Rotary evaporation equipment for preparing nicergoline impurity E

Abstract

The utility model discloses rotary evaporation equipment for preparing nicergoline impurities E, and relates to the technical field of pharmaceutical instruments. The rotary evaporation equipment comprises a base, a stand column, a clamping jaw, a connecting pipe, a rotary bottle, a first water bath container, a condenser, a collecting bottle and a second water bath container, the rotary bottle and the condenser are respectively connected with two ends of the connecting pipe; the first water bath container is pressed on the heating disc; the second water bath container is provided with a first containing cavity and a second containing cavity arranged below the first containing cavity, cooling liquid is arranged in the second containing cavity, and an electrically-driven semiconductor cooling fin is arranged on the bottom face of the second containing cavity in an inserted mode; a condensation pipe is arranged in the condenser, and the condensation pipe communicates with the second containing cavity through a conveying pipe and a liquid pump. After a mixture in the rotating bottle is heated in a water bath, an organic solvent is quickly evaporated and flows into the condenser along the connecting pipe, and then the gaseous organic solvent is in contact with the low-temperature condensing pipe, is condensed into a liquid state and drips into the collecting bottle, so that the organic solvent in the mixture is removed.

Description

TECHNICAL FIELD

[0001] The utility model relates to pharmaceutical instrument technical field, concretely relates to a rotating evaporation equipment for preparing nicergoline impurity E. BACKGROUND

[0002] Nicergoline is a drug for treating acute and chronic vascular or metabolic cerebral dysfunction.

[0003] Different impurities will be produced based on different preparation processes. Nicergoline impurity E is 10-hydroxy nicergoline. The patent "a preparation method of nicergoline impurity E" (publication number: CN 113461685 A) discloses the preparation process of nicergoline impurity E, which uses dichloromethane, acetone and the like as organic solvents, but it does not disclose the experimental equipment for removing organic solvents. SUMMARY

[0004] In order to overcome the demand of the above background technology for removing organic solvents, the utility model provides a rotating evaporation equipment for preparing nicergoline impurity E.

[0005] The utility model solves the technical scheme that the above technical problem adopts:

[0006] A rotating evaporation equipment for preparing nicergoline impurity E, including base, stand, clamping jaw, connecting pipe, rotary bottle, first water bath container, condenser, collecting bottle and second water bath container, the stand is vertically arranged on the upper surface of the base, the clamping jaw is installed on the front side of the stand and can move longitudinally, the connecting pipe is installed in the clamping jaw in an inclined manner, the rotary bottle and the condenser are connected with both ends of the connecting pipe respectively, the rotary bottle can rotate around the axis of the connecting pipe, the first water bath container is placed on the upper surface of the base directly below the rotary bottle, the upper surface of the base is provided with electrically driven heating disc, and the first water bath container is crimped on the heating disc, the collecting bottle is connected with the lower end of the condenser, the second water bath container is placed on the upper surface of the base directly below the collecting bottle, the second water bath container is provided with a first containing cavity and a second containing cavity arranged below the first containing cavity, a cooling liquid is arranged in the second containing cavity, and electrically driven semiconductor heat dissipation fins are arranged on the bottom surface of the second containing cavity, a condenser tube is arranged in the condenser, and the condenser tube is communicated with the second containing cavity through a conveying pipe and a liquid pump.

[0007] As a further optimization scheme of the utility model, the semiconductor heat dissipation fins are arranged in a straight line array with equal intervals.

[0008] As a further optimization scheme of the utility model, the base is internally provided with an air channel, and the air channel is internally provided with a heat dissipation airflow; the semiconductor heat dissipation fin comprises a heat absorbing end and a heat dissipation end, the heat absorbing end is placed in the second accommodating cavity and is in contact with the cooling liquid, and the heat dissipation end is placed in the air channel and is in contact with the heat dissipation airflow.

[0009] As a further optimization scheme of the utility model, the air channel is open at both ends.

[0010] As a further optimization scheme of the utility model, the air channel is internally provided with a heat dissipation fan blade, the heat dissipation fan blade is connected with a rotating motor, and the rotating motor is fixedly installed in the air channel through a support.

