Target alignment device and neutron capture treatment system

Abstract

The present application provides a target alignment device and a neutron capture therapy system, the target alignment device comprising: a target assembly having a target center; the supporting device is used for supporting the target assembly; the positioning device is arranged on the supporting device, the positioning device can move relative to the supporting device so as to be used for positioning the target assembly to a target position, and at the target position, the target center is located in a preset range with the supporting device as the reference. According to the positioning device in the embodiment of the invention, the target center of the target assembly can be positioned to the same position as the target center of the previous target assembly, so that the neutron beam of the neutron capture treatment system is in a stable state, meanwhile, the positioning device is simple in structure and low in failure rate, and unnecessary radiation of operators can be reduced.

Description

Technical Field

[0001] This application relates to the field of target alignment devices, and more particularly to a neutron capture therapy system. Background Technology

[0002] The description in this section provides only background information relevant to the disclosure of this application and does not constitute prior art.

[0003] With the development of atomic science, radiation therapy, such as cobalt-60, linear accelerators, and electron beams, has become one of the main methods of cancer treatment. However, traditional photon or electron therapy is limited by the physical conditions of radiation itself. While killing tumor cells, it also damages a large amount of normal tissue along the beam path. In addition, due to the different sensitivities of tumor cells to radiation, traditional radiation therapy is often ineffective for more radiation-resistant malignant tumors (such as glioblastoma multiforme and melanoma).

[0004] To reduce radiation damage to surrounding normal tissues, the concept of targeted therapy in chemotherapy has been applied to radiotherapy. Furthermore, for highly radiation-resistant tumor cells, radiation sources with high relative biological effectiveness (RBE) are being actively developed, such as proton therapy, heavy ion therapy, and neutron capture therapy. Neutron capture therapy combines these two concepts; for example, boron neutron capture therapy utilizes the specific accumulation of boron-containing drugs on tumor cells, combined with precise neutron beam modulation, to provide a better cancer treatment option than traditional radiation.

[0005] In neutron capture therapy systems, an accelerator accelerates a beam of charged particles to an energy level sufficient to overcome the Coulomb repulsion between the target nuclei within the beam shaper (BSA). The charged particles then undergo a nuclear reaction with the target to produce neutrons, which are then modulated by the BSA's energy spectrum for therapeutic use. However, during neutron production, the target is subjected to high-power irradiation from the accelerated charged particle beam, causing a significant increase in its temperature and consequently affecting its lifespan.

[0006] It should be noted that the above introduction to the technical background is only for the purpose of providing a clear and complete explanation of the technical solutions of this application and facilitating understanding by those skilled in the art. It should not be assumed that these technical solutions are known to those skilled in the art simply because they have been described in the background section of this application. Utility Model Content

[0007] Through repeated experiments and creative discovery, the inventors found that the performance of existing neutron capture therapy systems exhibits certain defects after each target replacement. These defects include, but are not limited to, inconsistent or unstable neutron beams. To further investigate the cause of these defects, the inventors conducted further repeated experiments and creatively discovered that the cause lies in the deviation between the target position after each installation and the previous target position. This deviation further leads to a shift in the target's position relative to the charged particle beam and / or beam shaper, resulting in the aforementioned defects.

[0008] Based on the aforementioned deficiencies in the prior art, the target alignment device and neutron capture therapy system in this application are used to solve the technical problem of inconsistent or unstable neutron flux in the neutron beam of the neutron capture therapy system in the prior art.

[0009] To achieve the above objectives, this application provides a target alignment device, comprising:

[0010] Target assembly, with a target center;

[0011] A support device for supporting the target assembly;

[0012] A positioning device is disposed on the support device, and the positioning device is movable relative to the support device to position the target assembly to a target position, wherein the target center is located within a preset range with the support device as a reference.

[0013] Preferably, the target assembly includes a target body and a target attachment disposed on the periphery of the target body, and the positioning device is used to support the target body and / or the target attachment to position the target assembly at the target location.

[0014] Preferably, the positioning device is used to support the target body, and the positioning device is in contact with the target body.

[0015] Preferably, the positioning device extends from between the outer periphery of the target attachment and the target body and abuts against the target body to support the surface of the target body; and / or,

[0016] The target attachment is configured to have a space between it and the positioning device extends into the space between it and the target body to position the target body.

[0017] Preferably, the target accessory includes a limiting portion disposed on the outer periphery of the target body and a cooling pipe passing through the limiting portion;

[0018] The positioning device is supported by the limiting part to position the target component.

[0019] Preferably, the positioning device includes a motion unit and a support unit, wherein the motion unit drives the support unit so that the support unit supports the target assembly.

[0020] Preferably, the support unit has a contoured portion, the target assembly has a mating surface, and the contoured portion can fit into the mating surface so that the support unit supports the target assembly.

[0021] Preferably, the number of the support units is at least two, one of the support units supports the target assembly along a first direction, and the other support unit supports the target assembly along a second direction, wherein the angle between the first direction and the second direction is greater than or equal to 0 degrees and less than or equal to 180 degrees.

[0022] Preferably, the positioning device includes:

[0023] At least one motion unit, the motion unit having a first pivot center, the motion unit being configured to pivot about the first pivot center;

[0024] At least one support unit, wherein the support mechanism is disposed at one end of the motion unit;

[0025] The first pivot center is configured to move in a direction from near the center of the target material to away from the center of the target body, so that the support unit is driven by the motion unit to move from a position away from the surface of the target assembly to a position that fits against the surface of the target assembly, so as to support the surface of the target assembly.

[0026] Preferably, the positioning device further includes a first guide portion, which is configured to extend in a direction from away from the center of the target assembly to near the center of the target assembly, and the first pivot center is configured to move along the first guide portion.

[0027] Preferably, the motion unit further has a second pivot center, which is disposed on the motion unit and located between the first pivot center and the support unit. The motion unit is configured to pivot about the second pivot center, which is configured to move in a direction from away from the center of the target assembly to near the center of the target assembly.

[0028] Preferably, the positioning device further includes a second guide portion, which is configured to extend in a direction from away from the center of the target assembly to near the center of the target assembly, and the second pivot center is configured to move along the second guide portion.

[0029] A second aspect of this application provides a neutron capture therapy system, comprising:

[0030] A charged particle beam generating device, used to output a charged particle beam;

[0031] Target assembly, used to react with a beam of charged particles to produce a neutron beam;

[0032] A conveying device is used to move the target assembly to a predetermined position;

[0033] A positioning device that can abut against the target assembly, the positioning device being used to position the target assembly at a target position after the conveying device has positioned the target assembly at a predetermined position.

[0034] Preferably, the target assembly includes a target body and a target attachment disposed on the periphery of the target body, the positioning device is used to support the target body, and the positioning device abuts against the target body.

[0035] Preferably, the neutron capture therapy system further includes:

[0036] Beam shaper, used to shape neutron beams;

[0037] The beam shaper can be used to accommodate at least a portion of the target assembly. The target assembly further includes a target material disposed in one end of the target body. The end of the target body with the target material is accommodated in the beam shaper. The positioning device is used to position the end of the target body away from the target material.

[0038] Preferably, it further includes a beam shaper, wherein after the target assembly moves to a predetermined position, the end of the target assembly that generates the neutron beam abuts against the beam shaper.

[0039] Beneficial effects:

[0040] By employing the above technical solutions, the target alignment device of this application can position the target center of the target assembly within a preset range relative to the reference of the support device, as the target center of one or more previously fired target assemblies used to generate the target beam is within this preset range. Within this preset range, the target center of the target assembly is at a target position, which ensures that the target center is in the same position as other structures in the beam system. This facilitates the positioning of multiple target assemblies to this target position, ensuring that the position of the target assembly after target material depletion and re-attaching is in the same corresponding position relative to other structures in the beam system. By ensuring that the target center is located at the target position through the target alignment device, the target assembly is positioned relative to the charged particle beam generating device and other structures in the neutron capture therapy system. This target position ensures that the center of the target assembly is in the same corresponding position relative to the charged particle beam generating device and other structures in the neutron capture therapy system after each target material depletion and re-attaching. This guarantees that the neutron beam of the neutron capture therapy system is in a stable state. Furthermore, this positioning device has a simple structure, low failure rate, and can reduce unnecessary radiation exposure for operators.

