Macrocyclic peptide purification ultrafiltration device based on molecular weight screening

Abstract

The utility model discloses a macrocyclic peptide purification ultrafiltration device based on molecular weight screening, which relates to the technical field of macrocyclic peptide purification ultrafiltration and comprises a base, a cavity is arranged in the base, a vibration motor is fixedly mounted on one side of the inner bottom wall of the cavity, a sliding plate is fixedly mounted on one side of the vibration motor, a sliding rod is fixedly mounted at the top of the sliding plate, and a sliding rod is fixedly mounted at the bottom of the sliding rod. The top of the sliding rod penetrates through the base and extends out of the base, and a sliding plate is fixedly mounted at the top of the sliding rod. According to the macrocyclic peptide purification ultrafiltration device based on molecular weight screening disclosed by the utility model, the vibration motor and the sliding plate are arranged, and the vibration motor works to drive the sliding rod on one side of the sliding plate to vibrate in the use process, so that the vertical pipe on the sliding plate vibrates, and the screen mesh is conveniently shaken in the use process; and therefore, the screening effect is achieved, shaking of the screen cloth is kept, blockage caused by the screen cloth is avoided, the subsequent filtering effect of the device is improved, and meanwhile the use convenience of the device is improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to macrocyclic peptide purification ultrafiltration technical field especially relates to a macrocyclic peptide purification ultrafiltration device based on molecular weight screening. BACKGROUND

[0002] The purification of macrocyclic peptides is a delicate process aimed at isolating a single macrocyclic peptide compound from a complex mixture. In this process, ultrafiltration technology plays a crucial role. Ultrafiltration is a pressure-driven membrane separation technique that allows small molecule solutes and solvents to pass through a specific pore size membrane, while larger molecules such as macrocyclic peptides are retained. This technology can effectively separate macrocyclic peptides from other impurities of different molecular sizes, achieving the separation and concentration of macrocyclic peptides. In the purification process of macrocyclic peptides, ultrafiltration can help remove small molecular impurities, salts and other unwanted by-products, which not only improves the purity of macrocyclic peptides, but also maintains their biological activity, ensuring the high quality of the final product.

[0003] The patent document with publication number CN117000050A discloses a collagen ultrafiltration purification device, which includes a base, the top of the base is fixedly installed with a stock solution barrel, a booster pump and two symmetrically arranged support columns. Through the setting of vibration shaft, eccentric wheel and other structures, the driving motor starts to drive the stirring shaft to rotate, which drives the rotating shaft to rotate through synchronous belts, and the transmission of the bevel gear one and the bevel gear two realizes the rotation of the transmission shaft, and the vibration shaft is driven to rotate through the synchronous belt one, and the eccentric wheel is driven to rotate by the vibration shaft, and the eccentric wheel reciprocally pushes the vibration plate, and the vibration of the vibration plate and the filter plate is realized through the cooperation of the return spring, thereby effectively avoiding the blockage of large particles after filtration affecting the transportation of collagen, so that the practicality of the device is better. Through the above technical scheme, the problems of poor practicality and poor working quality in the prior art are solved.

[0004] The above application solves the problems of poor practicality and poor working quality in the prior art, but in the actual application process, the filtering assembly is blocked during the screening process, which affects the subsequent filtering operation of the device and reduces the use convenience of the device, affecting the subsequent operation. UTILITY MODEL CONTENT

[0005] The utility model discloses a kind of macrocyclic peptide purification ultrafiltration devices based on molecular weight screening, to solve the technical problem proposed in the above background technology.

[0006] To achieve the above purpose, the utility model adopts the following technical scheme:

[0007] The application discloses a macrolide peptide purification ultrafiltration device based on molecular weight screening, which comprises a base, an inner bottom wall of a cavity in the base is fixedly installed with a vibration motor, one side of the vibration motor is fixedly installed with a sliding plate, the top of the sliding plate is fixedly installed with a sliding rod, the top of the sliding rod penetrates through the base and extends to the outside of the base, the top of the sliding rod is fixedly installed with a sliding plate, the top of the sliding plate is fixedly installed with a vertical pipe, the top of the vertical pipe is fixedly installed with a material box, the inner bottom wall of the material box is fixedly installed with a return spring, the top of the return spring is fixedly installed with a screen, and one side of the vertical pipe is communicated with a discharge pipe.

