Disinfectant composition

Abstract

Provided are: a disinfectant composition having an excellent effect of suppressing hand roughness and having a good effect of inactivating a non-enveloped virus; a disinfectant composition-impregnated article; a non-enveloped virus inactivation method; and a method for producing a disinfectant composition.　A disinfectant composition, according to the present invention, contains: (A) 40-95 mass% of ethanol; (B) 0.20-3.0 mass% of one or more substances selected from gluconic acid and alkali metal salts thereof; and (C) 0.10-2.0 mass% of a water-soluble polyhydric alcohol, and has a pH of 5.0 or less at 25°C.

Description

Disinfectant composition

[0001] The present invention relates to a disinfectant composition, a disinfectant composition-impregnated article, a method for disinfecting the body surface, a method for inactivating non-enveloped viruses, and a method for producing a disinfectant composition.

[0002] Background Art Viral acute gastroenteritis and diarrhea are not only confirmed as outbreaks in nursing homes, hospitals, schools, etc., but also frequently reported as outbreaks due to food poisoning through contaminated food in food processing facilities, restaurants, etc. Non-enveloped viruses such as norovirus, sapovirus, and rotavirus are known as causative viruses of food poisoning, and these viruses can cause severe symptoms when infecting children and the elderly.

[0003] In particular, norovirus is regarded as a problem virus that causes outbreaks. The infection route is well known to be oral infection by eating shellfish such as raw oysters, but in homes and public facilities, secondary infections from the virus present on the fingers of people who have touched contaminated food, cooking utensils, vomit or feces of patients, or the surrounding environment of patients have also been frequently reported. In particular, such secondary infections lead to outbreaks and the spread of infection, and are a major cause of the increase in the number of patients.

[0004] Non-enveloped viruses such as norovirus are covered with a strong capsid protein and are more difficult to inactivate than enveloped viruses, and simple alcohol alone is not sufficient for adequate inactivation. As a method for inactivating viruses, alcohol preparations mainly composed of ethanol are generally known, but a more effective disinfectant method is known to use a disinfectant composition mainly composed of ethanol with the pH adjusted to be acidic. Japanese Patent Publication No. 2008-255101 (Patent Document 1) discloses a disinfectant containing (a) 40-90% ethanol or isopropyl alcohol, (b) 0.1-2% lactic acid, (c) 0.01-2% citric acid, and (d) 0.001-0.1% zinc-containing compound that releases zinc ions, with a pH of 2.5-5.0. Japanese Patent Publication No. 2018-080126 (Patent Document 2) discloses a virus inactivator characterized by comprising ethanol and an acid selected from the group consisting of tartaric acid, pyrophosphate, polyphosphate, and phytic acid, having a pH of 1.0 to 6.0, and not containing antimicrobial fine particles. Japanese Patent Publication No. 2018-199635 (Patent Document 3) discloses a virus inactivator characterized by comprising ethanol and two acid selected from the group consisting of citric acid, tartaric acid, and phosphoric acid, having a pH of 1.0 to 6.0.

[0005] Furthermore, in the virus inactivation tests described in these patent documents, feline calicivirus, a non-enveloped virus, is used as a surrogate virus for norovirus. In the United States Environmental Protection Agency (EPA) norovirus testing method, feline calicivirus strain F9 is commonly used as a surrogate virus, and currently, feline calicivirus is mainly used as a surrogate virus for norovirus in antiviral tests and experiments both in Japan and abroad.

[0006] Summary of the Invention It is generally known that the higher the ethanol concentration, the greater the virus inactivation effect. It is also known that the more acidic the pH of an ethanol-based disinfectant is made with organic acids, the more effective it is at inactivating feline calicivirus. On the other hand, ethanol can cause skin irritation due to its dehydrating and protein denaturing effects, and since the pH of healthy skin is weakly acidic (4.5 to 6.0), there is a problem that making ethanol more acidic will cause skin irritation. Patent documents 1 to 3 describe compositions that have an inactivating effect on feline calicivirus, but all of them tend to cause skin irritation, and the aforementioned problem has not been solved.

[0007] This invention was made in view of the above problems, and provides a disinfectant composition that is excellent in suppressing skin irritation and has a good effect in inactivating non-enveloped viruses, an article impregnated with the disinfectant composition, a method for disinfecting a body surface, a method for inactivating non-enveloped viruses, and a method for producing the disinfectant composition.

[0008] The present invention relates to a disinfectant composition containing (A) 40% to 95% by mass of ethanol, (B) 0.20% to 3.0% by mass of one or more selected from gluconic acid and its alkali metal salts, and (C) 0.10% to 2.0% by mass of a water-soluble polyhydric alcohol, with a pH of 5.0 or less at 25°C.

[0009] Furthermore, the present invention relates to a disinfectant composition-impregnated article in which the above-mentioned disinfectant composition is impregnated into a substrate.

[0010] Furthermore, the present invention relates to a method for disinfecting a body surface, wherein the disinfectant composition contains 40% to 95% by mass of component (A), 0.20% to 3.0% by mass of component (B), and 0.10% to 2.0% by mass of component (C), and has a pH of 5.0 or less at 25°C, and is brought into contact with the body surface.

[0011] The present invention also relates to a method for inactivating non-enveloped viruses, comprising contacting a disinfectant composition containing 40% to 95% by mass of component (A), 0.20% to 3.0% by mass of component (B), and 0.10% to 2.0% by mass of component (C), with a pH of 5.0 or less at 25°C, with a target surface where non-enveloped viruses are present.

[0012] The present invention also relates to a method for producing a disinfectant composition, which involves mixing component (A), component (B), and component (C) to produce a disinfectant composition containing 40% to 95% by mass of component (A), 0.20% to 3.0% by mass of component (B), and 0.10% to 2.0% by mass of component (C), and having a pH of 5.0 or less at 25°C.

[0013] The present invention provides a disinfectant composition that is excellent in suppressing skin irritation and has a good effect in inactivating non-enveloped viruses, an article impregnated with the disinfectant composition, a method for disinfecting a body surface, a method for inactivating non-enveloped viruses, and a method for producing the disinfectant composition.