[0041] Specific embodiments of this application are disclosed in detail with reference to the following description and accompanying drawings, illustrating how the principles of this application can be employed. It should be understood that the embodiments of this application are not limited in scope. Within the spirit and scope of the appended claims, the embodiments of this application include many changes, modifications, and equivalents.

[0042] Features described and / or illustrated for one embodiment may be used in the same or similar manner in one or more other embodiments, combined with features in other embodiments, or substituted for features in other embodiments.

[0043] It should be emphasized that the term "including / comprises" as used herein refers to the presence of a feature, whole, step, or component, but does not exclude the presence or addition of one or more other features, wholes, steps, or components. Attached Figure Description

[0044] The accompanying drawings described herein are for illustrative purposes only and are not intended to limit the scope of this application in any way. Furthermore, the shapes and scales of the components in the drawings are merely illustrative to aid in understanding this application and do not specifically limit the shapes and scales of the components. Those skilled in the art, guided by the teachings of this application, can select various possible shapes and scales to implement this application according to specific circumstances. In the drawings:

[0045] Figure 1 This is a plan view of a neutron capture therapy system provided in an embodiment of the present invention.

[0046] Figure 2This is a three-dimensional schematic diagram of a neutron capture therapy system provided in an embodiment of the present invention.

[0047] Figure 3 This is a schematic diagram of the target assembly and delivery device provided in an embodiment of the present invention.

[0048] Figure 4 This is a schematic diagram of the target alignment device provided in an embodiment of the present invention from a first-view perspective.

[0049] Figure 5 This is a structural schematic diagram of the target alignment device provided in an embodiment of the present invention from a second perspective.

[0050] Figure 6 This is a schematic diagram of the positioning device provided in an embodiment of the present invention.

[0051] Figure 7 A simplified structural diagram of the positioning device and the target body in a clamping state provided in the first embodiment of this utility model.

[0052] Figure 8 A simplified structural diagram of the positioning device provided in the second embodiment of this utility model, showing the target body in a clamping state.

[0053] Figure 9 A simplified structural diagram of the positioning device provided in the third embodiment of this utility model, showing the target body in a clamping state.

[0054] Figure 10 This is a simplified structural diagram of the positioning device provided in the fourth embodiment of the present invention, showing the target body in a clamping state.

[0055] Figure 11 A simplified structural diagram of the positioning device provided in the fifth embodiment of this utility model, showing the target body in a clamping state.

[0056] Figure 12 This is a simplified structural diagram of the positioning device provided in the sixth embodiment of the present invention, showing the target body in a clamping state.

[0057] Figure 13 This is a simplified structural diagram of the positioning device provided in the seventh embodiment of the present invention, showing the target body in a clamping state.

[0058] The reference numerals in the above figures are as follows: 1. Charged particle beam generating device; 11. Accelerator; 12. Transmission device; 2. Target assembly; 21. Target body; 211. Fixing part; 212. Neck; 213. Extension part; 214. Protrusion part; 215. Target material; 23. Target accessory; 231. Cooling pipe; 232. Detection device; 233. Limiting part; 3. Conveying device; 31. Drive frame; 32. Power structure; 4. Positioning device; 41. Drive unit; 411. Output end; 42. Motion unit; 421. First connecting rod; 422. Second connecting rod; 423. First pivot center; 424. Second pivot center; 425. First guide groove; 42 6. Second guide groove; 4261. Inclined section; 43. Bearing unit; 431. First bearing component; 432. Second bearing component; 433. Rolling part; 44. Mounting bracket; 45. Guide mechanism; 451. Limiting plate; 452. Limiting groove; 453. Positioning pin; 5. Beam shaping body; 6. Support device; 61. Track; 62. Support column; 7. Shielding facility; 71. Shielding door; 72. First opening; 73. Second opening; M. Target center; R1. First space; R2. Second space; R3. Third space; W. Included angle; X. First central axis; Y. Second central axis; T1. First direction; T2. Second direction; Z. Gap. Detailed Implementation

[0059] To enable those skilled in the art to better understand the technical solutions in this application, the technical solutions in the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort should fall within the scope of protection of this application.

[0060] It should be noted that when an element is referred to as being "set on" another element, it can be directly on the other element or there may be an intervening element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or there may be an intervening element. The terms "vertical," "horizontal," "left," "right," and similar expressions used herein are for illustrative purposes only and do not represent the only embodiments.

[0061] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0062] The various embodiments in this specification are described in a progressive manner. Similar or identical parts between embodiments can be referred to mutually. Each embodiment focuses on describing the differences from other embodiments. In particular, the system embodiments are basically similar to the method embodiments, so the description is relatively simple; relevant parts can be referred to the descriptions in the method embodiments.

[0063] It should be noted that in the description of this application, the terms "first," "second," etc., are used only for descriptive purposes and to distinguish similar objects; there is no order between them, nor should they be construed as indicating or implying relative importance. Furthermore, in the description of this application, unless otherwise stated, "multiple" means two or more.

[0064] Neutron capture therapy has seen increasing application as an effective cancer treatment method in recent years, with boron neutron capture therapy being the most common. Neutrons for boron neutron capture therapy can be supplied by a nuclear reactor or accelerator 11. This application's embodiments use accelerator 11 boron neutron capture therapy as an example. The basic components of accelerator 11 boron neutron capture therapy typically include an accelerator 11 for accelerating a beam of charged particles (such as protons, deuterons, etc.), a radioactive consumable target 215 and a thermal removal system, and a beam shaper 5. The accelerated charged particle beam interacts with the metal target 215 to produce neutrons. A suitable nuclear reaction is selected based on the required neutron yield and energy, the available energy and current of the accelerated charged particle beam, and the physicochemical properties of the metal target 215. Commonly discussed nuclear reactions include... 7 Li(p,n) 7 Be and 9 Be(p,n) 9 B. Both of these reactions are endothermic, with energy thresholds of 1.881 MeV and 2.055 MeV, respectively. Since the ideal neutron source for boron neutron capture therapy is hyperthermic neutrons at the keV energy level, theoretically, bombarding lithium metal target 215 with protons at energies only slightly above the threshold could produce relatively low-energy neutrons, requiring minimal slowing treatment for clinical application. However, the interaction cross-section between lithium metal (Li) and beryllium metal (Be) targets 215 and protons at the threshold energy is not high. To generate a sufficiently large neutron flux, higher-energy protons are usually chosen to initiate the nuclear reaction.

[0065] Ideally, a radioactive consumable target 215 should possess characteristics such as high neutron yield, neutron energy distribution close to the hyperthermic neutron energy region (described in detail below), minimal strong penetration radiation, safety, low cost, ease of operation, and high temperature resistance. However, in reality, it is impossible to find a nuclear reaction that meets all these requirements. The embodiments of this application use a target 215 made of lithium metal. However, as those skilled in the art will know, the target 215 can also be made of other metallic materials besides those discussed above.

[0066] The requirements for a thermal removal system vary depending on the nuclear reaction selected, such as 7 Li(p,n) 7 Due to the poor melting point and thermal conductivity of the 215 (lithium metal) metal target, the requirements for the heat removal system are relatively high. 9 Be(p,n) 9 B is high. In the embodiments of this application, the following are used: 7 Li(p,n) 7 The nuclear reaction of Be. It can be seen that the temperature of the target 215 irradiated by a high-energy accelerated charged particle beam will inevitably rise significantly, thus affecting the service life of the target 215.

[0067] Therefore, neutron capture therapy systems, which are part of radioactive radiation irradiation systems, inevitably involve the replacement of the radioactive consumable target 215. In this embodiment, the neutron capture therapy system ensures that the target 215 remains in the same position after each replacement, thus guaranteeing a stable neutron beam. This allows the neutron capture therapy system to maintain a relatively stable or optimal operating state.

[0068] Figure 1 This is a plan view of a neutron capture therapy system according to an embodiment of the present invention. Figure 2 This is a three-dimensional schematic diagram of a neutron capture therapy system according to an embodiment of the present invention, as shown below. Figure 1 and Figure 2As shown, the neutron capture therapy system may include a charged particle beam generating device 1, a target assembly 2, and a beam shaper 5 (BSA). The charged particle beam generating device 1 may include an accelerator 11 for generating a charged particle beam and a transmission device 12 for transmitting the charged particle beam. The transmission direction of the charged particle beam is consistent with or substantially consistent with the arrangement direction of the transmission device 12. In this embodiment, the target assembly 2 may include a target body 21 whose extension direction is consistent with or substantially consistent with the transmission device 12. The target body 21 has a first end and a second end opposite to each other along its extension direction. The first end of the target body 21 can engage or disengage from the transmission device 12. When the target body 21 and the transmission device 12 are engaged, the charged particle beam output by the transmission device 12 can enter the target body 21 from the first end of the target body 21 and then reach the target material 215. The target material 215 is disposed at the second end of the target body 21. The target material 215 can react with the charged particle beam to generate a neutron beam.

