Ultrasonic glasses for wirelessly supplying energy to fundus device and enhancing intraocular administration

Abstract

The utility model discloses ultrasonic glasses for wirelessly supplying energy to a fundus device and enhancing intraocular administration, and belongs to the field of wearable ultrasonic devices. The instrument comprises a glasses framework, a silica gel eyeshade, an ultrasonic transducer and an ultrasonic generator, a pair of magnetic columns is arranged at each of two glasses frames of the glasses framework, and the magnetic columns are connected to the ultrasonic generator through wires; the silica gel eyeshade glasses frameworks are fixed, detached and replaced through buckles; the ultrasonic transducer comprises a cylindrical lead zirconate titanate piezoelectric ceramic, a silver electrode and a nylon shell; the silica gel eyeshade wraps the edge part of the transducer, so that the transducer and the silica gel eyeshade form a whole, and the position of the magnetic column on the back of the transducer corresponds to the position of the magnetic column on the glasses framework; the ultrasonic generator comprises an adjusting circuit, keys and a display screen. Ultrasonic waves are transmitted to the bottoms of the eyes in a wireless mode according to the mechanical principle of ultrasonic mechanical waves and can be used for supplying power to eye devices in a wireless mode, and therefore various advanced treatment strategies are expected to be carried out on the fundus.

Description

Technical Field

[0001] This invention belongs to the field of wearable ultrasound devices, and particularly relates to an ultrasound glasses that can be used to provide ultrasonic wireless power for fundus devices and enhance intraocular drug delivery. Background Technology

[0002] Eye diseases refer to diseases affecting the internal structures of the eye, including the retina, choroid, and optic nerve. There are many types of eye diseases, with common ones including diabetic retinopathy, age-related macular degeneration, retinal detachment, retinal vascular disease, and optic nerve atrophy. These diseases often severely affect vision and can even lead to blindness; therefore, early detection and treatment are crucial.

[0003] Many eye diseases often lead to irreversible damage to the retina and optic nerve. Once retinal cells or the optic nerve are damaged, they usually cannot be fully recovered. Even with modern treatments (such as anti-VEGF drugs and surgery), symptoms can only be partially improved or the progression of the disease slowed, but vision cannot be fully restored. This irreversibility limits the effectiveness of treatment for many late-stage patients. Treatment for most eye diseases is long-term, especially for anti-VEGF drugs used to treat wet macular degeneration or diabetic macular edema, which require monthly or regular intravitreal injections. This is not only expensive for patients but also leads to poor adherence. The pain, inconvenience, and potential complications of long-term injections also affect patients' ability to continue treatment.

[0004] Equipment used to treat eye diseases is typically large, stationary medical instruments, such as ophthalmic laser devices, ultrasound machines, and surgical microscopes. These devices are usually only available in specialized medical institutions, requiring patients to visit the hospital regularly for treatment, making it difficult to provide treatment or monitoring anytime, anywhere. Treatment procedures for eye diseases often involve complex instruments, such as intraocular injections and laser therapy. These treatments require high precision and are complex, typically performed by experienced physicians. Even minimally invasive surgery requires time and technical preparation. Patients in areas with insufficient equipment or less developed technology may struggle to access effective treatment. Furthermore, these treatments often require patients to maintain a fixed posture, making the process cumbersome and increasing psychological stress and discomfort.

[0005] The application of ultrasound technology in the treatment of ophthalmic diseases is gradually expanding, especially in the treatment of eye diseases and other eye conditions. As a non-invasive medical technique, ultrasound technology eliminates the need for surgery, reducing complications and postoperative recovery. Compared to traditional surgery, ultrasound does not require incisions, reducing the risk of infection and bleeding. Ultrasound technology can wirelessly deliver energy to the lesion area, acting through mechanical effects while having minimal impact on surrounding normal tissues. This provides a new treatment option for eye diseases such as glaucoma, central venous occlusion, eye tumors, and macular degeneration, effectively avoiding damage to other parts of the eye caused by surgery. Summary of the Invention

