Diffusion cell for drug transdermal tester

Abstract

The utility model relates to the technical field of transdermal testers, and discloses a diffusion cell for a drug transdermal tester, which comprises a base, the rear side of the top of the base is fixedly connected with an outer shell, the left side of the top of the outer shell is fixedly connected with a top shell, the top of the left side of the base is provided with a reaction cell, the top of the reaction cell is fixedly connected with a test plate, and the test plate is fixedly connected with the outer shell. The front side of the interior of the top shell is fixedly connected with a hydraulic press, the bottom of the hydraulic press is fixedly connected with a push rod, the interior of the push rod is fixedly connected with a converter, the bottom of the converter communicates with a plurality of puncture pipes, and the bottoms of the puncture pipes are fixedly connected with an inner three-hole puncture outfit; the outer wall of the inner three-hole puncture outfit is connected with a rebound device in a sliding mode. According to the device, the puncture depth is accurately controlled through the hydraulic press, the suction amount is stably controlled through the self-priming pump, the accuracy of the puncture amount is improved, experimental errors are reduced, and reliable data support is provided for a drug transdermal test.

Description

Technical Field

[0001] This utility model relates to the field of transdermal testing instrument technology, and in particular to a diffusion cell for a drug transdermal testing instrument. Background Technology

[0002] A diffusion cell for a drug transdermal testing instrument is a component in the field of drug transdermal research. In the drug development process, the diffusion cell can simulate the permeation environment of human skin. By placing the drug in a specific diffusion chamber, the drug can pass through the simulated skin layer under suitable conditions. Researchers can accurately measure the parameters of the drug's transdermal flux, thereby evaluating the drug's transdermal performance. The device is useful for optimizing drug formulations and improving the effectiveness of transdermal drug delivery equipment.

[0003] In existing diffusion cell technology for transdermal drug testing instruments, the puncture sampling process is generally carried out manually. When the receiving cell reaches a specific experimental time point, the operator uses a simple syringe to extract liquid samples through the pre-set puncture port in the receiving cell. This operation relies on human experience and requires the operator to accurately control the angle and depth of the puncture to ensure that a representative sample can be obtained for subsequent drug concentration analysis to help determine the transdermal effect of the drug.

[0004] Existing transdermal drug delivery systems suffer from uneven sampling during puncture using diffusion cells. With current manual puncture methods, operators rely entirely on their sense of touch to control the extraction volume due to the lack of precise quantitative extraction devices. Within the receiving cell, the drug, after transdermal diffusion, is not uniformly distributed; the drug concentration is higher near the simulated skin membrane and lower further away. When operators perform puncture sampling, variations in puncture location make it difficult to precisely control the puncture position and extraction volume, resulting in significant differences in the obtained sample drug concentration. This fails to accurately reflect the overall transdermal diffusion of the drug within the receiving cell, severely impacting the accuracy of transdermal drug throughput measurements and hindering the provision of reliable data support for drug development. Utility Model Content

[0005] To overcome the above shortcomings, this utility model provides a diffusion cell for a transdermal drug testing instrument, which aims to improve the problem of uneven puncture sampling in the prior art.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: a diffusion cell for a transdermal drug testing instrument, comprising a base, a shell fixedly connected to the top rear side of the base, a top shell fixedly connected to the top left side of the shell, a reaction cell disposed on the top left side of the base, a test plate fixedly connected to the top of the reaction cell, a hydraulic device fixedly connected to the inner front side of the top shell, a push rod fixedly connected to the bottom of the hydraulic device, a converter fixedly connected to the inside of the push rod, a plurality of puncture tubes connected to the bottom of the converter, an internal three-hole puncturist fixedly connected to the bottom of the plurality of puncture tubes, a rebound device slidably connected to the outer wall of the internal three-hole puncturist, a curved tube connected to the top of the converter and penetrating the inner rear side of the push rod, a self-priming pump fixedly connected to the rear end of the push rod, and a detection mechanism disposed at the bottom front left end of the top shell, the detection mechanism being used to improve the safety of the device operation.

[0007] As a further description of the above technical solution:

[0008] The detection mechanism includes an air intake shell, the top of which is fixedly connected to the bottom front left end of the top shell. Fixed rods are fixedly connected to the upper and lower sides of the interior of the air intake shell. A fan is rotatably connected between the middle of two adjacent fixed rods. Data bars penetrate the left and right sides of the inner wall of the air intake shell. Detection plates are fixedly connected between adjacent data bars. Detection lights are fixedly connected to the opposite sides of the two data bars. A data cable is connected to the top right side of the outer wall of the air intake shell, and a controller is fixedly connected to the rear end of the data cable.

