Biological sampler for pharmacokinetics

Abstract

The utility model belongs to the field of samplers, and particularly relates to a pharmacokinetics biological sampler which comprises a bottom plate, the top of the bottom plate is fixedly connected with a storage groove, the upper end of the bottom plate is fixedly connected with a support, the top of the support is fixedly provided with an air cylinder, and the output end of the air cylinder is connected with the support in a sliding mode. The lower end of the output end of the air cylinder is fixedly connected with a connecting plate, the connecting plate is slidably connected with the support, the back of the connecting plate is fixedly connected with a fixing frame, the top of the fixing frame is fixedly provided with a hydraulic cylinder, and the output end of the hydraulic cylinder is slidably connected with the fixing frame. Through the design of the hydraulic cylinder, the output end of the hydraulic cylinder can pull the sampling pipe to move for sampling, the sampling pipe can be supported through the connecting seat, and the sampling pipe can be limited under the contact of the convex block and the sampling pipe, so that the fixed use of the sampling pipe is realized, and the sampling pipe is convenient to take and place and convenient to use.

Description

Technical Field

[0001] This utility model relates to the field of sampler technology, specifically a biosampler for drug metabolism kinetics. Background Technology

[0002] Biosamplers for drug metabolism are tools or devices used to obtain information on drug metabolism kinetics in vivo. Depending on the need, these biosamplers can collect samples such as blood, urine, saliva, and liver tissue to perform quantitative analysis of drugs and their metabolites, in order to understand the metabolic characteristics and kinetic processes of drugs in the body. These samplers play an important role in drug development, pharmacodynamic studies, and clinical drug monitoring.

[0003] Utility model patent CN215464499U discloses a biosampler for drug metabolism kinetics, belonging to the field of medical device technology. Its key technical features include a support frame, where two electric actuators push two sliding blocks to move a support plate downwards, thereby moving the sampler and a fixing plate downwards until the lower end of the sampler enters the reagent bottle. Next, a motor drives two lead screws to rotate in opposite directions, causing two sliders to move two moving rods in opposite directions, which in turn moves two clamping components until they contact the outer wall of the sampler, thus fixing the sampler and preventing shaking during sampling. Then, two levers are manually lifted or pressed down, causing their lower ends to contact the lower end of the piston. Pulling the fixing plate upwards causes it to move the two levers upwards, which in turn causes the piston to rise within the sampler, achieving stable sampling.

[0004] In existing technologies, the sampling tube is clamped and fixed by a motor drive during the use of the sampler, which is costly and inconvenient to pick up and put down. Furthermore, after sampling, droplets remain at the tube opening, and these droplets can cause contamination. Therefore, improvements are needed. Utility Model Content

[0005] The purpose of this invention is to provide a biosampler for drug metabolism kinetics, which solves the problem of inconvenient sampling tube placement and removal, and also solves the problem of contamination caused by dripping liquid from the tube opening after sampling.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a biosampler for drug metabolism kinetics, comprising a base plate, a storage groove fixedly connected to the top of the base plate, a support fixedly connected to the upper end of the base plate, a cylinder fixedly mounted on the top of the support, the output end of the cylinder being slidably connected to the support, a connecting plate fixedly connected to the lower end of the cylinder output end, the connecting plate being slidably connected to the support, a fixing frame fixedly connected to the back of the connecting plate, a hydraulic cylinder fixedly mounted on the top of the fixing frame, the output end of the hydraulic cylinder being slidably connected to the fixing frame, a connecting seat fixedly connected to the lower end of the hydraulic cylinder output end, a sampling tube slidably sleeved inside the connecting seat, the sampling tube being slidably connected to the connecting plate, a fixing ring fixedly sleeved on the outer side of the sampling tube, the fixing ring contacting the connecting plate, a fixing mechanism provided on the connecting plate, and a leak-proof mechanism provided on the sampling tube.

[0007] Preferably, a guide block is fixedly connected to the outer side of the connecting plate, and the guide block is slidably connected to the bracket. By designing the guide block, the movement of the connecting plate can be guided.