[0008] The vibration motor and the sliding plate are arranged, the vibration motor works to drive the sliding rod on one side of the sliding plate to vibrate, the vertical pipe on the sliding plate vibrates, the screen is shaken during use, the screening effect is achieved, the shaking of the screen is maintained, the screen is prevented from being blocked, the subsequent filtering effect of the device is improved, and the use convenience of the device is improved.

[0009] The upper surface of the base is fixedly installed with a sedimentation box, and one side of the sedimentation box is communicated with a square tube.

[0010] The sedimentation box is arranged, sedimentation operation is facilitated during use, the square tube is arranged, the discharge operation of the filtrate after sedimentation is facilitated, and subsequent use is facilitated.

[0011] In a preferred scheme, the surface of the screen is slidably connected with the inner wall of the material box, the material box is matched with the screen, a sealing ring is fixedly installed on the upper surface of the screen, and the surface of the sealing ring is fixedly connected with the surface of the screen.

[0012] The sealing ring is arranged, the sealing ring is sealed on the screen during use, small objects are prevented from being blocked around, and the passability of the component is improved.

[0013] In a preferred scheme, the two sides of the bottom of the base are fixedly installed with mounting plates, mounting holes are formed in the mounting plates, the mounting holes are long circular holes, and anti-skid lines are formed in the lower surface of the mounting plate.

[0014] The mounting plate is arranged, the mounting plate is positioned during use, and the mounting stability of the device is maintained.

[0015] In a preferred scheme, the upper surface of the base is provided with rod grooves for the sliding rod to pass through, and the inner wall of the rod groove is slidably connected with the surface of the sliding rod.

[0016] The rod groove is arranged, the sliding rod is limited during use, and the passing stability of the sliding rod is maintained.

[0017] In a preferred scheme, the four corners of the bottom of the sliding plate are fixedly provided with round sliding blocks, and the bottom of the round sliding block is in sliding connection with the upper surface of the base.

[0018] Through the round sliding block, the bottom of the sliding plate is conveniently supported during use, thereby improving the use convenience of the device.

[0019] In a preferred scheme, the inside of the sedimentation box is fixedly provided with a guide plate, the guide plate is in an inclined state, and the inclination angle of the guide plate is 30-45 degrees.

[0020] Through the inclined guide plate, the passing of the filtrate is accelerated during use, thereby facilitating subsequent filtration operation, and the filtration effect of the device is improved.

[0021] In a preferred scheme, the low end of the guide plate is flush with the inner bottom wall of the square tube, and the side of the guide plate is fixedly provided with a blocking strip.

[0022] Through the guide plate and the blocking strip, the filtered filtrate is conveniently subjected to sedimentation operation, so that the fine pollutants are deposited on the gap of the blocking strip, and the filtration effect of the device is improved.

[0023] As can be seen from the above, the macrolide peptide purification ultrafiltration device based on molecular weight screening has the following technical effects.

[0024] Firstly, the vibration motor and the sliding plate are arranged, the vibration motor works to drive the slide rod on one side of the sliding plate to vibrate, so that the vertical pipe on the sliding plate vibrates, thereby facilitating the shaking of the screen during use, achieving the screening effect, keeping the shaking of the screen, avoiding the blocking, improving the subsequent filtration effect of the device, and improving the use convenience of the device.

[0025] Secondly, the guide plate and the blocking strip are arranged, the filtered filtrate is conveniently subjected to sedimentation operation, so that the fine pollutants are deposited on the gap of the blocking strip, and the filtration effect of the device is improved. BRIEF DESCRIPTION OF DRAWINGS

[0026] Figure 1 It is a three-dimensional structure schematic diagram of the utility model.

[0027] Figure 2 It is a first perspective three-dimensional sectional structure schematic diagram of the utility model.

[0028] Figure 3 It is a second perspective three-dimensional sectional structure schematic diagram of the utility model.

[0029] Figure 4 It is a three-dimensional structure schematic diagram of the utility model Figure 2Structure schematic view of the middle A.