[0009] As a further description of the above technical solution:

[0010] The self-priming pump is connected to a distributor on its right side, and the bottom of the distributor is connected to an outlet that extends through the interior of the casing.

[0011] As a further description of the above technical solution:

[0012] A storage slot is provided in the middle of the front side of the outer casing, and an observation window is slidably connected to the front side of the storage slot.

[0013] As a further description of the above technical solution:

[0014] A rubber pad is fixedly connected inside the storage tank, and a memory is disposed on the top of the rubber pad.

[0015] As a further description of the above technical solution:

[0016] A reaction seat is fixedly connected to the top left side of the base, and supports are fixedly connected to the top left and right sides of the reaction seat. A reaction pool is slidably connected between adjacent supports.

[0017] As a further description of the above technical solution:

[0018] The front and upper / lower ends of the reaction tank are both fixedly connected to connecting hoses, and the front ends of the two connecting hoses are both fixedly connected to circulation hoses.

[0019] As a further description of the above technical solution:

[0020] A circulating heater is fixedly connected to the inner left end of the base, and a processor is fixedly connected to the top right side of the base.

[0021] This utility model has the following beneficial effects:

[0022] 1. In this utility model, in the diffusion cell of the transdermal drug transdermal testing instrument, the hydraulic device pushes the push rod down, and the internal three-hole puncture device approaches the test plate. The self-priming pump provides suction to the internal three-hole puncture device through the curved tube and the converter. During the puncture process, the rebound device plays a buffering and resetting role. In the past, the puncture volume was often inaccurate due to manual operation or simple instruments. The device accurately controls the puncture depth through the hydraulic device and stably controls the suction volume through the self-priming pump, thereby improving the accuracy of the puncture volume.

[0023] 2. In this utility model, real-time monitoring and accurate alarm of harmful substances in puncture experiments are realized. The fan absorbs air in the experimental environment to improve detection efficiency. The detection strip can capture harmful substances. The detection light is switched between green safety light and red danger light by the controller to promptly remind staff and deal with the leakage of harmful gases and the failure of the device, effectively ensuring the safety of experimental personnel and experimental environment. Attached Figure Description

[0024] Figure 1 This is a three-dimensional view of a diffusion cell for a transdermal drug testing instrument proposed in this utility model;

[0025] Figure 2 This is a front view of a diffusion cell for a transdermal drug testing instrument proposed in this utility model;

[0026] Figure 3 This is a cross-sectional view of the detection mechanism of the diffusion cell for a drug transdermal testing instrument proposed in this utility model;

[0027] Figure 4 This is a cross-sectional view of a rebound spring for a diffusion cell in a transdermal drug testing instrument proposed in this utility model;

[0028] Figure 5 This is a top view of a diffusion cell for a transdermal drug testing instrument proposed in this utility model.

[0029] Legend:

[0030] 1. Base; 2. Detection mechanism; 201. Air inlet shell; 202. Fixing rod; 203. Fan; 204. Data bar; 205. Detection strip; 206. Detection light; 207. Data cable; 208. Controller; 3. Outer shell; 4. Top shell; 5. Reaction tank; 6. Test plate; 7. Hydraulic unit; 8. Converter; 9. Puncture tube; 10. Internal three-hole puncture device; 11. Rebound device; 12. Push rod; 13. Bending tube; 14. Self-priming pump; 15. Dispenser; 16. Dispenser; 17. Storage tank; 18. Observation window; 19. Memory; 20. Rubber pad; 21. Reaction seat; 22. Support; 23. Connecting hose; 24. Circulation hose; 25. Circulation heater; 26. Processor. Detailed Implementation

