Full-automatic magnetic solid-phase extraction device for veterinary drug residues

Abstract

The utility model discloses a full-automatic magnetic solid-phase extraction device for veterinary drug residues, which belongs to the field of veterinary drug residue separation devices and comprises a base, a container rotatably mounted at the upper end of the base, a magnet arranged at the upper end of the base and sleeved outside the container, a liquid inlet arranged at the top of the container, and a liquid discharge pipe communicated and fixedly mounted at the bottom of the container. A sealing plug is arranged in the liquid discharging pipe, a hole channel is formed in the sealing plug, an electric telescopic rod is fixedly installed on the machine base, the output end of the electric telescopic rod is fixedly connected with the sealing plug, and a liquid discharging opening is formed in the machine base. In the separation process of the magnetic nanoparticles (containing target veterinary drugs) and the solution, the container is driven by the servo motor to rotate, and the magnetic nanoparticles in the solution move towards the inner wall of the container under the action of centrifugal force, so that the magnetic nanoparticles are relatively completely adsorbed on the inner wall of the container; and the situation that the magnetic nanoparticles in the center of the container cannot be completely separated and adsorbed on the inner wall of the container due to insufficient adsorption force is avoided.

Description

Technical Field

[0001] This utility model relates to the technical field of veterinary drug residue separation devices, and in particular to a fully automatic magnetic solid phase extraction device for veterinary drug residues. Background Technology

[0002] The fully automated magnetic solid-phase extraction (MSPE) device for veterinary drug residues is a sample pretreatment device based on the combination of magnetic nanomaterials and automation technology. It is specifically designed for the rapid separation, enrichment, and purification of trace veterinary drug residues in complex matrices (such as food, environmental water samples, and animal tissues). Its core principle is the selective capture of target analytes by magnetic adsorbents, combined with an automated process to achieve efficient and precise pretreatment. This provides high-purity samples for subsequent detection (such as LC-MS / MS), significantly improving detection sensitivity and accuracy.

[0003] In existing magnetic solid-phase extraction devices for veterinary drug residues, the solution flows through a magnet, and the magnetic nanoparticles in the magnet adsorb onto the veterinary drug molecules in the sample. The magnetic nanoparticles (in the form of iron powder) are then adsorbed by the magnet. However, due to the gap between the magnetic nanoparticles in the inner layer of the solution and the magnet, the magnet's adsorption force on the magnetic nanoparticles is insufficient, and the magnetic nanoparticles in the inner layer of the solution cannot be completely adsorbed. To solve the above problems, we propose a fully automated magnetic solid-phase extraction device for veterinary drug residues. Utility Model Content

[0004] The purpose of this invention is to solve the problem that the magnetic nanoparticles in the inner layer of the solution cannot be completely adsorbed by the magnet in the existing magnetic solid phase extraction device for veterinary drug residues, and to propose a fully automatic magnetic solid phase extraction device for veterinary drug residues.

[0005] To achieve the above objectives, the present invention adopts the following technical solution:

[0006] An automated magnetic solid-phase extraction device for veterinary drug residues includes a base, a container rotatably mounted on the upper end of the base, a magnet placed on the upper end of the base and fitted over the container, a liquid inlet at the top of the container, a drain pipe connected to and fixedly installed at the bottom of the container, a sealing plug inside the drain pipe with a channel, an electric telescopic rod fixedly mounted on the base, the output end of the electric telescopic rod being fixedly connected to the sealing plug, and a drain port on the base.

[0007] A drive mechanism is installed on the base. The drive mechanism is connected to the drain pipe and is used to drive the container to rotate. A flow guide is provided on the outer sleeve of the electric telescopic rod. The flow guide is fixedly installed on the base and has a conical shape at its upper end.

[0008] Preferably, each of the bases is fixedly connected to a shock-absorbing pad.

[0009] Preferably, the drive mechanism includes a first gear ring fitted on the drain pipe, the first gear ring being fixedly connected to the drain pipe, a servo motor being fixedly mounted on the base, and a drive wheel being fixedly mounted on the output shaft end of the servo motor, the drive wheel meshing with the first gear ring.

