Solid-phase extraction rapid separation device

Abstract

The utility model discloses a solid-phase extraction rapid separation device which comprises a shell, a plurality of liquid-solid extraction columns are arranged in the shell, and a plurality of extraction units are fixed in each liquid-solid extraction column at equal intervals. The liquid-solid extraction device has the beneficial effects that the surface of each liquid-solid extraction column of the shell is wrapped with the right heating shell and the left heating shell which are of a semi-annular structure, and heat-conducting fins on the concave surfaces of the right heating shell and the left heating shell are connected with the outer surfaces of the liquid-solid extraction columns through heat-conducting silica gel; the water body in the cavities of the right heating shell and the left heating shell is heated by the heat generated by the electric heating tube, and a temperature sensor and an external temperature controller are combined, so that the water body which is heated at constant temperature in the right heating shell and the left heating shell heats the liquid-solid extraction column in a heat conduction form until volatile components in a sample solution are more easily released; water bath constant-temperature heating is adopted, and the extraction rate is increased while decomposition of volatile components of a sample is reduced.

Description

Technical Field

[0001] This utility model relates to the field of solid phase extraction technology, and more specifically, to a rapid separation device for solid phase extraction. Background Technology

[0002] Solid-phase extraction (SPE) is a sample pretreatment technique developed in recent years, combining liquid-solid extraction columns and liquid chromatography. It is primarily used for sample separation, purification, and concentration. Compared to traditional liquid-liquid extraction, it can improve analyte recovery, more effectively separate analytes from interfering components, reduce sample pretreatment steps, and is simple, time-saving, and labor-saving. It is widely used in pharmaceuticals, food, environmental protection, commodity inspection, and chemical industries.

[0003] Existing solid-phase extraction devices require heating the sample to improve extraction efficiency. However, the heating structure usually directly heats the sample solution and then introduces the heated sample solution into the liquid-solid extraction column for solid-phase extraction. This heating method can cause some components in the sample solution to decompose due to heat, which is not conducive to the separation, purification and concentration of the components in the sample. Utility Model Content

[0004] (a) Technical problems to be solved

[0005] To address the shortcomings of existing technologies, this invention provides a rapid solid-phase extraction separation device that has the advantages of accelerating the extraction rate and reducing the decomposition of volatile components in the sample using water bath heating, thereby solving the problems mentioned in the background technology.

[0006] (II) Technical Solution

[0007] To achieve the advantages of the water bath heating method in accelerating the extraction rate and reducing the decomposition of volatile components in the sample, the specific technical solution adopted by this utility model is as follows: A solid-phase extraction rapid separation device includes a shell, inside which are installed a plurality of liquid-solid extraction columns, and within each liquid-solid extraction column are a plurality of extraction units fixed at equal intervals. Each extraction unit has a filter plate embedded in its upper and lower surfaces, and each extraction unit is filled with a solid-phase extractant. Support frames are welded to the upper and lower ends of the shell, with an inlet pipe installed in the upper support frame and an outlet pipe installed in the lower support frame. The liquid-solid extraction column has connecting pipes at both ends that are connected to the inlet pipe and the outlet pipe, respectively. A flow regulating valve is installed on the surface of the connecting pipe at the upper end of the liquid-solid extraction column. The outer surface of the liquid-solid extraction column is covered with a right heating shell and a left heating shell. Electric heating tubes are installed in the cavities inside the right heating shell and the left heating shell. Heat-conducting plates are respectively provided on the concave surfaces of the right heating shell and the left heating shell. Temperature sensors are installed on the outer surfaces of the right heating shell and the left heating shell. The temperature probes of the temperature sensors extend into the cavity of the right heating shell or the left heating shell. The temperature sensors are electrically connected to an external temperature controller.

[0008] Furthermore, both the inlet pipe and the outlet pipe are equipped with valves at their ends, and a circulation pipe is installed at the joints of the inlet pipe and the outlet pipe. A liquid pump is installed on the surface of the circulation pipe, a one-way valve is installed on the surface of the inlet pipe, and a throttle valve is installed on the surface of the outlet pipe.

[0009] Furthermore, both the right heating shell and the left heating shell have semi-annular cross-sections, and a magnet that is attracted and connected to the left heating shell is embedded in the end face of the right heating shell. Liquid nozzles are installed at the upper and lower ends of the outer shells of the right heating shell and the left heating shell, and manual valves are installed on the surface of the liquid nozzles.