[0014] Mode for Carrying Out the Invention The inventors investigated various components in order to solve the above problems and found that by adding 0.20% to 3.0% by mass of one or more selected from gluconic acid and its alkali metal salts (component B) and 0.10% to 2.0% by mass of a water-soluble polyhydric alcohol (component C) to a hand sanitizer mainly composed of ethanol (component A), it is possible to achieve a sufficient hand-soothing effect even at a low pH and to exhibit an inactivation effect against non-enveloped viruses, thus completing the present invention. It is not foreseeable to those skilled in the art that a composition containing 0.20% to 3.0% by mass of one or more selected from gluconic acid and its alkali metal salts and 0.10% to 2.0% by mass of a water-soluble polyhydric alcohol can suppress hand soothing even at a low pH. In this invention, disinfection includes one or more selected from virus inactivation, antiviral, antiviral, sterilization of bacteria and fungi, and antibacterial. Therefore, the disinfectant composition of the present invention may be one or more compositions selected from virus inactivating agent compositions, antiviral agent compositions, antiviral agent compositions, bactericidal agent compositions, disinfectant agent compositions, and antibacterial agent compositions.

[0015] <Disinfectant Composition> The disinfectant composition of the present invention contains (A) ethanol [hereinafter referred to as component (A)], (B) one or more selected from gluconic acid and its alkali metal salts [hereinafter referred to as component (B)], and (C) a water-soluble polyhydric alcohol [hereinafter referred to as component (C)], and has a pH of 5.0 or less at 25°C. The disinfectant composition of the present invention may be a disinfectant composition comprising component (A), component (B), and component (C).

[0016] (A) As the raw material ethanol for component (A), ordinary types such as fermented ethanol, synthetic ethanol, bioethanol, and purified ethanol can be used, but it is preferable to use one of a quality that can ensure safety according to the disinfection application.

[0017] Examples of component (B) gluconic acid and its alkali metal salts include gluconic acid, sodium gluconate, potassium gluconate, etc. These may be used individually or in combination of two or more.

[0018] The water-soluble polyhydric alcohol of component (C) is preferably a water-soluble polyhydric alcohol with a molecular weight of 250 or less, such as glycerin, diglycerin, ethylene glycol, propylene glycol, 1,3-propanediol, butylene glycol, erythritol, and sorbitol, and polyethylene glycol with a weight-average molecular weight of 3,000 to 10,000. One or more of these can be used. Of these, component (C) is preferably one or more selected from glycerin and polyethylene glycol, with glycerin being more preferred. Furthermore, it is even more preferable to use glycerin and polyethylene glycol in combination for component (C). Polyethylene glycol can also be used as a texture modifier, and provides suitable spreadability when applied to fingers or skin. In this invention, water solubility refers to a solubility in water of 10 g / 100 g or more at 20°C.

[0019] <Composition and Other Components> The disinfectant composition of the present invention contains component (A) in an amount of 40% by mass or more, preferably 45% by mass or more, more preferably 55% by mass or more, from the viewpoint of obtaining sufficient disinfectant effects such as virus inactivation and / or sterilization, and from the viewpoint of solubility and storage stability of the blended components, in an amount of 95% by mass or less, preferably 90% by mass or less, more preferably 75% by mass or less.

[0020] The disinfectant composition of the present invention contains component (B) in an amount of 0.20% by mass or more, preferably 0.30% by mass or more, more preferably 0.40% by mass or more, even more preferably 0.60% by mass or more, and even more preferably 0.80% by mass or more, from the viewpoint of obtaining a sufficient inactivation effect on non-enveloped viruses and an effect of suppressing skin roughness, and from the viewpoint of solubility and storage stability of the blended components, 3.0% by mass or less, preferably 2.5% by mass or less, and even more preferably 2.0% by mass or less. In the present invention, the specification regarding the mass of component (B) shall be the value converted to the acid type.

[0021] The disinfectant composition of the present invention contains component (C) in an amount of 0.10% by mass or more, preferably 0.20% by mass or more, more preferably 0.30% by mass or more, from the viewpoint of obtaining an effect of suppressing rough hands, and 2.0% by mass or less, preferably 1.5% by mass or less, more preferably 1.0% by mass or less, even more preferably 0.8% by mass or less, and even more preferably 0.6% by mass or less, from the viewpoint of not leaving a sticky feeling after drying.

[0022] In the disinfectant composition of the present invention, the mass ratio (B) / (C) of the content of component (B) to the content of component (C) is preferably 0.5 or more, more preferably 0.6 or more, even more preferably 0.7 or more, even more preferably 0.8 or more, even more preferably 1.0 or more, even more preferably 1.5 or more, even more preferably 2.0 or more, even more preferably 2.5 or more, and preferably 10 or less, more preferably 8.0 or less, even more preferably 6.0 or less, even more preferably 5.0 or less, and even more preferably 4.5 or less.

[0023] Since the disinfectant composition of the present invention is acidic, it may optionally contain an acidic agent (D) [excluding component (B), hereinafter referred to as component (D)] in addition to component (B), as long as it does not impair the effect of suppressing skin irritation. In the disinfectant composition of the present invention, it is preferable to use component (D) together with component (B) as a pH adjuster from the viewpoint of virus inactivation effect and bactericidal effect. Examples of component (D) include hydrochloric acid, sulfuric acid, phosphoric acid, and organic acids with a molecular weight of 250 or less, such as citric acid, succinic acid, malic acid, fumaric acid, adipic acid, tartaric acid, and lactic acid, and one or more of these can be used. Component (D) is preferably one or more selected from hydrochloric acid, sulfuric acid, phosphoric acid, and citric acid, and more preferably one or more selected from sulfuric acid and phosphoric acid.

[0024] If the disinfectant composition of the present invention contains component (D), component (D) is preferably contained in the disinfectant composition in an amount of 0.01% by mass or more, more preferably 0.02% by mass or more, even more preferably 0.03% by mass or more, even more preferably 0.04% by mass or more, and preferably 2.0% by mass or less, more preferably 1.5% by mass or less, even more preferably 1.0% by mass or more, and even more preferably 0.5% by mass or less, from the viewpoint of inactivating non-enveloped viruses and suppressing skin roughness. If the disinfectant composition of the present invention contains phosphoric acid as component (D), from the viewpoint of inactivating non-enveloped viruses, the total content of component (B) and phosphoric acid is preferably 1.2% by mass or more and 1.5% by mass or less in the disinfectant composition.

[0025] When the disinfectant composition of the present invention contains phosphoric acid or an organic acid as component (D), the mass ratio (B) / (D) of the content of component (B) to the content of component (D) in the disinfectant composition of the present invention is 0.2 or more, more preferably 0.5 or more, even more preferably 1.0 or more, even more preferably 1.5 or more, and preferably 30 or less, more preferably 20 or less, even more preferably 10 or less, and even more preferably 7 or less, when converted to the acid type, from the viewpoint of inactivating non-enveloped viruses and suppressing skin roughness.