[0006] This invention aims to design an ultrasonic glasses device for wirelessly powering retinal devices and enhancing intraocular drug delivery. This device utilizes the mechanical principles of ultrasonic mechanical waves to wirelessly transmit ultrasound waves to the retina, enabling wireless power supply for ocular devices. This, in turn, holds promise for implementing various advanced treatment strategies on the retina, such as photodynamic therapy, mechanical therapy, controlled drug release and activation, etc. It can also be used for ultrasound-assisted treatment of the superficial surfaces of the eye, such as enhancing drug delivery. The advantages of this invention include: wireless energy delivery, long tissue delivery depth, good biocompatibility, high portability, and low cost. This device is expected to fill the current gap in portable treatment solutions for intraocular diseases both domestically and internationally, improving the portability of ultrasound therapy and providing patients with a comfortable treatment experience and highly effective therapeutic results.

[0007] To solve the above-mentioned technical problems, the present invention provides a specific technical solution for ultrasonic glasses used to wirelessly power fundus devices and enhance intraocular drug delivery:

[0008] An ultrasonic glasses for wirelessly powering fundus devices and enhancing intraocular drug delivery includes a glasses frame 1-1, a silicone eye mask 1-2, an ultrasonic transducer 2-1, and an ultrasonic generator 2-2.

[0009] The eyeglass frame has a pair of magnetic posts at each of the two frames, and the magnetic posts are connected to the ultrasonic generator via wires.

[0010] The silicone eye mask has two identical perforated holes, symmetrically located on the left and right sides, corresponding to the front of the person's two eyeballs; the silicone eye mask is fixed to the glasses frame with buckles and can be removed and replaced.

[0011] The ultrasonic transducer includes a cylindrical lead zirconate titanate piezoelectric ceramic, silver electrodes, and a nylon shell; the silver electrodes are located on the front and back of the piezoelectric ceramic and are connected to the ultrasonic generator via wires; two magnetic pillars are fixed on the back of the transducer and are connected to the silver electrodes on the front and back of the transducer via wires respectively; the nylon shell is a hollow cylindrical shape that encloses the piezoelectric ceramic.

[0012] The silicone goggles wrap around the edge of the transducer, making the transducer and the silicone goggles a whole. The position of the magnetic post on the back of the transducer corresponds to the position of the magnetic post on the eyeglass frame. The two are electrically connected by magnetic attraction.

[0013] The ultrasonic generator includes an adjustment circuit, buttons, and a display screen. The frequency, duty cycle, and power of the electrical signal applied to the transducer are adjusted via the adjustment circuit. The frequency adjustment range is 500kHz-2MHz, the power adjustment range is 0-10W, and the duty cycle and power adjustment ranges are both 10%-100%. The ultrasonic generator is adjusted via buttons and interacts with the user through the display screen.

[0014] The regulating circuit includes a charging module, a battery, a boost module, a buck module, an oscillation circuit, a MOS drive module, and a control center. The charging module uses a power adapter for charging, and the battery uses a rechargeable battery as a power source. The battery connects to the boost module and the buck module. The boost module increases the voltage to drive the oscillation circuit, while the buck module decreases the voltage to power the control center. The control center outputs a corresponding pulse width modulation waveform signal according to the instructions, which drives the current of the oscillation circuit through the MOS drive module. The oscillation circuit then drives the ultrasonic transducer to generate the required ultrasonic waves.

[0015] The control center is specifically an STM32 microcontroller, and the adjustment circuit also includes a battery power acquisition module; the battery power acquisition module continuously reads the battery voltage using the analog-to-digital converter port of the STM32 microcontroller to determine the power level.

[0016] The ultrasonic generator has buttons including an on / off switch, a duty cycle switch, a frequency switch, and a power switch, which are used to turn the device on / off, adjust the duty cycle, adjust the frequency, and adjust the power, respectively. The buttons are paired with a buzzer to ensure that users can get sound feedback when adjusting the working parameters of the glasses.

[0017] The STM32 microcontroller's internal phase-locked loop uses an 8MHz high-speed external clock source as its input clock source. The microcontroller continuously acquires ADC signals from the voltage and frequency across the transducer, processes the acquired signals, and adjusts the frequency of the current PWM wave.

[0018] The piezoelectric ceramics have diameters of 25mm and 20mm, thicknesses of 4mm and 2mm respectively, and corresponding resonant frequencies of 500kHz and 1MHz respectively.