[0069] In this embodiment, the target material 215, when projected onto its cross-section perpendicular to the extension direction of the target body 21, is circular, square, or other symmetrical. The target center M of the target assembly 2 can be the center point or axis of symmetry of the target material 215. Of course, in other optional embodiments, the projection of the target material 215 onto its cross-section perpendicular to the extension direction of the target body 21 may not be symmetrical. In this case, the target center M of the target assembly 2 can also be a point or axis defined artificially on the projected cross-section of the target material 215. Of course, in other optional embodiments, the target center M of the target assembly 2 can also be set based on the target body 21 or other rigid components or asymmetrical components in the target assembly 2 that have a center of symmetry.

[0070] Combination Figure 1 and Figure 2 As shown, the neutron capture therapy system can be divided into a first space R1 and a second space R2 based on a shielding facility 7 with opening and closing functions. The shielding facility 7 may include two shielding doors 71 that can move relative to each other. When the two shielding doors 71 are closed, the shielding facility 7 can form at least one first opening 72 through which the target assembly 2 and part of the transmission device 12 pass. In this embodiment, the first opening 72 is located at the transmission device 12, and the shape of the first opening 72 is adapted to the shape of the outer wall of the transmission device 12 through the first opening 72, including but not limited to circular, elliptical, rhomboid, square, irregular, and other shapes. Of course, in another optional embodiment, the first opening 72 is located at the transmission device 12, and the shape of the first opening 72 is adapted to the shape of the outer wall of the transmission device 12 through the first opening 72, including but not limited to circular, elliptical, rhomboid, square, irregular, and other shapes.

[0071] An accelerator 11 is installed in the first space R1. A beam shaper 5 is installed in the second space R2. When the neutron capture therapy system is in radiotherapy mode, the first end of the target body 21 is engaged with the transmission device 12. At this time, the target body 21 is located in the second space R2. The transmission device 12 can transmit the charged particle beam accelerated by the accelerator 11 from the first space R1 to the target material 215 in the second space R2. The accelerator 11 accelerates the charged particle beam to an energy sufficient to overcome the Coulomb repulsion of the atomic nuclei of the target material 215, causing it to interact with the target material 215. 7 Li(p,n) 7 The Be nuclear reaction produces neutrons, which form a neutron beam that exits from the beam exit of the beam shaper 5. The beam shaper 5 is typically large and is embedded within the wall. It includes a decelerator, a thermal neutron absorber, and a radiation shield (not shown in the attached figures). The decelerator is typically made of aluminum fluoride as the main material, and optionally one or more mixed materials such as lithium fluoride, aluminum, lead fluoride, alumina, calcium fluoride, or magnesium fluoride. Some of these materials are quite brittle, thus requiring sophisticated installation techniques. It slows down the neutrons generated from the target material 215 to the hyperthermal neutron energy region. Deviated neutrons are guided back to the decelerator by the reflector to increase the intensity of the hyperthermal neutron beam. The thermal neutron absorber absorbs the thermal neutrons to avoid unnecessary damage to superficial normal tissues due to excessive doses during treatment. The radiation shield is used to shield leaked neutrons and photons to reduce the dose to normal tissues in non-irradiated areas. The neutron capture therapy system further includes a third space R3 as an irradiation chamber, through which a qualified neutron beam can exit from the beam exit and enter the irradiation chamber for use.

[0072] When the target assembly 2 (target material 215) needs to be replaced, for example, after a certain period of use, a certain number of uses, or when the target material 215 malfunctions, the shielding facility 7 needs to be opened, the target body 21 of the target assembly 2 and the transmission device 12 need to be separated, and then the target assembly 2 to be replaced is moved from the second space R2 to the first space R1 for recovery. The new target assembly 2 is then transferred from the first space R1 to the second space R2, and the target body 21 and the transmission device 12 are connected again, while the shielding facility 7 is closed. During the replacement of the target assembly 2, the transmission device 12 and the target assembly 2 are preferably kept in a vacuum state.

[0073] Considering radiation contamination, it is generally necessary to set up a conveying device 3, which can transfer the target component 2 (e.g., the target component 2 that needs to be replaced) from the second space R2 to the first space R1, or transfer the target component 2 (e.g., the new target component 2) from the second space R2 to the first space R1.

[0074] In this embodiment, with both shielding doors 71 closed, the shielding facility 7 can form a second opening 73. The neutron capture therapy system may also include a support device 6 for supporting the target assembly 2. The support device 6 may include a track 61 passing through the second opening 73. The conveying device 3 may include a drive frame 31 and a power structure 32 mounted on the track 61 for carrying the target assembly 2. The power structure 32 includes, but is not limited to, electronic or pneumatic linkages, robots and their structures, robotic arms, etc. The track 61 of the support device 6 provides a certain degree of limitation and pre-positioning for the target assembly 2. However, considering the relative movement between the track 61 and the drive frame 31, the preferred fit between the track 61 and the drive frame 31 due to the relative movement requirements is a clearance Z-fit. This fit ensures the smoothness of the relative movement between the track 61 and the drive frame 31, while also maximizing the accuracy of the pre-positioning of the target assembly 2 by the conveying device 3. The track 61 provides a support surface for the drive frame 31. On this support surface, the machining form and position error of the mating part of the drive frame 31 and the support surface, the machining form and position error of the support surface itself, and the form and position error generated by the assembly of the support frame 31 and the support surface all affect the position of the drive frame 31 after it is supported, which in turn affects the position of the target assembly 2 carried by the drive frame 31. This results in a certain deviation between the position of the target assembly 2 and the previous position of the target assembly 2 after each target replacement and installation of the new target assembly 2.

[0075] Combination Figure 1As shown, to overcome this deviation and minimize its adverse effects, the neutron capture therapy system may further include a positioning device 4. The positioning device 4 is used to position the target center M of the target assembly 2 at a target position after the delivery device 3 has positioned the target assembly 2 in a predetermined position. This target position positions the target assembly 2 in the same position as other structures in the beam system, facilitating the positioning of multiple target assemblies 2 to this target position. This ensures that the position of the target assembly 2 after target replacement and reloading is in the same corresponding position relative to other structures in the beam system, thereby guaranteeing that the neutron beam generated by the target assembly 2 remains consistent with the previous neutron beam generated by the target assembly 2 after each target replacement and reloading, ensuring the stability of the neutron beam output. In this embodiment, the predetermined position can be the termination position of the delivery device 3's operation in transferring the target assembly 2 (e.g., the target assembly 2 that needs to be replaced) from the second space R2 to the first space R1. That is, the positioning device 4 starts operating after the conveying device 3 transfers the target assembly 2 to the termination position of the first space R1 (at which point the second end of the target assembly 2 can abut against the beam shaper 5, or, in other optional embodiments, the target material 215 of the target assembly 2 is located inside the beam shaper 5), thereby positioning the target assembly 2 until the target center M of the target assembly 2 is positioned to the same position as the previous target center M of the target assembly 2. Generally, the transmission device 12 can be connected to the target body 21 after the positioning device 4 positions the target center M of the target assembly 2 at the target position. Of course, in other optional embodiments, after the conveying device 3 transfers the target assembly 2 to the termination position of the first space R1, the transmission device 12 can also be connected to the target body 21 first, and then the positioning device 4 starts operating to position the target assembly 2.