[0031] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0032] Reference Figure 1 , Figure 4 and Figure 5This utility model provides an embodiment of a diffusion cell for a transdermal drug testing instrument, comprising a base 1 for supporting the device, a housing 3 fixedly connected to the top rear side of the base 1 for protecting internal components, a top shell 4 fixedly connected to the top left side of the housing 3 for providing installation space for the internal hydraulic unit 7, a reaction cell 5 disposed on the top left side of the base 1 for supporting drug reaction, a test plate 6 fixedly connected to the top of the reaction cell 5 for placing the sample to be tested, a hydraulic unit 7 fixedly connected to the front inside the top shell 4 for providing power to push a push rod 12, a push rod 12 fixedly connected to the bottom of the hydraulic unit 7 for transmitting power from the hydraulic unit 7, and a converter 8 fixedly connected inside the push rod 12 for converting multiple transdermal samples into a single unit. The puncture tube 9 is converted into a delivery tube. The bottom of the converter 8 is connected to multiple puncture tubes 9, which are used to extract and transfer liquid. The bottom of the multiple puncture tubes 9 is fixedly connected to an internal three-hole puncturist 10, which accurately punctures the sample. The outer wall of the internal three-hole puncturist 10 is slidably connected to a rebounder 11, which enables the internal three-hole puncturist 10 to automatically rebound after puncture. The top of the converter 8 is connected to a curved tube 13, which passes through the inner rear side of the push rod 12. The curved tube 13 is used to transfer the extracted liquid. The rear end of the push rod 12 is fixedly connected to a self-priming pump 14, which is used to extract liquid. The bottom front left end of the top shell 4 is provided with a detection mechanism 2, which detects whether there are harmful gases in the experimental range of the reaction tank 5, thereby improving the safety of the device operation.

[0033] Specifically, in the diffusion cell of the transdermal drug transdermal testing instrument, the base 1 provides support for the device, ensuring its stable placement. The sample to be tested is placed on the test plate 6 connected to the top of the reaction cell 5. The reaction cell 5 is used to support the drug reaction. When the test begins, the hydraulic device 7 connected to the front inside the top shell 4 is activated. The hydraulic device 7 provides power for the entire puncture and liquid extraction process. The generated power is transmitted through the push rod 12 connected to the bottom. Inside the push rod 12, there is a converter 8, which converts multiple puncture tubes 9 into a single delivery tube. The multiple puncture tubes 9 connected to the bottom of the converter 8 move downward under the power transmitted by the hydraulic device 7 through the push rod 12. The internal three-hole puncture device 10 connected to the bottom of the puncture tube 9 precisely punctures the sample placed on the test plate. The sample on plate 6 is punctured. The rebound device 11 connected to the outer wall of the three-hole puncturist 10 can automatically rebound after puncture. During puncture, the liquid extracted by the puncture tube 9 enters the curved tube 13 connected to the top through the converter 8. The curved tube 13 passes through the rear side of the push rod 12 and transfers the liquid to the self-priming pump 14 connected to the rear end of the push rod 12. The self-priming pump 14 draws out the liquid for subsequent analysis and detection. At the same time, the detection mechanism 2 set at the left end of the front side of the bottom of the top shell 4 works continuously to detect the gas situation in the experimental range of the reaction tank 5 in real time. Once a hazardous gas is detected, an alarm is issued in time to improve the safety of the device operation, ensure the safety of the operators and the smooth progress of the experiment.

[0034] Reference Figure 1 , Figure 2 and Figure 3 The detection mechanism 2 includes an air inlet shell 201, which guides gas into the detection area. The top of the air inlet shell 201 is fixedly connected to the bottom front left end of the top shell 4. Fixed rods 202 are fixedly connected to the upper and lower sides of the interior of the air inlet shell 201, supporting the fan 203. The fan 203 is rotatably connected between adjacent fixed rods 202. When the fan 203 operates, it absorbs the surrounding gas. Data rods 204 penetrate the left and right sides of the inner wall of the air inlet shell 201, transmitting detection data. Each adjacent data bar 204 is fixedly connected with a detection strip 205, which can detect the composition and concentration of the passing gas. Each data bar 204 is fixedly connected with a detection lamp 206 on the side furthest from each other. The detection lamp 206 can display the detection status as a red or green light. A data line 207 is connected to the top right side of the outer wall of the air inlet shell 201. The data line 207 is used to transmit the detection data to the controller 208. The controller 208 is fixedly connected to the rear end of the data line 207. The controller 208 analyzes and processes the detection data and controls the status of the detection lamp 206.

[0035] Specifically, the detection unit 2 analyzes the gas surrounding the experiment. At startup, the inlet housing 201 serves as a gas channel, guiding the gas into the detection area. Inside the inlet housing 201, the upper and lower fixing rods 202 support the fan 203. When the fan 203 starts operating, it draws the surrounding gas into the inlet housing 201 using suction. The fan 203 is installed in the middle between the two adjacent fixing rods 202. The drawn-in gas is detected within the inlet housing 201. Two data bars 204, penetrating the left and right sides of the inner wall, play a crucial role. The data bars 204 not only transmit detection data but also provide fixed support for the detection plate 205. Connected between two adjacent data bars 204, when gas flows through the detection plate 205, it can accurately detect the gas composition and concentration, and transmit the detected data to the data bars 204 in real time. After receiving the data, the data bars 204 transmit the data to the controller 208 connected to the back end via the data cable 207. The controller 208 performs in-depth analysis and processing of the data. When the data is abnormal and harmful gas is detected, the detection light 206 changes from green to red to remind the experimenters that a leak has occurred. When the data is normal, the green light stays on, realizing the detection of the experimental environment, enhancing the safety of the experimenters and improving the stability of the experimental device.