[0008] Preferably, the fixing mechanism includes protrusions. Two symmetrically distributed protrusions are slidably sleeved inside the connecting plate. The protrusions contact the sampling tube. A sliding rod is fixedly connected to the outer side of each protrusion. The sliding rod is slidably connected to the connecting plate. A fixing rod is slidably sleeved inside the sliding rod. The fixing rod is fixedly connected to the connecting plate. A first spring is provided on the outer side of the fixing rod. A spring block is fixedly connected to the end of the sliding rod away from the protrusion. The spring block is fixedly connected to the connecting plate. By designing the fixing mechanism, the sampling tube can be fixed.

[0009] Preferably, one end of the first spring is fixedly connected to the slide rod, and the other end of the first spring is fixedly connected to the connecting plate. The first spring is designed so that its force can be applied to the slide rod.

[0010] Preferably, the leak-proof mechanism includes a connecting sleeve, which is fixedly connected inside the connecting plate. A connecting rod is slidably connected inside the connecting sleeve. A second spring is provided inside the connecting sleeve. A connecting block is slidably connected inside the connecting sleeve and fixedly connected to the connecting rod. A ball bearing is movably connected inside the connecting block and movably connected to the connecting sleeve. A connecting ring is fixedly connected to the lower end of the connecting rod. A sponge pad is fixedly connected to the inner side of the connecting ring and contacts the sampling tube. By designing the leak-proof mechanism, the dripping of residual liquid droplets after sampling can be prevented.

[0011] Preferably, one end of the second spring is fixedly connected to the connecting sleeve, and the other end of the second spring is fixedly connected to the connecting block. By designing the second spring, its force can be applied to the connecting block.

[0012] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0013] 1. This utility model utilizes the design of a hydraulic cylinder. The output end of the hydraulic cylinder can pull the sampling tube to move for sampling. The sampling tube can be supported by the connecting seat, and the sampling tube can be limited by the contact between the protrusion and the sampling tube, thus achieving the fixed use of the sampling tube. The sampling tube is easy to pick up and put down, and convenient to use.

[0014] 2. By designing a sponge pad, this utility model allows the sponge pad to contact the opening of the sampling tube after sampling, absorbing any residual droplets at the opening and preventing contamination from dripping. It also protects the opening to some extent from contamination. Attached Figure Description

[0015] Figure 1 This is a three-dimensional view of the overall structure of this utility model;

[0016] Figure 2 This utility model Figure 1 A partial three-dimensional sectional view of the structure;

[0017] Figure 3 This utility model Figure 2 Top sectional view of the partial structure of the connecting plate;

[0018] Figure 4 This utility model Figure 2 The front sectional view of the connecting ring structure.

[0019] In the diagram: 1. Base plate; 2. Storage slot; 3. Bracket; 4. Cylinder; 5. Connecting plate; 6. Guide block; 7. Fixing frame; 8. Fixing mechanism; 9. Leak-proof mechanism; 10. Hydraulic cylinder; 11. Connecting seat; 12. Sampling tube; 13. Fixing ring; 81. Protrusion; 82. Slide rod; 83. Fixing rod; 84. First spring; 85. Spring block; 91. Connecting sleeve; 92. Connecting rod; 93. Second spring; 94. Connecting block; 95. Ball bearing; 96. Connecting ring; 97. Sponge pad. Detailed Implementation

[0020] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0021] Please see Figure 1 , Figure 2A biosampler for pharmacokinetic analysis includes a base plate 1, a storage slot 2 fixedly connected to the top of the base plate 1, a support 3 fixedly connected to the upper end of the base plate 1, a cylinder 4 fixedly mounted on the top of the support 3, the output end of the cylinder 4 being slidably connected to the support 3, a connecting plate 5 fixedly connected to the lower end of the output end of the cylinder 4, the connecting plate 5 being slidably connected to the support 3, and a guide block 6 fixedly connected to the outer side of the connecting plate 5, the guide block 6 being slidably connected to the support 3. By designing the guide block 6, the movement of the connecting plate 5 can be guided. A fixing frame 7 is fixedly connected to the back of plate 5. A hydraulic cylinder 10 is fixedly installed on the top of the fixing frame 7. The output end of the hydraulic cylinder 10 is slidably connected to the fixing frame 7. A connecting seat 11 is fixedly connected to the lower end of the output end of the hydraulic cylinder 10. A sampling tube 12 is slidably sleeved inside the connecting seat 11. The sampling tube 12 is slidably connected to the connecting plate 5. A fixing ring 13 is fixedly sleeved on the outside of the sampling tube 12. The fixing ring 13 contacts the connecting plate 5. A fixing mechanism 8 is provided on the connecting plate 5. A leak-proof mechanism 9 is provided on the sampling tube 12.

