Connecting piece and leukocyte-depleted filter composed of same

Abstract

The utility model discloses a connecting piece and a leukocyte-depleted filter composed of the same, and belongs to the technical field of blood separation. The connecting piece comprises a filter connecting pipe and a pipeline connecting pipe which are coaxially connected, the circumferential surface of the filter connecting pipe is an inclined surface, and a threaded area is arranged on the circumferential surface of the filter connecting pipe. The leukocyte-depleting filter comprises a filter body 201 and the connecting piece. Threaded areas are arranged on the inner walls of interfaces at the liquid inlet end and the liquid outlet end of the filter body, the inner walls of the interfaces are inclined planes, and the filter connecting pipe of the connecting piece is inserted into the interfaces and is in threaded connection with the interfaces. According to the application, the leukocyte-depleting filter made of the PP material is connected with the pipeline made of the PVC material through the connecting piece made of the polycarbonate material, and transition is performed through the connecting piece, so that the joint of the connecting piece and the leukocyte-depleting filter as well as the joint of the connecting piece and the pipeline are relatively stable in the damp-heat sterilization process, the phenomenon of separation is avoided, and the yield is increased.

Description

A connector and a leukocyte removal filter composed therefrom Technical Field

[0001] This application belongs to the field of blood separation technology, specifically relating to a connector and a leukocyte-removing filter composed therefrom. Background Technology

[0002] In the field of blood component separation technology, leukocyte-removing filters are one of the key devices for ensuring clinical transfusion safety. These filters effectively remove leukocytes from whole blood or blood components through physical interception or adsorption mechanisms, reducing the risk of transfusion-related immune reactions. Currently, the core filtration material of leukocyte-removing filters is mostly polypropylene (PP), which has advantages including high chemical stability, good biocompatibility, and the ability to form a uniform microporous structure through precision injection molding, meeting the accuracy requirements for leukocyte retention.

[0003] The inlet and outlet of the filter need to be connected to external tubing to create a closed blood transport channel. Due to cost and ease of processing considerations, such tubing is typically made of polyvinyl chloride (PVC). PVC is highly flexible and has strong compressive strength, allowing it to withstand repeated bending and pressure changes during clinical procedures. However, PP and PVC are different types of thermoplastic polymers with significant differences in molecular polarity, making direct fusion welding difficult. Therefore, current technologies mostly use adhesives to achieve interfacial bonding between the two.

[0004] In the medical device manufacturing process, moist heat sterilization is a necessary step to ensure product sterility, typically requiring maintenance at 120°C in a saturated steam environment for 20-30 minutes. However, PP and PVC have significantly different coefficients of thermal expansion, making them prone to stress concentration at the interface under moist heat conditions. Furthermore, the adhesives themselves have insufficient resistance to moist heat; prolonged exposure to high temperature and humidity can lead to molecular chain breakage or interfacial debonding. In actual production, it has been found that approximately 15%-20% of filter-pipeline connections experience sealing failure after sterilization, manifesting as leakage or complete separation at the interface, potentially leading to blood contamination or equipment malfunction.

[0005] For example, the patent for a series-connected leukocyte removal filter disclosed in the authorization announcement number CN203208428U shows that after the inlet and outlet of the leukocyte removal filter are directly connected to the PVC pipe by adhesive, the connection point between the two will separate during the moist heat sterilization process, reducing the yield. Summary of the Invention

[0006] The technical problem to be solved by this application is to overcome the shortcomings of the prior art and provide a connector and a leukocyte removal filter composed therefrom. This application uses a polycarbonate (PC) connector to connect a PP leukocyte removal filter to a PVC pipeline. The connector facilitates the transition, and during the moist heat sterilization process, the connection between the connector and the leukocyte removal filter, as well as the connection between the connector and the pipeline, remains relatively stable and will not separate, thereby improving the yield.

[0007] The technical solution adopted by this application to solve its existing problems is:

[0008] A connector includes a filter connecting pipe and a pipeline connecting pipe that are coaxially connected. The circumferential surface of the filter connecting pipe is inclined, and the circumferential surface of the filter connecting pipe is provided with a threaded area.

[0009] Preferably, the filter connecting pipe and the pipeline connecting pipe have the same inner diameter.

[0010] Preferably, an upper abutment seat is provided between the filter connecting pipe and the pipeline connecting pipe.

