Biocompatible microfluidic cell filter

Abstract

The utility model relates to the technical field of medical and laboratory equipment, and discloses a biocompatible microfluidic cell filter, which comprises a collector and a built-in fluidic mechanism, the outer wall of the collector is provided with a cover, the inner wall of the cover is provided with a storage port, the inner wall of the storage port is provided with a box body, the outer wall of the box body is provided with a dropper, and the dropper is connected with the collector. A guide pipe is arranged on the side, away from the dropper, of the box body, a connecting pipe is arranged on the outer wall of the guide pipe, and an extending block is arranged on the outer wall of the box body. According to the biocompatible microfluidic cell filter, symmetrical extension blocks are arranged on the outer wall of the box body, and elastic tension released by telescopic rods can push L-shaped clamping blocks to be buckled and fixed with placement blocks, so that when the box body is fixed in a storage opening, the box body is not easy to loosen, and a plurality of filter layers are arranged in the box body, so that the filter efficiency is improved. The filtering effect of the filter membrane on the solution can be effectively improved, so that the probability that cells are polluted can be effectively reduced.

Description

Technical Field

[0001] This utility model relates to the field of medical and laboratory equipment technology, specifically to a biocompatible microfluidic cell filter. Background Technology

[0002] Primary cell culture is one of the most commonly used methods in biological and medical research. It involves directly obtaining cells, tissues, and organs from an organism and culturing them until passage. Because the cells have just been isolated from living tissue, they more closely resemble their living state within the organism. This method provides a favorable means of studying the growth, metabolism, and reproduction of organismal cells, while also creating conditions for subsequent passage culture. This method can also directly serve clinical practice. After isolating and digesting tissues in an animal, in addition to primary cells, there are generally still incompletely dispersed original tissues, organs, cell clusters, and culture medium. Therefore, the collection of the products requires initial filtration after pipetting the mixture. Filtration of the mixture requires a cell filter, which can perform impurity filtration, cell dispersion, and sample separation.

[0003] Existing cell filters filter cells using screens with specific pore sizes. The multiple single-layer screens within the filter result in poor filtration efficiency of a single membrane during operation. Furthermore, the filtration efficiency decreases when the membrane is damaged, increasing the likelihood of cell contamination. Therefore, a biocompatible microfluidic cell filter is proposed. Utility Model Content

[0004] This utility model provides the following technical solution: a biocompatible microfluidic cell filter, including a collector and a built-in flow control mechanism. The outer wall of the collector is provided with a cover, the inner wall of the cover is provided with a storage port, the inner wall of the storage port is provided with a box, the outer wall of the box is provided with a dropper, the box is provided with a conduit on the side away from the dropper, the outer wall of the conduit is provided with a connecting tube, the outer wall of the box is provided with extension blocks, and the extension blocks are symmetrically distributed on the outer wall of the box, the outer wall of the box is provided with a telescopic rod, the outer wall of the telescopic rod is provided with an L-shaped locking block, the outer wall of the telescopic rod is provided with a spring, the inner wall of the box is provided with an internal rod, the outer wall of the internal rod is provided with multiple filter layers, and the multiple filter layers are distributed in a linear array on the outer wall of the telescopic rod.

[0005] As a preferred embodiment of this utility model, the outer wall of the lid is provided with a rubber tube, and the outer wall of the lid is provided with a mounting block, which is symmetrically distributed on the outer wall of the lid.

[0006] As a preferred embodiment of this utility model, the outer wall of the collector is provided with a discharge pipe, the outer wall of the collector is provided with a pad, the collector is provided with a connecting thread at the end away from the discharge pipe, and the collector and the cover are fixed together by a threaded connection, and the inner wall of the collector is provided with an internal filtration mechanism.

[0007] As a preferred embodiment of this utility model, the inner wall of the collector is provided with a circular filter, and the inner wall of the circular filter is provided with a honeycomb filter.

[0008] In a preferred embodiment of this invention, the tubing and the dropper are connected.

[0009] In a preferred embodiment of this invention, the dropper is connected to the connecting tube, and all the multiple filter layers are made of the same material.

[0010] Compared with the prior art, the present invention has the following beneficial effects:

[0011] This biocompatible microfluidic cell filter features symmetrical extension blocks on the outer wall of the housing. The elastic tension released by the telescopic rod can push the L-shaped locking block to lock and fix it in place. This prevents the housing from loosening when it is fixed in the storage port. Furthermore, the multiple filter layers inside the housing effectively improve the filtration efficiency of the filter membrane, thereby reducing the probability of cell contamination. Attached Figure Description

[0012] Figure 1 This is a schematic diagram of the three-dimensional structure of a biocompatible microfluidic cell filter;

[0013] Figure 2 This is a cross-sectional view of a biocompatible microfluidic cell filter;

[0014] Figure 3 This is a schematic diagram of the tubing structure in a biocompatible microfluidic cell filter;

[0015] Figure 4 This is a schematic diagram of a built-in flow control mechanism in a biocompatible microfluidic cell filter;

[0016] Figure 5 This is a schematic diagram of the internal filtration mechanism in a biocompatible microfluidic cell filter.