[0026] The disinfectant composition of the present invention preferably contains (E) a skin protectant [hereinafter referred to as (E) component] to an extent that does not impair the virus inactivation effect, bactericidal effect, and solution stability. Examples of (E) component include one or more selected from glycyrrhetinic acid, nicotinamide, ceramide, pseudoceramide, allantoin, hyaluronic acid, urea, tocopherol acetate, and dipotassium glycyrrhizinate, with glycyrrhetinic acid being preferred.

[0027] If the disinfectant composition of the present invention contains component (E), component (E) is preferably contained in the disinfectant composition in an amount of 0.01% by mass or more, more preferably 0.015% by mass or more, preferably 0.2% by mass or less, and more preferably 0.1% by mass or less.

[0028] The disinfectant composition of the present invention may optionally contain pH adjusters other than the acidic agents (components (B) and (D)), as long as they do not impair the virus inactivation effect and bactericidal effect. The pH adjuster is not particularly limited, as long as it is suitable for topical skin preparations such as pharmaceuticals and cosmetics when applied to the body surface. Examples of such pH adjusters include alkali metal hydroxides such as sodium hydroxide and potassium hydroxide; alkanolamines such as monoethanolamine, diethanolamine, and triethanolamine; alkylamines such as 2-amino-2-methyl-1-propanol and 2-amino-2-methyl-1,3-propanediol; and basic amino acids such as lysine and arginine. One or more of these can be used.

[0029] The disinfectant composition of the present invention may optionally contain a virus inactivating agent, provided that it does not impair the effects of the present invention. The inclusion of a virus inactivating agent in the disinfectant composition of the present invention further enhances its virus inactivation effect. Examples of virus inactivating agents include green tea extract, maqui berry extract, grape extract, evening primrose seed extract, oolong tea extract, and bilberry extract, and one or more of these can be used.

[0030] The disinfectant composition of the present invention may optionally contain solvents, surfactants, metal corrosion inhibitors, chelating agents, buffering agents, bactericides such as polylysine, antioxidants, preservatives, fragrances, and dyes [excluding components (A) to (E), pH adjusters, and virus inactivators].

[0031] From the viewpoint of obtaining a bactericidal effect and sufficient inactivation effect of non-enveloped viruses, the disinfectant composition of the present invention has a pH at 25°C that is preferably 5.0 or less, more preferably 4.5 or less, even more preferably 4.0 or less, and even more preferably 3.5 or less. From the viewpoint of preventing skin irritation, it is preferably 1.0 or more, more preferably 2.0 or more, even more preferably 2.5 or more, and even more preferably 3.0 or more. The pH of the disinfectant composition of the present invention was measured according to JIS Z-8802:2011 "Method for measuring pH", and specifically, it was measured according to the following measurement method.

[0032] <Method for measuring pH> A pH measuring composite electrode (Horiba, Ltd., glass ground-joint sleeve type) with saturated potassium chloride aqueous solution (3.33 mol / L) as the internal solution of the pH electrode is connected to a pH meter (Horiba, Ltd., pH / ion meter F-71). Next, calibration is performed using pH 4.01 standard solution (phthalate standard solution), pH 6.86 (neutral phosphate standard solution), and pH 9.18 standard solution (borate standard solution). The disinfectant composition to be measured is placed in a sample bottle and immersed in a 25°C constant temperature bath for 30 minutes beforehand. The electrode of the pH meter is immersed in the sample that has been adjusted to a constant temperature, and the pH is measured after 1 minute.

[0033] The disinfectant composition of the present invention contains water from the viewpoint of the solubility of the constituent components. The water is not particularly limited, but examples include tap water, well water, deionized water, and distilled water. It is preferable that the amount of water used is the remainder of the composition (an amount that totals 100% by mass). The disinfectant composition of the present invention may contain water in amounts of, for example, 4% by mass or more, further 10% by mass or more, further 16% by mass or more, further 20% by mass or more, and 59% by mass or less, further 54% by mass or less, and further 49% by mass or less.

[0034] The objects to be disinfected by the disinfectant composition of the present invention are not particularly limited, but include: (1) the body, such as human skin and fingers; (2) hard surfaces, such as cooking utensils, countertops, display cases, refrigerators, tables, desks, chairs, doorknobs, toilets (toilet bowls and seats), water faucets, tableware, food processing equipment, walls, floors, etc; and (3) food, such as the surfaces of food materials such as vegetables. The disinfectant composition of the present invention can be suitably used for disinfecting body surfaces, particularly body surfaces such as fingers.

[0035] The disinfectant composition of the present invention can be used in the same way as known alcohol-based disinfectants. For example, the disinfectant composition of the present invention can be sprayed onto the surface to be disinfected using a sprayer or the like, and then rubbed in with the fingers or wiped with a nonwoven fabric or the like, or the surface to be disinfected can be wiped with a nonwoven fabric or the like impregnated with the disinfectant composition.

[0036] The disinfectant composition of the present invention can be suitably used not only for sterilizing target surfaces, but also for inactivating, deviralizing, and antiviral non-enveloped viruses.

[0037] The disinfectant composition of the present invention has a good effect in inactivating non-enveloped viruses. Non-enveloped viruses may be, for example, single-stranded (+) RNA viruses, single-stranded (-) RNA viruses, double-stranded RNA viruses, single-stranded DNA viruses, and double-stranded DNA viruses that do not have a lipid layer or lipid bilayer on their surface. Examples of non-enveloped viruses include, for viruses with DNA genomes, adenoviruses, parvoviruses, papovaviruses, human papillomaviruses, etc., and for viruses with RNA genomes, rotaviruses, coxsackieviruses, enteroviruses, sapoviruses, noroviruses, polioviruses, echoviruses, hepatitis A virus, hepatitis E virus, rhinoviruses, astroviruses, bacteriophage MS2, etc.

[0038] <Method for Inactivating Non-Enveloped Viruses> The present invention provides a method for inactivating non-enveloped viruses by bringing the disinfectant composition of the present invention into contact with a target surface, particularly a target surface where non-enveloped viruses are present. That is, the present invention provides a method for inactivating non-enveloped viruses by bringing a disinfectant composition containing 40% to 95% by mass of component (A), 0.20% to 3.0% by mass of component (B), and 0.10% to 2.0% by mass of component (C), with a pH of 5.0 or less at 25°C, into contact with a target surface, particularly a target surface where non-enveloped viruses are present. The method for inactivating non-enveloped viruses of the present invention may be a method for inactivating non-enveloped viruses by bringing the disinfectant composition of the present invention into contact with a target surface where non-enveloped viruses are present. In the method for inactivating non-enveloped viruses of the present invention, the disinfectant composition of the present invention can be brought into contact with the target surface without dilution. The disinfectant composition used in the method for inactivating non-enveloped viruses of the present invention can be appropriately adapted from the embodiments described for the disinfectant composition of the present invention.

