Biopharmaceutical reaction kettle

Abstract

The utility model discloses a biopharmaceutical reaction kettle which comprises a base plate, vertical plates are symmetrically and fixedly mounted at the top of the base plate, a kettle body is arranged between the vertical plates, a first connecting shaft is fixedly mounted on one side of the kettle body, and a second connecting shaft is symmetrically and fixedly mounted on the other side of the kettle body. Biopharmaceutical raw materials are added into the inner kettle body of the kettle body through different adding ports of the kettle cover, a sealing plate covers the kettle cover, a first motor and a second motor work, the first motor drives a stirring shaft to rotate, the stirring shaft stirs the raw materials through a first stirring rod, a second stirring rod and a third stirring rod which are fixedly connected with the side wall, and meanwhile, the raw materials are uniformly stirred. The output end of the second motor drives the rotating wheel to rotate, the rotating wheel drives the rotating disc to swing back and forth through the connecting pin and the connecting rod, and the rotating disc swinging back and forth drives the kettle body to swing back and forth through the first connecting shaft, so that biopharmaceutical raw materials in the kettle body are fully mixed, and the raw materials react more uniformly and fully.

Description

Technical Field

[0001] This utility model relates to the field of reaction vessel technology, specifically a biopharmaceutical reaction vessel. Background Technology

[0002] Reactors are widely used in petroleum, chemical, rubber, pesticide, dye, pharmaceutical, and food industries as pressure vessels to complete processes such as vulcanization, nitration, hydrogenation, hydrocarbonation, polymerization, and condensation. Examples include reactors, reaction vessels, decomposers, and polymerization kettles. Materials typically include carbon manganese steel, stainless steel, zirconium, nickel-based alloys (Hastelloy, Monel, Inconel), and other composite materials. In a broad sense, a reactor is a stainless steel container where physical or chemical reactions occur. The structural design and parameter configuration of the container are tailored to different process requirements. Design conditions, processes, inspection, manufacturing, and acceptance must adhere to relevant technical standards to achieve the heating, evaporation, cooling, and low-to-high-speed mixing reaction functions required by the process.

[0003] However, current biopharmaceutical reactors often rely on stirring to mix biopharmaceutical raw materials during operation. Since the reactor cannot be shaken, the mixing efficiency is relatively low. To address this issue, a new biopharmaceutical reactor has been proposed. Utility Model Content

[0004] The purpose of this invention is to provide a biopharmaceutical reaction vessel to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, this utility model provides the following technical solution:

[0006] A biopharmaceutical reactor includes a base plate. Vertical plates are symmetrically fixedly mounted on the top of the base plate, and a reactor body is disposed between the vertical plates. A first connecting shaft is fixedly mounted on one side of the reactor body, and a second connecting shaft is symmetrically fixedly mounted on the other side of the reactor body. The first and second connecting shafts are rotatably connected to their respective vertical plates via bearings. The end of the first connecting shaft passes through the corresponding vertical plate, and a turntable is fixedly connected to one end of the first connecting shaft outside the vertical plate. A second motor is disposed below the first connecting shaft and fixedly mounted on the corresponding vertical plate. A wheel is fixedly connected to the output end of the second motor through the vertical plate. A connecting rod is disposed between the wheel and the turntable, and connecting rods are connected at both ends. The connecting rod has connecting pins at both ends, which are connected to the connecting holes on the turntable and the wheel at different eccentric distances. The connecting rod is hinged to the corresponding turntable and wheel by connecting pins at both ends. The top of the vessel is fixedly installed with a vessel cover by bolts. The top of the vessel cover is fixedly installed with a first motor. The bottom of the vessel cover is rotatably connected to a stirring shaft. The top of the stirring shaft passes through the vessel cover and is fixedly connected to the output end of the first motor. The side wall of the stirring shaft is fixedly installed with a first stirring rod, a second stirring rod, and a third stirring rod inside the vessel. The vessel cover has different addition ports. The end of the addition port is fixedly installed with a sealing plate by bolts. The discharge port of the vessel is installed with a discharge valve.

[0007] As a further embodiment of this utility model: a first scraper and a second scraper are provided inside the vessel body, and the first scraper and the second scraper are in contact with the inner wall of the vessel body and the inner wall of the vessel lid.