[0011] As a further optimization scheme of the utility model, the air channel is in an L-shaped structure.

[0012] As a further optimization scheme of the utility model, the connecting pipe comprises a first pipe body and a second pipe body which are coaxially arranged and can rotate relative to each other; the condenser is detachably connected and communicated with the top end of the first pipe body, and the rotary bottle is detachably connected and communicated with the bottom end of the second pipe body.

[0013] As a further optimization scheme of the utility model, the clamping claw is clamped on the outer surface of the first pipe body.

[0014] As a further optimization scheme of the utility model, the vertical column is provided with a longitudinal movement driving assembly, and the longitudinal movement driving assembly is connected with the clamping claw.

[0015] As a further optimization scheme of the utility model, the vertical column is in a shell-shaped structure with a top and a bottom being sealed, a front side wall of the vertical column is provided with a longitudinally arranged strip-shaped hole; the longitudinal movement driving assembly comprises a lead screw, a driving motor, a sliding block and an extension arm; the lead screw is vertically arranged in the inner cavity of the vertical column, the top end of the lead screw is connected with the output shaft of the driving motor, and the bottom end is connected with the inner wall of the vertical column through a bearing; the sliding block is sleeved on the surface of the lead screw and is connected through threads, the extension arm is inserted into the strip-shaped hole, and the extension arm is connected with the sliding block and the clamping claw at both ends.

[0016] In summary, the utility model has at least one of the following advantages:

[0017] (1) The utility model has simple structure and reliable function, after the mixture in the rotary bottle is heated in water bath, the organic solvent is rapidly evaporated and flows into the condenser along the connecting pipe, then the gaseous organic solvent is condensed into liquid after contacting the low-temperature condenser tube and drops into the collecting bottle, thereby realizing the removal of the organic solvent in the mixture.

[0018] (2) The cooling liquid in the second water bath container can achieve the cooling effect on the condenser tube, thereby accelerating the condensation; the cooling liquid in the second water bath container can achieve the cooling effect on the pure water in the first containing cavity, further achieving the cooling effect on the liquid organic solvent obtained by condensation in the collecting bottle, thereby reducing the evaporation of the organic solvent and avoiding the backflow of the organic solvent into the rotary bottle, thereby increasing the experimental efficiency.

[0019] (3) Unlike the natural heat dissipation form for cooling the cooling liquid in the traditional technology, the utility model adopts the electrically-driven semiconductor heat dissipation fin to cool the cooling liquid, so that the utility model can efficiently operate in a relatively high-temperature environment, thereby improving the environmental temperature compatibility of the utility model. BRIEF DESCRIPTION OF DRAWINGS

[0020] The application will be further described below in combination with the drawings:

[0021] Figure 1 It is a front view schematic diagram of the overall structure of the utility model;

[0022] Figure 2 It is a schematic diagram of the relative position and structure of the condenser and the condenser tube;

[0023] Figure 3 It is a front view schematic diagram of the vertical section of the second water bath container;

[0024] Figure 4 It is a front view schematic diagram of the vertical section of the second water bath container and the base;

[0025] Figure 5 It is a schematic diagram of the inclined view structure of the second water bath container and the semiconductor heat dissipation fin;

[0026] Figure 6 It is a schematic diagram of the connection structure of the delivery pipe and the liquid pump;

[0027] Figure 7 It is a schematic diagram of the vertical section of the vertical column and the longitudinal movement driving assembly;

[0028] Figure 8 It is a front view schematic diagram of the installation position and structure of the rotary motor.

[0029] BRIEF DESCRIPTION OF DRAWINGS

[0030] In the drawings,

[0031] 1, base; 11, heating disc; 12, air duct; 121, air inlet hole; 122, air outlet hole; 13, heat dissipation fin; 14, liquid pump;

[0032] 2, vertical column; 201, strip-shaped hole; 21, longitudinal movement driving assembly; 211, screw rod; 212, driving motor; 213, sliding block; 214, extension arm;

[0033] 3, clamping jaw; 31, first clamping finger; 311, rotary motor; 3111, drive gear; 32, second clamping finger;

[0034] 4, connecting tube; 41, first tube body; 42, second tube body; 421, tooth ring;