[0039] The non-enveloped virus inactivation method of the present invention may be a method of inactivating non-enveloped viruses by bringing the disinfectant composition of the present invention into contact with the hands, particularly the hands on which the virus is present.

[0040] The target surfaces for the non-enveloped virus inactivation method of the present invention are not particularly limited, but include: (1) the body, such as human skin and fingers; (2) hard surfaces, such as cooking utensils, countertops, display cases, refrigerators, tables, desks, chairs, doorknobs, toilets (toilet bowls and seats), water taps, tableware, food processing equipment, walls, floors, etc; and (3) food, such as the surface of food materials like vegetables. The target surfaces for the non-enveloped virus inactivation method of the present invention are human skin or body surfaces such as fingers, and body surfaces such as fingers are particularly preferred.

[0041] As a method of bringing the disinfectant composition of the present invention into contact with a target surface on which non-enveloped viruses are present, examples include spraying or applying the disinfectant composition of the present invention to a target surface on which non-enveloped viruses are present or are considered to be present, and immersing a target article in the disinfectant composition of the present invention. Further, the disinfectant composition of the present invention may be impregnated into a base material such as a non-woven fabric, and the base material impregnated with the disinfectant composition of the present invention may be brought into contact with the target surface.

[0042] When spraying or applying the disinfectant composition of the present invention to a target surface, the disinfectant composition of the present invention may be filled into a container equipped with a sprayer, sprayed in the form of droplets or bubbles, or the disinfectant composition of the present invention may be poured from the container onto the target surface and rubbed in with fingers or applied with a brush or the like. Examples of the container equipped with a sprayer include manual spray devices that do not use a propellant, such as a trigger-type spray container or a pump-type spray container, and aerosols that use a propellant. The container equipped with the sprayer is preferably a trigger-type spray that can spray the contents in the form of droplets or bubbles, and more preferably a trigger-type spray equipped with a mechanism for spraying the contents in the form of droplets or a trigger-type spray equipped with a mechanism for forming bubbles (foam-forming mechanism).

[0043] When impregnating the disinfectant composition of the present invention into a non-woven fabric and bringing it into contact with a target surface, a non-woven fabric processed into a sheet shape can be used, and the fibers constituting the non-woven fabric are preferably composed of one or more fibers selected from hydrophilic fibers and hydrophobic fibers. In the present invention, hydrophilic fibers refer to fibers having a moisture content (20°C, 65% RH) in the standard state exceeding 5% by mass. The moisture content in the standard state is measured by the methods specified in JIS L 1013 and JIS L1015. Hydrophobic fibers refer to fibers having a moisture content (20°C, 65% RH) in the standard state of 5% by mass or less. The method of impregnating the disinfectant composition of the present invention into a non-woven fabric and bringing it into contact with a target surface is to press the non-woven fabric impregnated with the disinfectant composition of the present invention against the target surface, apply an external force within a range that does not damage the target object, and transfer and bring the disinfectant composition of the present invention impregnated in the non-woven fabric into contact with the target surface, which may be either rubbing or wiping.

[0044] Although the amount of the disinfectant composition of the present invention used is not particularly limited, for example, when applying to fingers, from the viewpoints of bactericidal effect, non-enveloped virus inactivation effect, and prevention of rough hands, usually, for the palms of both hands, the disinfectant composition is preferably applied in an amount of 0.1 mL or more, more preferably 0.2 mL or more, and preferably 5 mL or less, more preferably 4 mL or less.

[0045] The time (standing time) for contacting the disinfectant composition of the present invention with the target surface where non-enveloped viruses are present is preferably 15 seconds or more from the viewpoint of non-enveloped virus inactivation performance. After contacting, it may be dried as it is, wiped off with a clean cloth or the like, or rinsed with water. When rinsing, an external force (physical force) may be applied with a sponge or the like, or it may be simply rinsed with running water.

[0046] <Disinfection method for body surface> The present invention provides a disinfection method for a body surface, which comprises contacting the disinfectant composition of the present invention with the body surface. That is, the present invention provides a disinfection method for a body surface, which comprises contacting a disinfectant composition containing 40% by mass or more and 95% by mass or less of the component (A), 0.20% by mass or more and 3.0% by mass or less of the component (B), and 0.10% by mass or more and 2.0% by mass or less of the component (C), and having a pH of 5.0 or less at 25°C, with the body surface. The disinfection method for the body surface of the present invention may exclude medical acts, particularly medical acts on humans. In the disinfection method for the body surface of the present invention, the disinfectant composition of the present invention can be contacted with the target surface without dilution. The disinfectant composition used in the disinfection method for the body surface of the present invention can be appropriately applied in the manner described for the disinfectant composition of the present invention. In the disinfection method for the body surface of the present invention, the modes described in the disinfectant composition of the present invention and the non-enveloped virus inactivation method of the present invention can be appropriately applied.

[0047] The body surface targeted by the disinfection method for the body surface of the present invention may be human skin, particularly fingers.

[0048] Methods for bringing the disinfectant composition of the present invention into contact with a body surface include spraying or applying the disinfectant composition of the present invention to the body surface, or immersing the body surface in the disinfectant composition of the present invention. Alternatively, the disinfectant composition of the present invention may be impregnated into a substrate such as a nonwoven fabric, and the substrate impregnated with the disinfectant composition of the present invention may be brought into contact with a body surface.

[0049] When spraying or applying the disinfectant composition of the present invention to a body surface, the disinfectant composition of the present invention may be filled into a container equipped with a sprayer and sprayed in droplet or foam form, or the disinfectant composition of the present invention may be poured from the container onto the body surface and rubbed in with fingers or applied with a brush or the like. Examples of containers equipped with a sprayer include manual spraying devices that do not use propellants, such as trigger-type spray containers and pump-type spray containers, and aerosols that use propellants. The container equipped with a sprayer is preferably a trigger-type spray that can spray the contents in droplet or foam form, and more preferably a trigger-type spray equipped with a mechanism for spraying the contents in droplet form or a trigger-type spray equipped with a mechanism for forming foam (foam-forming mechanism).

[0050] When the disinfectant composition of the present invention is impregnated into a nonwoven fabric and brought into contact with a body surface, the nonwoven fabric is the same as the embodiment described in the method for inactivating non-enveloped viruses of the present invention. The method for impregnating a nonwoven fabric with the disinfectant composition of the present invention and bringing it into contact with a body surface involves pressing the nonwoven fabric impregnated with the disinfectant composition of the present invention against the body surface and applying external force within a range that does not damage the object, thereby transferring the disinfectant composition impregnated into the nonwoven fabric to the object surface and bringing it into contact with it. This can be done by rubbing or wiping.

