Bulk drug superfine grinding device

Abstract

The utility model relates to the technical field of raw material medicine superfine grinding, and discloses a raw material medicine superfine grinding device which comprises a grinder body, a supporting frame is fixedly connected to the bottom of the grinder body, a feeding pipe is fixedly connected to the top of the grinder body, and a screening assembly is arranged at the top of the feeding pipe. A discharging pipe is arranged on the outer wall of the pulverizer body, a wall scraping assembly is arranged in the discharging pipe and comprises a scraping plate, the scraping plate is arranged in the discharging pipe, a first motor is fixedly connected to the outer wall of the discharging pipe, a first rotating rod is fixedly connected to the output end of the first motor, and a second rotating rod is fixedly connected to the output end of the first rotating rod. The other end of the first rotating rod is fixedly connected with a first gear. According to the utility model, the gear I and the gear II are meshed to drive the extension block, and then the extension block drives the scraping plate to scrape the inner wall of the discharge pipe, so that blockage caused by long-time retention and adhesion of raw material medicine powder is avoided, and meanwhile, the reduction of the purity and the quality of a product caused by chemical reaction of the raw material medicine powder can be avoided.

Description

Technical Field

[0001] This utility model relates to the field of ultrafine pulverization technology of pharmaceutical raw materials, and in particular to an ultrafine pulverization device for pharmaceutical raw materials. Background Technology

[0002] In the pharmaceutical industry, ultrafine grinding equipment for active pharmaceutical ingredients (APIs) plays a crucial role in improving drug bioavailability and efficacy. With the rapid development of the pharmaceutical industry, the requirements for API quality and production efficiency are becoming increasingly stringent. Ultrafine grinding technology can pulverize APIs to the micron or even nanometer scale, significantly increasing the specific surface area of ​​the drug, promoting its dissolution and absorption, and thus enhancing efficacy. Simultaneously, ultrafine-ground APIs can be better and more uniformly mixed with other excipients during formulation, improving the stability and homogeneity of the formulation. Therefore, high-performance API ultrafine grinding equipment has become one of the key pieces of equipment for pharmaceutical companies to achieve high-quality production and enhance market competitiveness.

[0003] Currently, most existing ultrafine grinding devices for active pharmaceutical ingredients (APIs) employ the principle of mechanical grinding. Mechanical grinding devices utilize the movement of grinding media; for example, ball mills use the rolling and impact of grinding balls to pulverize materials. Structurally, these devices typically include a feeding system, a grinding chamber, and a discharge system. The feeding system is responsible for conveying the API to the grinding chamber, where the grinding process is completed, and the material is discharged through the discharge system. A common structure in the discharge system is a pipe-type discharge port.

[0004] However, the discharge system of existing ultrafine pulverization devices for active pharmaceutical ingredients (APIs) has significant drawbacks. During the discharge process, due to the stickiness and adsorption properties of the API powder, it easily adheres to the inner wall of the discharge pipe. Over time, this adhered API powder reacts chemically with oxygen and moisture in the air, causing the API powder to deteriorate and thus reducing the purity and quality of the product. Furthermore, the gradual accumulation of API powder on the inner wall of the discharge pipe reduces the effective inner diameter of the pipe, hindering the normal flow of materials, slowing down the discharge speed, and in severe cases, even causing blockages. Once a blockage occurs, it not only requires a significant amount of time for cleaning but also interrupts the production process, greatly reducing work efficiency and increasing production costs, failing to meet the demands of the modern pharmaceutical industry for efficient and high-quality production. Therefore, this paper proposes an ultrafine pulverization device for APIs to solve the above problems. Utility Model Content

[0005] To overcome the above deficiencies, this utility model provides a raw material ultrafine pulverizing device, which aims to improve the problem of ultrafine powder adhering to the inner wall of the discharge pipe in the prior art.

[0006] To achieve the above objectives, the present invention adopts the following technical solution:

[0007] An ultrafine pulverization device for raw pharmaceutical materials includes a pulverizer body, a support frame fixedly connected to the bottom of the pulverizer body, a feed pipe fixedly connected to the top of the pulverizer body, a sieving component provided at the top of the feed pipe, a discharge pipe provided on the outer wall of the pulverizer body, a wall scraping component provided inside the discharge pipe, the wall scraping component including a scraper, the scraper being disposed inside the discharge pipe, a motor fixedly connected to the outer wall of the discharge pipe, a rotating rod fixedly connected to the output end of the motor, a gear fixedly connected to the other end of the rotating rod, a bearing fixedly connected to the bottom of the outer wall of the discharge pipe, a gear two fixedly connected to the outer wall of the bearing, the gear two meshing with the gear one, an extension block fixedly connected to the bottom of the gear two, and the outer wall of the extension block fixedly connected to one end of the scraper.