[0035] 5, rotary bottle;

[0036] 6, first water bath container;

[0037] 7, condenser; 71, shell; 72, condensing tube; 721, liquid inlet tube; 722, liquid outlet tube; 73, inclined tube;

[0038] 8, collection bottle;

[0039] 9, second water bath container; 901, first containing cavity; 902, second containing cavity; 903, cooling liquid; 91, semiconductor heat sink; 92, epitaxial fin; 93, first conveying tube; 94, second conveying tube; 95, third conveying tube. DETAILED DESCRIPTION

[0040] According to the above structural features of the present application, the embodiments of the present application are further described:

[0041] Referring to Figure 1 , the embodiment provides a rotary evaporation equipment for preparing nicotine impurity E, which comprises a base 1, a stand 2, a clamping jaw 3, a connecting tube 4, a rotary bottle 5, a first water bath container 6, a condenser 7, a collection bottle 8, and a second water bath container 9. The base 1 is horizontally placed on a workbench, the stand 2 is vertically placed on the upper surface of the base 1, the bottom end of the stand 2 is fixedly connected with the base 1 (for example, by bolted connection), and the clamping jaw 3 is installed on the front side of the stand 2 and can move longitudinally, thereby driving the rotary bottle 5, the condenser 7, and the collection bottle 8 to move longitudinally.

[0042] Referring to Figure 1 , the connecting tube 4 is obliquely inserted and installed in the clamping jaw 3; the rotary bottle 5 and the condenser 7 are respectively connected with and communicated with the two ends of the connecting tube 4, the top end of the connecting tube 4 is connected with the condenser 7, and the bottom end of the connecting tube 4 is connected with the rotary bottle 5. Then the solvent in the mixture (i.e., the mixture of nicotine impurity E and organic solvent) in the rotary bottle 5 flows upward along the connecting tube 4 into the condenser 7 after being evaporated by heat, thereby realizing the removal of the solvent.

[0043] Referring to Figure 1 , the rotary bottle 5 can rotate around the axis of the connecting tube 4. During the rotation of the rotary bottle 5, the mixture adheres to the position of the inner wall of the rotary bottle 5, thereby increasing the heating area of the mixture and improving the evaporation efficiency of the solvent.

[0044] Referring to Figure 1The first water bath container 6 is placed on the upper surface of the base 1 directly below the rotating flask 5. An electrically driven heating plate 11 is mounted on the upper surface of the base 1, and the first water bath container 6 is pressed against the heating plate 11. In use, the operator injects pure water into the first water bath container 6. Then, the clamping claw 3 descends, simultaneously driving the rotating flask 5, condenser 7, and collecting bottle 8 downwards until the lower part of the rotating flask 5 is submerged in the pure water within the first water bath container 6, thus achieving water bath heating of the mixture inside the rotating flask 5. Water bath heating can effectively separate organic solvents such as dichloromethane (boiling point 39.8 degrees Celsius) and acetone (boiling point 56.5 degrees Celsius).

[0045] Reference Figure 1 and Figure 2 The top opening of the collection bottle 8 is connected and communicates with the bottom opening of the condenser 7; the condenser 7 is upright; the collection bottle 8 is placed directly below the condenser 7. The collection bottle 8 and the condenser 7 are detachably connected (e.g., by threaded connection or by spring snap connection, and the connection position is provided with a sealing ring and vacuum grease).

[0046] Reference Figure 1 and Figure 3 The second water bath container 9 is placed on the upper surface of the base 1 directly below the collection bottle 8; the second water bath container 9 is provided with a first receiving cavity 901 and a second receiving cavity 902 located below the first receiving cavity 901. The first receiving cavity 901 is open at the top and sealed at the bottom, and the second receiving cavity 902 is sealed at both the top and bottom.

[0047] Reference Figure 1 and Figure 3 When in use, the user injects pure water into the first receiving chamber 901. Then, the clamping claw 3 moves downward, driving the rotating bottle 5, condenser 7 and collecting bottle 8 to move downward simultaneously until the lower part of the collecting bottle 8 is submerged in the pure water in the first receiving chamber 901. This achieves the cooling of the condensate at the bottom of the collecting bottle 8, reduces its natural evaporation, prevents backflow of gaseous solvent, and improves the solvent separation efficiency.

