 5 and the cleaning ring 9 to make vertical displacement.

[0041] S2. The drive shaft 12 drives the drive column 15 to rotate. The drive column 15 drives the internal gear ring 11 to rotate through the transmission wheel 8, which in turn drives the cleaning ring 9 and the cleaning brush 10 to rotate, so that the cleaning brush 10 rotates and moves vertically in sync to clean the inner wall of the column 1.

[0042] Compared with the prior art, the present invention has the following advantages:

[0043] 1. This centrifugal chromatography column for separating sulfur-containing compound metabolites comprises a cap 2, a driven shaft 4, a moving ring 5, a transmission wheel 8, a cleaning ring 9, a cleaning brush 10, an internal toothed ring 11, a drive shaft 12, and a drive column 15. When cleaning the inner wall of the column 1 is required, the drive assembly 14 drives the drive shaft 12 to rotate. The drive shaft 12, through the transmission assembly 13, drives the driven shaft 4 to rotate, which in turn drives the moving ring 5 and the cleaning ring 9 to move vertically. Simultaneously, the drive shaft 12 drives the drive column 15 to rotate, which, through the transmission wheel 8, drives the internal toothed ring 11 to rotate, which in turn drives the cleaning ring 9 and the cleaning brush 10 to rotate. This causes the cleaning brush 10 to rotate and move vertically in sync, cleaning the inner wall of the column 1. The operation is simple and convenient, enabling rapid cleaning of the inner wall of the column and making it well-suited for the separation of sulfur-containing compound metabolites.

[0044] 2. The centrifugal chromatography column used for separating the metabolites of sulfur compounds has a handle on the cap 2 for easy removal. Several driven shafts 4 are evenly arranged on the cap 2, driving the moving ring 5 from multiple positions, making the movement of the moving ring 5 more balanced and stable. By controlling the length of the drive column 15, the cleaning brush 10 can be kept in a rotating state throughout the process, ensuring the cleaning effect. An end plate is provided at the end of the driven shaft 4 to prevent the moving ring 5 from completely detaching from it.

Claims

1. A centrifugal chromatography column for separating metabolites of sulfur-vulcanizable compound, comprising a column body (1), a cover (2) inserted into the column body (1) is arranged at the top of the column body (1), and a discharge pipe (3) is arranged at the bottom of the column body (1); characterized in that, The bottom surface of the cover (2) is fixedly connected with driven shafts (4), the driven shafts (4) are threadedly connected with moving rings (5), the moving rings (5) are fixedly connected with connecting plates (7), the connecting plates (7) are rotatably connected with transmission wheels (8), the moving rings (5) are rotatably connected with cleaning rings (9), the outer side of the cleaning rings (9) is provided with cleaning brushes (10), the inner side of the cleaning rings (9) is fixedly connected with inner toothed rings (11), the inner toothed rings (11) are meshed with the transmission wheels (8); the bottom surface of the cover (2) is rotatably connected with a driving shaft (12), the driving shaft (12) and the driven shafts (4) are provided with transmission assemblies (13), the cover (2) is provided with a driving assembly (14) capable of driving the driving shaft (12) to rotate, the bottom end of the driving shaft (12) is fixedly connected with driving columns (15) meshed with the transmission wheels (8).

2. A centrifugal chromatography column for separating a metabolite of a sulfur-vulcanizable compound as claimed in claim 1, characterized in that: The cover (2) is fixedly connected with a handle, and the discharge pipe (3) is provided with a control valve.

3. A centrifugal chromatography column for separating a metabolite of a sulfur-vulcanizable compound as claimed in claim 2, characterized in that: The driven shafts (4) are evenly arranged on the cover (2), and the inner side of the moving ring (5) is fixedly connected with driving ears (6) threadedly connected with the driven shafts (4).

4. A centrifugal chromatography column for separating a metabolite of a sulfur-vulcanizable compound as claimed in claim 3, characterized in that: The moving ring (5) comprises an upper ring and a lower ring, and the upper ring and the lower ring are fixedly connected through the driving ears (6), and the cleaning ring (9) is arranged between the upper ring and the lower ring.

5. A centrifugal chromatography column for separating a metabolite of a sulfur-vulcanizable compound as claimed in claim 4, characterized in that: The connecting plates (7) are two and are fixedly connected with the upper ring and the lower ring of the moving ring (5), and the cleaning ring (9) adopts a T-shaped cross section.

6. A centrifugal chromatography column for separating a metabolite of a sulfur-vulcanizable compound as claimed in claim 5, characterized in that: The driving shaft (12) is arranged at the center position of the cover (2), and the transmission assembly (13) adopts gears arranged on the driving shaft (12) and the driven shafts (4) and meshed with each other.

7. A centrifugal chromatography column for separating a metabolite of a sulfur-vulcanizable compound as claimed in claim 6, characterized in that: The length of the driving column (15) is not less than the length of the driven shaft (4), and the bottom end of the driven shaft (4) is fixedly connected with an end plate.

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