Mobile phase bottle assembly capable of automatically supplementing liquid

Abstract

The utility model provides a mobile phase bottle assembly capable of automatically supplementing liquid, which is characterized in that a first mobile phase bottle is hermetically communicated with a liquid outlet pipe for providing a mobile phase for an instrument, an exhaust pipe is communicated with a negative pressure device and a space above the liquid level in the first mobile phase bottle, and the exhaust pipe is used for extracting air in the first mobile phase bottle; the second mobile phase bottle is communicated with the first mobile phase bottle through a drainage tube; two ends of the drainage tube respectively extend to the inner bottom of the first mobile phase bottle and the inner bottom of the second mobile phase bottle; at least the bottom of the second mobile phase bottle is located in the base, the bottom end of the elastic piece is fixed in the base, the upper end of the elastic piece is fixedly connected with the bottom of the second mobile phase bottle, and when liquid in the second mobile phase bottle is reduced, the elastic piece is used for driving the second mobile phase bottle to ascend. The relative positions of the two bottle bodies are adjusted in real time through the elastic supporting mechanism, manual liquid supplementing is not needed, and liquid supplementing for the first mobile phase bottle by the second mobile phase bottle is achieved.

Description

TECHNICAL FIELD

[0001] The utility model relates to experimental equipment technical field especially is related to a flow phase bottle subassembly of automatic liquid supplement. BACKGROUND

[0002] With the popular application of high performance liquid chromatography and high performance liquid chromatography mass spectrometry, the method becomes an important analysis technology in chemistry, medicine and other fields, and its main technical process is to use liquid as mobile phase, pump the solution into the chromatographic column by using high pressure infusion system, separate each component in the solution in the chromatographic column, and detect after separation to realize the analysis of sample solution.

[0003] The existing flow phase is all used independent flow phase bottle, therefore when encountering the case that the flow rate of laboratory flow phase is big or the detection duration is long, the flow phase bottle needs to be added with flow phase in time, and in the daily detection process, the instrument error is found, needs to be re-determined or the test sample is suddenly increased, so that the demand of flow phase is greater than the amount of existing prepared flow phase, and finally the instrument stops running.

[0004] The applicant finds that the prior art at least has the following technical problems: the flow phase is stored in the flow phase bottle, and as the experiment is carried out, the flow phase needs to be manually added into the bottle body frequently, if the detection process needs to be supplemented, the flow phase cannot be supplemented in time, or air bubbles are easily brought into the flow phase bottle when manually supplementing the liquid, and the operation is inconvenient. UTILITY MODEL CONTENT

[0005] The utility model discloses a flow phase bottle subassembly of automatic liquid supplement to solve the technical problems that the flow phase bottle needs to be manually supplemented with liquid in the prior art, the operation is inconvenient, and the experimental efficiency is affected.

[0006] To achieve the above object, the utility model provides the following technical scheme:

[0007] The utility model discloses a flow phase bottle subassembly of automatic liquid supplement, including first flow phase bottle, second flow phase bottle, base, elastic part, negative pressure device and air suction pipe, wherein:

[0008] The first flow phase bottle is sealedly connected with the liquid outlet pipe for providing the flow phase for the instrument, the air suction pipe is connected with the space above the liquid level in the first flow phase bottle and the negative pressure device, and the air suction pipe is used for extracting the air in the first flow phase bottle;

[0009] The second mobile phase bottle is communicated with the first mobile phase bottle through a drainage tube, two ends of the drainage tube respectively extend to the bottom of the first mobile phase bottle and the bottom of the second mobile phase bottle;

[0010] At least the bottom of the second mobile phase bottle is located in the base, the bottom end of the elastic member is fixed in the base, the upper end of the elastic member is fixedly connected with the bottom of the second mobile phase bottle, and the elastic member is used to drive the second mobile phase bottle to rise when the liquid in the second mobile phase bottle is reduced.

[0011] Preferably, the mobile phase bottle assembly capable of automatically supplementing liquid further comprises a tray, and the second mobile phase bottle is limited on the tray.

[0012] Preferably, a sliding block is arranged on the tray, opposite sides of the base are provided with guide rails, and the guide rails are vertically arranged, and the sliding block is in sliding connection with the guide rails.

[0013] Preferably, the elastic member comprises a spring, the upper end of the spring is fixedly connected with the bottom of the tray, and the spring is in a compressed state.