[0076] It is understood that, in other alternative embodiments, the predetermined position can be the intermediate position after the conveying device 3 transfers the target component 2 (e.g., the target component 2 that needs to be replaced) from the second space R2 to the first space R1. That is, within the range between the time the conveying device 3 transfers the target component 2 to the first space R1 and the time before the termination position, the positioning device 4 starts to operate to position the target component 2. During the transport of the target component 2 by the conveying device 3, the positioning device 4 can keep the target center M of the target component 2 in a position corresponding to the target position. After the conveying device 3 terminates the transport, the positioning device 4 can position the target center M of the target component 2 to the target position, that is, the same position as the target center M of the target component 2 before the replacement. In other words, the positioning device 4 is used to ensure that the target component 2 is in the same position after replacement as before replacement after the conveying device 3 has placed the target component 2 in the predetermined position. Preferably, the target assembly 2 or the target body 21 has a uniform surface. During the process of the conveying device 3 pushing the target assembly 2 from a preset position to the target position, the positioning device 4 can adaptively adapt to the uniform surface to achieve the positioning of the target assembly 2 at the target position. This ensures that after each target change and re-attaching, the position of the target assembly 2 is in the same position relative to the charged particle beam generating device 1 and other structures, so that the generated neutron beam is consistent with the neutron beam generated by the previous target assembly 2, ensuring the stability of the neutron beam output. In other optional embodiments, the target assembly 2 or the target body 21 may also have a non-uniform surface such as a slope or a conical part. The positioning device 4 can also adaptively adapt to the non-uniform surface, as long as it ensures that the target assembly 2 is in the same (corresponding) position relative to the previously hit target assembly 2 after each fixation.

[0077] Combination Figure 3 and Figure 5 As shown, in this embodiment, the drive frame 31 of the conveying device 3 can be sleeved on the outer periphery of the target body 21. When the target assembly 2 is retrieved or reinstalled, the conveying device 3 is retrieved or reinstalled synchronously with the target assembly 2. The first end of the target body 21 has an extension 214 extending out of the drive frame 31. The extension 214 is detachably connected to the transmission device 12, for example, by means of a quick-clamp structure, a connecting rod, a lock, a snap fastener, or the like. In another optional embodiment, the conveying device 3 and the transmission device 12 are detachably connected, for example, by means of a quick-clamp structure, a connecting rod, a lock, a snap fastener, or the like. When the conveying device 3 and the transmission device 12 are connected, the transmission device 12 can dock with or be sleeved with the first end of the target body 21 to achieve communication and engagement between the channel of the transmission device 12 and the channel of the target body 21.

[0078] Combination Figure 5As shown, in this embodiment, the target body 21 includes a fixing portion 211 passing through the drive frame 31, an extension portion 213 on which a target material 215 is provided, and a neck 212 located between the fixing portion 211 and the extension portion 213 along the extending direction of the target body 21. Compared to the fixing portion 211 and the extension portion 213, the neck 212 has the smallest projected area in the cross-section projected perpendicular to the extending direction of the target body 21. The extension portion 213, the neck 212, and the fixing portion 211 can be an integral structure, or they can be configured to be detachably connected or fixedly connected, etc., depending on actual needs.

[0079] Combination Figure 3 As shown, generally, a target attachment 23 is provided on the outer periphery of the target body 21. Therefore, in order to allow the positioning device 4 to have a larger operating space, the positioning device 4 can position and support the smaller outer diameter portion of the target body 21 (e.g., the neck 212 of the target assembly 2). In other alternative embodiments, the positioning device 4 can also position the target body 21 at its smallest diameter or other locations that are easy to clamp, as needed.

[0080] To minimize the impact of radiation generated during target firing on the positioning device 4, the positioning device 4 can be used to position the end of the target body 21 furthest from the target material 215. In other words, the positioning device 4 can be positioned as close as possible to the first end of the target body 21 and the transmission device 12. In other alternative embodiments, the positioning device 4 can also be located at any position between the first end and the second end of the target body 21. Preferably, a large distance needs to be maintained between the positioning position and the target material 215. In other alternative embodiments, the positioning device 4 can also be set according to actual needs; for example, the positioning device 4 may be located outside the beam shaping body 5.

[0081] Main reference Figure 4 and Figure 5 As shown in the figure, this application also discloses a target alignment device, which includes a target assembly 2, a support device 6, and a positioning device 4. Combined with... Figure 3As shown, the target assembly 2 may include a target body 21, a target material 215 disposed at one end of the target body 21, and a target accessory 23 disposed on the outer periphery of the target assembly 2. The target accessory 23 includes, but is not limited to, a cooling pipe 231 for contacting the target material 215 and a detection device 232 capable of detection. The cooling pipe 231 may be connected to an external cooling system. The target material 215, subjected to high-energy accelerated irradiation, experiences a temperature increase, and is efficiently cooled by a cooling medium flowing through the cooling pipe 231. The detection device 232 includes, but is not limited to, a temperature sensor for detecting the real-time temperature of the cooling device, a vacuum sensor for detecting the hollow interior of the target body 21, and a neutron detector for detecting the neutrons produced after a nuclear reaction. The detection device 232 includes, but is not limited to, electronic sensors, proximity sensors, capacitive sensors, transducers, or other types of sensors. The target center M of the target assembly 2 may be the center of symmetry of the target material 215 or its axis of symmetry. Of course, in other alternative embodiments, the target center M of the target assembly 2 can also be set based on the target body 21 or other rigid components in the target assembly 2 that have a center of symmetry. For example, in some embodiments, the target center M is set based on the axis of the cylindrical contour portion included in the target body 21. In this case, the target center M can be defined as the intersection of the target material 215 and the axis of the cylinder. In other embodiments, the target center M can be set based on the axis of symmetry of the cooling pipe 231, and the target center M can be defined as the intersection of the axes of symmetry of the cooling pipe 231. This utility model does not limit this, with the aim of achieving the positional calibration of the target assembly 2, so as to facilitate the placement of the target material 215 in a position that is compatible with the charged particle beam and the beam shaper 5.

[0082] In the positioning device 4 and the support device 6, the materials of the majority of the radiation-exposed components are composed of at least 90% (by weight) of the following elements: C, H, O, N, Si, Al, Mg, Li, B, Mn, Cu, Zn, S, Ca, and Ti. In this embodiment, if aluminum alloy is selected for the positioning device 4 and the support device 6, aluminum has a short half-life after neutron activation, only 2.2 minutes; while traditional steel materials, rich in elements such as iron, cobalt, and nickel, have longer half-lives after neutron activation, such as cobalt-60 with a half-life of 5.27 years. Using aluminum alloy significantly reduces the radioactivity derived from neutron activation within a limited time, which not only reasonably suppresses the dose caused by secondary radiation but also facilitates future equipment dismantling. The materials of the positioning device 4 and the support device 6 can further be aluminum-magnesium alloys, or carbon fiber composites, glass fiber composites, or combinations thereof.

[0083] Reference Figure 1 and Figure 4 As shown, as previously described, the support device 6 may include a track 61 whose extension direction is parallel or substantially parallel to the transmission direction of the charged particle beam. The support device 6 may also include a support column 62 disposed within the second space R2. One end of the support column 62 ( Figure 1 The lower middle end is fixed to the ground, and the other end of the support column 62 ( Figure 1 The upper middle section (of the support column 62) can be fixedly connected to the track 61 to provide support for the track 61. The support column 62 can also be set in other locations, such as within the first space R1 R2. In this case, the rigidity of the track 61 can be increased to ensure reliable support of the track 61 by the support column 62. The support column 62 can also be set in other locations to achieve stable support for the track 61.

[0084] In this embodiment, the target alignment device can position the target center M of the target assembly 2 within a preset range relative to the reference of the support device 6, where the target center M of one or more previously fired target assemblies 2 used to generate the target beam is within this preset range. Within this preset range, the target center M of the target assembly 2 is at a target position, which places the target center M in the same position corresponding to other structures in the beam system. This facilitates the positioning of multiple target assemblies 2 to this target position, ensuring that the position of the target assembly 2 after being replaced with a new target material 215 is in the same corresponding position relative to other structures in the beam system. The positioning device 4 can move or rotate relative to the support device 6 to support the target assembly 2, thereby ensuring that the target center M of the target assembly 2 is in the target position.

[0085] During the initial installation and debugging of the target assembly 2, at least one of the target assembly 2, beam shaper 5, and charged particle beam generating device 1 can be adjusted to ensure that the target center M, beam shaper 5, and the reference center of the charged particle beam are in a relatively suitable state. It is understood that the reference center of the charged particle beam can be a virtual positioning center set for the purpose of simplifying or analyzing the charged particle beam, and not the actual center point of the charged particle beam in the actual application scenario. Considering that in the actual application scenario, the charged particle beam is in a scanning and firing state, the actual center of the charged particle beam during the operation may deviate from the reference center of the charged particle beam.