[0019] Compared with the prior art, the present invention has the following advantages:

[0020] This invention provides an ultrasonic glasses for wirelessly powering fundus devices and enhancing intraocular drug delivery. The glasses generate ultrasonic waves that can be transmitted from the surface of the eyeball to the base of the eye, providing ultrasonic treatment for various eye diseases. Ultrasonic treatment has the advantages of being bio-friendly and having a long treatment depth.

[0021] This invention allows doctors / patients to easily and quickly adjust the working frequency, duty cycle, and power of ultrasound. Different frequencies of ultrasound can be quickly achieved by changing the silicone goggles, making the operation simple.

[0022] The present invention weighs approximately 400g, which, compared to traditional large ultrasound devices, has the advantages of being lightweight, wearable, easy to operate, and low-cost, allowing patients to perform ultrasound treatments for common ailments on their own, thus improving treatment efficiency.

[0023] This invention can wirelessly power the fundus axial length adjustment patch, verifying its function of effectively shortening the axial length by about 1mm, and is expected to provide a new approach for the correction of high myopia in humans.

[0024] This invention provides ultrasound stimulation for corneal drug delivery and has been verified to effectively enhance the delivery of dexamethasone sodium phosphate, increasing the concentration of conventionally delivered drugs to approximately twice the original level. Attached Figure Description

[0025] Figure 1 This is a schematic diagram illustrating the composition of the ultrasonic glasses of the present invention;

[0026] Figure 2 This is a detailed structural diagram of the ultrasonic glasses of the present invention;

[0027] Figure 3 This is a working framework diagram of an ultrasonic generator;

[0028] Figure 4 Comparison of axial length before and after treatment using ultrasound glasses on a fundus axial length adjustment model;

[0029] Figure 5 This is a comparison of dexamethasone sodium phosphate concentrations in the aqueous humor of the treated and untreated groups in an ultrasound glasses-based corneal drug delivery model. Detailed Implementation

[0030] To better understand the purpose, structure, and function of this invention, the following detailed description, in conjunction with the accompanying drawings, provides an ultrasonic glasses invention for wirelessly powering fundus devices and enhancing intraocular drug delivery.

[0031] Example 1

[0032] This embodiment provides a portable ultrasonic glasses for wirelessly powering fundus devices and enhancing intraocular drug delivery.

[0033] This embodiment is based on the inverse piezoelectric effect. When an alternating current signal is applied to the piezoelectric transducer, the transducer will undergo periodic mechanical deformation. This periodic mechanical vibration propagates through the surface of the transducer to generate ultrasonic waves (sound waves with a frequency higher than 20kHz are generally defined as ultrasonic waves).

[0034] This embodiment is a wearable ultrasound generating glasses that can convert electrical signals into ultrasound waves to provide ultrasound energy to the inside and surrounding parts of the eye, as well as the bottom of the eye.

[0035] The schematic diagram of the ultrasonic glasses in this embodiment is shown below. Figure 1 As shown, it includes an ultrasound frame 1 and an ultrasound generator 2. Figure 2 This is a detailed schematic diagram of ultrasonic glasses, which consists of a glasses frame 1-1, a silicone eye mask 1-2, an ultrasonic generator 2-1, and an ultrasonic transducer 2-2.

[0036] The eyeglass frame is made of 3D-printed resin, and its overall structure was designed using 3ds Max software. A 5mm diameter channel is provided on the left temple to accommodate the wiring connecting the ultrasound generator and transducer. Two 8mm diameter magnets are located on the frame, directly opposite the transducer's center; these magnets are soldered to the wiring within the frame. Each side of the frame has a 10mm wide clip for securing the silicone eye patch later. The frame itself is made of 3D-printed nylon. To improve patient comfort, silicone sleeves of the same size as the temples can be fitted onto the temples. For mass production, demolding can be used to improve efficiency.