[0010] Preferably, a rotating shaft is rotatably mounted on the container, the lower end of the rotating shaft extends into the container and is hollow inside, multiple stirring plates are fixedly mounted on the outside of the rotating shaft, a slidable movable plate is inserted into the stirring plate, an elastic element is fixedly connected between the movable plate and the stirring plate, a connecting rod is fixedly mounted on the movable plate, one end of the connecting rod is inserted into the rotating shaft, a vertical rod passes through the rotating shaft, the upper end of the vertical rod is threaded to the rotating shaft, and multiple cones are provided inside the rotating shaft, the cones are fixedly connected to the vertical rod.

[0011] Preferably, the rotating shaft is fitted with and fixedly connected to multiple agitator blades.

[0012] Preferably, a second gear ring is fixedly connected to the upper end of the rotating shaft, a stepper motor is fixedly installed on the top of the container, and a gear is fixedly installed on the output shaft end of the stepper motor, the gear meshing with the second gear ring.

[0013] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0014] During the separation process of magnetic nanoparticles (containing the target veterinary drug) from the solution, a servo motor drives the drive wheel to rotate, which in turn drives the first gear ring to rotate. The first gear ring, the drain pipe, and the container rotate synchronously. Under the action of centrifugal force, the magnetic nanoparticles in the solution move towards the inner wall of the container, thereby allowing the magnetic nanoparticles to be more completely adsorbed onto the inner wall of the container. This avoids the magnetic nanoparticles in the central part of the container from being unable to be completely separated and adsorbed onto the inner wall of the container due to insufficient adsorption force.

[0015] The stepper motor drives the gears to rotate, and the stirring plate and movable plate on the rotating shaft rotate synchronously. The stirring blades also rotate synchronously, thereby mixing the solution in the container. The solution can be mixed in multiple directions, both horizontally and vertically, so that the magnetic nanoparticles in the solution can fully contact the veterinary drug molecules in the sample, and the magnetic nanoparticles and veterinary drug molecules can be more completely adsorbed. Attached Figure Description

[0016] Figure 1 This is a three-dimensional structural diagram of a fully automated magnetic solid-phase extraction device for veterinary drug residues proposed in this utility model;

[0017] Figure 2 This is a cross-sectional view of the base and magnet in a fully automated magnetic solid phase extraction device for veterinary drug residues proposed in this utility model.

[0018] Figure 3 This is a cross-sectional view of the container in a fully automated magnetic solid-phase extraction device for veterinary drug residues proposed in this utility model.

[0019] Figure 4 This is a magnified schematic diagram of a portion of the structure of the drain pipe in a fully automated magnetic solid phase extraction device for veterinary drug residues proposed in this utility model.

[0020] Figure 5 This is an enlarged cross-sectional view of a portion of the structure of the container and the flow guide hood in a fully automated magnetic solid phase extraction device for veterinary drug residues proposed in this utility model.

[0021] Figure 6 This utility model proposes a fully automated magnetic solid-phase extraction device for veterinary drug residues. Figure 5 Enlarged diagram of point A in the diagram.

[0022] In the diagram: 1. Base; 2. Container; 3. Magnet; 4. Inlet; 5. Drain pipe; 6. Sealing plug; 7. Channel; 8. Electric telescopic rod; 9. Drain port; 10. Flow guide; 11. First gear ring; 12. Servo motor; 13. Drive wheel; 14. Shaft; 15. Stirring plate; 16. Movable plate; 17. Elastic element; 18. Connecting rod; 19. Vertical rod; 20. Cone; 21. Stirring blade; 22. Second gear ring; 23. Stepper motor; 24. Gear. Detailed Implementation

[0023] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present utility model without creative effort are within the protection scope of the present utility model.

[0024] Example 1

[0025] Reference Figure 1-6 An automated magnetic solid-phase extraction device for veterinary drug residues includes a base 1, a container 2 rotatably mounted on the upper end of the base 1, a magnet 3 placed on the upper end of the base 1 and sleeved around the container 2, an inlet 4 at the top of the container 2, a drain pipe 5 connected to and fixedly installed at the bottom of the container 2, a sealing plug 6 inside the drain pipe 5, a channel 7 on the sealing plug 6, an electric telescopic rod 8 fixedly mounted on the base 1, the output end of the electric telescopic rod 8 being fixedly connected to the sealing plug 6, and a drain port 9 on the base 1.