[0051] The amount of the disinfectant composition of the present invention used is not particularly limited, but for example, when applied to the hands, from the viewpoint of bactericidal effect, inactivation effect of non-enveloped viruses, and effect of suppressing skin roughness, the disinfectant composition is usually applied to the palms of both hands in a range of preferably 0.1 mL or more, more preferably 0.2 mL or more, preferably 5 mL or less, and more preferably 4 mL or less.

[0052] The time for which the disinfectant composition of the present invention is in contact with the body surface (the time it is left to stand) is preferably 15 seconds or more, from the viewpoint of inactivating non-enveloped viruses. After contact, it may be left to dry, wiped off with a clean cloth, or rinsed with water. When rinsing, external force (physical force) may be applied with a sponge, or it may simply be rinsed with a stream of water.

[0053] <Disinfectant Composition Impregnated Articles> The disinfectant composition of the present invention can also be used as a disinfectant composition impregnated article by impregnating a substrate with the disinfectant composition of the present invention. A disinfectant composition impregnated article, in which the disinfectant composition of the present invention is impregnated into a substrate, is preferable from the viewpoint of workability in disinfection work. That is, the present invention provides a disinfectant composition impregnated article in which the disinfectant composition of the present invention is impregnated into a substrate. The disinfectant composition impregnated article of the present invention may be a disinfectant composition-containing article for body surfaces such as hands, or a disinfectant composition impregnated article for hard surfaces. The disinfectant composition impregnated article of the present invention, in which the disinfectant composition of the present invention is impregnated into a substrate, can be suitably used in the non-enveloped virus inactivation method and the body surface disinfection method of the present invention. That is, the present invention may be a non-enveloped virus inactivation method in which the disinfectant composition impregnated article of the present invention, in which the disinfectant composition of the present invention is impregnated into a substrate, is brought into contact with a target surface. The embodiments described in the non-enveloped virus inactivation method of the present invention can be appropriately applied to this method. Furthermore, the present invention may also be a method for disinfecting a body surface, wherein an article impregnated with the disinfectant composition of the present invention, in which the disinfectant composition of the present invention is impregnated into a substrate, is brought into contact with the body surface. The embodiments described in the method for disinfecting a body surface of the present invention can be appropriately applied to this method.

[0054] The substrate used in the disinfectant composition-impregnated article of the present invention is flexible, pliable, or pliable, capable of impregnating with the disinfectant composition, possesses sufficient strength during use, and does not generate debris. It is preferable to use a substrate capable of impregnating the amount of disinfectant composition described below under no load.

[0055] Examples of such substrates include fibrous structures composed of fibrous materials, such as various types of paper, nonwoven fabrics, woven fabrics, or knitted fabrics. Examples of fibrous materials constituting these fibrous structures include cellulose fibers, modified cellulose fibers, synthetic fibers, and mixtures of two or more of these. In addition, porous structures obtained by dispersing air bubbles in a resin (for example, sponge-like structures) can also be used as the above substrate. These substrates may be substrate sheets.

[0056] In a method for disinfecting a target surface using a disinfectant composition-impregnated article impregnated with the disinfectant composition of the present invention, the disinfectant composition-impregnated article may be either a substrate pre-impregnated with the disinfectant composition, or a dried substrate impregnated with the disinfectant composition immediately before use. Furthermore, the disinfectant composition-impregnated article may be used attached to a mop-like cleaning tool, or it may be held directly in the hand and used for wiping or cleaning the body.

[0057] When the disinfectant composition is pre-impregnated into the substrate, the impregnation rate of the disinfectant composition is preferably 100% by mass or more, more preferably 150% by mass or more, preferably 1,000% by mass or less, more preferably 500% by mass or less, and even more preferably 350% by mass or less, from the viewpoint of non-enveloped virus inactivation performance, per the mass of the substrate [i.e., based on the mass of the substrate in an unimpregnated (dry) state]. If the impregnation rate is 100% by mass or more, a sufficient disinfecting effect can be obtained. Furthermore, if the impregnation rate is 1,000% by mass or less, the disinfectant composition can be used without contacting target surfaces other than the disinfection surface. From the viewpoint of further improving the disinfecting effect, when the substrate is a substrate sheet, the basis weight of the disinfectant composition before impregnation is, for example, 50 g / m², from the viewpoint of the retention of the disinfectant composition required for disinfecting a certain area, the operability of the sheet, and cost. ２ Preferably, it should be 100 g / m² or more. ２ It is more preferable that the amount be greater than or equal to 250 g / m². ２ Preferably, it is 150 g / m ２ The following is more preferable:

[0058] When using an article impregnated with the disinfectant composition of the present invention, the disinfectant composition of the present invention may also be sprayed separately onto the surface to be disinfected or the article impregnated with the disinfectant composition. This method of use allows for disinfection of a wider area.

[0059] <Method for Producing a Disinfectant Composition> The present invention provides a method for producing a disinfectant composition by mixing component (A), component (B), and component (C) to produce a disinfectant composition containing 40% to 95% by mass of component (A), 0.20% to 3.0% by mass of component (B), and 0.10% to 2.0% by mass of component (C), with a pH of 5.0 or less at 25°C. In the method for producing a disinfectant composition of the present invention, component (D) may be further mixed. In the method for producing a disinfectant composition of the present invention, component (E) may be further mixed. In the method for producing a disinfectant composition of the present invention, a pH adjusting agent (excluding acidifying agents (components (B) and (D))) may be further mixed. Component (A), component (B), component (C), component (D), component (E), and pH adjusting agent are the same as those described in the description of the disinfectant composition of the present invention. In the method for producing the disinfectant composition of the present invention, the amount of each component mixed and their mass ratio can be appropriately applied by replacing the content of each component with the amount of each component, as described in the description of the disinfectant composition of the present invention. In the method for producing the disinfectant composition of the present invention, the matters described in the description of the disinfectant composition of the present invention can be appropriately applied.

[0060] Regarding the method for producing the disinfectant composition of the present invention, more specifically, it is preferable to produce it by the following method after determining the proportions of each component in advance. It is preferable to first mix water, component (B), component (C), an arbitrary component (D), and an arbitrary component (E), and then mix in component (A). However, if the arbitrary component (E) is poorly soluble in water, it is preferable to mix water, component (B), component (C), and component (D), and then mix them as a solution in which component (E) and component (A) have been mixed in advance. The pH adjusting agent may be added after the final mixing, and if the pH is adjusted with an organic substance such as an alkanolamine, it is more preferable to add it after adding component (D), and finally add component (A).