[0010] Furthermore, the extraction unit is a hollow cylindrical structure, and the diameter of the filter plate on the top surface of the extraction unit is larger than the diameter of the filter plate on the bottom surface.

[0011] Furthermore, the shell has an overall rectangular frame structure, and the upper and lower ends of the shell are provided with U-shaped mounting ports corresponding to the liquid-solid extraction column.

[0012] Furthermore, the heat-conducting sheet has an arc-shaped structure, and thermally conductive silicone is filled between the heat-conducting sheet and the liquid-solid extraction column.

[0013] Furthermore, the support frame has an L-shaped cross-section, and a U-shaped pipe clamp is installed on the inner side of the support frame by screws.

[0014] (III) Beneficial Effects

[0015] Compared with the prior art, this utility model provides a solid-phase extraction rapid separation device, which has the following beneficial effects:

[0016] (1) In this utility model, two semi-annular right heating shells and left heating shells are wrapped on the surface of each liquid-solid extraction column of the shell. The heat-conducting sheets on the concave surfaces of the right heating shell and the left heating shell are connected to the outer surface of the liquid-solid extraction column by thermally conductive silicone. When the electric heating tubes built into the right heating shell and the left heating shell are started, the heat generated by the electric heating tubes heats the water in the cavity of the right heating shell and the left heating shell. Combined with the setting of temperature sensor and external temperature controller, the water in the right heating shell and the left heating shell is heated at a constant temperature to heat the liquid-solid extraction column in the form of heat conduction until the volatile components in the sample solution are more easily released. The constant temperature heating of water bath reduces the decomposition of volatile components in the sample and accelerates the extraction rate.

[0017] (2) In this utility model, a circulation pipe with a liquid pump is installed at the tail of the inlet pipe and the outlet pipe. As the valves installed at the tail of the inlet pipe and the outlet pipe are opened and the throttle valve of the outlet pipe is closed, the liquid pump is started to work, so that the injected solvent continuously circulates inside the liquid-solid extraction column, the inlet pipe and the outlet pipe, so that the solvent can circulate through several extraction units of the liquid-solid extraction column. In this way, the analyte enriched in the solid phase extractant can be completely eluted, thereby improving the extraction efficiency of the sample solution. Attached Figure Description

[0018] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0019] Figure 1 This is a schematic diagram of a solid-phase extraction rapid separation device according to an embodiment of the present utility model;

[0020] Figure 2 This is a structural diagram of the housing (without the right and left heating shells installed).

[0021] Figure 3 This is a cross-sectional view of a liquid-solid extraction column;

[0022] Figure 4 This is a schematic diagram of the left heating shell.

[0023] In the picture:

[0024] 1. Housing; 2. Support frame; 3. Liquid-solid extraction column; 4. Inlet pipe; 5. Outlet pipe; 6. Right heating shell; 7. Left heating shell; 8. Circulation pipe; 9. Liquid pump; 10. Connecting pipe; 11. Flow regulating valve; 12. Check valve; 13. Throttling valve; 14. Extraction unit; 15. Solid phase extractant; 16. Filter plate; 17. Electric heating tube; 18. Heat-conducting plate; 19. Temperature sensor; 20. Liquid nozzle; 21. Magnet. Detailed Implementation

[0025] To further illustrate the various embodiments, the present invention provides accompanying drawings, which are part of the disclosure of the present invention. These drawings are mainly used to illustrate the embodiments and can be used in conjunction with the relevant descriptions in the specification to explain the operating principles of the embodiments. With reference to these contents, those skilled in the art should be able to understand other possible implementation methods and the advantages of the present invention. The components in the figures are not drawn to scale, and similar component symbols are usually used to represent similar components.

[0026] According to an embodiment of the present invention, a rapid solid-phase extraction separation device is provided.