[0014] Preferably, the number of the springs is two or more, and all the springs are uniformly arranged.

[0015] Preferably, a groove is arranged on the tray, the bottom of the second mobile phase bottle is clamped and fixed in the groove, and the elastic member is uniformly arranged around the groove.

[0016] Preferably, the drainage tube comprises an integral horizontal section, a first vertical section and a second vertical section, wherein:

[0017] The first vertical section and the second vertical section are communicated with two ends of the horizontal section, the first vertical section extends into the bottom of the first mobile phase bottle, and the second vertical section extends into the bottom of the second mobile phase bottle.

[0018] Preferably, a first bottle cap is threadedly connected at the bottle mouth of the first mobile phase bottle, three through holes are arranged on the first bottle cap, and the first vertical section, the liquid outlet pipe and the gas pipe are sealed through the through holes, respectively.

[0019] Preferably, a second bottle cap is threadedly connected at the bottle mouth of the second mobile phase bottle, a sealing through hole is arranged on the second bottle cap, the second vertical section passes through the sealing through hole, and a sliding sealing ring is arranged between the second vertical section and the sealing through hole.

[0020] Preferably, a filter part is fixedly communicated with the bottom of the liquid outlet pipe.

[0021] The mobile phase bottle assembly capable of automatically supplementing liquid has the following beneficial effects compared with the prior art: the air suction pipe continuously sucks air to form negative pressure in the first mobile phase bottle, and the liquid in the second mobile phase bottle is forced to flow into the first mobile phase bottle through the drainage pipe. After the liquid in the second mobile phase bottle is reduced, the elastic member releases the stored elastic potential energy to push the bottle body to vertically rise, and the reference liquid level of the second mobile phase bottle is raised to maintain the pressure balance between the two containers. The design that the two ends of the drainage pipe are always immersed in the liquid ensures the one-way flow of the liquid and avoids air from entering the pipeline to form bubbles. The relative positions of the two bottle bodies are adjusted in real time through the elastic support mechanism, manual liquid supplementing is not needed, and the second mobile phase bottle supplements the liquid for the first mobile phase bottle. BRIEF DESCRIPTION OF DRAWINGS

[0022] In order to more clearly illustrate the technical solutions of the embodiments of the present application or the prior art, the following will briefly introduce the drawings needed to be used in the embodiment or prior art description. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative labor.

[0023] Figure 1 is a structural schematic view of the mobile phase bottle assembly capable of automatically supplementing liquid;

[0024] Figure 2 is a schematic view of the cooperation structure of the second mobile phase bottle and the first mobile phase bottle after the relative position changes;

[0025] Figure 3 is a top view structural schematic view of the tray;

[0026] Figure 4 is a bottom view structural schematic view of the tray.

[0027] In the figure, 1 is a first mobile phase bottle; 2 is a second mobile phase bottle; 3 is a base; 31 is a guide rail; 4 is an elastic member; 5 is a negative pressure device; 6 is an air suction pipe; 7 is a drainage pipe; 71 is a horizontal section; 72 is a first vertical section; 73 is a second vertical section; 8 is a tray; 81 is a sliding block; 82 is a groove; 9 is a filter part; 10 is a liquid outlet pipe; 11 is a first bottle cap; and 12 is a second bottle cap. DETAILED DESCRIPTION

[0028] In order to make the purpose, technical scheme and advantages of the present application more clear, the technical scheme of the present application will be described in detail below. Obviously, the described embodiments are only some embodiments of the present application, not all embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor belong to the scope of protection of the present application.

[0029] In the description of the utility model, it needs to be understood that the orientation or positional relationship indicated by the terms "center", "length", "width", "height", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "side" and the like is the orientation or positional relationship based on the drawings shown, and is only for the convenience of describing the utility model and simplifying the description, and does not indicate or imply that the device or element indicated must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the utility model. In the description of the utility model, unless otherwise specified, the meaning of "a plurality of" is two or more than two.

[0030] In the description of the utility model, it also needs to be explained that, unless otherwise specified and limited, the terms "set", "mount", "connect", "connect" should be understood broadly, for example, it can be fixedly connected, or it can be detachably connected, or integrally connected, it can be mechanically connected, or it can be electrically connected, it can be directly connected, or indirectly connected through an intermediate medium, or it can be the communication inside two elements. For ordinary skilled in the art, the specific meaning of the above terms in the utility model can be understood according to the specific circumstances.