[0061] In addition to the embodiments described above, the present invention discloses the following embodiments: <1> A disinfectant composition containing (A) ethanol [hereinafter referred to as component (A)] in an amount of 40% to 95% by mass, (B) one or more selected from gluconic acid and its alkali metal salts [hereinafter referred to as component (B)] in an amount of 0.20% to 3.0% by mass, and (C) a water-soluble polyhydric alcohol [hereinafter referred to as component (C)] in an amount of 0.10% to 2.0% by mass, wherein the pH is 5.0 or less at 25°C.

[0062] <2> The disinfectant composition according to <1>, wherein the mass ratio (B) / (C) of the content of component (B) to the content of component (C) is preferably 0.5 or more, more preferably 0.6 or more, even more preferably 0.7 or more, even more preferably 0.8 or more, even more preferably 1.0 or more, even more preferably 1.5 or more, even more preferably 2.0 or more, even more preferably 2.5 or more, and preferably 10 or less, more preferably 8.0 or less, even more preferably 6.0 or less, even more preferably 5.0 or less, and even more preferably 4.5 or less.

[0063] <3> The disinfectant composition according to <1> or <2>, further comprising (D) an acidifying agent [excluding component (B), hereinafter referred to as component (D)].

[0064] <4> The disinfectant composition according to any one of <1> to <3> above, wherein component (C) is one or more selected from water-soluble polyhydric alcohols with a molecular weight of 250 or less and polyethylene glycols with a weight-average molecular weight of 3,000 to 10,000, preferably one or more selected from glycerin, diglycerin, ethylene glycol, propylene glycol, 1,3-propanediol, butylene glycol, erythritol, sorbitol and polyethylene glycols with a weight-average molecular weight of 3,000 to 10,000, more preferably one or more selected from glycerin and polyethylene glycol, and even more preferably glycerin.

[0065] <5> The disinfectant composition according to any one of <3> to <4> above, wherein component (D) is one or more selected from hydrochloric acid, sulfuric acid, phosphoric acid, and organic acids with a molecular weight of 250 or less, preferably one or more selected from hydrochloric acid, sulfuric acid, phosphoric acid, citric acid, succinic acid, malic acid, fumaric acid, adipic acid, tartaric acid, and lactic acid, more preferably one or more selected from hydrochloric acid, sulfuric acid, phosphoric acid, and citric acid, and even more preferably one or more selected from sulfuric acid and phosphoric acid.

[0066] <6> The disinfectant composition according to any one of <1> to <5> above, wherein the disinfectant composition is for use on body surfaces, hard surfaces, or food composition surfaces, preferably for use on body surfaces.

[0067] <7> A disinfectant composition-impregnated article in which a disinfectant composition described in any of <1> to <6> above is impregnated into a substrate.

[0068] <8> The disinfectant composition impregnated article according to <7>, wherein the substrate is a fibrous structure composed of a fibrous material, or a porous structure obtained by dispersing air bubbles in a resin, preferably various types of paper, nonwoven fabric, woven fabric, or knitted fabric, more preferably a nonwoven fabric.

[0069] <9> A method for disinfecting a body surface, comprising bringing a disinfectant composition into contact with the body surface, the composition containing (A) ethanol (hereinafter referred to as (A)) in an amount of 40% to 95% by mass, (B) one or more selected from gluconic acid and its alkali metal salts (hereinafter referred to as (B)) in an amount of 0.20% to 3.0% by mass, and (C) a water-soluble polyhydric alcohol (hereinafter referred to as (C)) in an amount of 0.10% to 2.0% by mass, with a pH of 5.0 or less at 25°C.

[0070] <10> The method for disinfecting a body surface according to <9>, wherein the disinfectant composition contains (D) an acid (except for component (B)).

[0071] <11> The method for disinfecting a body surface according to <9> or <10> above, wherein component (C) is one or more selected from water-soluble polyhydric alcohols with a molecular weight of 250 or less and polyethylene glycol with a weight-average molecular weight of 3,000 or more and 10,000 or less, preferably one or more selected from glycerin, diglycerin, ethylene glycol, propylene glycol, 1,3-propanediol, butylene glycol, erythritol, sorbitol and polyethylene glycol with a weight-average molecular weight of 3,000 or more and 10,000 or less, more preferably one or more selected from glycerin and polyethylene glycol, and even more preferably glycerin.

[0072] <12> The method for disinfecting a body surface according to <10> or <11> above, wherein component (D) is one or more selected from hydrochloric acid, sulfuric acid, phosphoric acid, and organic acids with a molecular weight of 250 or less, preferably one or more selected from hydrochloric acid, sulfuric acid, phosphoric acid, citric acid, succinic acid, malic acid, fumaric acid, adipic acid, tartaric acid, and lactic acid, more preferably one or more selected from hydrochloric acid, sulfuric acid, phosphoric acid, and citric acid, and even more preferably one or more selected from sulfuric acid and phosphoric acid.

[0073] <13> A method for disinfecting a body surface according to any one of <9> to <12> above, wherein the mass ratio (B) / (C) of the amount of component (B) to the amount of component (C) in the disinfectant composition is preferably 0.5 or more, more preferably 0.6 or more, even more preferably 0.7 or more, even more preferably 0.8 or more, even more preferably 1.0 or more, even more preferably 1.5 or more, even more preferably 2.0 or more, even more preferably 2.5 or more, and preferably 10 or less, more preferably 8.0 or less, even more preferably 6.0 or less, even more preferably 5.0 or less, and even more preferably 4.5 or less.

[0074] <14> A method for disinfecting a body surface according to any one of <9> to <13> above, wherein the body surface is skin, preferably fingers.

[0075] <15> A method for inactivating non-enveloped viruses, comprising contacting a disinfectant composition containing (A) ethanol [hereinafter referred to as component (A)] in an amount of 40% to 95% by mass, (B) one or more selected from gluconic acid and its alkali metal salts [hereinafter referred to as component (B)] in an amount of 0.20% to 3.0% by mass, and (C) a water-soluble polyhydric alcohol [hereinafter referred to as component (C)] in an amount of 0.10% to 2.0% by mass, with a pH of 5.0 or less at 25°C, with a target surface where non-enveloped viruses are present.

[0076] <16> The method for inactivating non-enveloped viruses according to <15>, wherein the disinfectant composition contains (D) an acid (excluding component (B), hereinafter referred to as component (D)).

[0077] <17> The method for inactivating non-enveloped viruses according to <15> or <16> above, wherein component (C) is one or more selected from water-soluble polyhydric alcohols with a molecular weight of 250 or less and polyethylene glycols with a weight-average molecular weight of 3,000 or more and 10,000 or less, preferably one or more selected from glycerin, diglycerin, ethylene glycol, propylene glycol, 1,3-propanediol, butylene glycol, erythritol, sorbitol and polyethylene glycols with a weight-average molecular weight of 3,000 or more and 10,000 or less, more preferably one or more selected from glycerin and polyethylene glycol, and even more preferably glycerin.