[0027] The present invention will now be further described in conjunction with the accompanying drawings and specific embodiments, such as... Figure 1-4As shown, a solid-phase extraction rapid separation device according to an embodiment of the present invention includes a housing 1. A plurality of liquid-solid extraction columns 3 are installed inside the housing 1, and a plurality of extraction units 14 are fixed at equal intervals within each liquid-solid extraction column 3. Filter discs 16 are embedded in the upper and lower surfaces of each extraction unit 14, and each extraction unit 14 is filled with a solid-phase extractant 15. Support frames 2 are welded to the upper and lower ends of the housing 1. An inlet pipe 4 is installed in the support frame 2 at the upper end of the housing 1, and an outlet pipe 5 is installed in the support frame 2 at the lower end of the housing 1. Connecting pipes 10 are respectively provided at both ends of the liquid-solid extraction columns 3, connecting to the inlet pipe 4 and the outlet pipe 5. The upper end of the liquid-solid extraction column 3... A flow regulating valve 11 is installed on the surface of the connecting pipe 10. The outer surface of the liquid-solid extraction column 3 is wrapped with a right heating shell 6 and a left heating shell 7. Electric heating tubes 17 are installed in the cavities inside the right heating shell 6 and the left heating shell 7. Heat-conducting plates 18 are respectively provided on the concave surfaces of the right heating shell 6 and the left heating shell 7. Temperature sensors 19 are installed on the outer surfaces of the right heating shell 6 and the left heating shell 7. The temperature probe of the temperature sensor 19 extends into the cavity of the right heating shell 6 or the left heating shell 7. The temperature sensor 19 is electrically connected to an external temperature controller. The principle of constant temperature heating is as follows: the temperature controller mainly measures the temperature in real time through the temperature sensor 19 and compares the measured value with the set value. When the actual temperature is lower than the set temperature, the temperature controller will issue a command to start the electric heating tube 17 for heating; when the actual temperature is higher than the set temperature, the temperature controller will turn off the electric heating tube 17. In this way, the temperature controller can maintain the ambient temperature within the set range, achieving constant temperature control. The multiple extraction units 14 of the liquid-solid extraction column 3 can improve the completeness of extraction and ensure extraction efficiency.

[0028] In one embodiment, both the inlet pipe 4 and the outlet pipe 5 are equipped with valves at their ends, and a circulation pipe 8 is installed at the joints of the inlet pipe 4 and the outlet pipe 5. A liquid pump 9 is installed on the surface of the circulation pipe 8, a one-way valve 12 is installed on the surface of the inlet pipe 4, and a throttle valve 13 is installed on the surface of the outlet pipe 5. This structure is used to completely elute the analyte enriched in the solid phase extractant 15, thereby improving the extraction efficiency of the sample solution. The solid phase extractant 15 is a special filler containing C18 or C8, nitrile, amino, or other groups. The liquid pump 9 is equipped with a matching control switch. The installation position of the control switch is selected according to actual usage requirements to facilitate operation and control by the operator.

[0029] In one embodiment, the cross-sections of the right heating shell 6 and the left heating shell 7 are both semi-annular structures, and a magnet 21 that is attracted and connected to the left heating shell 7 is embedded in the end face of the right heating shell 6. Liquid nozzles 20 are respectively installed at the upper and lower ends of the outer shells of the right heating shell 6 and the left heating shell 7, and a manual valve is installed on the surface of the liquid nozzles 20. With this structure, it is easy to inject and discharge water into the cavity of the right heating shell 6 and the left heating shell 7, and it is convenient to attract and connect the right heating shell 6 and the left heating shell 7, making it easy to disassemble and assemble.

[0030] In one embodiment, the extraction unit 14 is a hollow cylindrical structure, and the diameter of the filter plate 16 on the top surface of the extraction unit 14 is larger than the diameter of the filter plate 16 on the bottom surface. This structure increases the time for the liquid to pass through the extraction unit 14, thereby improving the extraction efficiency.

[0031] In one embodiment, the housing 1 has a rectangular frame structure, and the upper and lower ends of the housing 1 are provided with U-shaped mounting openings corresponding to the liquid-solid extraction column 3. This structure facilitates the installation of the liquid-solid extraction column 3.

[0032] In one embodiment, the heat-conducting sheet 18 has an arc-shaped structure, and the space between the heat-conducting sheet 18 and the liquid-solid extraction column 3 is filled with thermally conductive silicone. This structure makes it easy to increase the heat conduction effect.

[0033] In one embodiment, the support frame 2 has an L-shaped cross-section, and a U-shaped clamp is installed on the inner side of the support frame 2 by screws. This structure is used to restrain the inlet pipe 4 or the outlet pipe 5.