[0008] As a further description of the above technical solution:

[0009] The screening assembly includes a screen, which is set at the top of the feed pipe. A second motor is fixedly connected to the outer wall of the support frame. A second rotating rod is fixedly connected to the output end of the second motor. A first rotating shaft is fixedly connected to the other end of the second rotating rod.

[0010] As a further description of the above technical solution:

[0011] The top of the support frame is fixedly connected to a fixing block one, and the top of the support frame is fixedly connected to a fixing block two;

[0012] As a further description of the above technical solution:

[0013] The inner walls of the fixed block 1 and the fixed block 2 are rotatably connected to a rotating rod 3, the outer wall of the rotating rod 3 is fixedly connected to a rotating shaft 2, a belt is provided between the rotating shaft 2 and the rotating shaft 1, and one end of the rotating rod 3 is fixedly connected to the rotating shaft 3.

[0014] As a further description of the above technical solution:

[0015] The rotating shaft is rotatably connected to a fixed column on its outer wall, a connecting arm is fixedly connected to the outer wall of the fixed column, and a rotating column is fixedly connected to the other end of the connecting arm.

[0016] As a further description of the above technical solution:

[0017] The two ends of the rotating column are rotatably connected to a fixing plate, and a waste bin is fixedly connected to the outer wall of each of the two fixing plates.

[0018] As a further description of the above technical solution:

[0019] The bottom of the waste bin is fixedly connected to a rotating wheel, the outer wall of the rotating wheel is slidably connected to the outer wall of the support frame, and the outer wall of the waste bin is fixedly connected to a fixing frame;

[0020] As a further description of the above technical solution:

[0021] The other end of the fixing frame is fixedly connected to a second fixing plate, the inner wall of the second fixing plate is fixedly connected to the outer wall of the screen, and the top of the second fixing plate is fixedly connected to a guide plate.

[0022] This utility model has the following beneficial effects:

[0023] 1. In this utility model, the extension block is driven by the gear two, and then the scraper is driven by the extension block. This achieves scraping of the inner wall of the discharge pipe during the discharge process, so that the raw material powder cannot stay and adhere to the wall of the discharge pipe for a long time. This effectively avoids the reduction of product purity and quality caused by chemical reactions between oxygen and moisture in the air. It also avoids problems such as the gradual accumulation of raw material powder causing the effective inner diameter of the discharge pipe to decrease, resulting in slow discharge speed and blockage. This speeds up work efficiency and improves product quality.

[0024] 2. In this utility model, the waste bin is driven by motor 2, and then the screen is driven by the waste bin. This achieves the screening of impurities in the raw materials before crushing, avoiding the reduction of crushing efficiency caused by unscreened materials entering the crushing equipment directly. This would result in a wider particle size distribution range of the final product, making it difficult to obtain uniform ultrafine powder, affecting the overall quality of the product, and potentially causing the product to fail to meet quality standards. This effectively increases the production quality of the product. Attached Figure Description

[0025] Figure 1 This is a three-dimensional schematic diagram of an ultrafine pulverization device for raw pharmaceutical materials proposed in this utility model;

[0026] Figure 2 This is a schematic diagram of the discharge port of an ultrafine pulverizing device for raw pharmaceutical materials proposed in this utility model;

[0027] Figure 3 for Figure 2 Enlarged view of point A in the middle;

[0028] Figure 4 This is a schematic diagram of the structure of the sieve in the ultrafine pulverization device for raw pharmaceutical materials proposed in this utility model;

[0029] Figure 5 for Figure 4 Enlarged view of point B in the middle.

[0030] Legend:

[0031] 1. Crusher body; 2. Feed pipe; 3. Support frame; 4. Discharge pipe; 5. Motor 1; 6. Rotating rod 1; 7. Gear 1; 8. Screen; 9. Bearing; 10. Gear 2; 11. Extension block; 12. Scraper; 13. Motor 2; 14. Rotating rod 2; 15. Rotating shaft 1; 16. Belt; 17. Fixing block 1; 18. Rotating rod 3; 19. Rotating shaft 2; 20. Fixing block 2; 21. Rotating shaft 3; 22. Fixing column; 23. Connecting arm; 24. Rotating column; 25. Fixing plate 1; 26. Waste bin; 27. Rotating wheel; 28. Fixing frame; 29. ​​Fixing plate 2; 30. Guide plate. Detailed Implementation

