Multi-stage centrifugal device for biological medicine extraction
By incorporating clamping and positioning structures into the multi-stage centrifuge unit, the problem of unstable inlet and outlet connections was solved, achieving sealing and stability in the biopharmaceutical extraction process, preventing liquid leakage, and ensuring production continuity and product quality.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-04-09
- Publication Date
- 2026-03-20
AI Technical Summary
The inlet and outlet connections of existing multi-stage centrifuges for biopharmaceutical extraction lack effective limiting, resulting in poor sealing and stability during high-speed operation, which easily leads to liquid leakage, affecting production continuity and product quality.
In a multi-stage centrifuge device, inlet and outlet clamping structures and auxiliary positioning structures are set up, including components such as connecting rings, clamping plates, return springs, positioning plates and screws. Through threaded engagement and elastic clamping, the tightness and stability of the pipeline connection are ensured.
It improves the sealing and stability of pipeline connections, prevents leakage of biopharmaceutical solutions, ensures the stability and accuracy of the extraction process, and reduces the risk of drug loss and environmental pollution.
Smart Images
Figure CN224010060U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of biopharmaceutical extraction technology, and in particular to a multi-stage centrifuge device for biopharmaceutical extraction. Background Technology
[0002] Multistage centrifuges for biopharmaceutical extraction are crucial separation devices in the biopharmaceutical field, playing a vital role in the extraction and purification of biopharmaceuticals. They utilize centrifugal force to separate components of different densities in a biopharmaceutical mixture, while the multistage design enhances extraction efficiency and purity. They are widely used in the production processes of various biopharmaceuticals, such as vaccines, antibodies, and cytokines. In practical applications, multistage centrifuges for biopharmaceutical extraction typically have the following structure:
[0003] 1. Rotary drum: As a core component, it is made of high-strength and corrosion-resistant materials. It has multiple compartments inside to contain the mixture and achieve phase separation under the centrifugal force generated by high-speed rotation. Its rotation speed can be adjusted by motor and frequency converter according to different extraction process requirements.
[0004] 2. Mixer: Located above or to the side of the drum, it uses structures such as turbine disks and impellers to fully mix the biopharmaceutical raw material liquid and the extractant in a short time, greatly improving the mass transfer efficiency and laying the foundation for subsequent extraction and separation.
[0005] 3. Weir plate: Located at the outlet of the drum, it is used to precisely control the outflow velocity and flow rate of the two-phase liquid. By adjusting the height and width of the weir plate, the separation effect of the two-phase liquid can be optimized, ensuring that the light phase and the heavy phase can smoothly enter their respective collection chambers.
[0006] 4. Collection chamber: Used to collect the separated light and heavy phase liquids respectively, connected to the drum outlet, and equipped with corresponding pipes and valves to transport the separated liquids to subsequent processing steps.
[0007] Currently, to improve the effectiveness and efficiency of biopharmaceutical extraction, the industry has adopted various multi-stage centrifuge devices and improvements. Some companies use centrifuges with higher rotation speeds and greater centrifugal forces to enhance separation; others optimize the internal structure of the drum, such as adding baffles or changing the shape of the compartments, to improve the flow efficiency and separation effect of the liquid within the device; some advanced devices are equipped with automated control systems that can monitor and adjust operating parameters in real time to ensure the stability of the extraction process.