[0026] A drive mechanism is installed on the base 1. The drive mechanism is connected to the drain pipe 5 and is used to drive the container 2 to rotate. The electric telescopic rod 8 is covered with a flow guide 10. The flow guide 10 is fixedly installed on the base 1 and has a conical shape at the upper end.

[0027] The drive mechanism includes a first gear ring 11 fitted onto the drain pipe 5, which is fixedly connected to the drain pipe 5. A servo motor 12 is fixedly mounted on the base 1, and a drive wheel 13 is fixedly mounted on the output shaft end of the servo motor 12. The drive wheel 13 meshes with the first gear ring 11. Shock-absorbing pads are fixedly connected to the bottom of the base 1 to reduce vibrations generated during device operation.

[0028] By adding the solution into container 2 through inlet 4, the magnetic nanoparticles in the solution adsorb the veterinary drug molecules in the solution. By placing magnet 3 outside container 2, the external magnetic field generated by magnet 3 "pulls" the magnetic nanoparticles (containing the target veterinary drug) out of the solution. The magnetic nanoparticles (containing the target veterinary drug) accumulate on the inner wall of container 2, which can achieve the separation of magnetic nanoparticles (containing the target veterinary drug) from the solution (containing impurities).

[0029] During the separation process of magnetic nanoparticles (containing the target veterinary drug) from the solution, the servo motor 12 drives the drive wheel 13 to rotate, and the drive wheel 13 drives the first gear ring 11 to rotate. The first gear ring 11, the drain pipe 5 and the container 2 rotate synchronously. Under the action of centrifugal force, the magnetic nanoparticles (containing the target veterinary drug) in the solution move towards the inner wall of the container 2, so that the magnetic nanoparticles (containing the target veterinary drug) are more completely adsorbed on the inner wall of the container 2. This avoids the magnetic nanoparticles in the central part of the container 2 from being unable to be completely separated and adsorbed on the inner wall of the container 2 due to insufficient adsorption force.

[0030] After separation, the sealing plug 6 is moved upward by the electric telescopic rod 8, and the upper port of the channel 7 is connected to the container 2. The liquid (including impurities) in the container 2 can flow out through the channel 7 and fall onto the guide cover 10. Finally, it is discharged from the drain port 9 and collected by the external collection device.

[0031] Next, magnet 3 is removed, and cleaning solution is added to container 2. The cleaning solution rinses the magnetic nanoparticles (containing the target veterinary drug) in container 2 and carries them out with it. The device automatically and rapidly separates the magnetic adsorbent (containing the target veterinary drug) from the solution using an external magnetic field, avoiding the cumbersome operations of traditional centrifugation or filtration.

[0032] Based on Example 1, Example 2:

[0033] Reference Figure 2-6A rotating shaft 14 is rotatably mounted on container 2. The lower end of the rotating shaft 14 extends into container 2 and is hollow inside. Multiple stirring plates 15 are fixedly mounted on the outside of the rotating shaft 14. A sliding movable plate 16 is inserted into the stirring plate 15. An elastic element 17 is fixedly connected between the movable plate 16 and the stirring plate 15. A connecting rod 18 is fixedly mounted on the movable plate 16. One end of the connecting rod 18 is inserted into the rotating shaft 14. A vertical rod 19 passes through the rotating shaft 14. The upper end of the vertical rod 19 is threaded to the rotating shaft 14. Multiple cones 20 are provided inside the rotating shaft 14. The cones 20 are fixedly connected to the vertical rod 19.

[0034] The rotating shaft 14 is fitted with and fixedly connected to multiple agitator blades 21. A second gear ring 22 is fixedly connected to the upper end of the rotating shaft 14. A stepper motor 23 is fixedly mounted on the top of the container 2. A gear 24 is fixedly mounted on the output shaft end of the stepper motor 23, and the gear 24 meshes with the second gear ring 22. The stepper motor 23 is powered by a battery, and the battery is fixedly mounted on the top of the container 2.