[0022] Please see Figure 1 , Figure 2 , Figure 3 The fixing mechanism 8 includes protrusions 81. Two symmetrically distributed protrusions 81 are slidably sleeved inside the connecting plate 5. The protrusions 81 are in contact with the sampling tube 12. A slide rod 82 is fixedly connected to the outside of the protrusions 81. The slide rod 82 is slidably connected to the connecting plate 5. A fixing rod 83 is slidably sleeved inside the slide rod 82. The fixing rod 83 is fixedly connected to the connecting plate 5. A first spring 84 is provided on the outside of the fixing rod 83. One end of the first spring 84 is fixedly connected to the slide rod 82, and the other end of the first spring 84 is fixedly connected to the connecting plate 5. By designing the first spring 84, the force of the first spring 84 can act on the slide rod 82. A spring block 85 is fixedly connected to the end of the slide rod 82 away from the protrusions 81. The spring block 85 is fixedly connected to the connecting plate 5. By designing the fixing mechanism 8, the sampling tube 12 can be fixed.

[0023] Please see Figure 1 , Figure 2 , Figure 4The leak-proof mechanism 9 includes a connecting sleeve 91. The connecting sleeve 91 is fixedly connected inside the connecting plate 5. The connecting rod 92 is slidably connected inside the connecting sleeve 91. A second spring 93 is provided inside the connecting sleeve 91. One end of the second spring 93 is fixedly connected to the connecting sleeve 91, and the other end of the second spring 93 is fixedly connected to the connecting block 94. By designing the second spring 93, the force of the second spring 93 can act on the connecting block 94. The connecting block 94 is slidably connected inside the connecting sleeve 91. The connecting block 94 is fixedly connected to the connecting rod 92. A ball bearing 95 is movably connected inside the connecting block 94. The ball bearing 95 is movably connected to the connecting sleeve 91. A connecting ring 96 is fixedly connected to the lower end of the connecting rod 92. A sponge pad 97 is fixedly connected to the inner side of the connecting ring 96. The sponge pad 97 is in contact with the sampling tube 12. By designing the leak-proof mechanism 9, the dripping of residual liquid droplets after sampling can be prevented.

[0024] The specific implementation process of this utility model is as follows: When sampling is required, the reagent bottle is first placed inside the storage slot 2, and then the cylinder 4 is activated. The output end of the cylinder 4 drives the connecting plate 5 to move down, and the connecting plate 5 drives the guide block 6 to slide along the bracket 3, so that the connecting ring 96 first contacts the reagent bottle. Then the connecting plate 5 continues to move down, and the sampling tube 12 slides relative to the connecting ring 96. The connecting plate 5 drives the connecting sleeve 91 to move down along the connecting block 94 and the connecting rod 92. The connecting sleeve 91 will squeeze the second spring 93, allowing the sampling tube 12 to pass through the sponge pad 97 and extend into the bottle. Inside the reagent bottle, the output end of the hydraulic cylinder 10 drives the connecting seat 11 to move upward, which can stretch the sampling tube 12 to sample the reagent bottle. After sampling is completed, the cylinder 4 controls the connecting plate 5 to move upward and reset. Under the elastic action of the second spring 93, the connecting rod 92 and the connecting ring 96 can be pushed to reset, so that the sponge pad 97 can reset and contact the sampling tube 12. The sponge pad 97 can absorb the residual droplets at the opening of the sampling tube 12 after sampling, avoiding the droplets from dripping and causing contamination. At the same time, it can also protect the opening, which can avoid contamination to a certain extent.