[0031] The utility model embodiment provides a kind of mobile phase bottle assembly of automatic liquid supplement, the relative position of two bottle bodies is adjusted in real time by elastic support mechanism, without manual liquid supplement, realize that second mobile phase bottle is the liquid supplement of first mobile phase bottle.

[0032] The technical scheme provided by the utility model is described in more detail below. Figures 1-4 The technical scheme provided by the utility model is described in more detail below.

[0033] In the prior art, the mobile phase storage system has long used single glass bottle structure, and the operator needs to frequently observe the liquid level change and manually supplement liquid during the experiment. When the detection task has sudden sample increment or the instrument is continuously operated for a long time, the lag of manual liquid supplement operation is easy to cause detection interruption. The traditional liquid supplement method has liquid exposure risk, and the manual pouring process is easy to introduce air bubbles, which interferes with the detection accuracy of the chromatograph and affects the reliability of experimental results.

[0034] The technical scheme provided by the utility model is described in more detail below. Figures 1-4 The technical scheme provided by the utility model is described in more detail below.

[0035] The application provides a flow phase bottle assembly capable of automatic liquid supplement, comprising a first flow phase bottle 1, a second flow phase bottle 2, a base 3, an elastic element 4, a negative pressure device 5 and an air extraction pipe 6, the first flow phase bottle 1 is sealed and communicated with a liquid outlet pipe 10, the air extraction pipe 6 connects the negative pressure device 5 and the space above the liquid level of the first flow phase bottle 1, the second flow phase bottle 2 is communicated with the first flow phase bottle 1 through a drainage pipe 7 extending to the bottom of the two bottles, and the bottom of the second flow phase bottle 2 is arranged in the base 3, the bottom end of the elastic element 4 is fixed to the base 3, and the top end is connected to the bottom of the second flow phase bottle 2, so that the second flow phase bottle 2 is driven to rise when the liquid in the second flow phase bottle 2 is reduced.

[0036] The negative pressure device 5 is a device for generating air suction, which can be realized by a vacuum pump or a micro air pump, and the air at the top of the first flow phase bottle 1 is continuously extracted through the air extraction pipe 6 to form a low-pressure environment. The elastic element 4 is a mechanical element with deformation recovery capability, which can be realized by a spiral spring or an elastic rubber column, and the elastic energy is stored in the pre-compressed state. The drainage pipe 7 is a conduit for communicating two containers, which can be realized by a corrosion-resistant silica gel pipe or a polytetrafluoroethylene pipe, and the two ends are always immersed in the liquid to form a liquid channel.

[0037] Specifically, when the liquid outlet pipe 10 continuously delivers the flow phase to the chromatograph, the liquid level of the first flow phase bottle 1 is lowered to trigger the negative pressure device 5 to start. The air extraction pipe 6 continuously extracts the air to form a negative pressure in the first flow phase bottle 1, so that the liquid in the second flow phase bottle 2 is forced to flow into the first flow phase bottle 1 through the drainage pipe 7. After the liquid in the second flow phase bottle 2 is reduced, the elastic element 4 releases the stored elastic potential energy to push the bottle body to vertically rise, so that the reference liquid level of the second flow phase bottle 2 is raised to maintain the pressure balance between the two containers. The design that the two ends of the drainage pipe 7 are always immersed in the liquid ensures the one-way flow of the liquid and avoids the air from entering the pipeline to form bubbles.

[0038] Compared with the prior art, the traditional single bottle structure needs manual intervention for liquid supplement, while the scheme realizes automatic supplement through mechanical linkage. The conventional communicating vessel relies on a fixed height difference and cannot be dynamically adjusted, while the scheme realizes real-time adjustment of the relative positions of the containers through the elastic supporting mechanism. The ordinary liquid supplement operation is easy to make the liquid contact with the air, while the scheme completely isolates the external environment through the closed flow path.

[0039] Through the above technical scheme, the application realizes continuous supply of the flow phase without manual intervention, and eliminates the risk of bubble mixing in the liquid supplement process. The pressure balance mechanism between the two containers guarantees stable delivery of the liquid, the elastic supporting structure automatically compensates the liquid level change, and the long-time continuous operation of the instrument is ensured. The closed liquid transfer path avoids solvent evaporation and external pollution, and improves the accuracy of experimental data.