[0032] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0033] Reference Figures 1-3 This utility model provides an embodiment of an ultrafine pulverization device for raw pharmaceutical materials, comprising a pulverizer body 1, a support frame 3 fixedly connected to the bottom of the pulverizer body 1, an inlet pipe 2 fixedly connected to the top of the pulverizer body 1, a sieving component provided at the top of the inlet pipe 2, an outlet pipe 4 provided on the outer wall of the pulverizer body 1, and a wall scraping component provided inside the outlet pipe 4. The wall scraping component includes a scraper 12, which is disposed inside the outlet pipe 4. The scraper 12 is made of food-grade polytetrafluoroethylene, which has excellent chemical stability, low coefficient of friction and non-stick properties, effectively preventing the raw pharmaceutical materials from adhering to the surface of the scraper 12, and also does not react chemically with the raw pharmaceutical materials. The scraper 12 is angled at an arc, and its curvature matches the inner wall of the discharge pipe 4. This ensures that it fits tightly against the inner wall of the discharge pipe 4 during scraping, accelerating the discharge speed of the raw material powder. A motor 5 is fixedly connected to the outer wall of the discharge pipe 4. A rotating rod 6 is fixedly connected to the output end of the motor 5. A gear 7 is fixedly connected to the other end of the rotating rod 6. A bearing 9 is fixedly connected to the bottom of the outer wall of the discharge pipe 4. A gear 10 is fixedly connected to the outer wall of the bearing 9. The outer ring of the bearing 9 fits tightly with the inner wall of the gear 10. The inner ring is tightly connected to the discharge pipe 4. Gear 2 10 and gear 1 7 mesh with each other and power is transmitted through gear transmission. An extension block 11 is fixedly connected to the bottom of gear 2 10. The outer wall of the extension block 11 is fixedly connected to one end of the scraper 12. When motor 1 5 starts, it drives gear 1 7 to rotate through rotating rod 1 6. Gear 1 7 then drives gear 2 10 to rotate. In turn, the extension block 11 drives the scraper 12 to make a circular motion inside the discharge pipe 4, thereby scraping the inner wall of the discharge pipe 4.

[0034] Reference Figure 1 , Figure 4 and Figure 5 The screening assembly includes a screen 8, which is set at the top of the feed pipe 2. A motor 2 13 is fixedly connected to the outer wall of the support frame 3. A rotating rod 2 14 is fixedly connected to the output end of the motor 2 13. A rotating shaft 1 15 is fixedly connected to the other end of the rotating rod 2 14. A fixing block 1 17 is fixedly connected to the top of the support frame 3. A fixing block 20 is fixedly connected to the top of the support frame 3. A rotating rod 3 18 is rotatably connected to the inner wall of the fixing block 1 17 and the fixing block 2 20. A rotating shaft 2 19 is fixedly connected to the outer wall of the rotating rod 3 18. A belt 16 is provided between the rotating shaft 2 19 and the rotating shaft 1 15. A rotating shaft 3 21 is fixedly connected to one end of the rotating rod 3 18. A fixing column 22 is rotatably connected to the outer wall of the rotating shaft 3 21. The connection point of the fixing column 22 is not at the center of the circle, but is eccentrically set at a radius of about two-thirds of the distance from the center. This side-mounted layout creates an asymmetrical torque distribution on the rotating shaft 21 during rotation. The force generated by the eccentric rotation drives the connecting arm 23 to move the screen 8 along a specific trajectory. The connecting arm 23 is fixedly connected to the outer wall of the fixed column 22, and a rotating column 24 is fixedly connected to the other end of the connecting arm 23. Fixed plates 25 are rotatably connected to both ends of the rotating column 24. Waste bins 26 are fixedly connected to the outer walls of both fixed plates 25. The waste bins 26 collect the screened waste and impurities. A rotating wheel 27 is fixedly connected to the bottom of the waste bin 26, and the outer wall of the rotating wheel 27 is slidably connected to the support. The outer wall of the support frame 3 has a rotating wheel 27 made of rubber, which can slide smoothly on the guide rail on the outer wall of the support frame 3. The outer wall of the waste bin 26 is fixedly connected to a fixed frame 28, and the other end of the fixed frame 28 is fixedly connected to a fixed plate 29. The inner wall of the fixed plate 29 is fixedly connected to the outer wall of the screen 8. The screen 8 can effectively screen out small dust impurities and unqualified raw material particles. The top of the fixed plate 29 is fixedly connected to a guide plate 30, which is set directly above the feed pipe 2. Its function is to guide the screened raw material smoothly into the feed pipe 2 and prevent the material from spilling.

[0035] Working principle: During the discharge process, motor 5 is turned on, which drives rotating rod 6 to rotate. Then, the rotation of rotating rod 6 drives gear 7 to rotate, which in turn drives gear 10 to rotate. Next, the rotation of gear 10 drives extension block 11 to rotate, which in turn drives scraper 12 to remove the raw material powder adhering to the inner wall of discharge pipe 4. This prevents the raw material powder from adhering to the inner wall of discharge pipe 4 for a long time during continuous production, causing a chemical reaction with oxygen and moisture in the air, which would affect product quality and even lead to blockage of discharge pipe, forcing production to stop.