[0008] As a further improvement of this utility model, the top of the first scraper is higher than the bottom of the second scraper.

[0009] As a further embodiment of this utility model: the vessel body includes an outer vessel body and an inner vessel body, the top and bottom of the inner vessel body are fixedly connected to the outer vessel body by bolts, and the discharge valve is fixedly installed at the discharge port at the bottom of the inner vessel body.

[0010] As a further embodiment of this utility model: the vessel body includes an outer vessel body and an inner vessel body, the top and bottom of the inner vessel body are fixedly connected to the outer vessel body by bolts, and the discharge valve is fixedly installed at the discharge port at the bottom of the inner vessel body.

[0011] As a further improvement of this utility model, an observation window is provided on the top of the kettle lid.

[0012] As a further improvement of this utility model, lifting rings are symmetrically fixedly installed on the top of the kettle lid.

[0013] Compared with the prior art, the beneficial effects of this utility model are:

[0014] 1. In use, the biopharmaceutical raw materials are added into the inner body of the vessel through different addition ports on the lid. After the sealing plate is closed, the first motor and the second motor operate. The first motor drives the stirring shaft to rotate. The stirring shaft stirs the raw materials through the first stirring rod, the second stirring rod, and the third stirring rod fixedly connected to the side wall. At the same time, the output end of the second motor drives the rotating wheel to rotate. The rotating wheel drives the turntable to swing back and forth through the connecting pin and the connecting rod. The swinging turntable drives the vessel body to swing back and forth through the first connecting shaft, thereby making the biopharmaceutical raw materials in the vessel fully mixed and making the raw material reaction more uniform and complete.

[0015] 2. In this utility model, the connecting rod is connected to the connecting holes of the rotating wheel with different eccentricities through the connecting pin, so as to adjust the swing amplitude of the vessel body.

[0016] 3. In this invention, the heat exchange medium is delivered to the heat exchange coil through the feed inlet. The heat exchange coil increases the heat exchange area and exchanges heat with the inner cavity of the outer vessel, thereby achieving heat exchange with the inner vessel. This is beneficial for providing constant temperature during pharmaceutical reactions and ensuring the efficiency of biopharmaceutical production.

[0017] 4. When the stirring shaft rotates, the rotating stirring shaft, through the first stirring rod, the second stirring rod, and the third stirring rod, drives the first scraper and the second scraper to rotate, cleaning the inner wall of the inner vessel body and the inner wall of the vessel lid, thus preventing the raw materials from sticking to the inner wall of the inner vessel body and the inner wall of the vessel lid. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the structure of a biopharmaceutical reactor.

[0019] Figure 2 This is a cross-sectional view of the vessel body in a biopharmaceutical reactor.

[0020] Figure 3 This is a schematic diagram of the transmission mechanism in a biopharmaceutical reactor.

[0021] In the diagram: 1. Base plate; 2. Vertical plate; 3. Cauldron body; 4. Cauldron lid; 5. First motor; 6. First connecting shaft; 7. Second connecting shaft; 8. Turntable; 9. Connecting rod; 10. Rotary wheel; 11. Second motor; 12. Feed inlet; 13. Discharge outlet; 14. Addition port; 15. Sealing plate; 16. Observation window; 17. Lifting ring; 18. Outer cauldron body; 19. Inner cauldron body; 20. Discharge valve; 21. Stirring shaft; 22. First scraper; 23. First stirring rod; 24. Second stirring rod; 25. Second scraper; 26. Third stirring rod; 27. Heat exchange coil; 28. Connecting pin; 29. ​​Connecting hole. Detailed Implementation