[0040] The application further provides the flow phase bottle assembly capable of automatic liquid supplement, which further comprises a tray 8, and the second flow phase bottle 2 is limited on the tray 8.

[0041] Wherein, the tray 8 refers to a plate-shaped structure for carrying the second mobile phase bottle 2, which can be made of metal or plastic material, and the surface is provided with a groove 82 or a clamping structure to limit the second mobile phase bottle 2. Limiting refers to limiting the movement path of the second mobile phase bottle 2 in the vertical direction through physical constraints, such as through the gap between the side wall of the groove 82 and the bottle body, or through the shape matching of the clamping structure. When the elastic member 4 drives the tray 8 and the second mobile phase bottle 2 to rise and fall, the rigid structure of the tray 8 can avoid horizontal deviation of the bottle body during movement.

[0042] Specifically, the tray 8 is fixedly connected with the bottom of the second mobile phase bottle 2, such as through groove 82 clamping or bolt locking, so that the second mobile phase bottle 2 moves synchronously with the tray 8. When the elastic member 4 is in a compressed state, the tray 8 is subjected to an upward elastic force, driving the second mobile phase bottle 2 to move upward; when the liquid in the second mobile phase bottle 2 decreases, the elastic member 4 extends to push the tray 8 and the bottle body to rise, and the cooperation between the edge of the tray 8 and the base 3 or the guide rail 31 can limit the horizontal displacement of the bottle body. For example, the edge of the tray 8 can be provided with a sliding block 81, which is in sliding connection with the vertical guide rail 31 of the base 3, so as to constrain the movement direction to vertical lifting. Through the rigid support of the tray 8, the movement trajectory of the second mobile phase bottle 2 is accurately controlled, and the two ends of the drainage tube 7 are always kept at the bottom of the two mobile phase bottles, avoiding the drainage tube 7 from being separated from the bottle bottom due to the inclination of the bottle body.

[0043] The application introduces a rigid carrier between the bottle body and the elastic member 4 by adding a tray 8 structure, and limits the movement direction to be vertical through the limiting design, effectively eliminating the influence of horizontal displacement on the communication state of the drainage tube 7.

[0044] Through the above technical solutions, the application solves the problem of drainage tube 7 failure caused by deviation of the second mobile phase bottle 2 during lifting, and the tray 8 maintains the vertical movement trajectory of the bottle body through physical constraints, ensuring that the drainage tube 7 is always connected to the bottom of the two mobile phase bottles, thereby ensuring the stable operation of the automatic liquid supplement function.

[0045] The application further provides that the sliding block 81 is arranged on the tray 8, and the vertical guide rail 31 is arranged on the opposite sides of the base 3, and the sliding block 81 is in sliding connection with the guide rail 31.

[0046] Wherein, the sliding block 81 refers to a sliding component fixedly installed on the two sides of the tray 8, which can be a block-shaped structure made of metal or plastic material, and the surface can be provided with a groove 82 or a protrusion to realize cooperation with the guide rail 31. Wherein, the sliding connection refers to the relative movement relationship between the sliding block 81 and the guide rail 31 through the contact surface or the embedded structure, such as the cooperation of the groove 82 and the protrusion, the ball sliding rail or the linear bearing, etc., to reduce the friction resistance.

[0047] Specifically, the cooperation of the sliding block 81 and the guide rail 31 enables the tray 8 to move only in the vertical direction under the driving of the elastic member 4. When the liquid in the second mobile phase bottle 2 decreases, the elastic member 4 pushes the tray 8 to rise, at which time the sliding block 81 slides along the guide rail 31 to limit the horizontal displacement and deflection of the tray 8. The vertical guide rail 31 provides rigid guidance for the lifting process to avoid tilting or deviation of the tray 8 during the movement; the sliding connection structure makes the lifting action of the tray 8 smoother by reducing the frictional resistance. The structure ensures that the second mobile phase bottle 2 always moves vertically along the predetermined path, avoiding misalignment or blockage of the drainage tube 7 due to deviation, thereby maintaining the continuity of the liquid supplementing process.

[0048] The technical scheme solves the problems of deviation or blockage that may occur during the lifting of the second mobile phase bottle 2, ensures the vertical movement of the container along a fixed path, avoids the blockage of the drainage tube 7 or the interruption of the liquid supplementing due to deviation, and reduces the frictional loss between the moving parts, thereby prolonging the service life of the device.

