Purification equipment

Abstract

The utility model relates to the technical field of exosome purification, in particular to purification equipment. Comprising a plurality of filtering boxes, a plurality of filtering mechanisms, a plurality of limiting mechanisms and a plurality of transmission assemblies, the plurality of filter boxes are arranged side by side; a partition plate is arranged on the inner side of the filter box; a communicating pipe is arranged on the partition plate, and a sealing plate used for blocking the communicating pipe is rotationally installed at the bottom end of the partition plate. The filtering mechanism comprises a rectangular frame and a filter screen mounted on the inner side of the rectangular frame; the plurality of limiting mechanisms are respectively mounted on the plurality of filtering boxes; each limiting mechanism comprises a connecting rod, two sliding plates, two first inserting columns and two second inserting columns; and the plurality of transmission assemblies are respectively mounted on the plurality of filter boxes. According to the technical scheme, the old filtering mechanism can be synchronously disassembled while a new filtering mechanism is installed, and the working efficiency is greatly improved.

Description

Technical Field

[0001] This utility model relates to the field of exosome purification technology, and in particular to a purification device. Background Technology

[0002] Exosomes are currently considered to be specifically secreted membrane vesicles that participate in intercellular communication. Research interest in exosomes is growing, whether for studying their function or understanding how to use them for the development of minimally invasive diagnostics. Therefore, the isolation and purification of exosomes are crucial in exosome research. Centrifugation and filtration purification are the most commonly used purification methods in existing technologies.

[0003] Patent CN218248694U discloses an exosome separation and purification device, including a base plate and a centrifuge. A fixed plate is fixedly provided on the upper side of the base plate, and a support plate is fixedly provided on the outer side of the centrifuge. One side of the support plate is fixedly connected to one side of the fixed plate. A support block is fixedly provided on one side of the fixed plate, and a filter box is fixedly provided on one side of the support block. Two fixed grooves are provided inside the filter box, and filter frames are slidably provided inside each fixed groove. Filter screen A is fixedly provided inside the upper filter frame, and filter screen B is fixedly provided inside the lower filter frame. A fixing device is provided on one side of the filter box.

[0004] The aforementioned patents still have the following technical defects: when replacing the filter plate, the old filter plate needs to be removed before the new filter plate can be replaced, which affects the replacement efficiency. Utility Model Content

[0005] The purpose of this invention is to address the problems existing in the background technology by proposing a purification device.

[0006] The technical solution of this utility model is a purification device, comprising:

[0007] Multiple filter boxes are arranged side by side, and the two adjacent filter boxes are interconnected; the inside of the filter box is equipped with a partition, which separates the buffer chamber and the filter chamber; the partition is equipped with a connecting pipe, and a sealing plate for blocking the connecting pipe is rotatably installed at the bottom of the partition.

[0008] Multiple filtration mechanisms are provided, each including a rectangular frame and a filter screen installed inside the rectangular frame. One end of the rectangular frame is provided with an inclined surface, and two slots are provided on the end of the rectangular frame away from the inclined surface. Both ends of the filter box are provided with through holes for the rectangular frame to pass through.

[0009] Multiple limiting mechanisms are installed on multiple filter boxes. Each limiting mechanism includes a connecting rod, two sliding plates, two first inserts, and two second inserts. Both ends of the filter box are provided with sliding grooves. The ends of the two sliding plates are slidably installed in the sliding grooves on both sides. The two sliding plates are connected by a connecting rod. The two first inserts are respectively connected to the inner ends of the two sliding plates, and the two second inserts are respectively connected to the outer ends of the two sliding plates. The bottom end of the first insert can be movably inserted through the inside of the perforation.

[0010] Multiple transmission components are installed on multiple filter boxes. The transmission components are used to convert the movement of the connecting rod into the rotational movement of the sealing plate.

[0011] Preferably, a rotating rod is connected to the sealing plate, and a rotating frame is provided at the lower end of the partition plate. The rotating rod is rotatably mounted on the rotating frame. The transmission assembly includes a horizontal rod, a vertical rod, a wedge block, and a connecting rod. The vertical rod is connected to the connecting rod, and the wedge block is connected to the end of the vertical rod. The horizontal rod moves through the inner and outer sides of the filter box. An movable hole is opened at the outer end of the horizontal rod. The two ends of the connecting rod are rotatably connected to the rotating rod and the horizontal rod, respectively.