[0030] Figure 5 The utility model discloses Figure 3 Structure schematic view of the middle B.

[0031] In the drawing: 1, base; 2, vibration motor; 3, sliding plate; 4, slide rod; 5, sliding plate; 6, vertical pipe; 7, material box; 8, reset spring; 9, screen; 10, discharge pipe; 11, sediment box; 12, square tube; 13, mounting plate; 14, round sliding block; 15, guide plate; 16, blocking bar; 17, sealing ring. DETAILED DESCRIPTION

[0032] The technical solutions in the embodiments of the utility model will be clearly and completely described below with reference to the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all the embodiments.

[0033] Referring to Figures 1-5 A kind of macrocyclic peptide purification ultrafiltration device based on molecular weight screening, including base 1, the bottom of base 1 Both sides are fixedly installed with mounting plate 13, mounting hole is long round hole, the lower surface of mounting plate 13 is equipped with anti-skid line, the mounting plate 13 being arranged, in the process of using, it is convenient to carry out installation positioning operation, so as to keep the installation stability of the device, the inside of base 1 is equipped with cavity, the inner bottom wall of cavity is fixedly installed with vibration motor 2 on one side, vibration motor 2 is fixedly installed with sliding plate 3 on one side, sliding plate 3 is fixedly installed with slide rod 4 on top, the upper surface of base 1 Both sides are equipped with the rod groove for the through of slide rod 4, and the inner wall of rod groove is slidably connected with the surface of slide rod 4, the rod groove being arranged, in the process of using, it is convenient to limit slide rod 4, also keep the through stability of slide rod 4, the top of slide rod 4 penetrates base 1 and extends to the outside of base 1, the top of slide rod 4 is fixedly installed with sliding plate 5, the four corners of sliding plate 5 bottom are fixedly installed with round sliding block 14, the bottom of round sliding block 14 is slidably connected with the upper surface of base 1, the round sliding block 14 being arranged, in the process of using, it is convenient to support the bottom of sliding plate 5, so as to improve the use convenience of the device, the top of sliding plate 5 is fixedly installed with vertical pipe 6, vertical pipe 6 is fixedly installed with material box 7 on top, the inner bottom wall of material box 7 is fixedly installed with reset spring 8, the top of reset spring 8 is fixedly installed with screen 9, the one side of vertical pipe 6 is communicated with discharge pipe 10, the surface of screen 9 is slidably connected with the inner wall of material box 7, and material box 7 is adapted with screen 9, a circle of upper surface of screen 9 is fixedly installed with sealing ring 17, the surface of sealing ring 17 is fixedly connected with the surface of screen 9, the sealing ring 17 being arranged, in the process of using, it is convenient to seal a circle of screen 9, avoid small objects around being jammed, improve the passability of the component.

[0034] The vibration motor 2 and the slide plate 3 are arranged, in the use process, the vibration motor 2 works and drives the slide rod 4 on the one side of the slide plate 3 to vibrate, so that the vertical pipe 6 on the slide plate 5 vibrates, thereby facilitating the shaking of the screen 9 in the use process, so that the screening effect is realized, the shaking of the screen 9 is maintained, the clogging is avoided, the subsequent filtering effect of the device is improved, and the use convenience of the device is improved.

[0035] The upper surface of the base 1 is fixedly provided with a sediment box 11, one side of the sediment box 11 is communicated with a square tube 12, the inside of the sediment box 11 is fixedly provided with a guide plate 15, the guide plate 15 is arranged in an inclined state, and the inclination angle of the guide plate 15 is 30-45 degrees; the guide plate 15 is arranged in an inclined state, so that the passing of the filtrate is accelerated in the use process, thereby facilitating the subsequent filtering operation, and the filtering effect of the device is improved; the sediment box 11 is arranged, so that the sedimentation operation is facilitated in the use process, and the square tube 12 is arranged, so that the discharged filtrate after sedimentation is facilitated, and subsequent use is facilitated; the low end of the guide plate 15 is flush with the inner bottom wall of the square tube 12, and the one side of the guide plate 15 is fixedly provided with a blocking strip 16; the guide plate 15 and the blocking strip 16 are arranged, so that the filtered filtrate is facilitated to be deposited in the use process, so that the fine pollutants are deposited on the gap of the blocking strip 16, and the filtering effect of the device is improved.