[0036] Reference Figure 1 , Figure 2 and Figure 5 The right side of the self-priming pump 14 is connected to a liquid distributor 15, which diverts the extracted liquid downwards. The bottom of the liquid distributor 15 is connected to a liquid outlet 16 that penetrates the interior of the outer casing 3 to facilitate the discharge of liquid. A storage tank 17 is provided in the middle of the front side of the outer casing 3. The storage tank 17 is used to store the memory 19. An observation window 18 is slidably connected to the front side of the storage tank 17 to facilitate observation of the liquid receiving status in the storage tank 17. A rubber pad 20 is fixedly connected inside the storage tank 17. The rubber pad 20 plays a buffering and protective role to prevent damage to the memory 19. The memory 19 is set on the top of the rubber pad 20 to receive the measured liquid in the transdermal drug testing experiment.

[0037] Specifically, after the self-priming pump 14 starts, it draws up the liquid from the transdermal drug testing experiment. The drawn liquid is then transported to the distributor 15 via a pipe to the right. The distributor 15 splits the incoming liquid downwards to ensure stable liquid delivery. The split liquid flows out from the bottom of the distributor 15 and through the connected outlet 16, thus exporting the liquid from the top to the bottom of the device. The exported liquid is guided to the storage tank 17. The observation window 18 connected to the front of the storage tank 17 allows the experimenter to observe the internal liquid reception at any time. When the storage tank 19 is placed inside, the rubber pad 20 acts as a buffer and protector to prevent the storage tank 19 from being damaged by collisions during the handling process after the liquid is dispensed. The storage tank 19 is placed on top of the rubber pad 20 to receive the liquid exported from the outlet 16, completing the storage of the sampled liquid in the transdermal drug testing experiment and providing a reliable sample for subsequent experimental operations.

[0038] Reference Figure 1 and Figure 5 A reaction seat 21 is fixedly connected to the top left of the base 1 to provide an installation base and support for the reaction tank 5 component. Supporters 22 are fixedly connected to the top left and right sides of the reaction seat 21 to support and guide the reaction tank 5, facilitating the sliding of the reaction tank 5. The reaction tank 5 is slidably connected between the adjacent supporters 22, enabling the reaction tank 5 to move flexibly for easy handling and observation. Connecting hoses 23 are fixedly connected to the upper and lower ends of the front side of the reaction tank 5 to connect to the circulation hoses 24, enabling the flow of liquid between the reaction tank 5 and the component. The front ends of the two connecting hoses 23 are fixedly connected to the circulation hoses 24, forming a liquid circulation channel, which, together with the circulation heater 25, enables the circulation heating of the liquid. The circulation heater 25 is fixedly connected to the inner left end of the base 1 to heat the circulating liquid to meet the temperature conditions required for the reaction. A processor 26 is fixedly connected to the top right of the base 1 to control the operation and data processing of the entire equipment, enabling automated operation of the equipment.

[0039] Specifically, during equipment operation, the reaction seat 21 provides basic support. The supports 22 on the left and right sides of the top of the reaction seat 21 support the reaction tank 5, allowing the reaction tank 5 to slide between them, which facilitates the operator's handling and observation of the reaction tank 5. The reaction tank 5 is connected to the circulation hose 24 via the connecting hose 23, forming a liquid circulation channel. When heating is required, the circulation heater 25 starts working to heat the circulating liquid. The heated liquid enters the reaction tank 5 through the circulation hose 24 and the connecting hose 23, providing the required temperature conditions for the reaction. Before the equipment is put into operation, the processor 26 is used to control the overall components to work automatically and orderly. Precise control and data processing realize the automated operation of the equipment, ensuring that the entire reaction process is carried out efficiently and stably.

[0040] Working principle: When the test begins, the sample to be tested is placed on the test plate 6 on top of the reaction tank 5. The reaction tank 5 is used to carry the drug reaction. The power generated by the hydraulic device 7 is transmitted through the push rod 12. The converter 8 converts multiple puncture tubes 9 into one delivery tube. Under the action of the power transmitted by the hydraulic device 7 through the push rod 12, it moves downward. The three-hole puncturist 10 at the bottom of the puncture tube 9 accurately punctures the sample placed on the test plate 6. The rebound device 11 connected to the outer wall of the three-hole puncturist 10 can automatically rebound after puncture. The liquid extracted during the puncture process enters the curved tube 13 through the converter 8 and is transferred to the self-priming pump 14 for subsequent analysis and detection of the liquid.