[0048] Reference Figures 1 to 3The second receiving cavity 902 contains a coolant 903 (e.g., pure water, brine, etc.), and an electrically driven semiconductor heat sink 91 is inserted into the bottom surface of the second receiving cavity 902. The condenser 7 contains a condenser tube 72, which is connected to the second receiving cavity 902 via a delivery pipe and a liquid pump 14. The semiconductor heat sink 91 is used to extract heat from the coolant 903, thereby reducing the temperature of the coolant 903 in the second receiving cavity 902, further reducing the temperature of the pure water in the first receiving cavity 901 and the temperature of the coolant 903 in the condenser tube 72. This avoids the problem of the coolant 903 being unable to dissipate heat naturally in relatively high-temperature environments (e.g., above 30 degrees Celsius, where the temperature difference from the boiling point of dichloromethane is small, leading to slow condensation). This improves the adaptability of this invention to high-temperature scenarios and increases solvent removal efficiency.

[0049] Reference Figure 3 The first receiving cavity 901 and the second receiving cavity 902 are separated by a glass partition, thereby enabling rapid heat transfer between the coolant 903 and the pure water in the first receiving cavity 901. The glass partition is integrally sealed and fixedly connected to the inner wall of the second water bath container 9.

[0050] Reference Figure 4 and Figure 5 The semiconductor heat sink 91 has several units arranged in a linear array at equal intervals.

[0051] Reference Figure 4 and Figure 5 The base 1 has an air passage 12, within which a cooling airflow is provided. The semiconductor heat sink 91 includes a heat-absorbing end and a heat-dissipating end. The heat-absorbing end is placed in the second receiving cavity 902 and in contact with the coolant 903, while the heat-dissipating end is placed in the air passage 12 and in contact with the cooling airflow. A gap of not less than 3 mm is formed between adjacent heat-dissipating ends, allowing the cooling airflow to expel hot air near the heat-dissipating end from the base 1 when passing through this gap. The length of this gap is along the length of the air passage 12.

[0052] Reference Figure 4 The air duct 12 is open at both ends. The openings at both ends of the air duct 12 are an air inlet 121 and an exhaust outlet 122, respectively. The air inlet 121 is located on the upper surface of the base 1, and the exhaust outlet 122 is located on the outer wall of the base 1. A cooling fan blade is installed inside the air duct 12, and the cooling fan blade is connected to the output shaft of a rotating motor. The rotating motor is fixedly installed inside the air duct 12 by a bracket, and the housing of the rotating motor is fixedly connected to the bracket by bolts. The top and bottom ends of the bracket are fixedly connected to the inner surfaces of the top and bottom of the air duct 12 by bolts. The bracket is a grid-shaped bracket with excellent load-bearing capacity and air permeability; its specific structure will not be described in detail. The rotating motor drives the cooling fan blade to rotate, thereby drawing in outside air from the air inlet and expelling it from the exhaust outlet 122, carrying away the heat of the cooled air in the process.

[0053] Referring to Figure 4 , the air passage 12 is in L-shaped structure.

[0054] Referring to Figure 4 With Figure 5 , the upper surface of the base 1 is provided with a circular through hole for accommodating the bottom of the second water bath container 9, the bottom of the second water bath container 9 is inserted into the circular through hole, and the semiconductor heat dissipation fins 91 are longitudinally inserted into the air passage 12; the outer side wall of the second water bath container 9 is provided with an outer extension fin 92 (for example, by integral fixed connection), and the outer extension fin 92 is crimped on the upper surface of the base 1.

[0055] Referring to Figure 1 , the connecting pipe 4 includes a first pipe body 41 and a second pipe body 42 which are coaxially arranged and can rotate relative to each other; the condenser 7 is detachably connected and communicated with the top end of the first pipe body 41 (for example, by threaded connection or by spring pull buckle connection, and a sealing ring and vacuum grease are provided at the connection position), and the rotary bottle 5 is detachably connected and communicated with the bottom end of the second pipe body 42 (for example, by threaded connection or by spring pull buckle connection, and a sealing ring and vacuum grease are provided at the connection position). The first pipe body 41 and the second pipe body 42 are connected by a sealing shaft, which is a conventional existing technology in the industry, and the specific structure will not be described here.