[0086] The positioning device 4 is mounted on the support device 6 and is movable relative to the support device 6 to position the target assembly 2 to a target position. At the target position, the target center M is located within a preset range relative to the support device 6. It is understood that the support device 6 is rigidly mounted in a fixed position. The target position (end point position) after the positioning device 4 positions the target assembly 2 is based on the support device 6. In some embodiments, the preset range can be understood as follows: when the positioning device 4 positions the target assembly 2 to the target position, assuming the same positioning reference is used for the support device 6, the vector formed between the target assembly 2 and this positioning reference is within the allowable range for operation; that is, both the distance and direction of the vector are within the allowable range. In some embodiments, such as setting the target assembly 2 at a target position, the target center M of the target assembly 2 or other positioning references in the target assembly 2, such as positioning points, positioning lines, or positioning surfaces, can be positioned at the target position. Thus, when the target assembly 2 is set at the target position, and the positioning reference of the support device 6 is a preset fixed point, preset fixed line, or preset fixed surface, assuming the same positioning reference as the support device 6 is used, the vector formed between the target assembly 2, i.e., the target center M of the target assembly 2 or other positioning references in the target assembly 2, such as positioning points, positioning lines, or positioning surfaces, and the positioning reference is within the allowable range for operation; that is, the distance value and direction of the vector are both within the allowable range. The above-mentioned allowable range for operation is related to the radioactive components of the target assembly 2, and may also be related to the characteristics of the beam shaper 5 and the charged particle beam. This invention does not limit this range.

[0087] In some embodiments, the preset range can be understood as follows: when the positioning device 4 positions the target component 2 at the target position, assuming a fixed point, a fixed line, or a fixed surface on the support device 6 is taken as a reference, the vector formed between the target component 2 and the reference is within the allowable range for operation; that is, the distance value and direction of the vector are both within the allowable range. In some embodiments, for example, when the target component 2 is set at the target position, the target center M of the target component 2 or other positioning references in the target component 2, such as positioning points, positioning lines, or positioning surfaces, may be placed at the target position. Thus, when the target component 2 is set at the target position, and the reference provided by the support device 6 is a fixed point, a fixed line, or a fixed surface, assuming the same reference as the fixed point, fixed line, or fixed surface provided by the support device 6 is taken, the vector formed between the target component 2, that is, the target center M of the target component 2 or other positioning references in the target component 2, such as positioning points, positioning lines, or positioning surfaces, and the positioning reference is within the allowable range for operation; that is, the distance value and direction of the vector are both within the allowable range. The permitted range of the above operations is related to the radioactive components of the target assembly 2, and may also be related to the characteristics of the beam shaper 5 and the charged particle beam. This utility model does not limit this range.

[0088] For ease of calculation, any fixed point, line, or surface on the support device 6 that is easy to calculate or locate can be used as a reference provided by the support device 6. Using this fixed point, line, or surface as a reference, the target position of the target center M falls within a calibrated range, which is the preset range. Correspondingly, after each reinstallation, the target center M of the target assembly 2, positioned by the positioning device 4, will be located at the target position. At this target position, the target center M lies within the range referenced by the fixed point, line, or surface provided by the support device 6. Specifically, if at the target location, the target center M is located within the range, i.e., the preset range, with the aforementioned fixed point as a reference, the preset range can be related to the position of the fixed point. That is, the height of the positioning device 4 after positioning the target component 2 can be determined by the fixed point, as well as the symmetrical plane of the contact point between the positioning device 4 and the surface of the target component 2 when positioning the target component 2 is completed. On the symmetrical plane, when the target component 2 is placed at the height position after positioning is completed, the projection position of the target center M on the symmetrical plane determines a projection point. Then, the preset range is the area based on the projection point. For example, the preset range is a circular area with a diameter within a preset value based on the projection point. The preset value can be determined according to the characteristics of the radioactive components of the target assembly 2. For example, the preset value can be any value between 0.01 cm and 1.5 cm. This utility model does not limit this value. Specifically, the preset value can be 1 mm, 4.5 mm or 8 mm. Within this preset range, after the target assembly 2 is positioned, it can be ensured that the target assembly 2 is in a fixed position relative to the support device 6 after each target is loaded. It can also be ensured that the target assembly 2 is in a matching position relative to the charged particle beam and the overall structure of the beam shaper 5. At this matching position, the neutron beam generated after each target change and reloading remains stable.

[0089] If, at the target location, the target center M is located within the range referenced by the line of the aforementioned fixed position, i.e., the preset range, this preset range can be related to the position of the line of the fixed position. That is, the height of the positioning device 4 after positioning the target component 2 can be determined by the line of the fixed position, as well as the symmetrical plane of the positioning device 4 with different contact points on the target component 2 when positioning the target component 2. On the symmetrical plane, when the target component 2 is placed at the height position after positioning, the projection position of the target center M on the symmetrical plane determines a projection point. Then, the preset range is the area based on the projection point. For example, the preset range is a circular area with a diameter within a preset value based on the projection point. The preset value can be determined according to the characteristics of the radioactive components of the target assembly 2. For example, the preset value can be any value between 0.01 cm and 1.5 cm. This utility model does not limit this value. Specifically, the preset value can be 1 mm, 4.5 mm or 8 mm. Within this preset range, after the target assembly 2 is positioned, it can be ensured that the target assembly 2 is in a fixed position relative to the support device 6 after each target is loaded. It can also be ensured that the target assembly 2 is in a matching position relative to the charged particle beam and the overall structure of the beam shaper 5. At this matching position, the neutron beam generated after each target change and reloading remains stable.

[0090] If, at the target location, the target center M is located within a range, i.e., a preset range, with the fixed position surface as a reference, this preset range can be related to the position of the fixed position surface. That is, the height of the positioning device 4 after positioning the target component 2 can be determined by the fixed position surface, as well as the symmetrical surface of the positioning device 4 with different contact points on the target component 2 when positioning the target component 2. On the symmetrical surface, when the target component 2 is placed at the height position after positioning, the projection position of the target center M on the symmetrical surface determines a projection point. Then, the preset range is the area based on the projection point. For example, the preset range is a circular area with a diameter within a preset value based on the projection point. The preset value can be determined according to the characteristics of the radioactive components of the target assembly 2. For example, the preset value can be any value between 0.01 cm and 1.5 cm. This utility model does not limit this value. Specifically, the preset value can be 1 mm, 4.5 mm or 8 mm. Within this preset range, after the target assembly 2 is positioned, it can be ensured that the target assembly 2 is in a fixed position relative to the support device 6 after each target is loaded. It can also be ensured that the target assembly 2 is in a matching position relative to the charged particle beam and the overall structure of the beam shaper 5. At this matching position, the neutron beam generated after each target change and reloading remains stable.

[0091] In some embodiments, the height of the positioning device 4 after positioning the target assembly 2 can be determined in the following way. Specifically, in some embodiments, the support device 6 is rigidly mounted on a reference plane, and the positioning device 4 is mounted on the support device 6. When the positioning device 4 is in the state of positioning the target assembly 2, the positioning device 4 has a target lifting height based on the reference plane. After the target assembly 2 is positioned, the target lifting height is the position that the target center M should theoretically be lifted to. During the positioning process from the start to the completion of positioning, the part of the positioning device 4 that supports the movement of the target assembly 2 has an elongation displacement from the starting position to the completion position. The target lifting height can be obtained by summing the shape and size value of the mating part between the target assembly 2 and the positioning device 4 with this elongation displacement. Specifically, the target lifting height is the sum of the projection distance of the line connecting the mating part of the target assembly 2 and the target center M along the axis of the target center M in the displacement direction from the starting position to the completion position, and the elongation displacement. The target lifting height is the height of the positioning device 4 after positioning the target assembly 2.

[0092] In some embodiments, the plane of symmetry between the positioning device 4 and different contact points on the target assembly 2 when the positioning device 4 completes the positioning of the target assembly 2 can be determined in the following way. Specifically, in some embodiments, the positioning device 4 is supported by the support assembly 6, and the positioning device 4 positions the target assembly 2 to the target position based on the fixation of the support assembly 6. The positioning device 4 achieves the positioning of the target assembly 2 by having a common contact position with the target assembly 24. At the common contact position, the positioning device 4 applies a force to the target assembly 2, thereby positioning the target assembly 24 to the target position through this force. At the contact position, the positioning device 4 supports the target component 2 by abutting against it. The positioning device 4 can support the target component 2 through surface contact, line contact, or point contact. Accordingly, the part on the target component 2 that is in contact with the target component 2 when the positioning device 4 and the target component 2 are in surface contact, line contact, or point contact is defined as the contact surface, contact line, or contact point. Accordingly, in some embodiments, the contact surface, contact line, or contact point is symmetrical about a symmetrical plane or located on the symmetrical plane, thereby determining the symmetrical plane of the positioning device 4 with different contact points on the target component 2 when it completes positioning the target component 2.

