Device for inactivating viruses of blood products

Abstract

The utility model relates to the technical field of blood product production, and discloses a blood product virus inactivation device which comprises a tank body, and a cover plate is arranged at the top of the tank body. Under the driving of the first bevel gear, the second bevel gear and the third bevel gear can rotate in opposite directions, and meanwhile, the rotating shaft and the connecting shell rotate along with the rotating shaft to respectively drive the first mixing paddle and the second mixing paddle to rotate in opposite directions on the same axis by taking the rotating shaft as a circle center, so that a blood product and a decontaminant are promoted to flow dispersedly; mixing and contacting can be more fully completed, and it is guaranteed that viruses are effectively inactivated; one end of the locking block is separated from the interior of the limiting groove, at the moment, the connecting block is not limited, meanwhile, the first spring pushes the connecting block to move upwards through accumulated resilience force, the connecting block is separated from the shell, then the cover plate is lifted upwards, the cover plate can be disassembled and separated from the top of the tank body, the disassembling and assembling steps are simple, and the overhauling efficiency is improved.

Description

Technical Field

[0001] This utility model relates to the field of blood product manufacturing technology, specifically to a device for inactivating viruses in blood products. Background Technology

[0002] In the production of blood products, it is necessary to inactivate any viruses that may be present to ensure the safety of the blood products. This process requires the use of a virus inactivation device. Such a device is designed to safely and effectively remove or inactivate viruses in blood products while maintaining their biological activity and therapeutic value. Typically, the device employs the solvent / detergent (S / D) method for virus inactivation, which involves using an organic solvent or detergent mixture (S / D) to disrupt the lipid membrane of enveloped viruses, achieving effective inactivation.

[0003] Existing devices for inactivating viruses in blood products require the detergent to be mixed evenly with the blood products to effectively inactivate the viruses. Typically, the device can only rotate and stir in one direction at a time during mixing. This unidirectional stirring easily leads to uneven distribution of the detergent, creating areas of varying concentrations. This reduces the opportunity for the virus to come into contact with the detergent, making it difficult to guarantee effective inactivation and thus lowering the device's inactivation efficiency. Furthermore, the device requires regular internal maintenance during long-term use. Typically, the device uses a sealed structure, with its cover plate fixed to the top of the tank by multiple bolts. Maintenance requires the use of tools to disassemble and reassemble these bolts sequentially, a cumbersome process that increases labor costs and reduces maintenance efficiency. Utility Model Content

[0004] The purpose of this invention is to provide a device for inactivating viruses in blood products, so as to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a device for inactivating viruses in blood products, comprising:

[0006] The tank body has a cover plate on its top, two connecting blocks are fixedly connected to the outside of the cover plate, and two outer shells are installed on the outside of the tank body;

[0007] The controller is located on the outside of the tank, and a heater for regulating the liquid temperature is provided at the bottom of the inner side of the tank. A temperature sensor is provided at the bottom of the cover plate.

[0008] Positioning components are provided on the outside of the tank body and the cover plate, and there are two sets of them. An adjustment component is provided on the inside of the outer shell.

[0009] A locking block is provided on the outside of the adjusting component. A limit groove is provided on the inner wall of the connecting block. Two sets of pop-out components are provided on the bottom inner side of the housing. A second spring for pushing it to reset is fixedly connected to the outside of the locking block.

[0010] A drive assembly is disposed on the top of the cover plate. A rotating shaft is disposed on the inner side of the drive assembly, and a connecting shell is rotatably connected to the outer side of the rotating shaft.

[0011] A transmission assembly is disposed on the outside of the rotating shaft and the connecting housing, and a mixing assembly is disposed on the outside of the connecting housing.

[0012] Preferably, the positioning component includes a positioning block fixed to the outside of the cover plate, a positioning groove is fixedly connected to the outside of the tank, and the outside of the positioning block is slidably connected to the inside of the positioning groove.

[0013] Preferably, the adjustment assembly includes a push button that slides inside the housing, and a fixed shaft is fixedly connected to the inner wall of the housing. The outer side of the fixed shaft is rotatably connected to the inner side of the locking block.

[0014] Preferably, the pop-out assembly includes a slide bar that slides on the inner wall of the bottom of the housing, and a first spring is sleeved on the outer side of the slide bar.