[0022] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0023] Please see Figures 1-3 In this embodiment of the present invention, a biopharmaceutical reactor includes a base plate 1. Vertical plates 2 are symmetrically fixedly mounted on the top of the base plate 1. A reactor body 3 is disposed between the vertical plates 2. A first connecting shaft 6 is fixedly mounted on one side of the reactor body 3, and a second connecting shaft 7 is symmetrically fixedly mounted on the other side of the reactor body 3. The first connecting shaft 6 and the second connecting shaft 7 are rotatably connected to the corresponding vertical plates 2 via bearings with mounting seats. The end of the first connecting shaft 6 passes through the corresponding vertical plate 2, and a turntable 8 is fixedly connected to one end of the first connecting shaft 6 outside the vertical plate 2. A second motor 11 is disposed below the first connecting shaft 6 and is fixedly mounted on the corresponding vertical plate 2. A rotating wheel 10 is fixedly connected to the output end of the second motor 11 through the vertical plate 2. A connecting rod 9 is disposed between the rotating wheel 10 and the turntable 8. Connecting pins 28 are provided through both ends of the connecting rod 9. A connecting hole 29 is eccentrically opened on the turntable 8, and the rotating wheel 10 is provided with different eccentric distances. The connecting hole 29 and the connecting pins 28 at both ends of the connecting rod 9 are connected to the connecting hole 29 on the turntable 8 and the rotating wheel 10, so that the connecting rod 9 is hinged to the corresponding turntable 8 and rotating wheel 10. The top of the vessel body 3 is fixedly installed with the vessel cover 4 by bolts. The top of the vessel cover 4 is fixedly installed with the first motor 5. The bottom of the vessel cover 4 is rotatably connected with the stirring shaft 21. The top end of the stirring shaft 21 passes through the vessel cover 4 and is fixedly connected to the output end of the first motor 5. The side wall of the stirring shaft 21 is fixedly installed with the first stirring rod 23, the second stirring rod 24 and the third stirring rod 26 inside the vessel body 3. The vessel cover 4 is provided with different addition ports 14. The end of the addition port 14 is fixedly installed with the sealing plate 15 by bolts. The discharge port of the vessel body 3 is installed with the discharge valve 20. The vessel body 3 includes an outer vessel body 18 and an inner vessel body 19. The top and bottom of the inner vessel body 19 are fixedly connected to the outer vessel body 18 by bolts. The discharge valve 20 is fixedly installed at the discharge port at the bottom of the inner vessel body 19.

[0024] In use, biopharmaceutical raw materials are added into the inner vessel 19 of the vessel body 3 through different addition ports 14 of the vessel lid 4. After the sealing plate 15 is closed, the first motor 5 and the second motor 11 work. The first motor 5 drives the stirring shaft 21 to rotate. The stirring shaft 21 stirs the raw materials through the first stirring rod 23, the second stirring rod 24 and the third stirring rod 26 fixedly connected to the side wall. At the same time, the output end of the second motor 11 drives the rotating wheel 10 to rotate. The rotating wheel 10 drives the turntable 8 to swing back and forth through the connecting pin 28 and the connecting rod 9. The swinging turntable 8 drives the vessel body 3 to swing back and forth through the first connecting shaft 6, thereby making the biopharmaceutical raw materials in the vessel body 3 fully mixed and making the raw material reaction more uniform and complete. The connecting rod 9 is connected to the connecting holes 29 of the rotating wheel 10 with different eccentricities through the connecting pin 28 to adjust the swing amplitude of the vessel body 3.

[0025] The vessel body 3 is provided with a first scraper 22 and a second scraper 25. The first scraper 22 and the second scraper 25 are in contact with the inner wall of the vessel body 3 and the inner wall of the vessel lid 4. The top of the first scraper 22 is higher than the bottom of the second scraper 25. When the stirring shaft 21 rotates, the rotating stirring shaft 21 drives the first scraper 22 and the second scraper 25 to rotate through the first stirring rod 23, the second stirring rod 24 and the third stirring rod 26, so as to clean the inner walls of the inner vessel body 19 and the vessel lid 4 and prevent the raw materials from sticking to the inner walls of the inner vessel body 19 and the vessel lid 4.

[0026] The outer vessel body 18 is provided with a heat insulation layer on its outer wall. A heat exchange coil 27 is fixedly installed inside the outer vessel body 18. The two ends of the heat exchange coil 27 extend out of the outer vessel body 18 and are respectively fixedly connected to the inlet 12 and the outlet 13. The inlet 12 and the outlet 13 are connected to the input and output ports of the circulating heating device through connecting pipes. The heat exchange medium is transported to the heat exchange coil 27 through the inlet 12. The heat exchange coil 27 increases the heat exchange area and exchanges heat with the inner cavity of the outer vessel body 18, thereby achieving heat exchange with the inner vessel body 19. This is beneficial for providing a constant temperature during the pharmaceutical reaction and ensuring the efficiency of biopharmaceutical production.