[0034] Working principle: First, the sample solution is injected into the inlet tube 4, causing it to flow through several connecting tubes 10 into several liquid-solid extraction columns 3. The extraction unit 14 of the liquid-solid extraction column 3 adsorbs the analyte from the sample solution through its built-in solid-phase extractant 15. At this time, the heating elements built into the right heating shell 6 and left heating shell 7 are activated, causing the heat generated to heat the water inside the cavities of the right heating shell 6 and left heating shell 7. Combined with the temperature sensor 19 and the external temperature controller, the water in the right heating shell 6 and left heating shell 7 is kept at a constant temperature, thus heating the liquid-solid extraction column 3 through heat conduction. Until the volatile components in the sample solution are more easily released, when eluting the analyte, the elution solvent is injected into the inlet pipe 4 to cause the elution solvent to elute the analyte in the solid phase extractant 15. During this process, the valves installed at the tail of the inlet pipe 4 and the outlet pipe 5 are opened, and the throttle valve 13 of the outlet pipe 5 is closed. Then the liquid pump 9 is started to work, so that the injected solvent continuously circulates inside the liquid-solid extraction column 3, the inlet pipe 4 and the outlet pipe 5, so that the solvent can circulate through several extraction units 14 of the liquid-solid extraction column 3. In this way, the analyte enriched in the solid phase extractant 15 can be completely eluted.

[0035] In this utility model, unless otherwise explicitly specified and limited, the terms "installation", "setting", "connection", "fixing", "screw connection", etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal connection of two components or the interaction between two components. Unless otherwise explicitly limited, those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0036] The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A solid phase extraction rapid separation device comprising a housing (1), characterized in that, The shell (1) is internally mounted with several liquid-solid extraction columns (3), and several extraction units (14) are fixed at equal intervals in each liquid-solid extraction column (3), the upper and lower surfaces of each extraction unit (14) are embeddedly mounted with filter discs (16), and each extraction unit (14) is internally filled with a solid phase extraction agent (15), the upper and lower ends of the shell (1) are weldedly mounted with support frames (2), the support frame (2) at the upper end of the shell (1) is internally mounted with a liquid inlet pipe (4), the support frame (2) at the lower end of the shell (1) is internally mounted with a liquid outlet pipe (5), the two ends of the liquid-solid extraction column (3) are respectively provided with communication pipes (10) connected with the liquid inlet pipe (4) and the liquid outlet pipe (5), the surface of the communication pipe (10) at the upper end of the liquid-solid extraction column (3) is mounted with a flow regulating valve (11), the outer surface of the liquid-solid extraction column (3) is wrapped with a right heating shell (6) and a left heating shell (7), the cavities in the right heating shell (6) and the left heating shell (7) are internally mounted with electric heating pipes (17), the concave surfaces of the right heating shell (6) and the left heating shell (7) are respectively provided with heat conducting fins (18), the outer shell surfaces of the right heating shell (6) and the left heating shell (7) are mounted with temperature sensors (19), the temperature measuring probes of the temperature sensors (19) extend to the inner sides of the cavities of the right heating shell (6) or the left heating shell (7), and the temperature sensors (19) are electrically connected with external temperature controllers.

2. The solid phase extraction rapid separation device according to claim 1, wherein, The tail portions of the liquid inlet pipe (4) and the liquid outlet pipe (5) are provided with joints with valves, the joints of the liquid inlet pipe (4) and the liquid outlet pipe (5) are mounted with circulation pipes (8), the surface of the circulation pipe (8) is mounted with a liquid pump (9), the surface of the liquid inlet pipe (4) is mounted with a check valve (12), and the surface of the liquid outlet pipe (5) is mounted with a throttling valve (13).

3. The solid phase extraction rapid separation device of claim 1, wherein, The cross sections of the right heating shell (6) and the left heating shell (7) are all semicircular structures, the end surface of the right heating shell (6) is embeddedly mounted with a magnet (21) adsorptively connected with the left heating shell (7), the outer shells of the right heating shell (6) and the left heating shell (7) are respectively mounted with liquid nozzles (20) at the upper and lower ends, and the surfaces of the liquid nozzles (20) are mounted with hand valves.

4. The solid phase extraction rapid separation device of claim 1, wherein, The extraction unit (14) is in a hollow cylindrical structure as a whole, and the diameter of the filter disc (16) on the top surface of the extraction unit (14) is greater than the diameter of the filter disc (16) on the bottom surface.

5. The solid phase extraction rapid separation device of claim 1, wherein, The shell (1) is in a rectangular frame structure as a whole, and U-shaped installation openings are formed in the upper and lower ends of the shell (1) corresponding to the liquid-solid extraction columns (3).

6. The solid phase extraction rapid separation device of claim 1, wherein, The heat conducting fin (18) is in a circular arc structure, and the heat conducting fin (18) is filled with heat conducting silica gel between the liquid-solid extraction column (3).

7. The solid phase extraction rapid separation device of claim 1, wherein, The cross section of the support frame (2) is in an L-shaped structure, and a U-shaped pipe clamp is mounted on the inner surface of the support frame (2) through screws.

Images