[0015] Preferably, the drive assembly includes a motor fixed to the top of the cover plate, the output end of the motor is provided with a first bevel gear, the top of the cover plate is fixedly connected to a fixing frame, one end of the first bevel gear is rotatably connected to the inner wall of the fixing frame, and the top of the fixing frame is rotatably connected to a rotating shaft.

[0016] Preferably, the transmission assembly includes a second bevel gear fixed to the outside of the rotating shaft, and a third bevel gear fixedly connected to the outside of the connecting shell, wherein the outer sides of the second bevel gear and the third bevel gear are both meshed with the outer side of the first bevel gear.

[0017] Preferably, the mixing assembly includes a connecting frame fixed to the outside of the connecting shell, a plurality of first mixing blades fixedly connected to the inner side of the connecting frame, and a plurality of second mixing blades fixedly connected to the outer side of the rotating shaft.

[0018] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0019] This invention utilizes a first bevel gear to drive a second and third bevel gear, which rotate in opposite directions. Simultaneously, the shaft and connecting shell rotate, driving the first and second mixing paddles to rotate in opposite directions around the shaft. This promotes the dispersion and flow of blood products and detergents, allowing them to mix and come into contact more thoroughly, ensuring effective inactivation of viruses. By pressing the push button, the locking block rotates along the fixed shaft, causing one end of the locking block to disengage from the limiting groove. At this point, the connecting block loses its limiting position, and the first spring, through its accumulated rebound force, pushes the connecting block upward, separating it from the outer shell. Then, the cover plate is lifted upward, causing the positioning block to slide out of the positioning groove, allowing the cover plate to be removed from the top of the tank. The disassembly and assembly steps are simple, improving maintenance efficiency. Attached Figure Description

[0020] Figure 1 A schematic diagram of a preferred embodiment of the device for inactivating viruses in blood products provided by this utility model;

[0021] Figure 2 This is a structural schematic diagram of the present invention;

[0022] Figure 3 This is a structural schematic diagram of the present invention;

[0023] Figure 4 This is a structural schematic diagram of the present invention.

[0024] In the diagram: 1. Tank body; 2. Cover plate; 3. Connecting block; 4. Outer shell; 5. Controller; 6. Heater; 7. Temperature sensor; 8. Positioning assembly; 81. Positioning block; 82. Positioning groove; 9. Adjustment assembly; 91. Push button; 92. Fixed shaft; 10. Locking block; 11. Limiting groove; 12. Pop-out assembly; 121. Slide rod; 122. First spring; 13. Second spring; 14. Drive assembly; 141. Motor; 142. First bevel gear; 143. Fixing frame; 15. Rotating shaft; 16. Connecting shell; 17. Transmission assembly; 171. Second bevel gear; 172. Third bevel gear; 18. Mixing assembly; 181. Connecting frame; 182. First mixing paddle; 183. Second mixing paddle. Detailed Implementation

[0025] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0026] Please see Figure 1-4 As shown, an apparatus for inactivating viruses in blood products includes a tank 1, a cover plate 2 on the top of the tank 1, two connecting blocks 3 fixedly connected to the outside of the cover plate 2, and two outer shells 4 installed on the outside of the tank 1; a controller 5, located on the outside of the tank 1; a heater 6 for regulating the liquid temperature is provided at the bottom of the inner side of the tank 1; and a temperature sensor 7 is provided at the bottom of the cover plate 2 for monitoring the temperature value of the liquid and transmitting the value to the controller 5.

[0027] Positioning components 8 are located on the outside of the tank body 1 and the cover plate 2, and there are two sets of them. Adjustment components 9 are located on the inside of the outer shell 4. Locking block 10 is located on the outside of adjustment components 9. Limiting groove 11 is opened on the inner wall of connecting block 3. When connecting block 3 slides into the inside of the outer shell 4, locking block 10 contacts the arc surface at the bottom of connecting block 3 and is pushed to one side by the arc surface of connecting block 3. As connecting block 3 gradually moves down, locking block 10 is pushed into the inner side of limiting groove 11 by second spring 13, so that connecting block 3 is limited. Two sets of pop-out components 12 are provided on the bottom of the inner side of the outer shell 4. A second spring 13 for pushing it to reset is fixedly connected to the outside of locking block 10, and its other end is fixedly connected to the inner wall of the outer shell 4. After locking block 10 rotates, it can be pushed to reset by elastic force.