[0049] The technical scheme solves the problems of deviation or blockage that may occur during the lifting of the second mobile phase bottle 2, ensures the vertical movement of the container along a fixed path, avoids the blockage of the drainage tube 7 or the interruption of the liquid supplementing due to deviation, and reduces the frictional loss between the moving parts, thereby prolonging the service life of the device.

[0050] The elastic member 4 includes a spring, the upper end of the spring is fixedly connected to the bottom of the tray 8, and the spring is in a compressed state.

[0051] The spring is a mechanical element that can store elastic potential energy by compression deformation, and can be implemented by a coil spring, which can be made of spring steel or stainless steel and has high elastic modulus and fatigue resistance. The compressed state means that the spring is shortened by being pre-applied with a pressure during installation.

[0052] Specifically, when the liquid in the second mobile phase bottle 2 decreases, the weight of the bottle body decreases, the elastic potential energy stored in the spring is released, and the spring pushes the tray 8 and the second mobile phase bottle 2 to rise in the vertical direction. The compressed state of the spring ensures that the restoring force always acts on the tray 8, so that the liquid supplementing action can be triggered at the initial stage of liquid reduction. Through the fixed connection of the spring and the tray 8, the force is uniformly transmitted to the bottom of the second mobile phase bottle 2, avoiding the driving failure caused by the separation of the elastic member 4 and the bottle body.

[0053] The spring with the preset compressed state makes the elastic potential energy available at any time, and the response speed of the liquid supplementing is significantly improved. In addition, the linear elastic property of the spring can accurately adjust the driving force according to the liquid level change, avoiding the vibration of the bottle body or the splashing of the liquid caused by the sudden change of the driving force.

[0054] By the technical scheme, the application solves the problem of liquid supplement interruption caused by unstable driving of the elastic member 4, ensures that the second mobile phase bottle 2 automatically rises with the liquid level, and the mobile phase is continuously supplemented to the first mobile phase bottle 1 through the drainage pipe 7. The compression state of the spring and the fixed connection design further avoid the air bubbles that may be introduced when manually supplementing the liquid, and improve the continuity of the detection process and the reliability of the data.

[0055] The application further provides that the number of springs is two or more, and all the springs are uniformly arranged.

[0056] The uniformly arranged springs refer to that the plurality of springs are distributed in an equidistant manner along the circumference or the radius of the bottom of the second mobile phase bottle 2. Specifically, the four springs can be symmetrically arranged at the bottom of the tray 8 to achieve the equidistant distribution. The balanced support structure is formed through the symmetric arrangement. The number of springs being two or more refers to that the support component is composed of at least two independent springs. Specifically, three or four springs can be uniformly arranged around the axis of the second mobile phase bottle 2 to achieve the equidistant arrangement. The gravity load is dispersed through the multi-point support.

[0057] Specifically, when the liquid in the second mobile phase bottle 2 decreases, the plurality of springs synchronously push the tray 8 and the second mobile phase bottle 2 to move upward under the action of the elastic restoring force. Since all the springs are uniformly arranged, the compression amount of each spring is consistent, so that the force of each support point of the second mobile phase bottle 2 is uniformly distributed during the upward movement, and the bottle body is prevented from tilting due to excessive force of a single spring.

[0058] The application provides that the number of springs is two or more, and all the springs are uniformly arranged.

[0059] The application further provides that the recess 82 is arranged on the tray 8, the bottom of the second mobile phase bottle 2 is clamped and fixed in the recess 82, and the elastic member 4 is uniformly arranged around the recess 82.

[0060] The recess 82 refers to a fixed structure matched with the shape of the bottom of the second mobile phase bottle 2. Specifically, the recess 82 can be implemented by an annular groove or a rectangular groove with an inner wall limiting function. The inner diameter of the recess 82 is slightly smaller than the outer diameter of the bottle bottom to achieve the interference fit. The uniformly arranged elastic member 4 around the recess 82 refers to that the plurality of elastic support units are distributed in an equidistant manner along the circumference of the recess 82. Specifically, the springs can be symmetrically arranged around the recess 82, and the axis direction of the spring is parallel to the central axis of the recess 82.