[0037] The silicone eye mask is obtained by demolding a 3D-printed mold. The resulting silicone eye mask is a single unit, directly demolded from the 3D-printed mold. The eye mask has two identical, symmetrical perforations on either side, corresponding directly in front of the eyeballs. The central circular hole varies in size to accommodate different transducer sizes. On each side of the silicone eye mask is a 10mm long and 2mm wide rectangular hole, corresponding to the snap-fit ​​positions on the eyeglass frame, used for securing it to the frame and facilitating the replacement of different ultrasonic transducers and the silicone eye mask as needed. The eye mask production process involves first 3D printing a negative mold of the eye mask, then injecting sufficient silicone into the mold, and then placing the silicone in a vacuum drying oven for vacuuming (approximately 10 minutes; if air bubbles are present, the vacuuming time can be increased). After vacuuming, the silicone is dried in a 90°C drying oven for 4 hours, and then demolded to obtain the silicone eye mask. The silicone eye mask and the eyeglass frame are electrically connected via magnetic attraction, and the wires inside the eyeglass frame are connected to the ultrasonic generator. Ultrasonic glasses integrate the frame, silicone eye mask, ultrasonic generator, and ultrasonic transducer into one unit. The ultrasonic generator can be charged and stored using a universal 12V power adapter.

[0038] The ultrasonic transducer consists of a cylindrical lead zirconate titanate piezoelectric ceramic, silver electrodes, and a nylon shell. In this embodiment, the piezoelectric ceramic mainly includes two sizes: 25mm and 20mm in diameter, with thicknesses of 4mm and 2mm respectively. Their corresponding resonant frequencies are 500kHz and 1MHz, respectively. The magnetic column has a diameter of 3mm and a thickness of 2mm. A thin layer of silver electrodes covers both the top and bottom surfaces of the piezoelectric ceramic for electrical connection, and wires are welded to both sides for connection to the ultrasonic generator. The front and back sides are welded to the magnetic column using thin wires, and the two magnetic columns are fixed to the back of the transducer using a small amount of epoxy resin. The nylon shell is a hollow cylinder, with both sizes having a wall thickness of 1mm and diameters corresponding to the two sizes of piezoelectric ceramics. The hollow structure allows the piezoelectric ceramic to be completely enclosed by the nylon shell, which primarily protects the piezoelectric ceramic.

[0039] Different sized silicone goggles are compatible with different sized ultrasonic transducers. The silicone goggles cover the edges of the transducer, forming a single unit. Different sized transducers correspond to different sized silicone goggles; they should be used together. Changing transducers to different sizes is achieved by simply replacing the silicone goggles. Since the holes in the silicone goggles are only slightly smaller than the ultrasonic transducers, the transducers can be inserted into the holes by slightly enlarging them. The two magnets of each transducer are magnetically connected to the corresponding two magnets on the frame, ensuring electrical connection.

[0040] The ultrasonic generator allows adjustment of the frequency, duty cycle, and power of the electrical signal applied to the transducer. The frequency is adjustable from 500kHz to 2MHz, the power from 0 to 10W, and both the duty cycle and power are adjustable from 10% to 100%. The modulated electrical signal, applied to the transducer, generates ultrasonic waves at the corresponding frequency based on the inverse piezoelectric effect, achieving electro-ultrasound conversion. Specifically, the ultrasonic generator is adjusted via buttons and interacts with the user through an OLED display. The PCB circuit board of the ultrasonic generator was designed using Altium Designer and fabricated. To reduce the generator's weight, a flexible polyimide material was chosen as the substrate during fabrication. The components on the circuit board were then soldered onto the PCB, and the STM32 chip was programmed. The ultrasonic generator's outer shell is also a 3D-printed nylon shell. Finally, the battery and generator are housed within the shell, resulting in an ultrasonic generator with dimensions of 12cm (length), 8cm (width), and 3cm (height).

[0041] Figure 3 This is a schematic diagram of the ultrasonic generator's operating framework. The charging module uses a 12V power adapter for charging, and a rechargeable battery provides the power supply. The battery connects to a boost module and a buck module. The boost module (XL6009 module) boosts the 12V voltage to 24V to drive the oscillation circuit. The buck module (MP1584_EN module) boosts the 12V voltage to 3.3V to power the control center. The control center outputs a corresponding pulse width modulation (PWM) waveform signal based on the operating mode parameters input by the doctor / patient. This signal is then used by the MOS driver module (connected to the PB13 pin of the microcontroller) to drive and adjust the current of the oscillation circuit, transforming the small current signal of the PWM waveform output from the control center into a large current signal. Using the aforementioned 24V voltage and the large current signal of the PWM waveform, an AC signal to drive the transducer can be obtained, enabling the adjustment of the transducer's operating mode and the generation of the required ultrasonic waves.