[0028] A drive assembly 14 is disposed on the top of the cover plate 2. A rotating shaft 15 is disposed on the inner side of the drive assembly 14, and a connecting shell 16 is rotatably connected to the outer side of the rotating shaft 15. A transmission assembly 17 is disposed on the outer side of the rotating shaft 15 and the connecting shell 16, and a mixing assembly 18 is disposed on the outer side of the connecting shell 16.

[0029] The positioning component 8 includes a positioning block 81 fixed to the outside of the cover plate 2. A positioning groove 82 is fixedly connected to the outside of the tank body 1. The outside of the positioning block 81 is slidably connected to the inside of the positioning groove 82. When the cover plate 2 is connected to the tank body 1, the positioning block 81 is first aligned and inserted into the inside of the positioning groove 82 so that the installation position of the cover plate 2 is initially fixed.

[0030] The adjustment component 9 includes a push button 91 that slides inside the housing 4, one end of which is in contact with the locking block 10. When the push button 91 is pressed, it will push one end of the locking block 10 to rotate accordingly. A fixed shaft 92 is fixedly connected to the inner wall of the housing 4. The outer side of the fixed shaft 92 is rotatably connected to the inner side of the locking block 10, and the locking block 10 will rotate around the fixed shaft 92 as the center.

[0031] The pop-out assembly 12 includes a slide rod 121 that slides on the inner wall of the bottom of the housing 4. A first spring 122 is sleeved on the outer side of the slide rod 121. A second spring 13 for pushing the locking block 10 to reset is fixedly connected to the outer side of the locking block 10. After the connecting block 3 loses its limit, the first spring 122 will push the connecting block 3 upward through the accumulated elastic force. A limit block is fixed at one end of the slide rod 121 to limit one end of the first spring 122. The other end of the first spring 122 is in contact with the inner wall of the housing 4. At the same time, the slide rod 121 can limit the compression path of the first spring 122 to improve its stability.

[0032] The drive assembly 14 includes a motor 141 fixed to the top of the cover plate 2. The output end of the motor 141 is provided with a first bevel gear 142. A fixing frame 143 is fixedly connected to the top of the cover plate 2. One end of the first bevel gear 142 is rotatably connected to the inner wall of the fixing frame 143. A rotating shaft 15 is rotatably connected to the top of the fixing frame 143. When the motor 141 starts, it drives the first bevel gear 142 to rotate. One end of the rotating shaft 15 rotates inside the bearing at the top of the fixing frame 143, ensuring that the rotating shaft 15 can rotate stably.

[0033] The transmission assembly 17 includes a second bevel gear 171 fixed to the outside of the rotating shaft 15, and a third bevel gear 172 fixedly connected to the outside of the connecting housing 16. The outer sides of the second bevel gear 171 and the third bevel gear 172 are meshed with the outer side of the first bevel gear 142. The second bevel gear 171 and the third bevel gear 172 are located on the upper and lower sides of the first bevel gear 142, respectively. Under the drive of the first bevel gear 142, the second bevel gear 171 and the third bevel gear 172 will rotate in opposite directions.

[0034] The mixing assembly 18 includes a connecting frame 181 fixed to the outside of the connecting shell 16. Multiple first mixing propellers 182 are fixedly connected to the inner side of the connecting frame 181, and multiple second mixing propellers 183 are fixedly connected to the outer side of the rotating shaft 15. Driven by the rotating shaft 15 and the connecting shell 16, the first mixing propellers 182 and the second mixing propellers 183 rotate in opposite directions on the same axis with the rotating shaft 15 as the center. The bottom inner side of the connecting frame 181 is connected to the rotating shaft 15 through a bearing, which improves rotational stability and prevents motion interference between them.