[0061] Specifically, after the second mobile phase bottle 2 is embedded in the groove 82, the inner wall of the groove 82 is in contact with the outer side of the bottle body to constrain the displacement freedom of the bottle body in the horizontal plane. When the liquid in the second mobile phase bottle 2 decreases, the restoring force generated by the elastic member 4 is transmitted to the bottom of the bottle body through the edges of the groove 82. Since the elastic member 4 is uniformly distributed around the groove 82, the forces of the support points on the bottle body are balanced in the circumferential direction, avoiding the generation of asymmetric moments. The spatial cooperation relationship between the groove 82 and the elastic member 4 makes the bottle body always keep vertical movement during the rising process, preventing the dislocation or sealing failure of the connection between the drainage tube 7 and the bottle body due to uneven force.

[0062] The present scheme forms a double positioning mechanism through the mechanical limiting function of the groove 82 and the symmetrical arrangement of the elastic member 4, overcomes the instability of the single elastic support structure, and ensures the controllability of the movement trajectory of the bottle body during the liquid supplementing process.

[0063] Through the above technical scheme, the present application effectively solves the deviation problem of the second mobile phase bottle 2 during the liquid supplementing process due to uneven force. The physical limiting function of the groove 82 and the symmetrical support of the elastic member 4 cooperate to make the bottle body always keep vertical state during the lifting process, avoiding the interruption of liquid delivery or the mixing of bubbles caused by inclination, and improving the reliability of the liquid supplementing process and the stability of the equipment operation.

[0064] The present application further proposes that the drainage tube 7 comprises an integrally formed horizontal section 71, a first vertical section 72 and a second vertical section 73, the first vertical section 72 and the second vertical section 73 are communicated at both ends of the horizontal section 71, the first vertical section 72 extends into the bottle bottom of the first mobile phase bottle 1, and the second vertical section 73 extends into the bottle bottom of the second mobile phase bottle 2.

[0065] The horizontal section 71 refers to a transverse pipeline connecting the two vertical sections, which can be realized by bending a metal pipe or a hard plastic pipe, and serves as the main channel for liquid transmission to reduce the number of interfaces caused by segmented splicing.

[0066] The first vertical section 72 refers to a vertical pipeline extending downward from one end of the horizontal section 71, which can be realized by integrally forming the same material as the horizontal section 71, and extends into the bottom of the first mobile phase bottle 1 to directly contact the liquid, ensuring that the liquid can still be continuously extracted when the liquid level drops.

[0067] The second vertical section 73 refers to a vertical pipeline extending downward from the other end of the horizontal section 71, which can be realized by synchronous injection molding with the horizontal section 71, and extends into the bottom of the second mobile phase bottle 2 to keep the end of the pipeline always immersed in the liquid, avoiding the entry of gas into the pipeline due to the change of liquid level during the liquid supplementing process.

[0068] Specifically, the horizontal section 71 serves as the main channel for liquid flow, and under the action of the negative pressure device 5, the liquid flows from the second flow phase bottle 2 through the second vertical section 73 into the horizontal section 71, and then is transported to the first flow phase bottle 1 through the first vertical section 72. The end of the first vertical section 72 is located at the bottom of the first flow phase bottle 1, which ensures that the liquid is extracted from the lowest position and avoids the exposure of the pipeline to cause bubbles after the liquid level is lowered. The end of the second vertical section 73 remains submerged when it rises in the second flow phase bottle 2, preventing the liquid flow from being interrupted. The one-piece structure eliminates the connection points of the traditional multi-section spliced pipeline, reduces the risk of leakage, and reduces the sealing failure caused by alignment errors during installation.

[0069] The present scheme completely avoids the leakage problem of spliced interfaces through the one-piece structure of the drainage pipe 7, and ensures stable transmission of the liquid from the bottom at all times through the design of the vertical section deep into the bottle bottom, avoiding the generation of bubbles.

[0070] Through the above structure, the mobile phase is continuously and stably transmitted without bubbles during liquid supplementing, and the pipeline installation steps are simplified and the system reliability is improved.

[0071] The present application further proposes that the first flow phase bottle 1 is threadedly connected with a first bottle cap 11 at the bottle mouth, and the first bottle cap 11 is provided with three through holes for the first vertical section 72, the liquid outlet pipe 10 and the air pipe to pass through, respectively.

[0072] Among them, the threaded connection refers to the detachable connection of two components through the cooperation of internal and external threads, which ensures the sealing while facilitating the installation and removal of the bottle cap.