[0008] However, the above-described implementation still has the following problems. Regarding pipe connections, ordinary inlet and outlet connections lack effective limiting mechanisms, making it difficult to maintain good sealing and stability under the vibrations and pressure changes generated by the high-speed operation of multi-stage centrifuges. This easily leads to liquid leakage, which not only causes loss of biopharmaceuticals but may also contaminate the working environment, affecting production continuity and product quality. Simultaneously, the lack of effective positioning methods during pipe installation makes it difficult to ensure the concentricity of pipe connections, resulting in the clamping device not applying pressure evenly, further reducing sealing performance and connection reliability. This application proposes a solution to this problem: incorporating inlet and outlet clamping structures and auxiliary positioning structures into the multi-stage centrifuge for biopharmaceutical extraction. This enhances the sealing and stability of pipe connections, improves installation efficiency and accuracy, and ensures the efficient and stable operation of the device. Utility Model Content
[0009] To address the shortcomings of existing technologies, this invention provides a multi-stage centrifuge device for biopharmaceutical extraction. It solves the problem that ordinary inlet and outlet connections lack effective limiting, making it difficult to maintain good sealing and stability under the vibration and pressure changes generated by the high-speed operation of multi-stage centrifuge devices. This can easily lead to liquid leakage, which not only causes the loss of biopharmaceuticals but may also pollute the working environment, affecting the continuity of production and product quality.
[0010] To achieve the above objectives, this utility model provides the following technical solution:
[0011] A multi-stage centrifuge device for biopharmaceutical extraction includes a frame and a centrifuge. Connecting rings are movably sleeved at the inlet and outlet of the centrifuge. Two clamping plates for holding are movably engaged within each connecting ring. A connecting block is fixedly connected to the lower surface of each connecting ring. Fixing blocks are fixedly connected to the opposing surfaces of the two pairs of connecting blocks. Two positioning plates for positioning are movably connected within each fixing block. A reset spring for resetting is fixedly connected to the surface of each clamping plate. A slot is formed within each fixing block, and each slot is movably connected to each pair of positioning plates.
[0012] Preferably, each of the fixed blocks is rotatably connected to a screw, each of the positioning plates has a threaded hole through its surface, each pair of threaded holes is threadedly engaged with each screw, and each of the connecting rings has two arc-shaped grooves on its inner wall, each pair of arc-shaped grooves being movably engaged with each pair of clamping plates.
[0013] Preferably, each pair of reset springs is fixedly connected to each pair of arc-shaped grooves, each clamping plate surface is fixedly connected to a connecting rod, and each connecting block upper surface is provided with a second slot, each second slot being movably sleeved with each pair of connecting rods.
[0014] Compared with the prior art, the present invention has the following beneficial effects:
[0015] 1. Move the connecting ring to the position where it is fitted onto the inlet and outlet delivery pipes. The clamping plate will be reset by the elastic force of the two reset springs. The rubber material of the clamping plate will fit tightly against the delivery pipe to ensure the tightness of the connection, prevent leakage of the biopharmaceutical solution, avoid drug loss and pollution of the working environment, and at the same time ensure the stability and accuracy of the extraction process.
[0016] 2. To ensure the stability of the connecting ring, during installation, first fit the two positioning plates on the other side of the connecting ring. Then, by rotating the screw, the two positioning plates fitted on it will move relative to each other due to the thread action. Adjust the distance between the two positioning plates to fit tightly with the inlet and outlet, ensuring the stability of the connecting ring while further improving the limiting effect, improving the sealing effect and the stability of the connection, and reducing the risk of leakage caused by pipeline misalignment. Attached Figure Description
[0017] The above description is only an overview of the technical solution of this utility model. In order to better understand the technical means of this utility model and to implement it in accordance with the contents of the specification, the preferred embodiments of this utility model are described in detail below with reference to the accompanying drawings.
[0018] Figure 1 This is an overall structural diagram of the present invention;
[0019] Figure 2 This is a structural diagram of the connecting block of this utility model;
[0020] Figure 3 This is a structural diagram of the positioning plate of this utility model;
[0021] Figure 4 This is a structural diagram of the clamping plate of this utility model.