[0035] Working Principle: During use, when inactivating viruses, the detergent is first added to the tank 1 through the injection pipe at the top of the cover plate 2. Then, the heater 6 operates, raising the temperature of the liquid inside the tank 1. Simultaneously, the temperature sensor 7 monitors the liquid temperature and transmits the value to the controller 5. When the temperature exceeds the appropriate range, the controller 5 adjusts the power of the heater 6 to maintain the temperature within the suitable range for inactivating pathogens. At the same time, the motor 141 drives the first bevel gear 142 to rotate. Since the second bevel gear 171 and the third bevel gear 172 are located on the upper and lower sides of the first bevel gear 142, under the drive of the first bevel gear 142, the second bevel gear 171 and the third bevel gear 172 will rotate in opposite directions. Simultaneously, the rotating shaft 15 and the connecting shell... 16 follows the rotation, driving the first mixing paddle 182 and the second mixing paddle 183 to rotate in opposite directions on the same axis with the rotating shaft 15 as the center, promoting the dispersion and flow of blood products and detergents, so that they can be more fully mixed and contacted, ensuring that the virus is effectively inactivated. When the device needs to be inspected, first press the push button 91 to push the locking block 10 to rotate along the fixed shaft 92, so that one end of the locking block 10 is disengaged from the limit groove 11. At this time, the connecting block 3 loses its limit, and the first spring 122 pushes the connecting block 3 upward through the accumulated rebound force, so that the connecting block 3 is separated from the outer shell 4. Then lift the cover plate 2 upward, so that the positioning block 81 slides out of the inner side of the positioning groove 82, and the cover plate 2 can be removed from the top of the tank 1.

[0036] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0037] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A device for viral inactivation of blood products, characterized in that, include: The tank (1) has a cover plate (2) on its top, and two connecting blocks (3) are fixedly connected to the outside of the cover plate (2). Two outer shells (4) are installed on the outside of the tank (1). A controller (5) is located on the outside of the tank (1), a heater (6) for adjusting the liquid temperature is provided on the bottom of the inner side of the tank (1), and a temperature sensor (7) is provided on the bottom of the cover plate (2). Positioning components (8) are provided on the outside of the tank body (1) and the cover plate (2), and there are two sets of them. An adjustment component (9) is provided on the inside of the outer shell (4). A locking block (10) is provided on the outside of the adjusting component (9). A limiting groove (11) is provided on the inner wall of the connecting block (3). Two sets of pop-out components (12) are provided on the bottom inner side of the outer shell (4). A second spring (13) for pushing it to reset is fixedly connected to the outside of the locking block (10). A drive assembly (14) is provided on the top of the cover plate (2). A rotating shaft (15) is provided on the inner side of the drive assembly (14), and a connecting shell (16) is rotatably connected to the outer side of the rotating shaft (15). A transmission assembly (17) is disposed on the outside of the rotating shaft (15) and the connecting shell (16), and a mixing assembly (18) is disposed on the outside of the connecting shell (16).

2. A device for viral inactivation of blood products according to claim 1, characterized in that: The positioning component (8) includes a positioning block (81) fixed to the outside of the cover plate (2), and a positioning groove (82) is fixedly connected to the outside of the tank body (1). The outside of the positioning block (81) is slidably connected to the inside of the positioning groove (82).

3. A device for viral inactivation of blood products according to claim 1, characterized in that: The adjustment component (9) includes a push button (91) that slides inside the housing (4). A fixed shaft (92) is fixedly connected to the inner wall of the housing (4). The outer side of the fixed shaft (92) is rotatably connected to the inner side of the locking block (10).

4. A device for viral inactivation of blood products according to claim 1, characterized in that: The pop-out assembly (12) includes a slide rod (121) that slides on the inner wall of the bottom of the housing (4), and a first spring (122) is sleeved on the outer side of the slide rod (121).

5. A device for viral inactivation of blood products according to claim 1, characterized in that: The drive assembly (14) includes a motor (141) fixed to the top of the cover plate (2). The output end of the motor (141) is provided with a first bevel gear (142). A fixing frame (143) is fixedly connected to the top of the cover plate (2). One end of the first bevel gear (142) is rotatably connected to the inner wall of the fixing frame (143), and a rotating shaft (15) is rotatably connected to the top of the fixing frame (143).

6. A device for viral inactivation of blood products according to claim 5, characterized in that: The transmission assembly (17) includes a second bevel gear (171) fixed to the outside of the rotating shaft (15), and a third bevel gear (172) fixedly connected to the outside of the connecting shell (16). The outer sides of the second bevel gear (171) and the third bevel gear (172) are both meshed with the outer side of the first bevel gear (142).

7. A device for viral inactivation of blood products according to claim 1, characterized in that: The mixing assembly (18) includes a connecting frame (181) fixed to the outside of the connecting shell (16), a plurality of first mixing blades (182) are fixedly connected to the inside of the connecting frame (181), and a plurality of second mixing blades (183) are fixedly connected to the outside of the rotating shaft (15).

Images