[0073] Specifically, the first bottle cap 11 is detachably and sealingly connected with the bottle mouth through threads, and when the first vertical section 72 of the drainage pipe 7, the liquid outlet pipe 10 and the air pipe 6 pass through the corresponding through holes, respectively, the outer surface of the pipe wall forms an interference fit with the silica gel sealing ring in the through hole, and under the action of the axial locking force, the liquid and the gas are independently sealed. The bottom of the drainage pipe 7 extends to the inner bottom of the first flow phase bottle 1, the liquid outlet pipe 10 is connected to the liquid delivery system of the chromatograph, and the air pipe 6 is connected to the interface of the negative pressure device 5, and the sealing isolation state of the three at the bottle cap avoids the cross interference of the pipelines. During the screwing process of the bottle cap, the axial pressure generated by the threads causes the radial deformation of the sealing ring, which fills the assembly gap between the pipeline and the through hole, forming multiple sealing interfaces.

[0074] Through the above technical scheme, the present application realizes the integrated sealing installation of the three functional pipelines at a single bottle cap, eliminating the leakage risk caused by the split connection structure. The threaded connection enables the bottle cap to be repeatedly disassembled and maintains airtightness, and the interference fit of the silica gel sealing ring and the pipeline effectively blocks the entry of external air into the flow phase liquid path. This structure reduces the assembly complexity of multiple pipeline interfaces and avoids the bubble pollution problem caused by sealing failure in manual liquid supplementing operations.

[0075] The second flow phase bottle 2 is further provided with a second bottle cap 12 screwed at the bottle mouth, and a sealing hole is arranged on the second bottle cap 12, the second vertical section 73 passes through the sealing hole, and a sliding sealing ring is arranged between the sealing hole and the second vertical section 73.

[0076] The sliding sealing ring refers to a sealing element with axial sliding capability, and can be a U-shaped shaft seal made of polytetrafluoroethylene, for example, an interference fit structure with an inner diameter smaller than the outer diameter of the drainage tube 7 by 0.2 mm, which is used to maintain dynamic sealing during the axial displacement of the pipeline.

[0077] Specifically, the second bottle cap 12 is screwed at the bottle mouth of the second flow phase bottle 2, and the preliminary sealing of the bottle mouth is achieved by the pre-tightening force generated by screwing. A penetrating sealing hole is arranged at the center of the second bottle cap 12, and the second vertical section 73 of the drainage tube 7 extends to the bottom of the bottle through the hole. A sliding sealing ring is installed in the annular gap between the sealing hole and the drainage tube 7, the inner wall of the sealing ring is in contact with the outer wall of the drainage tube 7 to achieve sealing, and the outer wall forms an interference fit with the inner wall of the hole. When the second flow phase bottle 2 is vertically displaced by the elastic member 4, the drainage tube 7 remains in a stationary state, the sliding sealing ring axially slides on the surface of the drainage tube 7, and simultaneously compensates for the displacement amount of the bottle body through elastic deformation. The mechanical constraint generated by screwing can prevent the bottle cap from loosening due to pipeline stress, and ensure the continuous and effective sealing interface.

[0078] The application further provides that the bottom of the liquid outlet pipe 10 is fixedly connected with a filter part 9.

[0079] The liquid outlet pipe 10 refers to a liquid delivery pipeline connecting the flow phase bottle and the detection instrument, which can be made of polytetrafluoroethylene or glass material with chemical corrosion resistance, and is used to deliver the flow phase to the detection system. The structure design of the fixedly connected bottom ensures the sealing integrity of the liquid flow path.

[0080] The filter part 9 refers to a filtering device with impurity interception function, which can be a microporous filter membrane with a pore size of 0.22 microns or a sintered filter element, and is fixed at the end of the liquid outlet pipe 10 by screwing or buckling, and is used to intercept undissolved particulate matter or residual impurities in the flow phase.

[0081] Specifically, when the flow phase is output from the liquid outlet pipe 10, the liquid needs to pass through the filter part 9 for final filtration. The fixed connection of the filter part 9 and the liquid outlet pipe 10 avoids the loosening or leakage problems that may exist in the traditional detachable filter head. When the liquid flows through the filter part 9, the microporous filter membrane or filter element can intercept particulate matter with a diameter greater than its pore size. The fixedly connected filter part 9 forms the last physical barrier before the flow phase enters the high-pressure pump, ensuring the cleanliness of the liquid entering the chromatographic column, thereby preventing pipeline blockage or detection signal interference by impurities.