[0078] <18> The method for inactivating non-enveloped viruses according to <16> or <17> above, wherein component (D) is one or more selected from hydrochloric acid, sulfuric acid, phosphoric acid, and organic acids with a molecular weight of 250 or less, preferably one or more selected from hydrochloric acid, sulfuric acid, phosphoric acid, citric acid, succinic acid, malic acid, fumaric acid, adipic acid, tartaric acid, and lactic acid, more preferably one or more selected from hydrochloric acid, sulfuric acid, phosphoric acid, and citric acid, and even more preferably one or more selected from sulfuric acid and phosphoric acid.

[0079] <19> A method for inactivating non-enveloped viruses according to any one of <15> to <18>, wherein the mass ratio (B) / (C) of the content of component (B) to the content of component (C) in the disinfectant composition is preferably 0.5 or more, more preferably 0.6 or more, even more preferably 0.7 or more, even more preferably 0.8 or more, even more preferably 1.0 or more, even more preferably 1.5 or more, even more preferably 2.0 or more, even more preferably 2.5 or more, and preferably 10 or less, more preferably 8.0 or less, even more preferably 6.0 or less, even more preferably 5.0 or less, and even more preferably 4.5 or less.

[0080] <20> A method for inactivating non-enveloped viruses according to any one of <15> to <19>, comprising spraying or applying the disinfectant composition to a target surface.

[0081] <21> A method for inactivating non-enveloped viruses according to any one of <15> to <19>, wherein an impregnated article, in which a base material is impregnated with the disinfectant composition, is brought into contact with a target surface.

[0082] <22> A method for inactivating non-enveloped viruses according to any one of <15> to <21>, wherein the target surface is a body surface, a hard surface, or a food material surface, preferably a body surface.

[0083] <23> The method for inactivating a non-enveloped virus according to <22>, wherein the body surface is human skin or fingers, preferably fingers.

[0084] <24> A method for producing a disinfectant composition, comprising mixing (A) ethanol [hereinafter referred to as component (A)], (B) one or more selected from gluconic acid and its alkali metal salts [hereinafter referred to as component (B)], and (C) a water-soluble polyhydric alcohol [hereinafter referred to as component (C)], wherein the disinfectant composition contains 40% by mass or more and 95% by mass or less of component (A), 0.20% by mass or more and 3.0% by mass or less of component (B), and 0.10% by mass or more and 2.0% by mass or less of component (C), and having a pH of 5.0 or less at 25°C.

[0085] <25> A method for producing a disinfectant composition according to <24>, further comprising mixing (D) an acid agent [excluding component (B), hereinafter referred to as component (D)] with components (A), (B), and (C) to produce a disinfectant composition containing 0.01% by mass or more and 2.0% by mass or less of component (D).

[0086] <26> A method for producing the disinfectant composition according to <24> or <25>, wherein component (C) is one or more selected from water-soluble polyhydric alcohols with a molecular weight of 250 or less and polyethylene glycols with a weight-average molecular weight of 3,000 or more and 10,000 or less, preferably one or more selected from glycerin, diglycerin, ethylene glycol, propylene glycol, 1,3-propanediol, butylene glycol, erythritol, sorbitol and polyethylene glycols with a weight-average molecular weight of 3,000 or more and 10,000 or less, more preferably one or more selected from glycerin and polyethylene glycol, and even more preferably glycerin.

[0087] <27> A method for producing the disinfectant composition described in <25> or <26>, wherein component (D) is one or more selected from hydrochloric acid, sulfuric acid, phosphoric acid, and organic acids with a molecular weight of 250 or less, preferably one or more selected from hydrochloric acid, sulfuric acid, phosphoric acid, citric acid, succinic acid, malic acid, fumaric acid, adipic acid, tartaric acid, and lactic acid, more preferably one or more selected from hydrochloric acid, sulfuric acid, phosphoric acid, and citric acid, and even more preferably one or more selected from sulfuric acid and phosphoric acid.

[0088] <28> A method for producing a disinfectant composition according to any one of <25> to <27>, wherein water, component (B), component (C), and component (D) are mixed, and then component (A) is mixed.

[0089] <29> A method for producing a disinfectant composition according to any one of <24> to <28>, further comprising mixing (E) a skin protectant (hereinafter referred to as component (E)) with component (A), component (B), component (C) and an optional component (D), thereby producing a disinfectant composition containing component (E) in an amount of 0.01% by mass or more and 0.2% by mass or less.

[0090] <30> A method for producing the disinfectant composition described in <29>, comprising mixing water, component (B), component (C), and component (D), and then mixing with a solution in which component (E) and component (A) have been mixed beforehand.

[0091] Examples [Ingredients] The following ingredients were used to prepare the disinfectant composition shown in Table 1. <(A) Ingredients> Ethanol (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) <(B) Ingredients> Gluconic acid: Gluconic acid solution (50% aqueous solution) (manufactured by Fuso Chemical Industries, Ltd.) <(C) Ingredients> Glycerin: Concentrated glycerin (manufactured by Kao Corporation) Polyethylene glycol: Macrogol 6000 (weight average molecular weight 8600, manufactured by Sanyo Chemical Industries, Ltd.) <(D) Ingredients> Phosphoric acid: Phosphate (manufactured by Yoneyama Pharmaceutical Co., Ltd.) Sulfuric acid: 0.5 mol / L sulfuric acid (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) Citric acid (manufactured by Fuso Chemical Industries, Ltd.) Tartaric acid (manufactured by Fuso Chemical Industries, Ltd.)

[0092] [Method for preparing disinfectant compositions] According to the compositions shown in Table 1, each component was mixed at 25°C to obtain 800 g of the disinfectant compositions of Examples 1-1 to 1-6 and Comparative Examples 1-1 to 1-5. Note that all component content amounts in Table 1 are effective amounts.