[0012] Preferably, a flow-dividing mechanism is provided on the inner side of each of the multiple filter boxes. The flow-dividing mechanism is located directly below the corresponding connecting pipe. The flow-dividing mechanism includes two sets of guide plate assemblies. One set of guide plate assemblies is obtained by rotating the other set of guide plate assemblies by 90 degrees. The two sets of guide plate assemblies are integrally formed. The guide plate assembly includes multiple guide plates, which are distributed in a fan-shaped skeleton pattern.

[0013] Preferably, an outer frame is provided at one end of the filter box adjacent to the limiting mechanism.

[0014] Preferably, a support plate is provided at the end of the filter box away from the limiting mechanism.

[0015] Preferably, the outer surface of the rectangular frame is provided with sealing rubber.

[0016] Compared with the prior art, the present invention has the following beneficial technical effects: the present invention can simultaneously disassemble the old filter mechanism while installing the new filter mechanism, which greatly improves the work efficiency. In addition, it can automatically prevent the liquid from continuing to flow out during the replacement process and can automatically resume the liquid supply after the replacement work is completed. Its degree of automation is high and has little impact on the filtration work. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the structure of this utility model.

[0018] Figure 2-4 All of these are cross-sectional structural diagrams of the filter box in this utility model.

[0019] Figure 5for Figure 2 A magnified schematic diagram of the structure at point A.

[0020] Figure 6 for Figure 3 A magnified schematic diagram of the structure at point B.

[0021] Figure 7 for Figure 4 A magnified structural diagram of point C.

[0022] Reference numerals: 1. Centrifuge; 2. Filter box; 201. Perforation; 202. Slide groove; 2001. Buffer chamber; 2002. Filter chamber; 3. Partition plate; 4. Rectangular frame; 401. Slot; 4001. Inclined surface; 5. Outer frame; 6. Filter screen; 7. Diverting mechanism; 8. Support plate; 91. First insertion post; 92. Second insertion post; 10. Sliding plate; 11. Connecting rod; 12. Horizontal bar; 121. Movable hole; 13. Vertical bar; 14. Wedge block; 15. Connecting pipe; 16. Rotating frame; 17. Sealing plate; 171. Rotating rod; 18. Connecting rod; 19. Drain pipe. Detailed Implementation

[0023] Example 1

[0024] like Figures 1-7 As shown in the figure, the purification device proposed in this embodiment includes multiple filter boxes 2, multiple filtration mechanisms, multiple limiting mechanisms, and multiple transmission components.

[0025] Multiple filter boxes 2 are arranged side by side, and the two adjacent filter boxes 2 are interconnected. A partition 3 is provided on the inner side of the filter box 2. The interior of the filter box 2 is divided into a buffer chamber 2001 and a filter chamber 2002 by the partition 3. The buffer chamber 2001 is located above the filter chamber 2002. A connecting pipe 15 is provided on the partition 3. A sealing plate 17 for sealing the connecting pipe 15 is rotatably installed at the bottom end of the partition 3. A drain pipe 19 is connected to the bottom filter box 2.

[0026] The filtration mechanism includes a rectangular frame 4 and a filter screen 6 installed inside the rectangular frame 4. The outer surface of the rectangular frame 4 is provided with sealing rubber. One end of the rectangular frame 4 is provided with an inclined surface 4001. Two slots 401 are opened on the end of the rectangular frame 4 away from the inclined surface 4001. Both ends of the filter box 2 are provided with through holes 201 for the rectangular frame 4 to pass through.

[0027] Multiple limiting mechanisms are installed on multiple filter boxes 2. The limiting mechanism includes a connecting rod 11, two sliding plates 10, two first inserts 91 and two second inserts 92. Both ends of the filter box 2 are provided with sliding grooves 202. The ends of the two sliding plates 10 are slidably installed in the sliding grooves 202 on both sides. The two sliding plates 10 are connected by the connecting rod 11. The two first inserts 91 are respectively connected to the inner ends of the two sliding plates 10, and the two second inserts 92 are respectively connected to the outer ends of the two sliding plates 10. The bottom end of the first insert 91 can be movably inserted through to the inside of the perforation 201.