[0041] The detection unit 2 analyzes the gas surrounding the experiment. At startup, the fan 203 rotates, drawing gas from the vicinity of the experiment into the intake housing 201. The fixing rod 202 on the inner wall of the intake housing 201 securely fixes the fan 203. The drawn-in gas is detected within the intake housing 201. When the gas flows through the detection plate 205, the gas composition and concentration are accurately detected, and the obtained data is transmitted in real time to the data bar 204. After receiving the data, the data bar 204 transmits the data via the data cable 207 to the controller 208 connected to the back end. The controller 208 performs in-depth analysis of the data. When abnormal data is detected and harmful gas is detected, the detection light 206 changes from green to red, alerting the experimenters to a leak. When the data is normal, the green light remains on, thus enabling real-time detection of the experimental environment, enhancing the safety of the experimenters, and improving the stability of the experimental apparatus.

[0042] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A diffusion cell for a transdermal drug testing instrument, comprising a base (1), characterized in that: A housing (3) is fixedly connected to the top rear side of the base (1), and a top shell (4) is fixedly connected to the top left side of the housing (3). A reaction pool (5) is provided on the top left side of the base (1), and a test plate (6) is fixedly connected to the top of the reaction pool (5). A hydraulic device (7) is fixedly connected to the front inside the top shell (4), and a push rod (12) is fixedly connected to the bottom of the hydraulic device (7). A converter (8) is fixedly connected inside the push rod (12), and the bottom of the converter (8) is connected to multiple... The bottom of the puncture tubes (9) is fixedly connected to an internal three-hole puncture device (10). The outer wall of the internal three-hole puncture device (10) is slidably connected to a spring (11). The top of the converter (8) is connected to a curved tube (13) and passes through the inner rear side of the push rod (12). The rear end of the push rod (12) is fixedly connected to a self-priming pump (14). A detection mechanism (2) is provided at the left end of the front side of the bottom of the top shell (4). The detection mechanism (2) is used to improve the safety of the device operation.

2. The diffusion cell for a drug transdermal testing instrument according to claim 1, characterized in that: The detection mechanism (2) includes an air intake shell (201). The top of the air intake shell (201) is fixedly connected to the bottom front left end of the top shell (4). Fixed rods (202) are fixedly connected to the upper and lower sides of the interior of the air intake shell (201). A fan (203) is rotatably connected between the middle of the two adjacent fixed rods (202). Data bars (204) penetrate the left and right sides of the inner wall of the air intake shell (201). Detection plates (205) are fixedly connected between the adjacent two data bars (204). Detection lamps (206) are fixedly connected to the opposite sides of the two data bars (204). A data cable (207) is connected to the top right side of the outer wall of the air intake shell (201). A controller (208) is fixedly connected to the rear end of the data cable (207).

3. The diffusion cell for a drug transdermal testing instrument according to claim 1, characterized in that: The right side of the self-priming pump (14) is connected to a distributor (15), and the bottom of the distributor (15) is connected to an outlet (16) that penetrates the interior of the outer casing (3).

4. The diffusion cell for a drug transdermal testing instrument according to claim 1, characterized in that: A storage slot (17) is provided in the middle of the front side of the outer shell (3), and an observation window (18) is slidably connected to the front side of the storage slot (17).

5. The diffusion cell for a drug transdermal testing instrument according to claim 4, characterized in that: A rubber pad (20) is fixedly connected inside the storage slot (17), and a memory (19) is provided on the top of the rubber pad (20).

6. The diffusion cell for a drug transdermal testing instrument according to claim 1, characterized in that: A reaction seat (21) is fixedly connected to the top left side of the base (1), and a support (22) is fixedly connected to the top left and right sides of the reaction seat (21). A reaction pool (5) is slidably connected between the two adjacent supports (22).

7. The diffusion cell for a drug transdermal testing instrument according to claim 1, characterized in that: The front upper and lower ends of the reaction tank (5) are fixedly connected with connecting hoses (23), and the front ends of the two connecting hoses (23) are fixedly connected with circulation hoses (24).

8. The diffusion cell for a drug transdermal testing instrument according to claim 1, characterized in that: A circulating heater (25) is fixedly connected to the left end of the base (1), and a processor (26) is fixedly connected to the right side of the top of the base (1).

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