[0093] In some embodiments, if the target center M is located at the target position, the target center M is located within a range, i.e., a preset range, with reference to the aforementioned fixed point. This preset range may be related to the position of the fixed point. For example, the fixed point and the support device 6 may define a vertical plane that is approximately perpendicular to the horizontal plane. This vertical plane and the target or the preset range are circular areas with a diameter within a fixed numerical range based on the fixed point.

[0094] Since the support device 6 and other structures of the neutron capture therapy system are rigidly configured, it must be on the same reference plane as the beam shaping body 5 and other rigidly configured structures. By using the support device 6 as a reference, the lifting position of the target assembly 2 after the support device 6 positions it can be determined. Based on the positioning of the target assembly 2 at the lifting position, the central axis of the target body 21 of the target assembly 2 is located in a compatible position with the beam shaping body 5.

[0095] In some embodiments, to ensure that the target center M of the target assembly 2 is always in the target position after each installation, the distance between the target center M and the support device 6 can be set to always be within a preset range. The preset range is based on the support device 6. Thus, under the action of the positioning device 4, the target assembly 2 can be in the same position after each reinstallation as the previous target assembly 2, thereby making the neutron beam of the neutron capture therapy system more stable.

[0096] Specifically, after the positioning device 4 positions the target assembly 2, the target assembly 2 can be supported by both the positioning device 4 and the drive frame 31 of the conveying device 3. Even if these two supports do not coincide with the ideal axis, and the ideal axis and the actual axis only intersect at the positioning device 4, as long as the deviation between the target assembly 2 and the reference center of the charged particle beam is within a certain range, that is, the distance between the target center M and the support device 6 is within the preset range, it can be ensured that the charged particle beam hits the target at the same position each time, and the neutron beam generated each time is in a stable state.

[0097] Considering that the positioning device 4 applies a certain force to the target assembly 2 during positioning, generally, the positioning device 4 provides a positioning and support force to the target body 21, which has relatively stable rigidity. Of course, in other optional embodiments, the positioning device 4 can also provide a positioning and support force to target accessories 23, such as cooling pipes 231, if design requirements are met.

[0098] Combination Figure 4 and Figure 6 As shown, in this embodiment, the positioning device 4 may include a driving unit 41 and two clamping mechanisms symmetrically arranged along the first central axis X. Under the action of the driving unit 41, the two clamping mechanisms can approach the target assembly 2 along the direction of the first central axis X, and then clamp the target body 21 from both sides toward the direction of approaching the target body 21.

[0099] Preferably, a gap Z can be formed between the outer wall of the target body 21 and the target attachment 23. The two clamping mechanisms can extend into the gap Z and clamp the two sides of the target body 21.

[0100] The positioning device 4 includes at least one motion unit 42 and at least one support unit 43. The at least one motion unit 42 and the at least one support unit 43 constitute a clamping mechanism. Each motion unit 42 has a first pivot center 423, which is configured to pivot about the first pivot center 423. Under the action of the drive unit 41, the first pivot center 423 is configured to move in a direction from near the center of the target material 215 to away from the center of the target body 21. The support unit 43 is disposed at one end of its corresponding motion unit 42. Under the action of the drive unit 41 and the motion unit 42, the support unit 43 can move from a position away from the surface of the target assembly 2 to a position close to the surface of the target assembly 2, thereby providing support to the surface of the target assembly 2. To limit the movement of the first pivot center 423, the positioning device 4 also includes a first guide portion, which is configured to extend in a direction from near the center of the target assembly 2 to away from the center of the target assembly 2, and the first pivot center 423 is configured to move along the first guide portion. The first guide portion may include a first guide groove 425, and the first pivot center 423 has a first pin that extends into the first guide groove 425 and moves under the limitation of the first guide groove 425.

[0101] The motion unit 42 also has a second pivot center 424, which is located between the first pivot center 423 and the support unit 43 in a direction from away from the center of the target assembly 2 to near the center of the target assembly 2. The motion unit 42 is configured to pivot about the second pivot center 424, which is configured to move in a direction from away from the center of the target assembly 2 to near the center of the target assembly 2, so as to transport the support unit 43 to a surface close to the target assembly 2.

[0102] To limit the movement of the second pivot center 424, the positioning device 4 further includes a second guide portion, which is configured to extend in a direction from away from the center of the target assembly 2 to near the center of the target assembly 2. The second pivot center 424 is configured to move along the second guide portion. The second guide portion is disposed on the side of the first guide portion near the target assembly 2. The second guide portion may include a second guide groove 426. The second pivot center 424 has a second pin that extends into the second guide groove 426 and moves under the limitation of the second guide groove 426.

[0103] Preferably, the second guide groove 426 includes a groove body and a ramp section 4261 disposed at one end of the groove body away from the drive unit 41. The ramp section 4261 extends from the groove body in a direction from away from the target assembly 2 toward the target assembly 2 and toward the first central axis X. In other words, the distance between one end (groove body) of the ramp section 4261 and the first central axis X is greater than the distance between the other end of the ramp section 4261 and the first central axis X. Thus, the support unit 43 can move toward the first central axis X under the guidance of the second pivot center 424 and the second guide groove 426.

[0104] Specifically, each motion unit 42 includes a first link 421. A first pivot center 423 is disposed on the first link 421. A second pivot center 424 is disposed at the end of the first link 421 near the support unit 43. The support unit 43 is disposed at the end of the first link 421 away from the drive unit 41.

[0105] Combination Figure 4 and Figure 6 As shown, in this embodiment, the supporting unit 43 includes a first supporting member 431 and a second supporting member 432. One end of the first supporting member 431 and one end of the second supporting member 432 are both fixed to the end of the first connecting rod 421 away from the driving unit 41. The other ends of the first supporting member 431 and the second supporting member 432 are respectively provided with rolling portions 433, which are configured to adapt to rolling on the surface of the target assembly 2 when supporting the target assembly 2.

[0106] In one embodiment of this utility model, the number of the supporting units 43 is at least two, wherein at least one supporting unit 43 is configured to support the target assembly 2 along a first direction T1, and at least another supporting unit 43 is configured to support the target assembly 2 along a second direction T2. ​​The included angle W between the first direction T1 and the second direction T2 is greater than or equal to 0 degrees and less than or equal to 180 degrees. The positioning device 4 is provided with at least two supporting units 43, each supporting unit 43 being connected to a motion unit 42, such that, driven by the motion unit 42, at least one supporting unit 43 supports the target assembly 2 along the first direction T1, and at least another supporting unit 43 supports the target assembly 2 along the second direction T2. ​​Specifically, as shown... Figure 7As shown, at least one of the bearing units 43 supports the target assembly 2 along a first direction T1, where T1 is the direction along T1. The supporting force provided by the at least one bearing unit 43 to the target assembly 2 is the resultant force of the supporting force of the first bearing member 431 to the target assembly 2 and the supporting force of the second bearing member 432 to the target assembly 2, and the direction of the resultant force is along the T1 direction. At least one other bearing unit 43 is configured to support the target assembly 2 along a second direction T2, where T2 is the direction along T2. The supporting force provided by the at least one other bearing unit 43 to the target assembly 2 is the resultant force of the supporting force of the first bearing member 431 to the target assembly 2 and the supporting force of the second bearing member 432 to the target assembly 2, and the direction of the resultant force is along the T2 direction. At this time, the included angle W between the first direction T1 and the second direction T2 is 180°. At least two bearing units 43 are respectively clamped at the intersection point or line of the same diameter and contour of the cylindrical portion on the surface of the target body 21. Preferably, the direction of the diameter of the cylindrical portion on the surface of the target body 21 is along the Y direction.