[0028] Multiple transmission components are installed on multiple filter boxes 2 respectively. The transmission components are used to convert the movement of the connecting rod 11 into the rotational movement of the sealing plate 17.

[0029] An outer frame 5 is provided at one end of the filter box 2 near the limiting mechanism. The outer frame 5 is provided to assist in the positioning of the filter mechanism, so that the filter mechanism can be easily aligned with the perforation 201.

[0030] A support plate 8 is provided at the end of the filter box 2 away from the limiting mechanism. The support plate 8 can support the old filter mechanism that can be removed.

[0031] Specifically, the technical solution also includes a centrifuge 1, through which exosomes are centrifuged and then flow into the interiors of multiple filter boxes 2 for further purification.

[0032] First, the exosomes flow into the buffer chamber 2001, and then into the filter chamber 2002 through the connecting pipe 15. The exosomes are filtered and purified by the filter screen 6. Subsequently, the exosomes flow into the interiors of multiple filter boxes 2 for further purification.

[0033] When filter 6 needs to be replaced, the new filter mechanism is aligned and inserted into the filter box 2. During insertion, the inclined surface 4001 at the end of the rectangular frame 4 first contacts the second insertion post 92. As the rectangular frame 4 continues to move, the second insertion post 92 continues to rise. The second insertion post 92 then drives the first insertion post 91 to move via the sliding plate 10. When the second insertion post 92 contacts the upper plane of the rectangular frame 4, it rises to the predetermined position. At this time, the first insertion post 91 moves out of the slot 401 of the old rectangular frame 4, thereby releasing the fixing of the old rectangular frame 4. With the cooperation of the transmission component, when the connecting rod 11 rises, the sealing plate 17 rotates and closes, realizing the... The connecting pipe 15 is sealed, and the exosomes no longer flow into the filter chamber 2002. After that, it is necessary to observe whether the liquid on the filter screen 6 is filtered clean. If all the liquid on the filter screen 6 is filtered, the new filter mechanism is pushed to continue moving. At this time, since the old filter mechanism is released from its limit, the new filter mechanism can move the old filter mechanism out of the filter box 2. When the slot 401 on the new filter mechanism is aligned with the first insertion post 91, the first insertion post 91 is inserted into the inside of the slot 401 under the action of gravity, which realizes the limit of the new filter mechanism. At this time, the connecting rod 11 moves downward and the sealing plate 17 is also rotated open, so that the connecting pipe 15 is in the open state, and the normal filtration work is restored.

[0034] Example 2

[0035] like Figure 5 and Figure 7 As shown, in this embodiment of the purification device, compared to Embodiment 1, a rotating rod 171 is connected to the sealing plate 17, and a rotating frame 16 is provided at the lower end of the partition plate 3. The rotating rod 171 is rotatably mounted on the rotating frame 16. The transmission assembly includes a horizontal rod 12, a vertical rod 13, a wedge block 14, and a connecting rod 18. The vertical rod 13 is connected to the connecting rod 11, and the wedge block 14 is connected to the end of the vertical rod 13. The horizontal rod 12 movably passes through the inner and outer sides of the filter box 2, and a movable hole 121 is opened at the outer end of the horizontal rod 12. The two ends of the connecting rod 18 are rotatably connected to the rotating rod 171 and the horizontal rod 12, respectively. When the connecting rod 11 moves upward, it drives the wedge block 14 to move. The wedge block 14 moves inside the movable hole 121, and the inclined surface of the wedge block 14 contacts one end of the inner side of the movable hole 121. As the wedge block 14 continues to move, it drives the crossbar 12 to move outward. With the cooperation of the connecting rod 18, the sealing plate 17 is driven. When the wedge block 14 rises to the limit position, the sealing plate 17 seals the connecting pipe 15. It should be added that in order to improve the sealing between the connecting pipe 15 and the sealing plate 17, a sealing strip is installed on the bottom edge of the connecting pipe 15.