[0022] Legend: 1. Frame; 2. Centrifuge; 3. Connecting block; 4. Connecting ring; 5. Positioning plate; 6. Fixing block; 7. Screw; 8. Slot 1; 9. Threaded hole; 10. Arc groove; 11. Clamping plate; 12. Return spring; 13. Connecting rod; 14. Slot 2. Detailed Implementation
[0023] This application provides a multi-stage centrifuge device for biopharmaceutical extraction, which effectively solves the problem that ordinary inlet and outlet connections lack effective limiting, making it difficult to maintain good sealing and stability under the vibration and pressure changes generated by the high-speed operation of the multi-stage centrifuge device. This easily leads to liquid leakage, which not only causes the loss of biopharmaceuticals but may also pollute the working environment, affecting the continuity of production and product quality. The multi-stage centrifuge device for biopharmaceutical extraction is equipped with inlet and outlet clamping structures and auxiliary positioning structures to enhance the sealing and stability of the pipeline connection, improve installation efficiency and accuracy, and ensure the efficient and stable operation of the device.
[0024] Example
[0025] like Figure 1 , Figure 2 , Figure 3 , Figure 4 As shown, the technical solution in this application effectively solves the problem that ordinary inlet and outlet connections lack effective limiting, making it difficult to maintain good sealing and stability under the vibration and pressure changes generated by the high-speed operation of multi-stage centrifuges. This easily leads to liquid leakage, which not only causes the loss of biopharmaceuticals but may also pollute the working environment, affecting the continuity of production and product quality. The overall approach is as follows:
[0026] To address the problems existing in the prior art, this utility model provides a multi-stage centrifuge device for biopharmaceutical extraction, including a frame 1 and a centrifuge 2. Connecting rings 4 are movably sleeved at both the inlet and outlet of the centrifuge 2. Two clamping plates 11 for holding are movably engaged within each connecting ring 4. A connecting block 3 is fixedly connected to the lower surface of each connecting ring 4. Fixing blocks 6 are fixedly connected to the opposing surfaces of the two pairs of connecting blocks 3. Two positioning plates 5 for positioning are movably connected within each fixing block 6. A reset spring 12 for resetting is fixedly connected to the surface of each clamping plate 11. A slot 8 is formed within each fixing block 6, and each slot 8 is movably connected to each pair of positioning plates 5. During use, the... After the delivery tube is fitted into the inlet and outlet of the centrifuge 2, the fixed clamping plates 11 are moved together by pressing the two connecting rods 13. At this time, the two clamping plates 11 will be completely locked into the arc-shaped groove 10 opened in the connecting ring 4, compressing the return spring 12. The ring opening of the connecting ring 4 is larger than the inlet and outlet of the centrifuge 2. The connecting ring 4 is moved to the position where it is fitted into the delivery tube at the inlet and outlet. The elastic force of the two return springs 12 drives the clamping plates 11 to reset. The rubber material of the clamping plates 11 will fit tightly with the delivery tube to ensure the tightness of the connection, prevent leakage of the biological drug solution, avoid drug loss and pollution of the working environment, and also ensure the stability and accuracy of the extraction process.
[0027] Each fixed block 6 is rotatably connected to a screw 7. Each positioning plate 5 has a threaded hole 9 through its surface. Each pair of threaded holes 9 is threadedly engaged with each screw 7. Each connecting ring 4 has two arc-shaped grooves 10 on its inner wall. Each pair of arc-shaped grooves 10 is movably engaged with each pair of clamping plates 11. Each pair of return springs 12 is fixedly connected to each pair of arc-shaped grooves 10. Each clamping plate 11 has a connecting rod 13 fixedly connected to its surface. Each connecting block 3 has a second slot 14 on its upper surface. Each second slot 14 is movably engaged with each pair of connecting rods 13. To ensure the stability of the connecting ring 4, during installation, the two positioning plates 5 on the other side of the connecting ring 4 are first engaged. At this time, by rotating the screw 7, the two positioning plates 5 engaged on it are moved relative to each other by the thread action. The distance between the two positioning plates 5 is adjusted to fit tightly with the inlet and outlet, ensuring the stability of the connecting ring 4 while further improving the limiting effect, improving the sealing effect and the stability of the connection, and reducing the risk of leakage caused by pipeline misalignment.
[0028] Among them, frame 1 serves as the supporting structure for the entire multi-stage centrifuge device, providing a stable mounting base for centrifuge 2 and other components, ensuring that the device remains stable during operation, avoiding the impact of shaking or displacement on the extraction effect, and ensuring the safety of equipment operation.