[0035] When the unseparated solution is added into container 2, the stepper motor 23 drives the gear 24 to rotate, the gear 24 drives the second gear ring 22 to rotate, which in turn drives the rotating shaft 14 to rotate. The stirring plate 15 and the movable plate 16 on the rotating shaft 14 rotate synchronously, and the stirring blade 21 also rotates synchronously, thereby mixing the solution in container 2. The solution can be mixed in multiple directions, both horizontally and vertically, so that the magnetic nanoparticles (with "hooks" on their surface) in the solution can fully contact the veterinary drug molecules in the sample, and the magnetic nanoparticles and veterinary drug molecules can be more completely adsorbed.

[0036] When removing magnet 3 and rinsing the magnetic nanoparticles (containing the target veterinary drug) in container 2, rotate vertical rod 19 and move it down. The cone 20 on vertical rod 19 moves down and pushes the end of connecting rod 18, causing the end of movable plate 16 to move toward the inner wall of container 2 until the end of movable plate 16 contacts the inner wall of container 2. Then rotate shaft 14 to drive movable plate 16 to rotate. The end of movable plate 16 can remove the magnetic nanoparticles remaining on the inner wall of container 2.

[0037] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.

Claims

1. A fully automated magnetic solid-phase extraction device for veterinary drug residues, comprising a base (1), characterized in that, A container (2) is rotatably mounted on the upper end of the base (1). A magnet (3) is placed on the upper end of the base (1). The magnet (3) is sleeved on the outside of the container (2). An inlet (4) is opened on the top of the container (2). A drain pipe (5) is connected to and fixedly installed on the bottom of the container (2). A sealing plug (6) is provided inside the drain pipe (5). A channel (7) is opened on the sealing plug (6). An electric telescopic rod (8) is fixedly installed on the base (1). The output end of the electric telescopic rod (8) is fixedly connected to the sealing plug (6). A drain port (9) is opened on the base (1). A drive mechanism is installed on the base (1). The drive mechanism is connected to the drain pipe (5) and is used to drive the container (2) to rotate. The electric telescopic rod (8) is covered with a flow guide (10). The flow guide (10) is fixedly installed on the base (1) and has a conical shape at the upper end.

2. The fully automated magnetic solid-phase extraction device for veterinary drug residues according to claim 1, characterized in that, The bottom of each base (1) is fixedly connected with a shock-absorbing pad.

3. The fully automated magnetic solid-phase extraction device for veterinary drug residues according to claim 1, characterized in that, The drive mechanism includes a first gear ring (11) fitted on the drain pipe (5), the first gear ring (11) being fixedly connected to the drain pipe (5), a servo motor (12) being fixedly installed on the base (1), and a drive wheel (13) being fixedly installed at the output shaft end of the servo motor (12), the drive wheel (13) meshing with the first gear ring (11).

4. The fully automated magnetic solid-phase extraction device for veterinary drug residues according to claim 1, characterized in that, A rotating shaft (14) is rotatably mounted on the container (2). The lower end of the rotating shaft (14) extends into the container (2) and is hollow inside. Multiple stirring plates (15) are fixedly mounted on the outside of the rotating shaft (14). A sliding movable plate (16) is inserted into the stirring plate (15). An elastic element (17) is fixedly connected between the movable plate (16) and the stirring plate (15). A connecting rod (18) is fixedly mounted on the movable plate (16). One end of the connecting rod (18) is inserted into the rotating shaft (14). A vertical rod (19) passes through the rotating shaft (14). The upper end of the vertical rod (19) is threadedly connected to the rotating shaft (14). Multiple cones (20) are provided inside the rotating shaft (14). The cones (20) are fixedly connected to the vertical rod (19).

5. The fully automated magnetic solid-phase extraction device for veterinary drug residues according to claim 4, characterized in that, The rotating shaft (14) is fitted with and fixedly connected to multiple stirring blades (21).

6. The fully automated magnetic solid-phase extraction device for veterinary drug residues according to claim 4, characterized in that, The upper end of the rotating shaft (14) is fixedly connected to a second gear ring (22), and a stepper motor (23) is fixedly installed on the top of the container (2). A gear (24) is fixedly installed on the output shaft end of the stepper motor (23), and the gear (24) meshes with the second gear ring (22).

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