[0042] The battery power acquisition module continuously reads the battery voltage to determine the battery level after the generator starts working, using the analog-to-digital converter (ADC) port (PB0 and PB1 pins of the microcontroller). The ultrasound generator has four buttons on its surface: from left to right, power, duty cycle, frequency, and power (corresponding to PA9, PA10, PA11, and PA12 pins of the microcontroller), used for powering on / off, adjusting the duty cycle, adjusting the frequency, and adjusting the power, respectively. The buttons are paired with a buzzer to provide audible feedback when doctors or patients adjust the glasses' operating parameters. The OLED display (corresponding to PA4, PA5, PA7, and PB10 pins of the microcontroller) shows the current ultrasound parameters, including frequency, duty cycle, and power.

[0043] The STM32 microcontroller outputs a pulse width modulation (PWM) waveform signal corresponding to the duty cycle and frequency to the oscillation circuit. When the electrical signal matches the resonant frequency of the transducer, the transducer can reach a resonant state, generating the most ideal ultrasonic signal with the highest sound pressure level. An 8MHz crystal oscillator (connected to the microcontroller's PD0_OSC_IN and PD1_OSC_OUT pins) serves as a high-speed external clock source, providing the microcontroller with a high-precision clock signal. The STM32 microcontroller's internal phase-locked loop can use the 8MHz high-speed external clock source as its input clock source, and through frequency multiplication, generate a higher frequency system clock to meet the system's high-speed operation requirements.

[0044] In addition, the microcontroller's PA0 and PA1 pins continuously acquire ADC signals from the voltage and frequency across the transducer. The microcontroller processes these signals and slightly adjusts the frequency of the current PWM wave. If the voltage across the transducer is higher after adjustment, it indicates that the adjusted frequency is closer to the transducer's resonant frequency. When the electrical signal supplied to the transducer by the oscillation circuit reaches the resonant frequency of each transducer size, the transducer can operate at its optimal state, generating ultrasonic signals with higher sound pressure levels compared to other frequencies.

[0045] Connect the output of the ultrasonic generator to the wires on the temple of the glasses. Embed the ultrasonic transducer into the silicone goggles, and then fix the goggles to the frame of the glasses, ensuring that the magnet on the back of the transducer adheres well to the magnet on the frame. Adjust the operating frequency, duty cycle, and power of the ultrasonic generator to produce ultrasonic waves in the transducer.

[0046] Ultrasound waves can propagate through media such as gels and tissues. After applying sufficient ultrasound gel to the eye, the ultrasound generator is tuned to the desired working mode, and the ultrasound glasses are worn for treatment. Combined with an adjustment patch implanted in the retina, it provides wireless, battery-free adjustment of the eye axis. Treatment drops can also be applied to the eyes to improve drug delivery to the cornea. The ultrasound glasses weigh approximately 400g and offer advantages such as wearability, lightweight design, ease of operation, long-distance ultrasound transmission, and adjustable ultrasound signals, allowing patients to use them directly in hospitals or at home.

[0047] Example 2

[0048] This embodiment provides an ultrasonic glasses model for wirelessly adjusting the axial length of the eye. Based on the ultrasonic / piezoelectric coupling effect, it can wirelessly power the adjustment patch implanted in the fundus, realizing wireless and battery-free power supply for the implanted fundus patch.

[0049] Step 1: Soak the axial length adjustment patch in 70% ethanol solution for 30 minutes, and then sterilize the patch by exposing it to ultraviolet light for 30 minutes in a laminar flow cell culture incubator.

[0050] Step 2: Inject sodium pentobarbital solution (3% concentration) into the ear vein of the New Zealand white rabbit at a rate of 1 mg / kg based on the rabbit's weight. After anesthetizing the rabbit, place it on the operating table with its right eye facing upwards and measure the axial length of the rabbit's eye. Perform routine disinfection of the rabbit's eye using an ophthalmoscope. Make a 360° circular conjunctival incision on the rabbit's right eye to fully expose the posterior sclera of the eyeball.