[0107] In other embodiments, at least one support unit 43 supports the target assembly 2 along a first direction T1. The included angle W between the first direction T1 and the second direction T2 can be any one of 0°, 30°, 60°, 90°, 120° or 150°, or other angle values ​​other than the above angle values ​​within the range of 0° to 180°, so as to facilitate the adaptation of the assembly structure of the target body 21 and the target assembly 2. This allows the motion unit 42 and the support unit 43 of the positioning device 4 to approach the target assembly 2 from the direction away from the target assembly 2 after the target assembly 2 has moved to the predetermined position and fix the target assembly 2 to the target position. This arrangement increases the adaptability of the positioning device 4 to different shape and position combinations between the target body 21 and the target accessory 23.

[0108] Preferably, the first bearing member 431 and the second bearing member 432 can be fixed to the motion unit 42 by fixing them to a certain position. By fixing them to this positioning point, the first bearing member 431 and the second bearing member 432 are symmetrically arranged along the second central axis YY, which can be a perpendicular line from the positioning point to the first central axis X. When the positioning device 4 finishes its operation and is in the clamping state of the target assembly 2, the first bearing member 431 and the second bearing member 432 can make the target center M of the target assembly 2 coincide with the intersection of the first central axis X and the second central axis YY. That is to say, after the positioning device 4 has finished its operation, the position of the target center M is consistent for the same target assembly 2 each time it is clamped.

[0109] Guided by the first pivot center 423 and the second pivot center 424 of each motion unit 42, the two support units 43 can clamp the target body 21 from both sides of the first central axis X, while the first support member 431 and the second support member 432 can clamp the target body 21 from both sides of the second central axis YY. During the movement of the target assembly 2 to the target position, due to the engagement of the rolling wheel with the surface cylindrical contour of the target body 21, after the rolling part 433 adaptively engages with the surface cylindrical contour of the target body 21, and in the final state at the target position, the target center M of the target assembly 2 not only matches the reference center of the charged particle beam and the beam shaper 5, but also remains in the same position as the previous target assembly 2 (e.g., the target assembly 2 before replacement). Specifically, before the target assembly 2 is replaced, the support unit 43 continuously clamps and fixes the target assembly 2 to ensure that the target assembly 2 remains in the target position positioned by the support unit 43. In other words, the support unit 43 ensures that the target center M of the target assembly 2 remains in the same position, and always corresponds to the same position as the reference center of the charged particle beam and the beam shaper 5. This guarantees that the target assembly 2 is in a suitable position relative to the charged particle beam and the beam shaper 5 after multiple target changes, allowing the neutron beam to remain stable after repeated target changes and remounting. When the target assembly 2 needs to be replaced, the drive unit 41 can drive the motion unit 42 to retract from the target assembly 2 in a direction away from the target assembly 2. Thus, the positioning device 4 will not affect the target assembly 2 during disassembly. After the new target assembly 2 is transported to the preset position by the conveying device 3, the positioning device 4 can operate under the action of the drive unit 41 until the support unit 43 clamps the target assembly 2. This also avoids interference between the target assembly 2 and the positioning device 4 during installation onto the beam shaper 5.

[0110] In this embodiment, the drive unit 41 has one and only one output end 411. Each clamping unit also includes a second link 422, one end of which is connected to the first link 421 via a first pivot center 423. The other end of the second link 422 is pivotally connected to the output end 411, ensuring the reliability of the power transmission of the positioning device 4.

[0111] Combination Figure 5 and Figure 6As shown, in this embodiment, the support column 62 has a side facing the beam exit. The drive unit 41 is mounted on the side of the support column 62 via a mounting bracket 4. A first guide portion and a second guide portion are formed on the mounting bracket 4. A guide mechanism 45 is also provided between the drive unit 41 and the mounting bracket 4. The guide mechanism 45 may include a limiting plate 451, one end of which is connected to the drive unit 41, and the other end of which is connected to the motion unit 42 (e.g., the second link 422) via pivoting or other connection methods. The limiting plate 451 is provided with a limiting groove 452 extending in a direction from away from the center of the target assembly 2 to near the center of the target assembly 2. The guide mechanism 45 also includes a positioning pin 453 fixedly mounted on the mounting bracket 4 and passing through the limiting groove 452. In another optional embodiment, the limiting groove 452 may also be provided on the mounting bracket 4, and correspondingly, the positioning pin 453 may also be fixedly mounted on the limiting plate 451.

[0112] In this embodiment, the positioning device 4 can move a certain distance along the first central axis X before clamping the target body 21, avoiding direct clamping from both sides of the target body 21. This simpler structure avoids potential interference with the target attachments 23 on both sides of the target assembly 2. Furthermore, the positioning device 4 has a simple structure, low failure rate, and can be remotely controlled via the drive unit 41, reducing unnecessary radiation exposure for operators.

[0113] In other alternative embodiments, the position of the support column 62 can also be set as needed. The positioning device 4 can also be adaptively set according to the position of the support column 62. For example, the positioning device 4 can clamp and fix from other directions according to the actual setting.

[0114] For example, one end of the support column 62 can be fixedly connected to the beam shaper 5, and the other end of the support column 62 directly supports the lower part of the target assembly 2.

[0115] For example, the support column 62 can be positioned above the target assembly 2. The upper end of the support column 62 is fixedly connected to the wall or the top wall of the beam shaping body 5, and the lower end of the support column 62 supports the target assembly 2. The positioning device 4 can move from top to bottom to approach the target assembly 2 and thus position the target assembly 2.

[0116] For example, the support device 6 can be understood as a mechanism that provides rigid support to the target assembly 2, such as the track 61, or provides rigid support to the target assembly 2 when it is in a predetermined or target position. The positioning device 4 can also be provided on other components of the support device 6, such as the track 61.

[0117] Reference Figure 8As shown, in the second embodiment of this utility model, the positioning device 4 includes at least two support units 43. The support unit 43 is located in... Figure 8 The supporting unit 43 on the left side supports the target assembly 2 along the first direction T1. The unit located on the left side... Figure 9 The supporting unit 43 on the left side supports the target assembly 2 along the second direction T2. ​​In this embodiment, the included angle WW formed between the first direction T1 and the second direction T2 can be 90°. As long as the force conditions and clamping accuracy are met, the included angle WW formed between the first direction T1 and the second direction T2 can be between 0° and 180°.

[0118] In the third embodiment of this utility model, referring to Figure 9 As shown, the positioning device 4 includes a drive unit 41 and a motion unit 42 mounted on the support device 6. The first end of the motion unit 42 is connected to the drive unit 41, allowing it to reciprocate towards or away from the target assembly 2 under the action of the drive unit 41. The second end of the motion unit 42, opposite to the first end, can abut against the target assembly 2, thereby providing support. The drive unit 41 may include, but is not limited to, cylinders, hydraulic cylinders, electronic or pneumatic linkages, robots and their structures, robotic arms, etc. The second end of the motion unit 42 is provided with a support unit 43 for supporting the target assembly 2. The support unit 43 has a contoured portion that abuts against the contact surface of the target body 21. During positioning, the contoured portion of the support unit 43 abuts against the contact surface of the target body 21. Generally, the contact surface of the target body 21 is an arc surface. Adaptably, the contoured portion of the support unit 43 can also be arc-shaped. Of course, in other optional embodiments, the contact surface of the target body 21 can also be a plane, a wavy surface, a V-shaped surface, etc., as needed. At this time, the contouring part of the bearing unit 43 can be adapted to the conforming surface of the target body 21.

[0119] In the fourth embodiment of this utility model, referring to Figure 10 As shown, the target assembly 2 includes a target body 21 and a target attachment 23 disposed on the outer periphery of the target body 21. The target attachment 23 includes multiple cooling pipes 231 arranged at intervals. A gap Z is formed between adjacent cooling pipes 231. The positioning device 4 includes a drive unit 41 and a motion unit 42 disposed on the support device 6. The drive unit 41 enables the motion unit 42 to extend into the gap Z, thereby providing support to the target body 21. For example, the drive unit 41 may include a first drive device that moves in a direction of approach or distance, and a second drive device disposed on the first drive device. The second drive device enables the motion unit 42 to enter or exit the gap Z between the cooling pipes 231 by moving or rotating.

[0120] In the fifth embodiment of this utility model, referring to Figure 11As shown, the target assembly 2 includes a target body 21 and a target attachment 23 disposed on the outer periphery of the target body 21. The target attachment 23 forms a through gap Z. The positioning device 4 includes a drive unit 41 and a motion unit 42 disposed on the support device 6. The drive unit 41 enables the motion unit 42 to extend into the gap Z, thereby providing support to the target body 21.