[0093] [Method for Evaluating the Inactivation Effect of Feline Calicivirus] The virus inactivation test was conducted with reference to the "2015 Survey Report on Inactivation Conditions for Norovirus" (National Institute of Health Sciences) and ASTM E1052, which are generally known as standard methods for evaluating virus inactivation. 90 μL of each disinfectant composition and 1.5 × 10⁻⁶ of each disinfectant composition were used in Examples 1-1 to 1-6 and Comparative Examples 1-1 to 1-5. ９10 μL of feline calicivirus solution (F-9 strain, ATCC VR-782) adjusted to PFU / mL was placed in an Eppendorf tube and thoroughly mixed. After mixing at room temperature for 30 seconds, the reaction was stopped by diluting the solution 1 / 10 with a quenching solution (SCDLP solution). As a blank, the same procedure was performed using 90 μL of distilled water instead of 90 μL of the disinfectant composition. After stopping the reaction, the mixture was further serially diluted at 10-fold intervals in HEPES-containing (hydroxyethylpiperazine ethanesulfonic acid-containing) DMEM medium (Dulbecc's modified Eagle medium). 0.5 mL of this solution was used to infect CRFK cells (feline kidney-derived cell line) (ATCC CCL-94) washed with PBS (phosphate-buffered saline), and after 1 hour, the medium was replaced with methylcellulose-containing medium. Two days later, the cells in each sample taken at a predetermined time were stained with crystal violet, the number of plaques was counted, and the logarithmic difference between the number of plaques in the sample and the blank sample was calculated as the logarithmic reduction value and evaluated according to the following criteria: A: Logarithmic reduction value of 4 or more B: Logarithmic reduction value of 3 or more but less than 4 C: Logarithmic reduction value of 2 or more but less than 3 D: Logarithmic reduction value less than 2

[0094] [Method for Evaluating the Hand-Drying Prevention Effect] Ten panelists sprayed 3 mL of each hand sanitizer composition onto their hands, applied it to both hands, and allowed it to air dry. This procedure was repeated 10 times at 5-minute intervals. Skin irritation and the condition of the hands were observed until the next day, and the hand-drying prevention effect was evaluated as follows: no skin irritation or dryness was good, and the presence of skin irritation or dryness was bad.

[0095] Each panelist's evaluation was based on the following criteria: 5: Excellent, 4: Good, 3: Neutral, 2: Not very good, 1: Poor.

[0096] Table 1 shows the average evaluation results from 10 participants regarding the effect of suppressing rough hands.

[0097]

[0098] As shown in Table 1, the disinfectant compositions of Examples 1-1 to 1-6, which correspond to the present invention, had a sufficient effect in inactivating feline calicivirus and also had an effect in suppressing skin irritation. On the other hand, Comparative Example 1-1, which did not contain water-soluble polyhydric alcohol, and Comparative Examples 1-2 to 1-4, which did not contain gluconic acid, did not have a sufficient effect in suppressing skin irritation. Furthermore, Comparative Example 1-5, which contained gluconic acid and water-soluble polyhydric alcohol but had a pH greater than 5, did not have a sufficient effect inactivating feline calicivirus. Other examples include compositions in which each of the disinfectant compositions of the Examples in Table 1 further contains glycyrrhetinic acid as a skin protectant, a known fatty acid triglyceride as an emollient, hydroxypropyl cellulose as a thickener, and one, two, three, or four components selected from fragrances, each in an amount of 0.01% to 0.2% by mass, and these are also products of the present invention.

Claims

1. A disinfectant composition containing (A) ethanol (hereinafter referred to as component (A)) in an amount of 40% to 95% by mass, (B) one or more selected from gluconic acid and its alkali metal salts (hereinafter referred to as component (B)) in an amount of 0.20% to 3.0% by mass, and (C) a water-soluble polyhydric alcohol (hereinafter referred to as component (C)) in an amount of 0.10% to 2.0% by mass, wherein the pH is 5.0 or less at 25°C.

2. The disinfectant composition according to claim 1, wherein the mass ratio (B) / (C) of the content of component (B) to the content of component (C) is 0.5 or more and 10 or less.

3. The disinfectant composition according to claim 1 or 2, further comprising (D) an acidifying agent [excluding component (B), hereinafter referred to as component (D)].

4. The disinfectant composition according to any one of claims 1 to 3, wherein component (C) is glycerin.

5. The disinfectant composition according to claim 3 or 4, wherein component (D) is one or more selected from sulfuric acid and phosphoric acid.

6. A disinfectant composition according to any one of claims 1 to 5, for use on the surface of the body.

7. A disinfectant composition-impregnated article in which a disinfectant composition according to any one of claims 1 to 6 is impregnated into a substrate.

8. A method for disinfecting a body surface, comprising bringing a disinfectant composition into contact with the body surface, the composition containing (A) ethanol (hereinafter referred to as (A)) in an amount of 40% to 95% by mass, (B) one or more selected from gluconic acid and its alkali metal salts (hereinafter referred to as (B)) in an amount of 0.20% to 3.0% by mass, and (C) a water-soluble polyhydric alcohol (hereinafter referred to as (C)) in an amount of 0.10% to 2.0% by mass, with a pH of 5.0 or less at 25°C.

9. The method for disinfecting a body surface according to claim 8, wherein the disinfectant composition further contains (D) an acid (excluding component (B), hereinafter referred to as component (D)).

10. The method for disinfecting a body surface according to claim 8 or 9, wherein component (C) is glycerin.

11. The method for disinfecting a body surface according to claim 9 or 10, wherein component (D) is one or more selected from sulfuric acid and phosphoric acid.

12. A method for disinfecting a body surface according to any one of claims 8 to 11, wherein the body surface is the fingers.

13. A method for inactivating non-enveloped viruses, comprising contacting a disinfectant composition containing (A) ethanol (hereinafter referred to as (A)) in an amount of 40% to 95% by mass, (B) one or more selected from gluconic acid and its alkali metal salts (hereinafter referred to as (B)) in an amount of 0.20% to 3.0% by mass, and (C) a water-soluble polyhydric alcohol (hereinafter referred to as (C)) in an amount of 0.10% to 2.0% by mass, with a pH of 5.0 or less at 25°C, with a target surface where non-enveloped viruses are present.

14. The method for inactivating a non-enveloped virus according to claim 13, wherein the disinfectant composition further contains (D) an acid (excluding component (B), hereinafter referred to as component (D)).

15. The method for inactivating a non-enveloped virus according to claim 13 or 14, wherein component (C) is glycerin.

16. The method for inactivating a non-enveloped virus according to claim 14 or 15, wherein component (D) is one or more selected from sulfuric acid and phosphoric acid.

17. The method for inactivating a non-enveloped virus according to any one of claims 13 to 16, wherein the target surface is a body surface.

18. The method for inactivating a non-enveloped virus according to claim 17, wherein the body surface is the fingers.

19. A method for inactivating a non-enveloped virus according to any one of claims 13 to 18, comprising spraying or applying the disinfectant composition to a target surface.

20. A method for inactivating a non-enveloped virus according to any one of claims 13 to 19, wherein a disinfectant composition-impregnated article, in which the disinfectant composition is impregnated into a substrate, is brought into contact with a target surface.

Images