[0051] Step 3: Implant the axial length adjustment patch behind the right eye and adjust its position to ensure that the patch is located on the sclera where the axial length needs to be adjusted. Then, use absorbable sutures to firmly suture the patch to the sclera.

[0052] Step 4: Inject 0.5 ml of 0.5 mmol / L genipin solution, a scleral cross-linking agent, into the scleral surface corresponding to the patch implantation site to induce cross-linking of the posterior sclera of the rabbit's eyeball and enhance the biomechanical properties of the scleral strip.

[0053] Step 5: Suture the conjunctiva to complete the implantation procedure, and wait 10 minutes to ensure that the cross-linking agent is completely infiltrated into the sclera.

[0054] Step 6: Apply coupling agent to the rabbit eye surface as an ultrasound medium, turn on the ultrasound glasses, adjust the working mode to 620kHz ultrasound frequency and 100% duty cycle, point the ultrasound probe at the rabbit eye, and maintain operation for 6 minutes. During this process, the PZT on the patch receives the ultrasound signal, and due to the piezoelectric effect, converts the ultrasound waves into electrical signals, causing electrolysis and expansion of the patch as a whole. This results in the macular region of the posterior sclera contracting towards the central region, thus adjusting the posterior scleral axial length at the implantation site. After the procedure, measure the axial length of the rabbit eye again.

[0055] Figure 4 This study demonstrates a comparison of axial length before and after treatment using ultrasonic glasses in a fundus axial length adjustment model. The rabbit eye axial length before treatment was designated as the control group, and the subsequent axial length was designated as the experimental group. Compared to the control group, the experimental group showed a significant reduction in rabbit eye axial length, with an average adjustment of approximately 1 mm. This demonstrates that this embodiment can provide ultrasonic waves for implanted intraocular / fundus devices, effectively and wirelessly driving the fundus devices.

[0056] Example 3

[0057] This embodiment provides an ultrasonic glasses model that enhances corneal drug delivery. Based on the ultrasonic cavitation effect, applying ultrasound to the corneal location can effectively improve the delivery effect of dexamethasone sodium phosphate antibiotic in the cornea.

[0058] Step 1: Use gas to anesthetize the free-moving rabbit and fix it so that its right eye is facing upward.

[0059] Step 2: Place a single drop of dexamethasone sodium phosphate solution (0.1%) into the rabbit's eye, wait for 1 minute, and then use a cotton swab dipped in PBS solution to gently wipe away any excess solution around the rabbit's eye.

[0060] Step 3: Apply coupling gel to the side of the rabbit's eyeball as an ultrasound medium. Adjust the ultrasound glasses to a 1MHz ultrasound frequency and a 100% duty cycle. Turn on the ultrasound glasses and treat for 5 minutes. After 5 minutes, stop the ultrasound treatment and carefully remove the ultrasound glasses from the animal.

[0061] Step 4: After 1 hour of ultrasound treatment, carefully insert a syringe from the outer side of the rabbit's eyeball until the needle reaches the aqueous humor. Collect approximately 0.3 ml of aqueous humor sample from the rabbit's eyeball and use chromatography to measure the concentration of dexamethasone sodium phosphate in the aqueous humor samples from rabbits that have not undergone ultrasound treatment and those that have undergone ultrasound treatment.

[0062] Figure 5This study demonstrates the application of ultrasound glasses to enhance the concentration of dexamethasone sodium phosphate in the aqueous humor of rabbits in both the treated and untreated groups of a corneal drug delivery model. Compared to the untreated group, the ultrasound-treated group showed a significantly higher concentration of dexamethasone sodium phosphate in the aqueous humor, approximately twice the level of the untreated group, demonstrating that this embodiment effectively enhances corneal drug delivery.

[0063] It is understood that the present invention has been described through some embodiments, and those skilled in the art will recognize that various changes or equivalent substitutions can be made to these features and embodiments without departing from the spirit and scope of the invention. Furthermore, under the teachings of the present invention, these features and embodiments can be modified to adapt to specific situations and materials without departing from the spirit and scope of the invention. Therefore, the present invention is not limited to the specific embodiments disclosed herein, and all embodiments falling within the scope of the claims of this application are within the protection scope of the present invention.