[0121] In the sixth embodiment of this utility model, referring to Figure 12 As shown, the target assembly 2 includes a target body 21 and target attachments 23 disposed on the outer periphery of the target body 21. There are multiple target attachments 23, and some of the positioning devices 4 can extend into the gap Z formed between at least two of the target attachments 23 to position the target body 21. A gap Z may also be formed between the outer wall of the target body 21 and the target attachments 23. Some of the positioning devices 4 can extend into the gap Z formed between the outer wall of the target body 21 and the target attachments 23.

[0122] In the seventh embodiment of this utility model, referring to Figure 13 As shown, the target accessory 23 includes a limiting part 233 disposed on the outer periphery of the target body 21, and a cooling pipe 231 passing through the limiting part 233; the positioning device 4 is used to support the limiting part 233 to position the target assembly 2. Of course, in other optional embodiments, the positioning device 4 can also position other target accessories such as the cooling pipe 231 in the target assembly 2 while meeting the requirements of force and positioning.

[0123] In one embodiment, the operation method of the neutron capture therapy system includes the following steps:

[0124] Remove the target component 2 that needs to be replaced from the target location;

[0125] The new target component 2 is delivered to the preset position;

[0126] Position the new target component 2, which is in a preset position, so that the target component 2 is in the target position.

[0127] Before the step of “removing the target component 2 that needs to be replaced from the target position”, the positioning device 4 can be retracted first to avoid interference.

[0128] In the step "transporting the new target component 2 to the preset position", the preset position of the target component 2 corresponds to the end position of the movement of the conveying device 3 that transports the target component 2.

[0129] It should be understood that the above description is for illustrative purposes and not for limitation. Many embodiments and applications beyond the provided examples will be apparent to those skilled in the art upon reading the above description. Therefore, the scope of this teaching should not be determined by reference to the above description, but rather by reference to the foregoing claims and the full scope of their equivalents. For purposes of completeness, all articles and references, including patent applications and publications, are incorporated herein by reference. The omission of any aspect of the subject matter disclosed herein in the foregoing claims is not intended as a waiver of that subject matter, nor should it be construed as an indication that the applicant has not considered that subject matter as part of the disclosed application subject matter.

Claims

1. A target alignment device, characterized by, The target assembly comprises a target body and a target accessory arranged at the periphery of the target body, and the positioning device is used to support the target body and / or target accessory to position the target assembly to the target position. The positioning device is used to support the target body, and the positioning device is in contact with the target body. The positioning device is inserted into the target body from the space between the target accessory and the periphery of the target body and is in contact with the target body to support the surface of the target body; and / or The target accessory is arranged to have a spacing space, and the positioning device is inserted into the target body from the spacing space to position the target body.

2. The target alignment apparatus of claim 1, wherein, The target accessory comprises a limiting part arranged at the periphery of the target body and a cooling pipe passing through the limiting part.

3. The target alignment apparatus of claim 2, wherein, The positioning device is supported on the limiting part to position the target assembly.

4. The target alignment apparatus of claim 2, wherein, The positioning device comprises a moving unit and a carrying unit, the moving unit drives the carrying unit to support the target assembly, the carrying unit has a profiling part, the target assembly has a fitting surface, and the profiling part can be fitted with the fitting surface to support the target assembly. The positioning device comprises a moving unit and a carrying unit, the moving unit drives the carrying unit to support the target assembly, and the number of the carrying units is at least two, wherein at least one of the carrying units is arranged to support the target assembly in a first direction, and at least another one of the carrying units is arranged to support the target assembly in a second direction, and the included angle between the first direction and the second direction is greater than or equal to 0 degrees and less than or equal to 180 degrees.

5. The target alignment apparatus of claim 2, wherein, The positioning device comprises: At least one moving unit, the moving unit has a first pivot center, and the moving unit is arranged to pivot around the first pivot center; 6. The target alignment apparatus of claim 1, wherein, At least one carrying unit, the carrying mechanism is arranged at one end of the moving unit; 7. The target alignment apparatus of claim 1 wherein, The first pivot center is arranged to be movable in a direction from close to the center of the target material to far away from the center of the target body, so that the carrying unit is driven by the moving unit to move from a position far away from the surface of the target assembly to a position close to the surface of the target assembly to support the surface of the target assembly.

8. The target alignment apparatus of claim 1, wherein, The target assembly comprises a target body and a target accessory arranged at the periphery of the target body, and the positioning device is used to support the target body and / or target accessory to position the target assembly to the target position. The positioning device is used to support the target body, and the positioning device is in contact with the target body. The positioning device is inserted into the target body from the space between the target accessory and the periphery of the target body and is in contact with the target body to support the surface of the target body; and / or The target accessory is arranged to have a spacing space, and the positioning device is inserted into the target body from the spacing space to position the target body.

9. A neutron capture therapy system characterized by, The target accessory comprises a limiting part arranged at the periphery of the target body and a cooling pipe passing through the limiting part. The positioning device is supported on the limiting part to position the target assembly. The positioning device comprises a moving unit and a carrying unit, the moving unit drives the carrying unit to support the target assembly, the carrying unit has a profiling part, the target assembly has a fitting surface, and the profiling part can be fitted with the fitting surface to support the target assembly. The positioning device comprises a moving unit and a carrying unit, the moving unit drives the carrying unit to support the target assembly, and the number of the carrying units is at least two, wherein at least one of the carrying units is arranged to support the target assembly in a first direction, and at least another one of the carrying units is arranged to support the target assembly in a second direction, and the included angle between the first direction and the second direction is greater than or equal to 0 degrees and less than or equal to 180 degrees. The positioning device comprises: At least one moving unit, the moving unit has a first pivot center, and the moving unit is arranged to pivot around the first pivot center; At least one carrying unit, the carrying mechanism is arranged at one end of the moving unit; The first pivot center is arranged to be movable in a direction from close to the center of the target material to far away from the center of the target body, so that the carrying unit is driven by the moving unit to move from a position far away from the surface of the target assembly to a position close to the surface of the target assembly to support the surface of the target assembly. The target assembly comprises a target body and a target accessory arranged at the periphery of the target body, and the positioning device is used to support the target body and / or target accessory to position the target assembly to the target position. The positioning device is used to support the target body, and the positioning device is in contact with the target body. The positioning device is inserted into the target body from the space between the target accessory and the periphery of the target body and is in contact with the target body to support the surface of the target body; and / or The target accessory is arranged to have a spacing space, and the positioning device is inserted into the target body from the spacing space to position the target body. The target accessory comprises a limiting part arranged at the periphery of the target body and a cooling pipe passing through the limiting part. The positioning device is supported on the limiting part to position the target assembly. The positioning device comprises a moving unit and a carrying unit, the moving unit drives the carrying unit to support the target assembly, the carrying unit has a profiling part, the target assembly has a fitting surface, and the profiling part can be fitted with the fitting surface to support the target assembly. The positioning device comprises a moving unit and a carrying unit, the moving unit drives the carrying unit to support the target assembly, and the number of the carrying units is at least two, wherein at least one of the carrying units is arranged to support the target assembly in a first direction, and at least another one of the carrying units is arranged to support the target assembly in a second direction, and the included angle between the first direction and the second direction is greater than or equal to 0 degrees and less than or equal to 180 degrees. The positioning device comprises: At least one moving unit, the moving unit has a first pivot center, and the moving unit is arranged to pivot around the first pivot center; At least one carrying unit, the carrying mechanism is arranged at one end of the moving unit; The first pivot center is arranged to be movable in a direction from close to the center of the target material to far away from the center of the target body, so that the carrying unit is driven by the moving unit to move from a position far away from the surface of the target assembly to a position close to the surface of the target assembly to support the surface of the target assembly.

10. The neutron capture therapy system of claim 9, wherein, The target assembly includes a target body and a target accessory arranged at the periphery of the target body, the positioning device is used for supporting the target body, and the positioning device is in abutment with the target body.

11. The neutron capture therapy system of claim 10, wherein, Further comprising: a beam shaping body for shaping a neutron beam; wherein the beam shaping body is used for accommodating at least part of the target assembly, the target assembly further includes a target material arranged in one end of the target body, and the end of the target body provided with the target material is accommodated in the beam shaping body, and the positioning device is used for positioning the end of the target body away from the target material.

12. The neutron capture therapy system of claim 9, wherein, Further comprising a beam shaping body, after the target assembly moves to the predetermined position, the end of the target assembly generating the neutron beam abuts against the beam shaping body.

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