[0056] Referring to Figure 2 With Figure 6 , the condenser 7 includes a vertical hollow cylindrical shell 71, and a condensing pipe 72 including a double helix pipe is arranged at the top position of the inner cavity of the shell 71; the bottom ends of the double helix pipes are connected and communicated with each other (for example, by integral fixed connection), and the top ends of the double helix pipes are respectively connected and communicated with a liquid inlet pipe 721 and a liquid outlet pipe 722 (for example, by integral fixed connection); the liquid inlet pipe 721 and the liquid outlet pipe 722 are both longitudinally inserted into the top surface of the shell 71 and are sealingly fixedly connected (for example, by integral fixed connection). The conveying pipe includes a first conveying pipe 93, a second conveying pipe 94 and a third conveying pipe 95; the first conveying pipe 93, the second conveying pipe 94 and the third conveying pipe 95 are all flexible pipes; the left and right side walls of the second water bath container 9 are respectively provided with a pipe insertion, which is sealingly fixedly connected (for example, by integral fixed connection) with the side wall of the second water bath container 9, and the two pipe insertions are respectively communicated with the left and right ends of the second containing cavity 902, and the length direction of the gap between the semiconductor heat dissipation fins 91 points to the pipe insertions; one end of the first conveying pipe 93 is connected and communicated with one side of the pipe insertion, and the other end is connected and communicated with the liquid outlet pipe 722; one end of the second conveying pipe 94 is connected and communicated with the other side of the pipe insertion, and the other end is connected and communicated with the liquid pump 14; one end of the third conveying pipe 95 is connected and communicated with the liquid pump 14, and the other end is connected and communicated with the liquid inlet pipe 721; the liquid pump 14 can realize the circulation flow between the second containing cavity 902 and the condensing pipe 72, so as to ensure the low temperature state of the condensing pipe 72, thereby facilitating the condensation of the solvent.

[0057] Referring to Figure 1 With Figure 7 , the clamping jaw 3 is clamped on the outer surface of the first pipe body 41.

[0058] Referring to Figure 1 With Figure 7 , the column 2 is provided with a longitudinal movement driving assembly 21 connected with the clamping jaw 3.

[0059] Referring to Figure 7 , the column 2 is in a top-bottom sealed shell structure, and the front side wall of the column 2 is provided with a longitudinally arranged strip-shaped hole 201; the longitudinal movement driving assembly 21 includes a lead screw 211, a driving motor 212, a sliding block 213 and an extension arm 214; the lead screw 211 is vertically arranged in the inner cavity of the column 2, the top end of the lead screw 211 is connected with the output shaft of the driving motor 212 (for example, through a key connection), and the bottom end is connected with the inner wall of the column 2 through a bearing; the sliding block 213 is sleeved on the surface of the lead screw 211 and is connected through threads, and the sliding block 213 is provided with a screw hole matched with the external thread of the lead screw 211. The extension arm 214 is inserted into the strip-shaped hole, and the two ends of the extension arm 214 are respectively connected with the sliding block 213 and the clamping jaw 3. The extension arm 214 is fixedly connected with the sliding block 213 through bolts. The cross section of the inner cavity of the column 2 is in a horizontal rectangular shape, the cross section of the sliding block 213 is in a rectangular shape with a rectangular outer contour, and the four outer side walls of the sliding block 213 are matched and fitted with the four inner side walls of the column 2, so as to avoid rotation of the sliding block 213. The driving motor 212 drives the lead screw 211 to rotate, thereby driving the sliding block 213, the extension arm 214 and the clamping jaw 3 to move longitudinally, and the strip-shaped hole 201 provides space for movement of the extension arm 214.