[0036] Working principle: in the use process, the vibration motor 2 works and drives the slide rod 4 on the one side of the slide plate 3 to vibrate, so that the vertical pipe 6 on the slide plate 5 vibrates, thereby facilitating the shaking of the screen 9 in the use process, so that the screening effect is realized, the shaking of the screen 9 is maintained, the clogging is avoided, the subsequent filtering effect of the device is improved, and the use convenience of the device is improved; the guide plate 15 and the blocking strip 16 are arranged, so that the filtered filtrate is facilitated to be deposited in the use process, so that the fine pollutants are deposited on the gap of the blocking strip 16, and the filtering effect of the device is improved.

[0037] The above is only a preferred specific embodiment of the present application, but the protection scope of the present application is not limited to this. The replacement can be the replacement of part of the structure, device, method step, or the complete technical solution. According to the technical solution and the inventive concept of the present application, equivalent replacement or change should be covered in the protection scope of the present application.

Claims

1. A purification ultrafiltration device of macrocyclic peptides based on molecular weight fractionation, comprising a base (1), characterized in that, The inside of the base (1) is provided with a cavity, and the inner bottom wall of the cavity is fixedly installed with a vibration motor (2). One side of the vibration motor (2) is fixedly installed with a sliding plate (3). The top of the sliding plate (3) is fixedly installed with a sliding rod (4). The top of the sliding rod (4) penetrates through the base (1) and extends to the outside of the base (1). The top of the sliding rod (4) is fixedly installed with a sliding plate (5). The top of the sliding plate (5) is fixedly installed with a vertical pipe (6). The top of the vertical pipe (6) is fixedly installed with a material box (7). The inner bottom wall of the material box (7) is fixedly installed with a return spring (8). The top of the return spring (8) is fixedly installed with a screen (9). One side of the vertical pipe (6) is communicated with a discharge pipe (10). The upper surface of the base (1) is fixedly installed with a sedimentation box (11). One side of the sedimentation box (11) is communicated with a square tube (12).

2. A molecular weight fractionation-based macrocyclic peptide purification ultrafiltration device according to claim 1, wherein, The surface of the screen (9) is slidably connected with the inner wall of the material box (7). The material box (7) is matched with the screen (9). A sealing ring (17) is fixedly installed on the upper surface of the screen (9). The surface of the sealing ring (17) is fixedly connected with the surface of the screen (9).

3. A molecular weight fractionation based macrocyclic peptide purification ultrafiltration device according to claim 1, wherein, The bottom of the base (1) is fixedly installed with a mounting plate (13) on both sides. The mounting plate (13) is provided with a mounting hole. The mounting hole is an oblong hole. The lower surface of the mounting plate (13) is provided with an anti-skid pattern.

4. The ultrafiltration device for purification of a macrocyclic peptide based on molecular weight fractionation according to claim 1, characterized in that, The upper surface of the base (1) is provided with a rod groove for the sliding rod (4) to pass through on both sides. The inner wall of the rod groove is slidably connected with the surface of the sliding rod (4).

5. The ultrafiltration device for purification of a macrocyclic peptide based on molecular weight fractionation according to claim 1, characterized in that, The bottom of the sliding plate (5) is fixedly installed with a circular sliding block (14) at four corners. The bottom of the circular sliding block (14) is slidably connected with the upper surface of the base (1).

6. The ultrafiltration device for purification of a macrocyclic peptide based on molecular weight fractionation according to claim 1, characterized in that, The inside of the sedimentation box (11) is fixedly installed with a guide plate (15). The guide plate (15) is arranged in an inclined state. The inclination angle of the guide plate (15) is 30-45 degrees.

7. A molecular weight fractionation-based macrocyclic peptide purification ultrafiltration device according to claim 6, wherein, The low end of the guide plate (15) is flush with the inner bottom wall of the square tube (12). One side of the guide plate (15) is fixedly installed with a blocking strip (16).

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