[0082] The scheme directly filters the mobile phase output link in real time through the end fixed filtering mode, without relying on external filtering equipment or frequently replacing filter heads, thus simplifying the operation process and improving the filtering reliability.

[0083] Through the above technical scheme, the pump valve blockage problem caused by particulate matter entering the high-pressure infusion system can be effectively avoided, baseline noise or chromatographic peak abnormality caused by mobile phase pollution can be reduced, and the stability and accuracy of detection data can be ensured.

[0084] In the description of the specification, the specific features, structures or characteristics can be combined in any one or more embodiments or examples in a suitable manner.

[0085] In the description of the specification, the description of the terms "one embodiment", "some embodiments", "example", "specific example" or "some examples" means that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the utility model. In the description, the illustrative description of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art can combine and combine the different embodiments or features of the embodiments or examples described in the specification without contradiction.

[0086] The above is only a specific embodiment of the utility model, but the protection scope of the utility model is not limited to this, any skilled person in the art can easily think of changes or replacements within the technical range disclosed by the utility model, which should be covered in the protection scope of the utility model. Therefore, the protection scope of the utility model should be subject to the protection scope of the claims.

Claims

1. A mobile phase bottle assembly with automatic liquid replenishment, characterized in that, It includes a first mobile phase bottle, a second mobile phase bottle, a base, an elastic element, a negative pressure device, and a suction pipe, wherein: The first mobile phase bottle is sealed and connected to a liquid outlet pipe that provides the mobile phase to the instrument. The air extraction pipe is connected to the negative pressure device and the space above the liquid level in the first mobile phase bottle. The air extraction pipe is used to extract air from the first mobile phase bottle. The second mobile phase bottle is connected to the first mobile phase bottle through a drain tube, the two ends of which extend to the bottom of the first mobile phase bottle and the bottom of the second mobile phase bottle, respectively. At least the bottom of the second mobile phase bottle is located inside the base. The bottom end of the elastic member is fixed inside the base, and the upper end of the elastic member is fixedly connected to the bottom of the second mobile phase bottle. When the liquid in the second mobile phase bottle decreases, the elastic member is used to drive the second mobile phase bottle to rise.

2. The self-replenishing mobile phase bottle assembly of claim 1, wherein, The automatically replenishable mobile phase bottle assembly also includes a tray, on which the second mobile phase bottle is positioned.

3. The self-replenishing mobile phase bottle assembly of claim 2, wherein, The tray is equipped with a slider, and the base is provided with guide rails on opposite sides. The guide rails are vertically arranged, and the slider is slidably connected to the guide rails.

4. The self-replenishing mobile phase bottle assembly of claim 2, wherein, The elastic element includes a spring, the upper end of which is fixedly connected to the bottom of the tray, and the spring is in a compressed state.

5. The self-replenishing mobile phase bottle assembly of claim 4, wherein, The number of springs is two or more, and all the springs are arranged at even intervals.

6. The self-replenishing mobile phase bottle assembly of claim 2, wherein, The tray is provided with a groove, the bottom of the second flow phase bottle is snapped and fixed in the groove, and the elastic element is evenly arranged around the groove.

7. The self-replenishing mobile phase bottle assembly of claim 1, wherein, The drainage tube includes an integrally formed horizontal section, a first vertical section, and a second vertical section, wherein: The first vertical segment and the second vertical segment are connected to the two ends of the horizontal segment. The first vertical segment extends into the bottom of the first flowing phase bottle, and the second vertical segment extends into the bottom of the second flowing phase bottle.

8. The auto-replenishable mobile phase bottle assembly of claim 7, wherein, The first mobile phase bottle is threadedly connected to a first cap, which has three through holes for the first vertical section, the liquid outlet pipe, and the gas pipe to pass through in a sealed manner.

9. The self-replenishing mobile phase bottle assembly of claim 7, wherein, The second mobile phase bottle is threadedly connected to a second cap at its neck. The second cap has a sealing perforation through which the second vertical section passes, and a sliding sealing ring is provided between the sealing perforation and the second vertical section.

10. The self-replenishing mobile phase bottle assembly of claim 1, wherein, The bottom of the liquid outlet pipe is fixedly connected to a filter section.

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