[0060] Referring to Figure 7 , the clamping jaw 3 includes a first clamping finger 31 and a second clamping finger 32 capable of being buckled to form a ring, one end of the first clamping finger 31 is fixedly connected with the end of the extension arm 214 (for example, through integral fixed connection or through bolted fixed connection), one end of the second clamping finger 32 is rotatably connected with the first clamping finger 31 through a rotating shaft, and the other end of the first clamping finger 31 is detachably connected with the other end of the second clamping finger 32 through bolts (for example, through detachable bolt connection); the inner walls of the first clamping finger 31 and the second clamping finger 32 are respectively provided with anti-skid rubber layers (for example, through adhesive fixing), and in use, the second clamping finger 32 is opened, the first pipe body 41 is placed between the first clamping finger 31 and the second clamping finger 32, and then the first clamping finger 31 and the second clamping finger 32 are buckled, so as to realize clamping and fixing of the first pipe body 41.

[0061] Referring to Figure 8The rotating motor 311 is inlaid and fixedly installed in the second clamping finger 32, an output shaft of the rotating motor 311 is provided with a driving gear 3111, the second pipe body 42 is fixedly provided with a gear ring 421 (for example, fixedly connected through heat melting) on the outer wall, the gear structure of the gear ring 421 is arranged at the outer edge position of the gear ring 421, the gear ring 421 is sleeved on the outer wall of the middle part of the second pipe body 42, and the driving gear 3111 is engaged with the gear ring 421. The rotating motor 311 can drive the gear ring 421, the second pipe body 42 and the rotating bottle 5 to rotate through the driving gear 3111.

[0062] With reference to Figure 1 With Figure 2 The condenser 7 further comprises an inclined through pipe 73 which is arranged in an inclined manner; one end of the inclined through pipe 73 is fixedly connected and communicated with the shell 71 (for example, fixedly connected in an integrated mode), and the other end is detachably connected with the first pipe body 41 (for example, connected through threads or connected through a spring pull buckle, and a sealing ring and vacuum grease are arranged at the connection position).

[0063] The semiconductor heat sink 91 adopts a semiconductor material (for example, Bi2Te3-Sb2Te3 and Bi2Te3-Bi2Se3 semiconductor materials based on bismuth telluride).

[0064] The utility model further includes an electrical box which is fixedly installed in the base 1 through bolts; the driving motor 212, the rotating motor 311, the heating disc 11, the semiconductor heat sink 91 and the liquid pump 14 are connected with the electrical box through wires and signal lines respectively; the electrical box is connected with an external power supply and an external computer through wires and signal lines respectively, and the computer controls the driving motor 212, the rotating motor 311, the heating disc 11, the semiconductor heat sink 91 and the liquid pump 14 in the utility model through the electrical box.

[0065] The utility model has the advantages of simple structure and reliable function, after the mixture in the rotating bottle 5 is heated in the water bath, the organic solvent is rapidly evaporated and flows into the condenser 7 along the connecting pipe 4, then the gaseous organic solvent is condensed into liquid after contacting the low-temperature condenser pipe 72 and drops into the collecting bottle 8, so that the removal of the organic solvent in the mixture is realized.

[0066] In the description of the utility model, it should be explained that the terms "upper", "lower", "left", "right" and the like indicate the position or location relationship based on the position or location relationship shown in the drawings, and are only for the convenience of describing the utility model and simplifying the description, and do not indicate or imply that the indicated device or element must have a specific position, be constructed and operated in a specific position, so it cannot be understood as a limitation on the utility model.

[0067] It should be noted that, unless otherwise explicitly specified and limited, the terms "arrange", "mount", "connect" should be understood in a broad sense, for example, it can be fixed connection, or detachable connection, or integrally connected, it can be mechanical connection, or electrical connection, it can be direct connection, or connected through intermediate medium, it can be the communication inside two elements. For those skilled in the art, the specific meaning of the above terms in the utility model can be understood according to the specific circumstances.

[0068] In summary, for those skilled in the art, according to the guidance of the utility model, the changes, modifications, replacements, deformations of the utility model still fall within the protection scope of the utility model without departing from the principles and spirits of the utility model.