[0017] In the diagram: 1. Collector; 2. Discharge pipe; 3. Cover; 4. Pad; 5. Connecting thread; 6. Internal filtration mechanism; 61. Circular filter; 62. Honeycomb filter; 7. Tube; 8. Placement block; 9. Storage port; 10. Built-in flow control mechanism; 101. Box body; 102. Dropper; 103. Guide tube; 104. Connecting pipe; 105. Extension block; 106. Telescopic rod; 107. Spring; 108. L-shaped locking block; 109. Built-in rod; 110. Filter layer. Detailed Implementation

[0018] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0019] Please see Figure 1-5A biocompatible microfluidic cell filter includes a collector 1 and a built-in flow control mechanism 10. The collector 1 has a cover 3 on its outer wall, and a storage opening 9 on the inner wall of the cover 3. A housing 101 is located on the inner wall of the storage opening 9. A dropper 102 is located on the outer wall of the housing 101. A conduit 103 is located on the side of the housing 101 away from the dropper 102. A connecting pipe 104 is located on the outer wall of the conduit 103. Extension blocks 105 are symmetrically distributed on the outer wall of the housing 101. A telescopic rod 106 is located on the outer wall of the housing 101, and an L-shaped locking block 108 is located on the outer wall of the telescopic rod 106. The outer wall of the rod 106 is provided with a spring 107, and the inner wall of the housing 101 is provided with an internal rod 109. The outer wall of the internal rod 109 is provided with multiple layers of filter 110, which are distributed in a linear array on the outer wall of the telescopic rod 106. The diameter of the connecting pipe 104 is much larger than the diameter of the conduit 103, which enhances the efficiency of the device in collecting cell solutions and effectively prevents solution leakage when injected into the device. The dropper 102 can play a role in centralized collection. The outer wall of the cover 3 is provided with a rubber tube 7 and a mounting block 8, which are symmetrically distributed on the outer wall of the cover 3. When the housing 101 is fixed, the mounting block 8 can contact and engage with the L-shaped locking block 108, and the tubing 7 is connected to the dropper 102, so that the solution discharged from the dropper 102 will be further filtered and screened in the tubing 7 before being discharged. The outer wall of the collector 1 is provided with a discharge pipe 2 and a pad 4. The collector 1 has a connecting thread 5 at the end away from the discharge pipe 2, and the collector 1 and the cover 3 are fixed together by a threaded connection. The inner wall of the collector 1 is provided with an internal filtration mechanism 6. By fixing the collector 1 and the cover 3 with a threaded connection, the connection of the equipment can be effectively protected when the collector 1 and the cover 3 are connected. The connection stability of the cover 3 effectively prevents the collector 1 from separating from the cover 3 during operation, thus preventing solution leakage. The inner wall of the collector 1 is equipped with a circular filter 61, and the inner wall of the circular filter 61 is equipped with a honeycomb filter 62. The honeycomb filter 62 can perform secondary filtration on the solution discharged from the tube 7, thereby improving the accuracy of the solution. The dropper 102 is connected to the connecting tube 104, and the multiple filter layers 110 are all made of the same material. The filter layers 110 made of the same material can effectively prevent changes in solution density caused by different materials when filtering the solution.

[0020] Working principle: When the device is needed, the user presses the circular filter 61 into the collector 1, screws the cover 3 to fix the collector 1 to the cover 3, presses down the box 101 to fix the box 101 into the storage port 9, then the user aligns the cell solution with the connecting tube 104, presses the pump to inject the solution into the collector 1, and after passing through layers of filtration, it can be discharged from the device through the discharge tube 2.

[0021] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A biocompatible microfluidic cell filter comprising a collector (1) and an integrated fluidic mechanism (10), characterized in that: The outer wall of the collector (1) is provided with a cover (3), the inner wall of the cover (3) is provided with a storage opening (9), the inner wall of the storage opening (9) is provided with a box (101), the outer wall of the box (101) is provided with a dropper (102), the side of the box (101) away from the dropper (102) is provided with a conduit (103), the outer wall of the conduit (103) is provided with a connecting pipe (104), the outer wall of the box (101) is provided with an extension block (105), and the extension block (105) is symmetrically distributed on the outer wall of the box (101), the outer wall of the box (101) is provided with a telescopic rod (106), the outer wall of the telescopic rod (106) is provided with an L-shaped clamping block (108), the outer wall of the telescopic rod (106) is provided with a spring (107), the inner wall of the box (101) is provided with an embedded rod (109), the outer wall of the embedded rod (109) is provided with a plurality of filter layers (110), and the plurality of filter layers (110) are linearly arrayed on the outer wall of the telescopic rod (106).

2. The biocompatible microfluidic cell filter of claim 1, wherein: The outer wall of the cover (3) is provided with a rubber tube (7), the outer wall of the cover (3) is provided with a mounting block (8), and the mounting block (8) is symmetrically distributed on the outer wall of the cover (3).

3. The biocompatible microfluidic cell filter of claim 2, wherein: The outer wall of the collector (1) is provided with a discharge pipe (2), the outer wall of the collector (1) is provided with a cushion layer (4), one end of the collector (1) away from the discharge pipe (2) is provided with a connecting thread (5), and the collector (1) and the cover (3) are fixed by thread connection, the inner wall of the collector (1) is provided with an internal filter mechanism (6).

4. The biocompatible microfluidic cell filter of claim 3, wherein: The inner wall of the collector (1) is provided with a circular filter (61), and the inner wall of the circular filter (61) is provided with a honeycomb filter (62).

5. The biocompatible microfluidic cell filter of claim 2, wherein: The rubber tube (7) penetrates through the dropper (102).

6. The biocompatible microfluidic cell filter of claim 1, wherein: The dropper (102) penetrates through the connecting pipe (104), and the plurality of filter layers (110) are made of the same material.

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