[0027] The top of the lid 4 is provided with an observation window 16, through which staff can observe the condition inside the body 3, facilitating their judgment.

[0028] The top of the vessel lid 4 is symmetrically fixed with lifting rings 17, which are connected to the lifting end of the lifting mechanism to facilitate the assembly and disassembly of the vessel lid 4.

[0029] Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A biopharmaceutical reactor vessel comprising a base plate (1), characterized in that: The vertical plate (2) is symmetrically and fixedly installed on the top of the substrate (1), the kettle body (3) is arranged between the vertical plates (2), the first connecting shaft (6) is fixedly installed on one side of the kettle body (3), the second connecting shaft (7) is symmetrically and fixedly installed on the other side of the kettle body (3), the first connecting shaft (6) and the second connecting shaft (7) are rotationally connected with the corresponding vertical plate (2) through a bearing with a seat, the end of the first connecting shaft (6) penetrates through the corresponding vertical plate (2), and one end of the first connecting shaft (6) outside the vertical plate (2) is fixedly connected with the rotating disc (8), the second motor (11) is arranged below the first connecting shaft (6), the second motor (11) is fixedly installed on the corresponding vertical plate (2), the output end of the second motor (11) penetrates out of the vertical plate (2) and is fixedly connected with the rotating wheel (10), the connecting rod (9) is arranged between the rotating disc (8) and the rotating wheel (10), the connecting pins (28) are arranged at the two ends of the connecting rod (9), the connecting holes (29) are arranged eccentrically on the rotating disc (8), the connecting holes (29) with different eccentric distances are arranged on the rotating wheel (10), the connecting pins (28) at the two ends of the connecting rod (9) are connected with the connecting holes (29) arranged on the rotating disc (8) and the rotating wheel (10), so that the connecting rod (9) is hinged with the corresponding rotating disc (8) and rotating wheel (10), the kettle cover (4) is fixedly installed on the top of the kettle body (3) through bolts, the first motor (5) is fixedly installed on the top of the kettle cover (4), the stirring shaft (21) is rotationally connected to the bottom of the kettle cover (4), the top end of the stirring shaft (21) penetrates out of the kettle cover (4) and is fixedly connected with the output end of the first motor (5), the first stirring rod (23), the second stirring rod (24) and the third stirring rod (26) are fixedly installed on the side wall of the stirring shaft (21) in the kettle body (3), different adding openings (14) are arranged on the kettle cover (4), the end of the adding opening (14) is fixedly installed with the sealing plate (15) through bolts, and the discharge valve (20) is installed on the discharge opening of the kettle body (3).

2. The biopharmaceutical reaction vessel of claim 1, wherein: The first scraper (22) and the second scraper (25) are arranged in the kettle body (3) and are attached to the inner wall of the kettle body (3) and the inner wall of the kettle cover (4).

3. The biopharmaceutical reaction vessel of claim 2, wherein: The top end of the first scraper (22) is higher than the bottom end of the second scraper (25).

4. The biopharmaceutical reaction vessel of claim 1, wherein: The kettle body (3) comprises an outer kettle body (18) and an inner kettle body (19), the top and bottom of the inner kettle body (19) are fixedly connected with the outer kettle body (18) through bolts, and the discharge valve (20) is fixedly installed at the discharge opening at the bottom end of the inner kettle body (19).

5. The biopharmaceutical reaction vessel of claim 4, wherein: The outer wall of the outer kettle body (18) is provided with a heat insulation layer, and the heat exchange coil (27) is fixedly installed in the outer kettle body (18), and the heat exchange coil (27) penetrates out of the outer kettle body (18) at both ends and is fixedly connected with the feeding opening (12) and the discharge opening (13) respectively.

6. The biopharmaceutical reaction vessel of claim 1, wherein: An observation window (16) is arranged on the top of the kettle cover (4).

7. The biopharmaceutical reaction vessel of claim 1, wherein: Symmetrical lifting rings (17) are fixedly installed on the top of the kettle cover (4).

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