[0029] Centrifuge 2: The core equipment for biopharmaceutical extraction. It generates strong centrifugal force through high-speed rotation, which promotes the separation of components of different densities in the biopharmaceutical mixture, thereby completing the biopharmaceutical extraction operation. Its performance directly affects the extraction efficiency and quality.
[0030] Connecting block 3: Fixes the connecting ring 4, so that the connecting ring 4 can be stably set at the inlet and outlet of the centrifuge 2; at the same time, it provides an installation position for components such as positioning plate 5 and fixing block 6, and plays the role of connecting and supporting other components to ensure that all components work together.
[0031] Connecting ring 4: It is movably sleeved at the inlet and outlet of centrifuge 2, and cooperates with clamping plate 11, return spring 12, etc. to firmly clamp the delivery pipe at the inlet and outlet of centrifuge 2, prevent the biological drug solution from leaking at the inlet and outlet, and ensure the sealing and continuity of the extraction process.
[0032] Positioning plate 5: It is movably connected within the fixing block 6. By rotating the screw 7, its own spacing can be adjusted so that it fits tightly with the inlet and outlet of the centrifuge 2, improving the stability of the connecting ring 4 and further enhancing the limiting effect, reducing the risk of leakage caused by pipeline deviation.
[0033] Fixed block 6: Fixed on the opposite surface of connecting block 3, with a slot 8 and a rotating connecting screw 7 inside, providing installation and movement space for components such as positioning plate 5 and screw 7, ensuring that positioning plate 5 can move and be positioned stably inside it;
[0034] Screw 7: Rotatably connected within the fixed block 6, it is threadedly engaged with the threaded hole 9 on the surface of the positioning plate 5. When rotated, it drives the positioning plate 5 to move relative to each other, thereby achieving precise adjustment of the spacing between the positioning plates 5 to accommodate conveying pipes of different diameters and improve the stability and sealing of the connection.
[0035] Slot 1 8: It is opened in the fixed block 6 and is movably connected to each pair of positioning plates 5. It not only provides a moving track for the positioning plates 5, but also limits the range of motion of the positioning plates 5, ensuring the stability and accuracy of the positioning plates 5 during the adjustment process.
[0036] Threaded hole 9: It is opened through the surface of the positioning plate 5 and threadedly connected to the screw 7. It is the key structure to realize the rotation of the screw 7 to drive the positioning plate 5 to move. Through the threaded engagement, the movement distance and position of the positioning plate 5 can be precisely controlled.
[0037] Arc groove 10: It is formed on the inner wall of the connecting ring 4 and is movably engaged with each pair of clamping plates 11. It plays a guiding role when the clamping plates 11 move. At the same time, it cooperates with the return spring 12 to ensure that the clamping plates 11 can accurately return to the position of being tightly fitted with the conveying pipe when resetting, thereby enhancing the clamping effect.
[0038] Clamping plate 11: It is movably snapped into the connecting ring 4 and is made of rubber. It can be moved by pressing the connecting rod 13 and compressing the return spring 12. The elastic force of the return spring 12 makes it fit tightly against the delivery tube after reset, preventing leakage of biological drug solution and ensuring tight connection.
[0039] Return spring 12: Fixed on the surface of clamping plate 11 and arc groove 10, it provides the return force for clamping plate 11. After clamping plate 11 is pressed and compressed, it can quickly return to the initial position, ensuring that clamping plate 11 is always in close contact with the conveying pipe and maintaining a good sealing effect.
[0040] Connecting rod 13: Fixed on the surface of clamping plate 11, making it convenient for operators to press manually. By pressing the connecting rod 13, the clamping plate 11 is moved to achieve clamping and loosening of the conveying pipe, making pipe connection and disassembly more convenient.
[0041] Slot 2 14: It is formed on the upper surface of the connecting block 3 and is movably sleeved with each pair of connecting rods 13. It plays a limiting role in the connecting rods 13, preventing the connecting rods 13 from shifting or falling off during movement, and ensuring the stable movement and normal operation of the clamping plate 11.