Claims

1. A rotary evaporator apparatus for preparing an ergotamine impurity E, characterized by: Base (1), stand (2), clamping claw (3), connecting pipe (4), rotating bottle (5), first water bath container (6), condenser (7), collection bottle (8) and second water bath container (9) are included. The stand (2) is vertically arranged on the upper surface of the base (1), and the clamping claw (3) is installed on the front side of the stand (2) and can move longitudinally; the connecting pipe (4) is obliquely inserted into the clamping claw (3); the rotating bottle (5) and the condenser (7) are respectively connected with two ends of the connecting pipe (4); the rotating bottle (5) can rotate around the axis of the connecting pipe (4). The first water bath container (6) is arranged on the upper surface of the base (1) directly below the rotating bottle (5); a heating disc (11) driven by electricity is arranged on the upper surface of the base (1), and the first water bath container (6) is press-bonded on the heating disc (11). The collection bottle (8) is connected with the lower end of the condenser (7). The second water bath container (9) is arranged on the upper surface of the base (1) directly below the collection bottle (8); the second water bath container (9) is provided with a first containing cavity (901) and a second containing cavity (902) arranged below the first containing cavity (901), the second containing cavity (902) is provided with a cooling liquid (903), and a semiconductor heat sink (91) driven by electricity is inserted into the bottom surface of the second containing cavity (902); the condenser (7) is provided with a condenser pipe (72), and the condenser pipe (72) is communicated with the second containing cavity (902) through a conveying pipe and a liquid pump (14).

2. The rotary evaporator apparatus for preparing Nicergoline impurity E as claimed in claim 1 wherein: The semiconductor heat sink (91) is arranged in a straight line array with equal intervals.

3. The rotary evaporator apparatus for preparing Nicergoline impurity E according to claim 2, characterized by: The base (1) is provided with an air channel (12), and the air channel (12) is provided with a cooling air flow; the semiconductor heat sink (91) comprises a heat absorbing end and a heat radiating end, the heat absorbing end is arranged in the second containing cavity (902) and contacts with the cooling liquid (903), and the heat radiating end is arranged in the air channel (12) and contacts with the cooling air flow.

4. The rotary evaporator apparatus for preparing Nicergoline impurity E as claimed in claim 3 wherein: The air channel (12) is open at both ends.

5. The rotary evaporator apparatus for preparing Nicergoline impurity E as claimed in claim 4 wherein: The air channel (12) is provided with a cooling fan blade, the cooling fan blade is connected with a rotating motor, and the rotating motor is fixedly installed in the air channel (12) through a support.

6. The rotary evaporator apparatus for preparing Nicergoline impurity E as claimed in claim 5 wherein: The air channel (12) has an L-shaped structure.

7. The rotary evaporator apparatus for preparing Nicergoline impurity E as claimed in claim 6 wherein: The connecting pipe (4) comprises a first pipe body (41) and a second pipe body (42) arranged coaxially and capable of rotating relative to each other; the condenser (7) is detachably connected and communicated with the top end of the first pipe body (41), and the rotating bottle (5) is detachably connected and communicated with the bottom end of the second pipe body (42).

8. The rotary evaporator apparatus for preparing Nicergoline impurity E as claimed in claim 7 wherein: The clamping claw (3) is clamped on the outer surface of the first pipe body (41).

9. The rotary evaporator apparatus for preparing Nicergoline impurity E as claimed in claim 8 wherein: The stand (2) is provided with a longitudinal movement driving assembly (21), and the longitudinal movement driving assembly (21) is connected with the clamping claw (3).

10. The rotary evaporator apparatus for preparing Nicergoline impurity E as claimed in claim 9 wherein: The column (2) is a top-bottom sealed shell structure, and the front side wall of the column (2) is provided with a longitudinally arranged strip-shaped hole (201); the longitudinal movement driving assembly (21) comprises a lead screw (211), a driving motor (212), a sliding block (213) and an extension arm (214); the lead screw (211) is vertically arranged in the inner cavity of the column (2), the top end of the lead screw (211) is connected with the output shaft of the driving motor (212), and the bottom end is connected with the inner wall of the column (2) through a bearing; the sliding block (213) is sleeved on the surface of the lead screw (211) and is connected through threads, and the extension arm (214) is inserted into the strip-shaped hole, and the two ends of the extension arm (214) are respectively connected with the sliding block (213) and the clamping claw (3).

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