[0036] Before pulverizing the raw drug, motor 213 drives rotating rod 214 to rotate, which in turn drives rotating shaft 15 to rotate. Rotating shaft 15 then drives belt 16, which in turn drives rotating shaft 219 to rotate. Rotating shaft 219 then drives rotating rod 318 to rotate, which in turn drives rotating shaft 321 to rotate. Rotating shaft 321 then drives fixed column 22 to rotate, which in turn drives connecting arm 23 to... The movement of the connecting arm 23 then drives the rotating column 24 to move, which in turn drives the fixed plate 25 to move. Subsequently, the fixed plate 25 drives the waste bin 26 to move, which in turn drives the screen 8 to move. Then, the movement of the waste bin 26 drives the rotating wheel 27 to slide on the surface of the support frame 3, thus screening the raw material before pulverization. This prevents impurities in the raw material from entering the pulverization equipment, which would reduce pulverization efficiency and ultimately lead to a wider particle size distribution range in the product, making it difficult to obtain a raw material powder product with uniform particle size.

[0037] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A raw material drug ultrafine pulverizing device comprising a pulverizer main body (1), characterized by: The bottom of the pulverizer body (1) is fixedly connected with a support frame (3), the top of the pulverizer body (1) is fixedly connected with a feeding pipe (2), the top of the feeding pipe (2) is provided with a screening assembly, the outer wall of the pulverizer body (1) is provided with a discharge pipe (4), the inside of the discharge pipe (4) is provided with a wall scraping assembly; The wall scraping assembly comprises a scraper (12), the scraper (12) is arranged in the inside of the discharge pipe (4), the outer wall of the discharge pipe (4) is fixedly connected with a motor one (5), the output end of the motor one (5) is fixedly connected with a rotating rod one (6), the other end of the rotating rod one (6) is fixedly connected with a gear one (7), the bottom of the outer wall of the discharge pipe (4) is fixedly connected with a bearing (9), the outer wall of the bearing (9) is fixedly connected with a gear two (10), the gear two (10) and the gear one (7) are engaged, the bottom of the gear two (10) is fixedly connected with an extension block (11), and the outer wall of the extension block (11) is fixedly connected with one end of the scraper (12).

2. The raw material medicine ultrafine pulverization device according to claim 1, characterized in that: The screening assembly comprises a screen (8), the screen (8) is arranged at the top of the feeding pipe (2), the outer wall of the support frame (3) is fixedly connected with a motor two (13), the output end of the motor two (13) is fixedly connected with a rotating rod two (14), and the other end of the rotating rod two (14) is fixedly connected with a rotating shaft one (15).

3. The raw material medicine ultrafine pulverization device according to claim 2, characterized in that: The top of the support frame (3) is fixedly connected with a fixed block one (17), and the top of the support frame (3) is fixedly connected with a fixed block two (20).

4. The raw material medicine ultrafine pulverization device according to claim 3, characterized in that: The inner wall of the fixed block one (17) and the fixed block two (20) is rotatably connected with a rotating rod three (18), the outer wall of the rotating rod three (18) is fixedly connected with a rotating shaft two (19), a belt (16) is arranged between the rotating shaft two (19) and the rotating shaft one (15), and one end of the rotating rod three (18) is fixedly connected with a rotating shaft three (21).

5. The raw material drug ultrafine grinding device according to claim 4, characterized in that: The outer wall of the rotating shaft three (21) is rotatably connected with a fixed column (22), the outer wall of the fixed column (22) is fixedly connected with a connecting arm (23), and the other end of the connecting arm (23) is fixedly connected with a rotating column (24).

6. The raw material drug ultrafine grinding device according to claim 5, characterized in that: Both ends of the rotating column (24) are rotatably connected with a fixed plate one (25), and the outer wall of each of the two fixed plate ones (25) is fixedly connected with a waste box (26).

7. The raw material drug ultrafine grinding device according to claim 6, characterized in that: The bottom of the waste box (26) is fixedly connected with a rotating wheel (27), the outer wall of the rotating wheel (27) is slidably connected to the outer wall of the support frame (3), and the outer wall of the waste box (26) is fixedly connected with a fixing frame (28).

8. The raw material drug ultrafine grinding device according to claim 7, characterized in that: The other end of the fixing frame (28) is fixedly connected with a fixed plate two (29), the inner wall of the fixed plate two (29) is fixedly connected to the outer wall of the screen (8), and the top of the fixed plate two (29) is fixedly connected with a flow guide plate (30).

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