[0042] Working principle:
[0043] During use, after the delivery pipe is fitted onto the inlet and outlet of the centrifuge 2, pressing the two connecting rods 13 relative to each other moves the fixed clamping plates 11 together. At this time, the two clamping plates 11 will be completely engaged in the arc-shaped groove 10 opened in the connecting ring 4, compressing the return spring 12. The overall opening of the connecting ring 4 is larger than the inlet and outlet of the centrifuge 2. Moving the connecting ring 4 to the position where it is fitted onto the delivery pipe at the inlet and outlet, the elastic force of the two return springs 12 drives the clamping plates 11 to return to their original position. The rubber material of the clamping plates 11 will fit tightly against the delivery pipe, ensuring a tight connection and preventing... To prevent leakage of biological drug solutions, avoid drug loss and pollution of the working environment, and ensure the stability and accuracy of the extraction process, in order to ensure the stability of the connecting ring 4, during the installation process, the two positioning plates 5 on the other side of the connecting ring 4 are first connected. At this time, by rotating the screw 7, the two positioning plates 5 connected on it are moved relative to each other by the thread action, adjusting the distance between the two positioning plates 5 to fit tightly with the inlet and outlet, ensuring the stability of the connecting ring 4 while further improving the limiting effect, improving the sealing effect and connection stability, and reducing the risk of leakage caused by pipeline misalignment.
[0044] Finally, it should be noted that the above embodiments are merely examples for clearly illustrating the present invention and are not intended to limit the implementation. Those skilled in the art can make other variations or modifications based on the above description. It is neither necessary nor possible to exhaustively list all possible implementations. However, obvious variations or modifications derived therefrom are still within the protection scope of this invention.
Claims
1. A multi-stage centrifuge device for biopharmaceutical extraction, comprising a frame (1) and a centrifuge (2), characterized in that, The centrifuge (2) has connecting rings (4) movably sleeved at both the inlet and outlet. Each connecting ring (4) has two clamping plates (11) movably snapped into it. Each connecting ring (4) has a connecting block (3) fixedly connected to its lower surface. Among them, the two pairs of connecting blocks (3) are fixedly connected to the opposite surfaces of the fixing blocks (6), and each fixing block (6) is movably connected to two positioning plates (5) for positioning, and each clamping plate (11) is fixedly connected to a reset spring (12) for resetting.
2. The multi-stage centrifuge device for biopharmaceutical extraction as described in claim 1, characterized in that: Each of the aforementioned fixing blocks (6) is provided with a slot (8); Each of the card slots (8) is movably connected to each pair of positioning plates (5).
3. The multi-stage centrifuge device for biopharmaceutical extraction as described in claim 1, characterized in that: Each of the fixed blocks (6) is rotatably connected to a screw (7).
4. The multi-stage centrifuge device for biopharmaceutical extraction as described in claim 3, characterized in that: Each of the positioning plates (5) has a threaded hole (9) through it on its surface; Each pair of threaded holes (9) is threadedly connected to each screw (7).
5. The multi-stage centrifuge device for biopharmaceutical extraction as described in claim 1, characterized in that: Each of the connecting rings (4) has two arc-shaped grooves (10) on its inner wall; Each pair of arc-shaped grooves (10) is movably engaged with each pair of clamping plates (11).
6. The multi-stage centrifuge device for biopharmaceutical extraction as described in claim 5, characterized in that: Each pair of the reset springs (12) is fixedly connected to each pair of arc-shaped grooves (10).
7. The multi-stage centrifuge device for biopharmaceutical extraction as described in claim 1, characterized in that: Each of the clamping plates (11) is fixedly connected to a connecting rod (13).
8. The multi-stage centrifuge device for biopharmaceutical extraction as described in claim 7, characterized in that: Each of the connecting blocks (3) has a slot 2 (14) on its upper surface; Each of the card slots (14) is movably connected to each pair of connecting rods (13).