[0025] When it is necessary to remove the sampling tube 12, simply pull the sampling tube 12 horizontally. The sampling tube 12 will squeeze and push the protrusion 81 to move horizontally. The protrusion 81 will drive the slide rod 82 to move into the connecting plate 5. The slide rod 82 squeezes the spring block 85. At the same time, the slide rod 82 will slide along the fixed rod 83 to squeeze the first spring 84. Then the sampling tube 12 can be pulled out from the inside of the connecting plate 5. The sampling tube 12 is easy to pick up and put down and convenient to use.

[0026] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A pharmacokinetic biopunch comprising a base plate (1), characterized in that: The top of the bottom plate (1) is fixedly connected with a storage groove (2), the upper end of the bottom plate (1) is fixedly connected with a support (3), the top of the support (3) is fixedly installed with a pneumatic cylinder (4), the output end of the pneumatic cylinder (4) is slidably connected with the support (3), the lower end of the output end of the pneumatic cylinder (4) is fixedly connected with a connecting plate (5), the connecting plate (5) is slidably connected with the support (3), the back of the connecting plate (5) is fixedly connected with a fixing frame (7), the top of the fixing frame (7) is fixedly installed with a hydraulic cylinder (10), the output end of the hydraulic cylinder (10) is slidably connected with the fixing frame (7), the lower end of the output end of the hydraulic cylinder (10) is fixedly connected with a connecting seat (11), the inside of the connecting seat (11) is slidably sleeved with a sampling pipe (12), the sampling pipe (12) is slidably connected with the connecting plate (5), the outside of the sampling pipe (12) is fixedly sleeved with a fixing ring (13), the fixing ring (13) is in contact with the connecting plate (5), the connecting plate (5) is provided with a fixing mechanism (8), and the sampling pipe (12) is provided with a leakage prevention mechanism (9).

2. The pharmacokinetic bioreactor of claim 1, wherein: The outside of the connecting plate (5) is fixedly connected with a guide block (6), and the guide block (6) is slidably connected with the support (3).

3. The pharmacokinetic bioreactor of claim 1, wherein: The fixing mechanism (8) comprises a lug (81), the inside of the connecting plate (5) is slidably sleeved with two symmetrically distributed lugs (81), the lugs (81) are in contact with the sampling pipe (12), the outside of the lug (81) is fixedly connected with a sliding rod (82), the sliding rod (82) is slidably connected with the connecting plate (5), the inside of the sliding rod (82) is slidably sleeved with a fixing rod (83), the fixing rod (83) is fixedly connected with the connecting plate (5), the outside of the fixing rod (83) is provided with a first spring (84), one end of the sliding rod (82) away from the lug (81) is fixedly connected with an elastic block (85), and the elastic block (85) is fixedly connected with the connecting plate (5).

4. A pharmacokinetic bio-sampler according to claim 3, wherein: One end of the first spring (84) is fixedly connected with the sliding rod (82), and the other end of the first spring (84) is fixedly connected with the connecting plate (5).

5. The pharmacokinetic bioreactor of claim 1, wherein: The leakage prevention mechanism (9) comprises a connecting sleeve (91), the inside of the connecting plate (5) is fixedly connected with the connecting sleeve (91), the inside of the connecting sleeve (91) is slidably sleeved with a connecting rod (92), the inside of the connecting sleeve (91) is provided with a second spring (93), the inside of the connecting sleeve (91) is slidably sleeved with a connecting block (94), the connecting block (94) is fixedly connected with the connecting rod (92), the inside of the connecting block (94) is movably sleeved with a ball (95), the ball (95) is movably connected with the connecting sleeve (91), the lower end of the connecting rod (92) is fixedly connected with a connecting ring (96), the inside of the connecting ring (96) is fixedly connected with a sponge pad (97), and the sponge pad (97) is in contact with the sampling pipe (12).

6. A pharmacokinetic bio-sampler according to claim 5, wherein: One end of the second spring (93) is fixedly connected with the connecting sleeve (91), and the other end of the second spring (93) is fixedly connected with the connecting block (94).

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