[0011] Preferably, the outer diameter of the upper abutment seat is larger than the outer diameter of the large end of the filter connecting pipe and the outer diameter of the pipeline connecting pipe.

[0012] A leukocyte-removing filter includes a filter body 201 and a connector as described above. The inner wall of the inlet and outlet interfaces of the filter body is provided with a threaded area and the inner wall of the interface is inclined. The filter connecting tube of the connector is inserted into the interface and is threadedly connected to the interface.

[0013] Preferably, the interface has an annular lower abutment seat inside, and the bottom of the filter connecting pipe abuts against the top surface of the lower abutment seat.

[0014] Preferably, the end face of the upper abutment seat opposite to the interface is recessed with a sleeve groove, and the sleeve groove is fitted outside the interface.

[0015] Preferably, the inner diameter of the socket groove is the same as the outer diameter of the interface.

[0016] Preferably, the end face of the upper abutment seat opposite to the interface is provided with a plurality of coaxially arranged protruding rings;

[0017] The interface end face is recessed with several coaxially arranged grooves, and the convex ring is inserted into the grooves.

[0018] Compared with the prior art, the beneficial effects of this application are as follows:

[0019] (1) Transitional connection is made by using PC material connectors. Taking advantage of the fact that PC material has less deformation after high-temperature sterilization than PP material, the connection between the two will not break during the moist heat sterilization process, thereby improving the yield.

[0020] (2) The mating surface of the filter connecting pipe and the interface is frustum-shaped and threaded, which ensures the strength and airtightness after the adhesive is cured. Attached Figure Description

[0021] The present application will be further described below with reference to the accompanying drawings and embodiments.

[0022] Figure 1 is a first structural diagram of a connector according to this application.

[0023] Figure 2 is a second structural diagram of a connector according to this application.

[0024] Figure 3 is a third structural diagram of a connector according to this application.

[0025] Figure 4 is a structural diagram of the leukocyte removal filter of this application.

[0026] Figure 5 is a cross-sectional view of the first structure of the leukocyte removal filter of this application.

[0027] Figure 6 is a magnified view of part A in Figure 5.

[0028] Figure 7 is a cross-sectional view of the second structure of the leukocyte removal filter of this application.

[0029] Figure 8 is a magnified view of part B in Figure 7.

[0030] Figure 9 is a cross-sectional view of the third structure of the leukocyte removal filter of this application.

[0031] Figure 10 is a magnified view of part C in Figure 9.

[0032] In the diagram: 101-Filter connecting pipe, 102-Upper abutment seat, 1021-Socket groove, 1022-Protruding ring, 103-Pipe connecting pipe, 201-Filter body, 202-Interface, 2021-Disc surface, 2022-Groove, 203-Lower abutment seat. Detailed Implementation

[0033] The attached figure shows a preferred embodiment of the connector and the leukocyte removal filter composed therefrom. The present application will be further described in detail below with reference to the attached figure.

[0034] As shown in Figure 1, a connector is integrally formed from PC material. It includes a filter connecting pipe 101 and a pipeline connecting pipe 103 connected coaxially. The circumferential surface of the filter connecting pipe 101 is inclined, that is, the axial cross-sectional shape of the filter connecting pipe 101 is a frustum shape with a smaller bottom and a larger top. The circumferential surface of the filter connecting pipe 101 is provided with a threaded area.

[0035] To reduce frictional resistance, the filter connecting pipe 101 has the same inner diameter as the pipeline connecting pipe 103.

[0036] To optimize the sealing effect after connection with the leukocyte removal filter, an upper abutment 102 is provided between the filter connecting pipe 101 and the pipeline connecting pipe 103. The outer diameter of the upper abutment 102 is larger than the outer diameter of the large end of the filter connecting pipe 101 and the outer diameter of the pipeline connecting pipe 103.

[0037] A leukocyte removal filter, comprising a filter body 201 and the aforementioned connector, has several different structural forms:

[0038] The first structural form of the leukocyte-removing filter:

[0039] As shown in Figures 4 to 6, the inner wall of the interface 202 at the liquid inlet and liquid outlet ends of the filter body 201 is provided with a threaded area, the inner wall of the interface 202 is inclined, and the filter connecting pipe 101 of the connector is inserted into the interface 202 and the filter connecting pipe 101 is threadedly connected to the interface 202.