Claims

1. An ultrasonic ophthalmoscope for wireless powering of ocular fundus devices and for enhancing intraocular drug delivery, characterized in that, The glasses framework (1-1), the silica gel eyecup (1-2), the ultrasonic transducer (2-1), the ultrasonic generator (2-2); There is a pair of magnetic columns at each of the two frames of the glasses framework, which are connected to the ultrasonic generator through wires; The silica gel eyecup has two identical hollow holes, which are located on the left and right sides of the eyecup and correspond to the front of the person's two eyeballs; the silica gel eyecup is fixed and disassembled and replaced with the glasses framework through buckles; The ultrasonic transducer includes a cylindrical lead zirconate titanate piezoelectric ceramic, silver electrodes, and a nylon shell; the silver electrodes are located on the front and back of the piezoelectric ceramic, and the silver electrodes are connected to the ultrasonic generator through wires; two magnetic columns are fixed on the back of the transducer, and the two magnetic columns are connected to the silver electrodes on the front and back of the transducer through wires; the nylon shell is a hollow cylindrical shape that wraps the piezoelectric ceramic; The silica gel eyecup wraps the edge of the transducer, making the transducer and the silica gel eyecup form a whole, and the position of the magnetic column on the back of the transducer corresponds to the position of the magnetic column on the glasses framework, and the two are electrically connected by magnetic attraction; The ultrasonic generator includes an adjusting circuit, a button, and a display screen; the adjusting circuit adjusts the frequency, duty cycle, and power of the electrical signal applied to the transducer, the frequency adjustment range is 500kHz-2MHz, the power adjustment range is 0-10W, and the duty cycle and power adjustment range is 10%-100%; the ultrasonic generator is adjusted by the button and interacts with the user through the display screen.

2. An ultrasonic ophthalmic lens for wireless powering of ocular devices and enhancing intraocular drug delivery according to claim 1, wherein, The diameter of the piezoelectric ceramic includes a diameter of 25mm, a diameter of 20mm, a thickness of 4mm, and a thickness of 2mm, and the corresponding resonant frequencies are 500kHz and 1MHz, respectively.

3. An ultrasonic ophthalmic lens for wireless powering of ocular devices and enhancing intraocular drug delivery according to claim 2, wherein, The adjusting circuit includes a charging module, a battery, a boost module, a buck module, an oscillation circuit, a MOS drive module, and a control center; the charging module is charged by a power adapter, the battery uses a rechargeable battery as a power supply; the battery is connected to the boost module and the buck module, the boost module increases the voltage to drive the oscillation circuit to work, the buck module reduces the voltage to power the control center, the control center outputs the corresponding pulse width modulation waveform signal according to the indication, the MOS drive module drives the current of the adjusting oscillation circuit, and the oscillation circuit drives the ultrasonic transducer to generate the required ultrasonic wave.

4. An ultrasonic ophthalmic lens for wireless powering of ocular devices and enhancing intraocular drug delivery according to claim 3, wherein, The control center is specifically an STM32 single-chip microcomputer, and the adjusting circuit further includes a battery power acquisition module; the battery power acquisition module uses the analog-to-digital conversion port of the STM32 single-chip microcomputer to read the battery voltage at all times to determine the power.

5. An ultrasonic contact lens for wireless powering of ocular devices and enhancing intraocular drug delivery according to claim 4, wherein, The buttons of the ultrasonic generator include an on / off key, a duty cycle key, a frequency key, and a power key, which are used for switching on and off, adjusting the duty cycle, adjusting the frequency, and adjusting the power, respectively; the buttons are matched with a buzzer to ensure that the user can obtain sound feedback when adjusting the working parameters of the glasses.

6. An ultrasonic contact lens for wireless powering of ocular devices and enhancing intraocular drug delivery according to claim 5, wherein, The phase-locked loop inside the STM32 single-chip microcomputer uses an 8MHz high-speed external clock source as an input clock source.

7. An ultrasonic contact lens for wireless powering of ocular devices and enhancing intraocular drug delivery according to claim 6, wherein, The single-chip microcomputer continuously collects ADC signals of the voltage and frequency at both ends of the transducer, and adjusts the frequency of the current PWM wave according to the collected signals.

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