[0036] Example 3

[0037] like Figures 2-4 As shown, the purification device proposed in this embodiment, compared with the first embodiment, has a diversion mechanism 7 installed on the inner side of each of the multiple filter boxes 2. The diversion mechanism 7 is located directly below the corresponding connecting pipe 15. The diversion mechanism 7 includes two sets of guide plate assemblies. One set of guide plate assemblies is obtained by rotating the other set of guide plate assemblies by 90 degrees. The two sets of guide plate assemblies are integrally formed. The guide plate assembly includes multiple guide plates, which are distributed in a fan-shaped skeleton shape. Through the above-mentioned diversion mechanism 7, not only can the impact force of the liquid on the filter screen 6 be reduced, but the liquid can also be diverted, so that the liquid can flow evenly to various positions of the filter screen 6, thereby achieving a uniform filtration effect.

[0038] The embodiments of the present invention have been described in detail above with reference to the accompanying drawings. However, the present invention is not limited thereto. Various changes can be made within the scope of knowledge possessed by those skilled in the art without departing from the spirit of the present invention.

Claims

1. A purification apparatus, characterized by, include: Multiple filter boxes (2) are arranged side by side, and the two filter boxes (2) that are adjacent to each other are interconnected; a partition (3) is provided on the inner side of the filter box (2), and the interior of the filter box (2) is separated into a buffer chamber (2001) and a filter chamber (2002) by the partition (3); a connecting pipe (15) is provided on the partition (3), and a sealing plate (17) for sealing the connecting pipe (15) is rotatably installed at the bottom end of the partition (3); Multiple filtration mechanisms are provided, including a rectangular frame (4) and a filter screen (6) installed inside the rectangular frame (4). One end of the rectangular frame (4) is provided with an inclined surface (4001), and two slots (401) are provided on the end of the rectangular frame (4) away from the inclined surface (4001). Both ends of the filter box (2) are provided with through holes (201) for the rectangular frame (4) to pass through. Multiple limiting mechanisms are installed on multiple filter boxes (2). The limiting mechanism includes a connecting rod (11), two sliding plates (10), two first inserts (91) and two second inserts (92). Both ends of the filter box (2) are provided with sliding grooves (202). The ends of the two sliding plates (10) are slidably installed in the sliding grooves (202) on both sides. The two sliding plates (10) are connected by the connecting rod (11). The two first inserts (91) are respectively connected to the inner ends of the two sliding plates (10), and the two second inserts (92) are respectively connected to the outer ends of the two sliding plates (10). The bottom end of the first insert (91) can be moved through to the inside of the perforation (201). Multiple transmission components are installed on multiple filter boxes (2) respectively. The transmission components are used to convert the movement of the connecting rod (11) into the rotational movement of the sealing plate (17).

2. A purification apparatus according to claim 1, wherein, A rotating rod (171) is connected to the sealing plate (17). A rotating frame (16) is provided at the lower end of the partition plate (3). The rotating rod (171) is rotatably mounted on the rotating frame (16). The transmission assembly includes a horizontal rod (12), a vertical rod (13), a wedge block (14), and a connecting rod (18). The vertical rod (13) is connected to the connecting rod (11). The wedge block (14) is connected to the end of the vertical rod (13). The horizontal rod (12) moves through the inner and outer sides of the filter box (2). The outer end of the horizontal rod (12) is provided with a movable hole (121). The two ends of the connecting rod (18) are rotatably connected to the rotating rod (171) and the horizontal rod (12), respectively.

3. A purification apparatus according to claim 1, wherein, Multiple filter boxes (2) are provided with a flow diversion mechanism (7) on their inner side. The flow diversion mechanism (7) is located directly below the corresponding connecting pipe (15). The flow diversion mechanism (7) includes two sets of guide plate assemblies. One set of guide plate assemblies is obtained by rotating the other set of guide plate assemblies by 90 degrees. The two sets of guide plate assemblies are integrally formed. The guide plate assembly includes multiple guide plates, which are arranged in a fan-shaped skeleton.

4. A purification apparatus according to claim 1, wherein An outer frame (5) is provided on one end of the filter box (2) near the limiting mechanism.

5. A purification apparatus according to claim 1, wherein A support plate (8) is provided at the end of the filter box (2) away from the limiting mechanism.

6. A purification apparatus according to claim 1, wherein The outer surface of the rectangular frame (4) is provided with sealing rubber.

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