[0040] The second type of leukocyte-removing filter structure:

[0041] As shown in Figures 2, 7 and 8, the inner wall of the interface 202 at the liquid inlet and liquid outlet ends of the filter body 201 is provided with a threaded area, the inner wall of the interface 202 is inclined, and the filter connecting pipe 101 of the connector is inserted into the interface 202 and is threadedly connected to the interface 202.

[0042] The upper abutment 102 has a recessed sleeve groove 1021 on its end face opposite to the interface 202, and the sleeve groove 1021 is fitted onto the outside of the interface 202. The inner diameter of the sleeve groove 1021 is the same as the outer diameter of the interface 202. The sleeve groove 1021 increases the contact area between the upper abutment 102 and the interface 202, thereby improving the sealing effect.

[0043] The third type of leukocyte-removing filter structure:

[0044] As shown in Figures 3, 9 and 10, the inner wall of the interface 202 at the liquid inlet and liquid outlet ends of the filter body 201 is provided with a threaded area, the inner wall of the interface 202 is inclined, and the filter connecting pipe 101 of the connector is inserted into the interface 202 and is threadedly connected to the interface 202.

[0045] The upper abutment 102 has a plurality of coaxially arranged protruding rings 1022 on its end face opposite to the interface 202; the interface 202 has a plurality of coaxially arranged grooves 2022 recessed on its end face, and the protruding rings 1022 are inserted into the grooves 2022.

[0046] Each concave ring 1022 and each groove 2022 form a labyrinth seal, which improves the sealing effect by increasing the friction resistance.

[0047] Based on the above three structural forms of leukocyte removal filters, the interface 202 is provided with an annular lower abutment seat 203 inside, and the bottom of the filter connecting pipe 101 abuts against the top surface of the lower abutment seat 203, further optimizing the sealing effect after the two are connected.

[0048] The embodiments of this application have been described in detail above with reference to the accompanying drawings. However, this application is not limited to the above embodiments. Within the scope of knowledge possessed by those skilled in the art, various changes can be made without departing from the spirit of this application.

Claims

1. A connector, characterized in that: It includes a filter connecting pipe (101) and a pipeline connecting pipe (103) connected coaxially. The circumferential surface of the filter connecting pipe (101) is inclined, and the circumferential surface of the filter connecting pipe (101) is provided with a threaded area.

2. A connector according to claim 1, characterized in that: The filter connecting pipe (101) has the same inner diameter as the pipeline connecting pipe (103).

3. A connector according to claim 1 or 2, characterized in that: An upper abutment seat (102) is provided between the filter connecting pipe (101) and the pipeline connecting pipe (103).

4. A connector according to claim 3, characterized in that: The outer diameter of the upper abutment seat (102) is larger than the outer diameter of the large end of the filter connecting pipe (101) and the outer diameter of the pipeline connecting pipe (103).

5. A leukocyte-removing filter, comprising a filter body (201) and a connector as described in claim 4, characterized in that: The inner wall of the interface (202) at the liquid inlet and liquid outlet of the filter body (201) is provided with a threaded area. The inner wall of the interface (202) is inclined. The filter connecting pipe (101) of the connector is inserted into the interface (202) and the filter connecting pipe (101) is threadedly connected to the interface (202).

6. A leukocyte-removing filter according to claim 5, characterized in that: The interface (202) is provided with an annular lower abutment seat (203) inside, and the bottom of the filter connecting pipe (101) abuts against the top surface of the lower abutment seat (203).

7. A leukocyte-removing filter according to claim 5 or 6, characterized in that: The upper abutment (102) has a recessed sleeve groove (1021) on the end face opposite to the interface (202), and the sleeve groove (1021) is sleeved on the outside of the interface (202).

8. A leukocyte-removing filter according to claim 7, characterized in that: The inner diameter of the socket groove (1021) is the same as the outer diameter of the interface (202).

9. A leukocyte-removing filter according to claim 5 or 6, characterized in that: The upper abutment (102) and the interface (202) have several coaxially arranged protruding rings (1022) on their opposite end faces; the interface (202) has several coaxially arranged grooves (2022) recessed on its end face, and the protruding rings (1022) are inserted into the grooves (2022).

Images